Could a simple gas help heal the brain after injury?
NCT ID NCT05616910
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether inhaling nitric oxide gas can improve blood flow in the brain after a traumatic brain injury (TBI). The trial enrolls adults aged 18 to 75 with moderate TBI or mild TBI with abnormal scans. Participants receive either inhaled nitric oxide or standard care for 4 hours daily, and researchers measure brain metabolism, blood markers, and recovery over 6 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
inhaled nitric oxide
What this could lead to
If it works, this could point toward a new treatment to improve recovery after traumatic brain injury by restoring blood flow to the brain.
What could go wrong
This is a small early-phase trial, so results may not apply to all TBI patients. Risks include methemoglobinemia, low blood pressure, or neurological worsening.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, 19104, United States