Could a simple gas help heal the brain after injury?
NCT ID NCT05616910
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether inhaling nitric oxide gas can improve blood flow in the brain after a traumatic brain injury (TBI). The trial enrolls adults aged 18 to 75 with moderate TBI or mild TBI with abnormal scans. Participants receive either inhaled nitric oxide or standard care for 4 hours daily, and researchers measure brain metabolism, blood markers, and recovery over 6 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- inhaled nitric oxide
- What this could lead to
- If it works, this could point toward a new treatment to improve recovery after traumatic brain injury by restoring blood flow to the brain.
- What could go wrong
- This is a small early-phase trial, so results may not apply to all TBI patients. Risks include methemoglobinemia, low blood pressure, or neurological worsening.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, 19104, United States
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