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Gut bacteria may drive Long-Term inflammation after sepsis or major trauma

NCT ID NCT05357170

Recruiting now Knowledge-focused Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study investigates how the community of bacteria in the mouth and gut changes after sepsis or severe trauma in people who have been in the intensive care unit. Researchers will compare these patients to healthy individuals to see if microbiome disruption is linked to ongoing inflammation. The goal is to better understand why some ICU survivors experience persistent health problems.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could point toward new ways to reduce chronic inflammation in ICU survivors by targeting the microbiome.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The findings may not lead to treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Accidental Injuries infectious disease with sepsis injury Sepsis traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEPSIS, TRAUMA INJURY

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • UF Health at Shands Hospital

    RECRUITING

    Gainesville, Florida, 32610, United States

    Contact Phone: •••-•••-••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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