TRAUMATIC BRAIN INJURY

This study tests whether a special egg yolk powder called Salovum can help people with severe traumatic brain injury. About 20 participants will receive either Salovum or a placebo powder alongside standard care. Researchers will measure brain pressure, oxygen levels, and inflamm…

This study looks at two medicines, levetiracetam and lacosamide, to see which one is better at preventing seizures in people who have had a traumatic brain injury. Researchers will also check which drug causes fewer side effects like agitation or behavior changes. The study will …

This study tests whether baricitinib, a drug used for arthritis, can help people recover from moderate to severe traumatic brain injuries that involve bleeding. About 100 adults aged 18-79 will receive the drug or a placebo within 24 hours of injury. The main goal is to see if it…

This study tests whether sildenafil (the drug in Viagra) can improve blood flow in the brains of people who had a traumatic brain injury (TBI) at least 6 months ago. Researchers will give 160 adults different doses to find the safest and most effective one. The goal is to help th…

This study looks at 60 people who already have a deep brain stimulation (DBS) device for movement problems like tremor, stroke, or brain injury. Researchers will adjust the device's settings and then test how well participants can move their hands, speak, swallow, and control fac…

This study is testing whether a single intravenous infusion of stem cells taken from a patient's own fat can safely improve brain structure and function after a traumatic brain injury. The trial enrolls 51 adults aged 18-55 who have had a brain injury for at least 6 months but no…

This study tests whether an early injection of tranexamic acid (TXA) can reduce brain bleeding, disability, and death in adults aged 50 and older who have had a mild head injury. Participants receive either TXA or a placebo within 3 hours of injury. The goal is to see if this com…

This study tests whether using a brain wave monitor to guide a step-by-step treatment plan can reduce harmful electrical events after severe traumatic brain injury. About 72 adults who need emergency brain surgery will be randomly assigned to standard care or the monitor-guided a…

This study tests whether giving high-pressure oxygen (hyperbaric oxygen therapy) soon after a severe traumatic brain injury can improve recovery. About 200 adults aged 16 to 65 will receive the treatment within hours of injury. The goal is to find the best oxygen dose and schedul…

This study tests a portable device called SENSE to see if it can quickly and accurately detect traumatic brain injury (TBI) and internal bleeding. Researchers will enroll 150 adults aged 22 and older, including those with and without brain injury, plus healthy volunteers. The goa…

This study is testing a new device called Crainio that measures pressure inside the skull without needing to insert a probe into the brain. It uses light signals from the forehead to detect high pressure, which is common after a traumatic brain injury. The goal is to see if the d…

This study aims to create a blood test that helps doctors quickly diagnose traumatic brain injury (TBI) and predict how patients will recover. It will also test if the same blood test can spot complications in hospitalized patients. The study will enroll 2000 adults who come to t…

This study aims to create an objective way to diagnose and monitor light sensitivity by measuring facial expressions, pupil reactions, and nerve responses to light. Researchers will compare 120 people with and without light sensitivity (due to traumatic brain injury or migraine) …

This study tests whether taking branched chain amino acids (BCAAs) twice a day for 21 days can improve sleep in people with traumatic brain injury. Researchers will enroll 300 veterans and community members, randomly assigning them to receive BCAAs or a placebo. The goal is to se…

This study tests whether a computer program called BrainHQ can help adults with traumatic brain injury improve their memory and attention. About 150 people with mild to severe brain injuries will either use BrainHQ or play regular brain games. Researchers will compare their think…

This study tests whether a mobile health system can help people with chronic conditions like spinal cord injury, cerebral palsy, spina bifida, or traumatic brain injury improve their wellness and self-management skills. About 160 participants aged 12 and older will use the system…

This study tests whether a gentle, non-invasive brain stimulation technique called high-definition transcranial direct current stimulation (HD-tDCS) can improve word-finding difficulties in people who have had a traumatic brain injury (TBI) at least one year ago. Researchers will…

This small study looks at whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis pay better attention and feel less tired. Researchers will use EEG to watch brain activity during hypnosis sessions. The goal is to see if this approach is practi…

This study looks at a special stitch called STRATAFIX, already approved for use, to close wounds after brain or spine surgery. Researchers want to see if it helps wounds heal better and with fewer problems. About 160 adults having these surgeries will take part. The goal is to ma…

This study tests a device called SSMD to see if it can improve arm movement in adults who have had a stroke or traumatic brain injury within the past year. About 150 participants will either use the SSMD device or standard electrical stimulation, along with usual rehab, for 5-6 w…

This study tests whether adding aerobic exercise to a memory-training program helps people with moderate to severe traumatic brain injury learn and remember better. Sixty participants will be assigned to either memory training plus exercise or memory training plus stretching. The…

This study tests a portable virtual reality system called VERVE that uses eye-tracking to deliver automated eye exercises. It aims to improve convergence insufficiency—a common vision problem after mild traumatic brain injury—in 100 veterans. Participants will be divided into act…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can reduce long-term symptoms like headaches, memory problems, and mood changes in veterans and active military with mild to moderate traumatic brain injury. About 420 participants…

This study tests a nurse-guided brief behavioral treatment for insomnia in people recovering from traumatic brain injury. About 93 participants will receive either in-person or mobile-delivered therapy to improve sleep, mood, and thinking. The goal is to find a simple, effective …

This study tests two types of talk therapy—cognitive behavioral therapy (CBT) and mindfulness-based therapy—to see which works better for treating insomnia and related depression in people who have had a mild to moderate traumatic brain injury (TBI) and also have post-traumatic s…

This study tests whether a low-level electric stimulation called tDCS, applied to a memory-related brain area, can improve word recall in military veterans who have had a mild traumatic brain injury. Researchers will compare changes in verbal retrieval tests between treatment and…

This study tests a virtual program that teaches mindfulness, exercise, and nutrition to adults who had a traumatic brain injury at least a year ago. The goal is to see if it helps with emotional well-being, physical health, and quality of life. About 138 participants will be rand…

This study tests whether stimulating a nerve in the wrist can safely help improve thinking and memory in people who recently had a traumatic brain injury. Thirty adults aged 18-64 with moderate injuries will receive either real or sham stimulation. The goal is to see if this simp…

This study tests a noninvasive device called REAC that uses gentle electrical signals to help rebalance brain activity in people with a severe type of traumatic brain injury called diffuse axonal injury (DAI). Researchers will compare real REAC treatment to a sham (fake) treatmen…

This study looks at whether Xeomin injections can reduce migraine pain and frequency in people who have had a traumatic brain injury or an unexplained health incident. Researchers will compare how well the treatment works for each group. The goal is to find better ways to manage …

This study tests if a gentle, non-invasive brain stimulation (tDCS) combined with computer-based brain games can improve attention, memory, and decision-making in veterans aged 65 and older who have had a mild traumatic brain injury. Participants will do brain training at home wh…

This study tests whether cannabidiol (CBD) can reduce PTSD symptoms and improve thinking problems. It includes 120 adults with PTSD, half of whom also have a mild traumatic brain injury. Participants take either a daily CBD capsule (400 mg or 800 mg) or a placebo for 8 weeks. The…

This study tests a guided online program for insomnia in 80 adults who had a moderate to severe traumatic brain injury at least one year ago. The program is a computerized version of cognitive behavioral therapy for insomnia (cCBT-I) and is compared to usual care. The goal is to …

This study tests a non-trauma psychotherapy for military veterans and service members who have both PTSD and a mild or moderate traumatic brain injury (TBI). The treatment involves individual talk therapy sessions to help manage PTSD symptoms. The study will enroll 30 participant…

This study tests whether listening to favorite music can improve awareness in people with severe brain injuries who are in a coma or minimally conscious state. Researchers will measure changes in consciousness using a standard scale and brain scans. The goal is to see if passive …

This study tests whether a special liquid diet (semi-elemental nutrition) can reduce stomach and bowel problems like vomiting, diarrhea, and bloating in people with severe traumatic brain injury. About 100 adults will be randomly assigned to receive either this special diet or st…

This study tests if Botox can reduce light sensitivity (photophobia) in people who have had a traumatic brain injury (TBI) at least a year ago. About 50 adults with chronic light sensitivity will receive Botox injections, and researchers will measure changes in pain and vision ov…

This study tests whether combining cognitive training with targeted brain stimulation (using magnetic or electrical pulses) can improve thinking and quality of life in veterans who have had a mild traumatic brain injury. About 108 participants will receive either real or sham sti…

This study tests whether using prismatic lenses (special glasses that shift vision) combined with brain-training computer games can improve thinking and behavior in people recovering from a traumatic brain injury. Fifty adults who had a brain injury within the last 90 days will b…

This study tests a light therapy called transcranial photobiomodulation (tPBM) in 70 older adults (ages 55-85) who had a moderate or severe traumatic brain injury 1-2 years ago. The goal is to see if shining light on the head can increase blood flow to the brain and improve think…

This study tests a procedure called cryoneurolysis, which uses cold to freeze specific nerves in the shoulder, to see if it can reduce pain and improve movement in people with spasticity (muscle tightness) after a stroke, brain injury, or other conditions. Half of the 50 particip…

This study looks at whether a procedure called a bilateral cervical sympathetic block (BCSB) can help reduce symptoms of PTSD, anxiety, and traumatic brain injury in Special Operations Veterans. Some participants will receive the block alone, while others will also get structured…

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders (like spinal cord injury, stroke, or multiple sclerosis) control assistive devices just by thinking about moving. Researchers will use EEG to read brain signals and comb…

This study looks at whether a computer program that helps doctors make decisions can improve how often patients with traumatic brain injury get the right treatment to prevent blood clots. About 15,000 adults across 7 hospitals will take part. The goal is to see if the tool increa…

This study tests whether vibrating certain muscles can help the brain recover after a stroke or traumatic brain injury. Researchers will measure changes in nerve and brain activity in 56 people with leg weakness. The goal is to understand how this therapy might promote brain rewi…

This study checks if a pressure-sensitive smart insole (Ceriter Stride One) can accurately measure walking patterns in people recovering from stroke, brain injury, or spinal cord injury. About 30 participants will wear the insoles while walking on a high-tech treadmill (GRAIL) to…

This study aims to develop a non-invasive way to measure pressure inside the skull (intracranial pressure or ICP), which is currently done by drilling a hole in the head. Researchers will collect data from 581 patients who already have the standard surgical monitor, while also us…

This study explores whether breathing small amounts of carbon dioxide (CO2) can safely increase the movement of proteins from the brain into the blood, which may indicate better waste clearance. Researchers will compare 200 adults with and without a history of traumatic brain inj…

This study looks at a small leg muscle called the plantaris and its role in treating tight ankles (ankle equinus) in children aged 4-17. About 42 kids having surgery for this condition will have the plantaris and larger calf muscles lengthened in a random order. The goal is to se…

This study places special electrodes on the brain surface of people who have had severe traumatic brain injury and need surgery. The goal is to record and locate abnormal brain waves called cortical spreading depolarizations. The research involves 10 participants and uses brain s…

This study is testing whether a new digital test battery, Mindmore Distance, can accurately assess thinking and memory skills in people with brain conditions like stroke, Parkinson's, or multiple sclerosis. Researchers will compare results from home-based tests with standard in-p…

This study looks at whether a noninvasive device that stimulates the vagus nerve can improve the ability to understand speech in noisy environments for people who have had a traumatic brain injury. Researchers will compare two types of stimulation in 55 adults aged 25-55, some wi…

This study tests a new method to personalize TMS (a brain stimulation therapy) for people with PTSD, with or without mild traumatic brain injury. Researchers will use a brain imaging technique called fNIRS to directly measure brain activity and adjust the TMS dose for each person…

This study tests whether a mild electrical current applied to the scalp (tDCS) can improve executive functions like memory, attention, and decision-making. Researchers will enroll 600 adults with conditions such as traumatic brain injury, depression, bipolar disorder, schizophren…

This study is creating a checklist to help doctors decide which head-injured patients on blood thinners can safely skip a CT scan. Researchers will study 4,000 emergency room patients to find out who is at very low risk for serious brain bleeding. The goal is to avoid unnecessary…

This study looks at how a traumatic brain injury (TBI) can lead to heart problems like irregular heartbeat or heart failure. Researchers will use MRI scans to see which brain areas are affected and link them to heart changes in 90 people with mild to moderate TBI. The goal is to …

This study follows 130 patients with severe brain injuries (from stroke, trauma, or lack of oxygen) who are in a coma or minimally conscious state. Researchers will use brain scans, EEGs, and other tests to find clues that might predict if and when a patient will regain conscious…

This study looks at how traumatic brain injury (TBI) may lead to thinking problems and blood vessel damage in the brain. Researchers will follow 300 active-duty military members and veterans, measuring blood markers and thinking skills over time. The goal is to better understand …

This study looks at how deep brain stimulation (DBS) changes brain activity and movement in people with conditions like Parkinson's disease and essential tremor. About 60 people scheduled for DBS surgery will have temporary brain recordings during their procedure. The goal is to …

This study tests a brain implant that lets people with locked-in syndrome control a computer using their thoughts. Two participants will have electrodes placed on their brain to try typing or selecting words. The goal is to see if they can use the system at home on their own.

This study is looking at whether simple, non-invasive eye scans can help detect and track brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will use special cameras to take detailed pictures of the retina in 2,000 adults—both those with and without…

This study follows 110 people with moderate to severe traumatic brain injury (TBI) for up to 3 years to see how their brains change compared to healthy individuals. Participants will give blood samples, have MRI scans, and take thinking and memory tests. The goal is to measure ho…

This study looks at how sleep problems (like trouble falling asleep or waking up often) affect people who have had a traumatic brain injury. Researchers will track sleep with a wearable device and ask about mood, thinking, and daily activities. The goal is to better understand th…

This study is collecting health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to better understand these illnesses and help…

This study looks at whether unconscious patients with brain injuries show brain activity when they hear music or language. Researchers use a simple bedside EEG test to measure this. They want to see if those who respond are more likely to wake up and recover. The study involves 3…

This study tests a computer program that aims to predict when a person with severe traumatic brain injury is about to have dangerous brain pressure or low oxygen levels. About 120 adults in intensive care will be monitored, and the tool's predictions will be checked for accuracy.…

This study looks at Veterans aged 50-75 who had a moderate traumatic brain injury (TBI) at least 15 years ago. Researchers want to see if these past injuries cause hidden problems with balance and thinking, even if the person feels fine. The goal is to learn more so future progra…

This study looks at how people with moderate or severe traumatic brain injury (TBI) walk and navigate in complex, real-life-like environments, such as avoiding other people. Researchers will track eye movements, walking paths, and speed in 40 adults with TBI to better understand …

This observational study looks at whether the settings on a breathing machine (like pressure and power) are linked to how severe a person's brain injury is. It includes 19 adults with brain injuries from stroke, trauma, or bleeding who need a breathing machine. The goal is to see…

This study looks at how a single dose of ketamine affects brain pressure and oxygen levels in 10 adults with severe traumatic brain injury who already have brain monitors in place. The goal is to gather early data on safety and brain response, not to treat the injury. Results may…

This study is testing a new monitor that tracks brain pressure over time in 250 adults with serious brain injuries from trauma or bleeding. The goal is to see if the pressure readings can help predict which patients will have good or bad outcomes, including survival. The research…

This study looks at how special moving patterns (like a spinning disk or VR dots) affect balance in people who feel dizzy after a concussion, those with other dizziness, and healthy volunteers. Researchers will measure body sway and symptoms to find better ways to diagnose visual…

This study looks at small molecules in the blood (called metabolites) to find differences between people with severe traumatic brain injury and those with other injuries like broken bones. Researchers will take blood samples from 60 adults and analyze them to see if certain patte…

This study is testing a new questionnaire called the Pressure Relief Frequency Scale (PReFS) to see if it can reliably help wheelchair users with neurologic disorders (like spinal cord injury, stroke, or traumatic brain injury) decide how often they need to relieve pressure. Rese…