University Of Florida

This study tests a personalized RNA vaccine for children and young adults (ages 3–39) whose medulloblastoma has returned after standard treatment. The vaccine is made from the patient's own tumor and aims to train the immune system to fight the cancer. The main goals are to see i…

This early-phase trial tests a custom-made RNA vaccine designed to help the immune system recognize and attack tumors in people with advanced melanoma or soft tissue sarcoma whose cancer has worsened despite standard immunotherapy. Up to 18 adults will receive three doses of the …

This early-phase trial tests a personalized RNA vaccine made from each patient's own tumor. It aims to train the immune system to fight aggressive brain cancers like glioblastoma and high-grade glioma in children and adults. The study focuses on safety, manufacturing feasibility,…

This study tests a stem cell transplant that removes certain immune cells (alpha/beta T cells and CD19+ B cells) and adds a drug called zoledronic acid. The goal is to help the donor cells attack the tumor without causing severe side effects. It is for children and young adults a…

This study compares three ways to help people stop smoking: two mobile health apps (iCanQuit and iCanQuit+Motiv8) and the Florida quit line. About 1,332 adults who get care at participating clinics and have a smartphone will take part. The goal is to see which approach works best…

This study looks at whether switching from a standard blood thinner (clopidogrel) to a lower dose of another blood thinner (prasugrel) can better control clotting risk in heart patients who have had a stent placed. The study includes 40 adults who are at high risk for both bleedi…

This study tests a new type of brain implant that uses two leads instead of one to control severe essential tremor. Ten adults who already have a standard implant will receive the new system. The goal is to see if it can provide better tremor control and eventually lead to a smar…

This expanded access program offers a special stem cell filtering technique (CD34+ selection) to patients with severe blood disorders like sickle cell disease and immune deficiencies. The goal is to lower the risk of graft-versus-host disease, a serious complication where donor c…

This study tests a new triple combination therapy for adults with recurrent glioblastoma, an aggressive brain cancer. The treatment combines tumor-treating fields, laser ablation surgery, and an immunotherapy drug. The goal is to see if this approach is safe and feasible for 20 p…

This study tests whether adding melatonin to standard cooling treatment can improve brain outcomes in newborns with hypoxic-ischemic encephalopathy (HIE), a serious birth complication. About 70 full-term infants will receive different doses of melatonin to find the safest and mos…

This study tests whether a mobile app that lets teens record themselves taking their anti-rejection medication can improve how consistently they take it. About 100 heart transplant recipients aged 10-21 will use the app or standard care. The goal is to reduce hospitalizations and…

This study looks at whether removing the parathyroid gland can improve physical function and mobility in adults aged 60 and older with primary hyperparathyroidism. Participants will do walking and strength tests, wear an activity tracker, and give blood samples before and after s…

This study looks at whether adjusting the dose of a blood thinner called cangrelor based on individual test results can better control clotting risk in people with coronary artery disease who are waiting for surgery. About 50 adults will receive either a standard or personalized …

This study tests a decision tool to identify women with bladder cancer who may safely keep their reproductive organs during bladder removal surgery. Currently, standard surgery removes the bladder along with the uterus, ovaries, and part of the vagina, which can harm sexual healt…

This study tests whether a two-step treatment can help young people with newly diagnosed type 1 diabetes keep making their own insulin. First, participants receive a low dose of anti-thymocyte globulin (ATG) to calm the immune system, followed by verapamil to reduce stress on ins…

This study compares two strategies to reduce bleeding from standard blood thinners after a heart stent procedure: lowering the dose of one drug versus switching to a different drug. About 78 adults who have had a stent and are on dual antiplatelet therapy will be randomly assigne…

This study tests whether a lower dose of the blood thinner ticagrelor works better than the standard clopidogrel in stable heart disease patients who are at high risk of a heart attack during a stent procedure. Researchers will measure how well the drugs prevent blood clots using…

This study compares two blood thinners, prasugrel and ticagrelor, when used alone after heart stent placement. About 48 adults with coronary artery disease who have been on dual therapy for at least 90 days will switch to just one of these medications. The goal is to see which on…

This early-stage study tests whether a drug called tocilizumab-aazg is safe for people who have had a burst brain aneurysm. The goal is to see if it can prevent strokes that sometimes happen after the initial bleed. About 30 adults will take part, and researchers will closely mon…

This study tests whether giving fluoxetine (Prozac) immediately after a serious injury can prevent or lessen PTSD, depression, pain, and the need for opioids. About 200 adults with fractures or other bodily trauma will receive either fluoxetine or a placebo during their hospital …

This study tests whether minocycline, an antibiotic, can lower blood pressure in people whose hypertension does not respond to standard treatments. Researchers will explore if changes in gut bacteria, inflammation, or brain activity explain the effects. 120 adults will take minoc…

This study tests whether a full-body exercise program can help protect the heart in women undergoing chemotherapy for breast cancer. Researchers will measure heart and blood vessel function before and after the exercise program. The goal is to find a safe, practical way to reduce…

This study tests whether using a genetic score (ABCD-GENE) to guide reducing blood thinners after heart stent placement works better than the usual approach. About 90 adults who have had a stent and are on two blood thinners will be randomly assigned to either a score-guided or u…

This study is for people with a type of throat cancer linked to HPV that has a good outlook. Researchers want to see if using a less intense combination of radiation and chemotherapy can control the cancer just as well as the standard stronger treatment, but with fewer side effec…

This study compares two strategies to reduce bleeding in people with coronary artery disease who have had a stent placed and are on blood thinners. One approach switches to a milder antiplatelet drug while keeping aspirin, and the other stops aspirin while keeping a stronger drug…

This pilot study tests whether adding a GLP-1RA weight-loss drug (like semaglutide) to a hormonal IUD can reverse precancerous changes in the uterus lining of obese women. About 20 women who are not good candidates for hysterectomy or wish to preserve fertility will be followed f…

This study compares high-intensity interval training (HIIT) to moderate-intensity continuous exercise for improving heart health in 158 women who completed chemotherapy for breast cancer. Participants will be assigned to one of two exercise programs to see which better reduces ca…

This study tests whether a combination of two chemotherapy drugs (gemcitabine and docetaxel) given directly into the bladder can prevent low-grade bladder cancer from returning. About 34 adults with intermediate-risk, non-invasive bladder cancer will receive this treatment. The g…

This study tests a new way to treat advanced liver cancer by using artificial intelligence to find the best dose of three drugs (sorafenib, sonidegib, and irinotecan) for each patient. The goal is to make treatment more effective while reducing side effects. About 12 adults with …

This study tests whether adding a special PET-CT scan (POSLUMA) to standard MRI can better detect serious prostate cancer in men with unclear MRI results (PIRADS 2 or 3). About 30 men who haven't had a biopsy before will get the scan before their scheduled biopsy. The goal is to …

This study looks at ways to help more 9- to 12-year-olds in rural Florida get the HPV vaccine, which prevents certain cancers. Researchers will test different combinations of strategies, like training doctors, sending reminders to parents, and helping families access healthcare. …

This study tests a free, self-paced online program that teaches adults how to reduce their risk of colorectal cancer through better nutrition and regular screening. Participants complete six lessons covering diet tips and screening options like colonoscopy and home stool tests. T…

This study tests a web-based program that teaches parents how to manage their child's exposure to substance use in movies, TV, and online. Researchers will enroll 120 parents of middle-schoolers to see if the program improves media parenting behaviors. The goal is to reduce youth…

This study tests a new way to program deep brain stimulation (DBS) for Parkinson's disease using the brain's own electrical signals. Instead of the usual slow, manual process, doctors will use local field potentials to pick the best stimulation settings. The goal is to improve mo…

This study tests a program called MyCarePulse and ASCENT that helps cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either get the program or standard care. Researchers will check if the program improves food securit…

This early-phase study tests whether adding oxytocin (a natural hormone) to the opioid oxycodone can reduce its abuse potential while improving pain relief. Researchers will give 45 older adults different combinations of the drugs across six sessions and measure pain, subjective …

This study looks at whether a new type of deep brain stimulation (called patterned DBS) is safe and tolerable for people with Parkinson's disease when used at home. About 60 adults who already have a DBS device will try the new stimulation pattern for two weeks. The goal is to se…

This study tests whether walking exercise can help reduce fatigue in older breast cancer survivors. About 24 women aged 60 and older who finished cancer treatment within the past year will take part. They will either walk at a center or at home for 12 weeks. The goal is to see if…

This study tests a device called Walkasins, worn on the legs, that provides gentle vibrations to replace lost foot sensation in older adults. Researchers want to see if it helps people aged 65-95 with numb feet walk more automatically and with less mental effort. The study involv…

This study tests whether a 6-week exercise program before reverse shoulder replacement surgery can improve how well you can rotate your arm inward afterward. About 64 adults aged 40 to 80 will take part. Half will do the pre-surgery exercises, and half will follow standard care. …

This pilot study tests whether a gentle nerve-stimulation technique (taVNS) can improve the ability to understand speech in noisy environments for adults aged 55-80 with age-related hearing loss. Participants will complete speech-in-noise tasks while receiving either active or in…

This study looks at whether a special dye called Magtrace can help women with non-invasive breast cancer (DCIS) avoid an extra surgery to remove lymph nodes. Normally, women having a mastectomy get this lymph node surgery just in case cancer has spread, but it's often not needed.…

This study tests a 6-week exercise program for older adults (ages 65-90) who recently finished home health care and have trouble moving or thinking. Participants will do task-oriented resistance exercises at home with a care partner. The goal is to see if this program is practica…

This study tests a wearable device that sends gentle, low-frequency electromagnetic fields to the brain to help people who had a stroke more than 6 months ago recover arm movement and reduce disability. About 25 adults with chronic stroke will use the device in a clinic setting. …

This study tests a new way to use deep brain stimulation (DBS) for essential tremor. Normally, DBS runs all the time, which can cause side effects and make the treatment less effective over time. The new approach automatically turns off the stimulation when the person is asleep, …

This study tests whether regular, friendly phone calls can improve mental health and reduce loneliness in older adults who are homebound. About 400 people aged 65 and older who receive home services will be assigned to one of two types of supportive phone calls or a control group…

This study tests a new, non-invasive treatment called transcranial pulse stimulation (TPS) that uses gentle magnetic pulses on key brain areas. Researchers want to see if it can improve memory and thinking in 10 healthy older adults and 10 people with mild dementia. Participants …

This study explores whether Parent-Child Interaction Therapy (PCIT) can help parents of children aged 2-7 with behavioral issues. Researchers will measure changes in stress, anxiety, depression, and oxytocin levels through surveys and saliva samples. The goal is to see if this th…

This study tests whether a wearable device that gently vibrates the arm muscles can improve arm and hand function in people with multiple sclerosis. Fifteen adults with relapsing-remitting MS will use the device at home for four weeks. Researchers will measure dexterity and arm f…

This study tests whether taking zinc supplements daily can make Botox injections last longer for people with cervical dystonia, a condition causing painful neck muscle spasms. About 20 adults will receive either zinc or a placebo for 3 months, then switch, while getting regular B…

This study looks at how to improve quality of life for people with a Left Ventricular Assist Device (LVAD) and their family caregivers. Participants complete two surveys—one in the hospital and one two months after discharge—and may receive mental health resources. The goal is to…

This study explores whether a 2-week gratitude journaling activity is practical and helpful for people with temporomandibular disorder (TMD) and other chronic pain conditions. Participants will write in a journal three times a week and attend two in-person visits to measure pain …

This study tests whether a mild nerve stimulation device (tVNS) can make exposure therapy work better for people with OCD. Researchers will enroll 56 adults with moderate to severe OCD. The goal is to see if adding tVNS to standard therapy improves symptoms and is well-tolerated.

This study tests whether a nutritional supplement called Epidiferphane can lessen common side effects of taxane chemotherapy, like anemia and nerve damage, in breast cancer patients. About 74 adults starting taxane chemo will take Epidiferphane alongside their treatment. Research…

This study tests whether giving extra oxygen early after a spinal cord injury can help recovery. It involves 12 adults with traumatic spinal cord injuries who are on breathing machines. The goal is to see if this therapy is safe and feasible, and if it improves oxygen levels in t…

This small pilot study tests whether the drug linaclotide, taken with Gatorade, can clean the bowel well enough for a colonoscopy. Ten adults scheduled for a colonoscopy will take two doses of linaclotide and drink 2 liters of Gatorade instead of the standard 4 liters of polyethy…

This study looks at whether adding four virtual physical therapy sessions to standard home exercises helps runners with leg pain feel better and move better. About 85 runners aged 18 to 65 who run at least 12 miles a week will take part. The goal is to see if the extra support im…

This study tests whether a special light treatment (photobiomodulation) can reduce pain from temporomandibular disorder (TMD), a condition causing jaw and face pain. About 130 adults with TMD pain will receive either the light therapy or a sham treatment to see if it works. The g…

This study looks at whether adding polyphenol-rich foods like beans and lentils to your daily diet can make your skin healthier. Researchers will measure how skin reacts to UV light, its moisture barrier, and redness in 50 women aged 45-65 over 12 weeks. The goal is to see if the…

This study tests a new method of arm massage guided by a special dye (ICG) to prevent swelling after breast cancer surgery. About 30 women having lymph node removal will be assigned to either standard massage or dye-guided massage. The goal is to see if the new method helps patie…

This study is testing whether cannabidiol (CBD) placed under the tongue can safely reduce knee pain from osteoarthritis and help people use fewer over-the-counter pain relievers like ibuprofen. Researchers will enroll 30 adults with moderate to severe knee pain. The goal is to se…

This study is for adults with heart failure who have too much fluid in their body. Instead of going to the hospital for treatment, participants will receive a medication called Lasix (furosemide) through a small needle under the skin at home. The goal is to see if this approach i…

This study tests a gentle, noninvasive brain stimulation method called iTBS to see if it can improve memory, attention, and planning in older adults who had delirium while in the ICU. About 40 people aged 50 to 75 who are three months past their ICU stay will receive either real …

This study looks at whether taking kava daily can help smokers who want to quit by reducing stress and improving sleep. About 76 adult smokers will take kava and be monitored for how well they stick with it, how much they smoke, and their stress and sleep quality. The goal is to …

This study looks at whether drinking cranberry juice every day for 70 days can help healthy adults aged 30-55 think more clearly and feel less stressed during challenging tasks. Researchers will measure changes in mood, focus, and stress-related body signals, and also check if th…

This study tests whether a numbing injection in the face can reduce severe headaches and the need for strong painkillers after a brain bleed. About 195 adults who had a brain bleed will receive either the active injection or a placebo. The goal is to see if this approach safely c…

This study tests a group counseling program combined with peer support to help adults with obesity, skin disease, cancer, HIV, diabetes, or chronic pain reduce the internal shame and worry caused by health-related stigma. Researchers want to see if this approach improves quality …

This study looks at how emergency department (ED) doctors handle dental pain that isn't caused by injury. Researchers want to understand why some patients get antibiotics or opioids and how often they return to the hospital. They will interview 60 ED providers and review national…

This study tests whether adding oxytocin (the 'love hormone') to oxycodone can reduce pain while lowering the risk of addiction. Researchers will give 45 recreational opioid users different combinations of the two drugs and measure pain relief, subjective effects, and brain activ…

This study aims to understand why pain levels vary in people with muscle pain and those without. Researchers will test if the body's natural ability to manage pain can be improved through training, similar to athletic performance. The study involves 180 adults, including those wi…

This study collects brain tumor tissue samples from children and adults undergoing brain surgery. The samples are stored in a tissue bank at the University of Florida for future research. The goal is to help scientists find better treatments and, eventually, cures for brain tumor…

This study tests a noninvasive light sensor placed on the thumb to measure oxygen levels in children with heart failure. Researchers will temporarily stop blood flow to the hand and watch how oxygen levels change, then release the pressure to see how quickly oxygen returns. The g…

This study looks at whether a single session of breathing exercises or spinal stimulation can prevent the diaphragm from weakening when a breathing machine is used. 16 healthy adults will try these rehab methods before using a noninvasive ventilator. The goal is to see if these a…

This study looks at how losing weight and improving diabetes after bariatric surgery changes brain function and thinking skills. Researchers will also test if a non-invasive nerve stimulation device, started 30 days after surgery, can further improve brain health. The study invol…

This study looks at how serious injuries change the way bone marrow stem cells work and how this affects muscle loss and recovery. Researchers will compare trauma patients to healthy people to understand why some patients have long-term problems like anemia and muscle wasting. Th…

This study tests whether short, repeated sessions of breathing low-oxygen air can improve breathing and other motor functions in people with chronic spinal cord injury. Researchers will also look for genetic markers that might predict who benefits most. About 62 adults with spina…

This study looks at how certain genes affect the immune system and the risk of developing type 1 diabetes. Researchers will follow 2,800 people and track who develops the disease. No treatment is given; the goal is to better understand the disease process.

This study tests a tele-education program for primary care providers at community health centers across the U.S. The goal is to help them better manage diabetes in their patients. Researchers will measure changes in blood sugar levels and use of diabetes technology like continuou…

This study looks at whether a noninvasive device that stimulates the vagus nerve can improve the ability to understand speech in noisy environments for people who have had a traumatic brain injury. Researchers will compare two types of stimulation in 55 adults aged 25-55, some wi…

This study aims to learn more about Alpha-1 Antitrypsin Deficiency, a genetic condition that can affect the lungs and liver. Researchers will follow up to 50,000 people who are at risk due to symptoms or family history. Participants will fill out questionnaires to help track how …

This study is testing two new blood tests that look for HPV DNA and RNA to see how well cervical cancer responds to standard treatments like surgery, radiation, and chemotherapy. About 55 adults with HPV-related cervical cancer will give blood samples before and after treatment. …

This study tests whether wearing goggles that briefly block vision during balance training can help people improve their balance more effectively. Healthy adults aged 18-30 or 65-89 will practice walking on a narrow beam while wearing special goggles. Researchers will measure bal…

This study looks at whether improving the clarity of instructions for first-time radiotherapy patients helps them attend all their treatment sessions and feel more at ease. Researchers will compare updated, easy-to-understand materials with standard ones in 650 adults starting ra…

This study looks at how a treatment called High-Intensity Focused Ultrasound (HiFU) affects the brain's communication networks in people with essential tremor. Ten adults over 50 who have not responded to at least two tremor medications will have their brain activity recorded bef…

This study looks at whether a special score that combines genetics and patient information can identify people with stable coronary artery disease who are at higher risk for a heart attack or heart injury during a planned stent procedure. About 500 adults will be enrolled and fol…

This study tests whether a special website with a virtual health educator can help more Black and Hispanic cancer patients in Florida find and sign up for cancer clinical trials. About 350 patients will be split into two groups: one gets standard online information, the other get…

This study tests a workshop for dentists, hygienists, and assistants to improve how they interact with children aged 2-10 and their parents. The training is based on a proven behavior program for preschoolers. Researchers want to see if providers use the skills more and find the …

This study uses MRI scans to measure muscle damage and fat buildup in boys and men with Duchenne or Becker muscular dystrophy over 5-10 years. Researchers compare these images with healthy volunteers and track how changes relate to daily activities like walking. The goal is to de…

This study looks at how aging affects the ability to learn who to trust. Researchers will use real-time brain scans to train 68 older adults to improve trust-related learning. The goal is to see if this training can help older adults make smarter decisions about whom to trust.

This study uses artificial intelligence (AI) to analyze brain MRI scans from 75 older adults with mild memory problems. The goal is to see if the AI can predict who will improve with a computer-based cognitive training program. Researchers hope this will help personalize future t…

This study looks at whether a gentle electrical current applied to the brain (tDCS) can improve working memory in older adults with mild cognitive impairment. Researchers will compare results from 110 participants aged 60-95, including both those with memory concerns and healthy …

This study looks at how severe injuries change the brain, bone marrow, and gut, and how these changes cause long-term anemia and slow recovery. Researchers will study 275 adults with serious blunt trauma to understand these interactions. The goal is to find new ways to help peopl…

This study looks at how the immune system goes wrong in people with sepsis or serious injuries. Researchers will measure certain immune cells in 450 adults to find patterns that lead to ongoing inflammation or immune weakness. The goal is to better understand these problems, not …

This study tests a new imaging method that uses sound waves to monitor proton radiation treatment in real time for prostate cancer patients. The goal is to see if this technique can accurately track where the radiation dose is delivered inside the body. 30 participants will recei…

This study looks at how people with fibromyalgia or rheumatoid arthritis experience pain differently. Researchers will measure pain thresholds in 150 adults to better understand the underlying pain mechanisms. The goal is to improve knowledge, not to test a new treatment.

This study looks at a new method to mark the area where breast cancer was removed during surgery. The goal is to help radiation doctors see the exact spot on scans so they can aim radiation more precisely. It also aims to reduce the need for repeat surgeries when cancer cells are…

This study looks at how Friedreich's ataxia affects the heart and nerves using advanced imaging, exercise tests, and small tissue samples. Researchers will compare results from people with the condition and healthy volunteers aged 6 to 70. The goal is to find better ways to measu…

This study tests two types of short, repeated low-oxygen breathing sessions to see if they can improve breathing strength and cough function in people who had a spinal cord injury 2 weeks to 6 months ago. The goal is to find out which method works better and to identify genetic f…

This study looks at how body position and the type of anesthesia used during robotic surgery for gynecologic cancer affect pressure inside the eye. About 40 women will take part. The goal is to see if using only IV anesthesia keeps eye pressure lower than standard anesthesia, whi…

This study looks at how the thoughts and beliefs of people with low back pain and their physical therapists influence how much patients improve. About 90 adults with chronic low back pain will receive standard physical therapy including spinal manipulation, exercise, and educatio…

This study looks at how the shoulder tendon changes right after two different exercise programs. Researchers will use ultrasound to measure tendon thickness before and after exercise in 24 adults, some with shoulder pain and some without. The goal is to understand normal tendon r…

This study is looking at how well a procedure called endoscopic submucosal dissection (ESD) works for removing early-stage abnormal growths in the digestive tract. Researchers will track 300 adults who are already scheduled for ESD as part of their regular care. The goal is to se…

This study from the University of Florida looks at how listening to calming music might help your health and well-being. Researchers will measure heart rate, collect saliva samples, and use surveys to see how music affects your body's stress response. The study involves two phase…

This study looks at how dry needling works to relieve chronic low back pain. Researchers will study 71 adults aged 18-65 who have had low back pain for at least 3 months. Participants will receive dry needling and complete surveys and tests to measure pain, muscle stiffness, and …

This study looks at how Alpha-1 Antitrypsin Deficiency and Cystic Fibrosis affect white blood cells in the lungs called macrophages. Researchers will collect blood samples from 220 adults to measure how well these cells work. The goal is to better understand these diseases, not t…

This observational study looks at how severe trauma changes the body's blood and bone marrow, aiming to understand why some patients become immune-suppressed and develop infections like sepsis. Researchers will collect blood and bone marrow samples from 255 trauma patients and co…

This study compares red light and blue light used in dental procedures to see which causes less heat and less pain afterward. Researchers will measure temperature changes in the tooth during treatment and check in with 50 participants after their procedure. The goal is to find ou…

This study looks at whether measuring big toe strength can help doctors understand nerve damage caused by chemotherapy. Researchers will test 30 adults—some with nerve problems from chemo and some healthy—using a special device called ToeScale. Participants will also answer quest…