University Of Florida

This program provides expanded access to a special machine that filters stem cells before a transplant. The goal is to reduce a dangerous side effect called graft-versus-host disease (GVHD) by removing certain immune cells. It is for patients, including children over 1 month old,…

This study is testing whether washing the bladder with a combination of two chemotherapy drugs (gemcitabine and docetaxel) can help prevent low-grade bladder cancer from coming back. The treatment is given directly into the bladder through a catheter. Researchers will track how w…

This study is testing whether a mild, non-invasive electrical stimulation applied to the spine can boost the benefits of walking rehabilitation for people with chronic, incomplete spinal cord injuries. Eighteen participants will receive either the real stimulation or a sham (fake…

This study is testing if using a personalized score (the ABCD-GENE score) is better than a standard approach when switching heart patients from a strong blood thinner to a milder one months after getting a stent. It involves 90 patients who have had a stent placed. The goal is to…

This study aims to find a safer medication option for heart stent patients who are at high risk for both blood clots and serious bleeding. It will compare two blood-thinning drugs (clopidogrel vs. a lower dose of prasugrel) in 40 patients who have already had a stent placed. The …

This study is testing a wearable device that uses gentle electromagnetic fields to stimulate the brain, paired with physical exercises, to help people recover arm function and daily independence after a stroke. It involves 25 participants who had a stroke between 6 months and 5 y…

This early-stage study is testing a drug called tocilizumab-aazg (TYENNE) in patients who have recently had a brain aneurysm bleed. The main goal is to see if the drug is safe for these patients and to get an early signal on whether it might help prevent delayed strokes, a common…

This study is testing a new three-drug combination for advanced liver cancer. The main goal is to find safe dose ranges and see if using artificial intelligence to personalize each patient's dose can improve results and reduce side effects. It will enroll about 12 adults whose ca…

This study compares two blood-thinning medications (prasugrel and ticagrelor) when used alone in patients with coronary artery disease who have had a stent placed. Researchers want to see if one drug works as well as the other at preventing dangerous blood clots while potentially…

This study is testing whether a specific type of exercise can help protect the heart health of breast cancer survivors who have finished chemotherapy. Researchers are comparing high-intensity interval training (short bursts of very hard effort) to traditional moderate exercise to…

This study is testing a decision-making tool to help surgeons decide which women with bladder cancer can safely have a less invasive surgery. The goal is to avoid removing healthy reproductive organs during bladder removal, which may improve long-term quality of life, sexual heal…

This study is testing a new support program for cancer survivors who struggle to afford or access healthy food. Researchers will compare 100 patients who receive help from a patient navigator to those getting standard care, to see if the program improves food security, diet quali…

This early-stage trial is testing a new, personalized vaccine made from a patient's own tumor. The goal is to see if this vaccine can help the patient's immune system recognize and fight their cancer, especially when standard immunotherapy has stopped working. The study will enro…

This study is checking if a surgery to remove a small gland in the neck (parathyroidectomy) helps older adults with a specific hormone problem walk farther, get stronger, and be more active. It will follow 80 people aged 60 and older having this surgery at UF Health. Researchers …

This study is testing if a special arm and leg exercise program can help protect the heart and blood vessels in women undergoing chemotherapy for breast cancer. Researchers will compare this new exercise approach to traditional treadmill walking to see which is more feasible and …

This study is testing if a two-step treatment can help young people recently diagnosed with type 1 diabetes. First, some will receive a low-dose immune therapy (ATG) or a placebo. Then, all will have the option to take a blood pressure drug (verapamil) for a second year. The main…

This study is testing whether people with worsening heart failure can safely receive fluid-reducing medication at home instead of in the hospital. Researchers are evaluating a small injection device called Lasix ONYU that patients or caregivers can use themselves. The goal is to …

This study is testing a new way to mark the area where a breast tumor was removed during surgery. The goal is to help doctors more accurately target radiation therapy afterward and to better identify if any additional tissue needs to be removed. It involves 50 adults with early-s…

This study tests which of three smoking cessation methods works best for underserved adults in primary care: two different smartphone apps or a traditional telephone quitline. Researchers will enroll 1,332 adult smokers and randomly assign them to one of the three programs. They …

This study is testing whether popular weight-loss medications (GLP-1RAs) can help treat early-stage endometrial cancer when used alongside a hormonal IUD. It is for obese patients who are not good candidates for surgery or who wish to preserve their fertility. The goal is to see …

This study is testing whether a breathing treatment called acute intermittent hypoxia (AIH) can improve breathing strength in people with chronic spinal cord injury. Participants will receive brief sessions of low-oxygen air, sometimes with added carbon dioxide, along with breath…

This study is testing if the antibiotic minocycline can lower blood pressure in people whose high blood pressure doesn't respond well to standard medications. Researchers want to see if the drug works by changing gut bacteria and reducing body-wide inflammation. About 120 partici…

This study is testing a new method to program deep brain stimulation (DBS) devices for Parkinson's disease. It aims to use the brain's own electrical signals to find the best settings faster than the current manual process. Researchers will compare this new approach to the standa…

This study is testing whether doctors can safely give less radiation and chemotherapy to people with a specific type of throat cancer linked to HPV. The goal is to see if using a blood test to measure HPV levels can identify patients who can get milder treatment with the same goo…

This study is testing a smartphone app designed to help teenagers who have had a heart transplant take their life-saving anti-rejection medications on time. Missing these pills is a major cause of organ rejection and serious health problems. The app lets teens record short videos…

This study is testing whether adding the natural hormone melatonin to standard cooling therapy can better protect the brains of newborns who experienced oxygen deprivation during birth. Researchers will give increasing doses to 30 newborns to find the safest and most effective am…

This study aims to see if a newer blood-thinning drug (low-dose ticagrelor) works better than the standard drug (clopidogrel) for a specific group of patients. It focuses on 50 people with stable heart disease who are getting a stent placed and who have a high score on a special …

This small pilot study is testing two different low-oxygen breathing treatments to see if they can help restore breathing and cough strength in people with recent spinal cord injuries. Researchers want to find out which method works better and if a person's genetics affect their …

This study is testing the safety and feasibility of a three-part treatment for adults whose aggressive brain cancer (glioblastoma) has returned. The treatment combines a wearable device that uses electric fields to disrupt cancer cells, a precise laser surgery to destroy the tumo…

This study is testing a new type of stem cell transplant for children and young adults whose solid tumors have returned or not responded to standard treatments. Doctors are using a donor's stem cells that have been specially processed to remove certain immune cells, then combinin…

This study aims to find the best way to reduce bleeding risk for people who have had a stent placed in their heart. Researchers will compare two different medication strategies that are already known to help. They will measure how well each approach prevents dangerous blood clots…

This study is testing if a gentle, non-invasive stimulation of a nerve in the ear (called tVNS) can make standard OCD therapy more effective. It will involve about 56 adults with moderate to severe OCD who will receive therapy sessions. Researchers will measure changes in OCD sym…

This study is testing a new type of stem cell transplant for children and young adults with serious blood cancers like leukemia. The transplant uses donor cells that have been specially prepared in a lab. Researchers want to see if this new method is safe and can help patients re…

This study is testing a new 'smart' version of deep brain stimulation (DBS) for people with essential tremor, a condition causing uncontrollable shaking. The goal is to see if the implanted device can automatically turn off stimulation when it detects you are asleep, which may re…

This study is testing a new, smarter version of a brain implant for people with severe essential tremor whose current implant is no longer working well. The new system has two leads and is designed to detect when a tremor is about to start and deliver stimulation only when needed…

This study is testing whether taking kava, a natural herb, can help people quit smoking. Researchers want to see if kava reduces the stress and sleep problems that often make quitting difficult. The trial involves 76 adult smokers who want to quit and will track their smoking hab…

This study is testing if taking a zinc supplement can help the benefits of Botox injections last longer for people with cervical dystonia, a condition that causes painful, involuntary neck muscle contractions. About 20 patients who already get regular Botox injections will take e…

This study is testing a new precision medicine tool called the ABCD-GENE score. It aims to identify which patients with stable heart disease are at higher risk of heart muscle damage during a planned stent placement procedure. Researchers will enroll 500 patients to see if this s…

This small pilot study is testing whether a drug called Linaclotide, taken as two pills with Gatorade, can adequately clean the bowel for a colonoscopy. It aims to see if this simpler regimen works as well as the standard preparation, which involves drinking four liters of a spec…

This study is testing a new, non-invasive imaging method called iRAI that uses sound waves to monitor proton radiation therapy for prostate cancer in real-time. The goal is to see if this technology can accurately track where the radiation dose is being delivered inside the body …

This study tests an online educational program that teaches adults how to reduce their risk of colorectal cancer through better diet and understanding screening options. Participants work through six personalized lessons about nutrition risks and cancer screening guidelines. The …

This study aims to find the best combination of support methods to increase HPV vaccination rates among 9-12 year olds in rural North Central Florida. Researchers will test three different approaches across 30 clinics: training doctors, adding parent reminders and counseling, and…

This study is testing whether a simple 2-week gratitude journaling activity is practical and helpful for people with chronic jaw pain. Researchers want to see if writing about things they're grateful for three times a week can reduce pain intensity and how much pain interferes wi…

This study is testing whether briefly blocking a person's vision during balance training can help them improve faster. Researchers will have participants walk on a low balance beam while wearing special goggles that intermittently go dark. They will measure changes in balance, bo…

This study is testing whether gentle electrical stimulation of a neck nerve through the ear can help people with traumatic brain injury hear speech better in noisy environments. Researchers will compare two different stimulation approaches in 55 participants, including both peopl…

This study is testing whether a 6-week exercise program is practical and helpful for older adults who have just finished home health care. The program combines strength training with everyday movement tasks. Researchers want to see if it improves participants' physical mobility a…

This study is testing if a special 6-week exercise program before shoulder replacement surgery helps patients move their arm better afterward. Researchers will compare two groups of 64 patients: one group does the pre-surgery exercises, and the other follows standard care. The ma…

This study aims to understand how dry needling works to relieve chronic low back pain. Researchers will examine factors like muscle stiffness, mobility, and pain sensitivity in 71 adults with persistent back pain. By identifying what makes the treatment effective, they hope to de…

This study is testing if updated, clearer instructions help first-time radiation therapy patients. It will measure if better information helps patients complete their full treatment, miss fewer appointments, and feel more comfortable during the process. The goal is to find the be…

This study is testing if using red light instead of the standard blue light to harden dental fillings causes less heat and leads to less pain afterward. Researchers will measure the temperature in the tooth and gum during the procedure in 50 participants and ask about any sensiti…

This study is developing and testing a new breathing therapy program for adults with chronic low back pain. Participants will attend eight weekly, one-on-one guided breathing sessions to see if the practice is helpful and acceptable. The main goal is to see if this approach can r…

This study is testing if a targeted nerve block injection can safely reduce severe headaches and the need for strong opioid painkillers in people recovering from a ruptured brain aneurysm. About 195 adults who recently had this type of brain bleed will receive either the real ner…

This study is testing whether a special light therapy called photobiomodulation can reduce chronic jaw pain from temporomandibular disorder (TMD). Researchers will compare the real light treatment against a fake treatment in 130 adults who have had jaw pain for at least three mon…

This study is testing whether a liquid form of CBD (cannabidiol) placed under the tongue is safe and can help reduce pain and improve daily function for people with knee osteoarthritis. Researchers will compare the effects of CBD to a placebo (inactive substance) in 30 adults wit…

This study is exploring whether a therapy program for parents and young children can reduce parental stress, anxiety, and depression while improving the parent-child relationship. Researchers will enroll 80 parents of children aged 2-7 and measure stress levels, a bonding hormone…

This study is testing if adding a short virtual physical therapy program to standard home exercises helps runners with chronic lower body pain recover better. Researchers will compare pain levels and movement quality in about 85 runners over six months. The goal is to see if remo…

This study is testing whether a gentle, noninvasive form of brain stimulation can help improve memory, attention, and thinking skills in older adults who experience cognitive problems after a serious illness in the ICU. Researchers will use a magnetic coil placed on the scalp to …

This study is testing whether a wearable device called Walkasins can help older adults with foot numbness walk more safely. The device provides sensory feedback to the legs, aiming to make walking more automatic and less mentally taxing. Researchers will measure walking performan…

This study is testing whether a walking program can help reduce severe fatigue in older women who have finished breast cancer treatment. Researchers will compare a supervised group walking program to a home-based walking plan over 8 weeks. The goal is to see if regular walking ca…

This study is testing whether gentle electrical stimulation of a nerve in the ear can help older adults understand speech in noisy environments, like restaurants. It's for people aged 55-80 with age-related hearing loss, with or without hearing aids. The goal is to see if this no…

This study is testing whether weekly, supportive phone calls can improve mental health for homebound older adults. Over 8 weeks, trained volunteers will call 400 participants to provide social connection and support. Researchers want to see if these calls reduce feelings of lonel…

This study is testing whether group counseling can help people who feel shame or stigma because of their health condition. Researchers are enrolling 195 adults with conditions like obesity, cancer, HIV, diabetes, or chronic pain who report feeling stigmatized. Participants will t…

This study is testing a new, personalized way to perform a special arm massage (manual lymphatic drainage) to prevent painful swelling (lymphedema) after breast cancer surgery. Researchers will compare this new method, which uses a safe dye to map a patient's unique lymph system,…

This small pilot study is testing whether a home-based wearable vibration therapy device can help improve arm and hand function in people with multiple sclerosis (MS). Fifteen adults with a stable form of MS will use the device on their arm muscles for four weeks. The main goal i…

This study is testing whether drinking cranberry juice every day for about 10 weeks can help healthy adults handle stress better and improve their focus during demanding tasks. Researchers will measure changes in thinking skills, mood, stress hormones, and gut bacteria in 84 part…

This study is testing a nutritional supplement called Epidiferphane in people with breast cancer who are receiving taxane chemotherapy. The goal is to see if the supplement can reduce common and often severe side effects like nerve pain and anemia, which frequently force patients…

This study aims to help patients with a left ventricular assist device (LVAD) and their family caregivers feel better mentally and improve their quality of life during the challenging first months after leaving the hospital. Researchers will provide information on mental health a…

This early-stage study is testing whether oxytocin (a hormone sometimes called the 'love hormone') given as a nasal spray can help reduce pain and potentially lower the amount of opioid medication needed. Researchers will study 45 healthy adults who use opioids recreationally but…

This study is testing whether a supplement made from yeast (called yeast mannan) can help healthy adults who go to the bathroom once a day or less to go more frequently. Researchers will give 70 participants either the supplement or a placebo daily for 28 days to see if it makes …

This study aims to understand why emergency rooms struggle to properly treat patients with severe toothaches and other non-injury dental problems. Researchers will interview emergency room doctors and nurses to identify barriers, then test a new decision-support tool designed to …

This study aims to understand how a mild, non-invasive electrical brain stimulation technique might temporarily improve working memory in older adults with mild cognitive impairment. Researchers will compare 55 adults with memory concerns to 55 healthy peers, giving each person b…

This study aims to use artificial intelligence (AI) to predict which older adults with mild memory problems will improve from a brain training program. Researchers will use initial brain scans and cognitive tests from 75 participants to train an AI model. The goal is to identify …

This study aims to understand why pain levels vary and if the body's natural ability to control pain can be improved through training. Researchers will compare people with fibromyalgia to healthy individuals to see if a specific muscle training program can strengthen the brain's …

This study is testing a one-day workshop designed to teach dentists, hygienists, and assistants better ways to interact with children aged 2-10 and their parents during dental appointments. The training is based on a proven parenting program. Researchers will film appointments be…

This study aims to find better, non-invasive ways to measure how Friedreich's ataxia affects the heart and muscles. Researchers will use scans, exercise tests, and other measures in about 200 patients and healthy volunteers. The goal is to create tools that can detect if future t…

This study is testing an online training program for primary care doctors working in community health centers across the U.S. The goal is to see if giving doctors specialized diabetes education and support through video calls improves care for their patients. Researchers will mea…

This study is testing two different blood tests to see if they can accurately measure how well a patient's cervical cancer is responding to treatments like surgery, radiation, or chemotherapy. Researchers will check if levels of HPV-related genetic material in the blood go down w…

This study aims to understand how listening to 15 minutes of calming music affects people's stress levels, heart rate, and feelings of calmness. Researchers will enroll about 100 adults to listen to music and measure their body's responses through surveys, heart rate monitors, an…

This study aims to understand why older adults have trouble recovering from severe injuries like major fractures. Researchers will compare bone marrow and blood samples from 400 trauma patients, elective hip surgery patients, and healthy people to see how injury changes stem cell…

This study is creating a large collection of brain tumor tissue samples to help future research. It involves people who are already scheduled for brain surgery to remove a tumor. The leftover tissue, along with some health information, is saved in a bank so scientists can study i…

This study measures how eye pressure changes in women undergoing robotic surgery for gynecologic cancers. Researchers want to see if using different anesthesia methods affects eye pressure when patients are positioned head-down during surgery. The study involves 40 female patient…

This study aims to understand why some people don't recover well after a severe infection (sepsis) or major injury. Researchers will observe 450 adults with sepsis or severe trauma to see how their immune system cells change over time. The goal is to learn what causes long-term i…

This study aims to understand how weight loss and improved diabetes control after bariatric surgery affect brain function and thinking. Researchers will follow 120 participants, testing their memory and brain scans before surgery, after 12 weeks, and at 18 months. They will also …

This study aims to understand how severe physical trauma disrupts communication between the brain, bone marrow, and gut. Researchers will observe 275 adults who have suffered major injuries, along with a smaller group having elective hip surgery for comparison. The goal is to lea…

This study aims to understand how two genetic conditions—Alpha-1 Antitrypsin Deficiency and Cystic Fibrosis—affect the function of special immune cells in the lungs called macrophages. Researchers will recruit 220 adults with these conditions to collect blood samples and measure …

This study aims to understand if weakness in the big toe is linked to the severity of nerve damage caused by chemotherapy, a common side effect. Researchers will test a new, portable device called the ToeScale to measure toe strength in about 30 people with this nerve damage and …

This study aims to understand if a simple, non-invasive finger sensor can measure oxygen levels in the tissue of children with heart failure. Researchers will test 130 participants under 25 years old, comparing those with heart failure to healthy children. The goal is to see if t…

This study aims to understand the real-world use and impact of genetic testing for Alpha-1 Antitrypsin Deficiency, a rare inherited condition. It will enroll 50,000 people at risk for the disease to learn about who gets tested, why, and what happens afterward. The research focuse…

This study aims to understand what happens to the immune system after severe injuries like car crashes or falls. Researchers will collect blood and bone marrow samples from 255 trauma patients and compare them to people having routine hip surgery. They want to learn why some inju…

This study aims to develop better ways to track muscular dystrophy progression using MRI scans instead of invasive tests. Researchers will follow 550 boys and men with Duchenne or Becker muscular dystrophy for 5-10 years, comparing their muscle scans to healthy individuals. The g…

This study aims to understand how the thoughts and beliefs of patients with chronic low back pain and their physical therapists influence the benefits patients get from therapy. Ninety participants will receive standard physical therapy, which may include spinal manipulation, exe…