Can oxytocin curb opioid abuse? new study investigates

NCT ID NCT04218409

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase study at the University of Florida is testing whether combining oxytocin (a nasal spray) with the opioid oxycodone can reduce pain while lowering the drug's abuse potential. Forty-five healthy adults who have used opioids recreationally will take part in six lab sessions. Researchers will measure pain relief, subjective effects, and brain activity to see if the combination works better than either drug alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
oxytocin nasal spray and oxycodone oral tablets
What this could lead to
If successful, this could point toward a way to make opioid painkillers safer and less addictive.
What could go wrong
This is a very early, small lab study in healthy recreational users, not patients with chronic pain. Results may not translate to real-world use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Florida

    RECRUITING

    Gainesville, Florida, 32611, United States

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Other studies related to the condition(s) this trial covers.