PAIN

This study follows 4800 adults who use a Boston Scientific neurostimulation device for pain. It aims to see how well the device works in everyday life, including pain relief and quality of life. Participants are already scheduled to get the device as part of their normal care. Th…

This study tests whether a combined PET/MRI scan using a sugar tracer (FDG) can pinpoint the exact source of chronic pain that lingers after joint surgery. About 128 adults with persistent pain or no pain will be scanned and followed for up to a year. If successful, the method co…

This study tests if artificial intelligence can analyze facial expressions to recognize pain in people with fibromyalgia, a condition causing widespread body pain. Researchers will also check saliva for biological markers of pain. 61 fibromyalgia patients and 61 healthy volunteer…

This study tests whether the oral medication venlafaxine can prevent postherpetic neuralgia, a chronic pain condition that often follows shingles. Researchers will enroll 832 adults with active shingles and moderate to severe pain. The goal is to see if early treatment with venla…

This study looks at whether listening to live or recorded music can help lower stress, pain, and anxiety in people about to have brain surgery. About 132 patients will take part. Researchers will check things like heart rate, blood pressure, and mood before and after the music se…

This study looks at whether standing in the shower to urinate, instead of sitting on a toilet, can reduce pain and help women empty their bladder more fully after benign vaginal surgery. About 100 adult women will be randomly assigned to one of two positions for their first urina…

This study tests whether a flurbiprofen patch can safely reduce pain from shingles. Researchers will enroll 750 adults with moderate to severe pain. The patch delivers medicine directly to the skin, aiming to relieve pain with fewer side effects than oral painkillers.

This study looks at whether adding kinesiotaping (a special tape) to prenatal stretching exercises can reduce low back pain, improve movement, and enhance quality of life in pregnant women. About 34 women between 20-34 weeks of pregnancy and aged 18-35 will take part. Participant…

This study looks at whether the BETY exercise program, which combines physical exercises with emotional and social support, can improve pain and quality of life in people with knee osteoarthritis who have already received a joint injection. About 60 adults with moderate knee oste…

This study tests if using a stress ball can lower pain, anxiety, and changes in heart rate during chest tube removal after open heart surgery. About 46 adults will either squeeze a stress ball or receive standard care. Researchers will measure pain and anxiety levels right after …

This study tests whether using a virtual reality headset (REALICA) can lower pain and anxiety in people having common outpatient urology procedures like prostate biopsy, cystoscopy, or circumcision. About 56 adults will use the VR device during their procedure and report their an…

This study looks at whether a physiotherapist-led online exercise program can reduce pain and improve physical function in remote white-collar workers. About 33 adults who work from home and have low back or neck pain will take part. They will follow a guided exercise routine, an…

This study compares methadone (a long-acting opioid) to standard short-acting opioids for pain control after cleft palate repair in infants and young children aged 6 months to 4 years. The goal is to see if methadone reduces the total amount of opioids needed during recovery. Six…

This study tests a mobile app designed to help cancer survivors manage pain and other symptoms after finishing treatment. Researchers want to see if the app is easy to use and helpful. About 25 adults who have completed cancer treatment and still have pain will try the app for a …

This study looks at whether using a stress ball during cataract surgery can lower patients' pain and fear while increasing their satisfaction. Researchers will ask 60 adults having their first cataract surgery to squeeze a stress ball during the procedure. They will then measure …

This study looks at whether a numbing injection near the cheekbone before nose surgery can lower the amount of strong pain medicine needed during the operation and improve recovery. About 90 adults having nose surgery will either get the nerve block plus general anesthesia or jus…

This study tests whether applying special mud (peloid) to the jaw and chewing muscles can reduce pain and improve jaw function in adults with temporomandibular joint (TMJ) disorder. Forty participants will receive 20-minute mud treatments five days a week for two weeks. Researche…

This study looks at whether giving oxytocin (a natural hormone) along with oxycodone can lower the risk of addiction and improve pain relief in older adults. About 45 people who have used opioids before but do not have chronic pain will take part in 6 lab sessions. Researchers wi…

This study tests whether moderate to high doses of LSD can reduce anxiety, pain, and depression in 60 adults with advanced or terminal diseases who have 12 weeks to 2 years to live. Participants receive either two moderate-to-high LSD doses or two very low (active placebo) doses,…

This study tests whether a special leg reflex training can reduce the burning or stabbing nerve pain that often follows a spinal cord injury. Researchers will work with 15 people who have had this pain for at least a year. Over about 6.5 months, participants will do many training…

This early-stage study tests a new drug, TT5, for safety and how the body processes it. About 94 healthy adults and surgical patients will receive either TT5 or a placebo. The goal is to find a safe dose and see if it can help manage pain.

This study tests a training program that helps family caregivers assist their loved ones with mild to moderate dementia who also have chronic pain. The program teaches coping skills to reduce pain interference and improve quality of life. Researchers will enroll 60 participants (…

This study tests whether using a standardized, best-practice method for giving blood-thinning injections can reduce bruising and pain in heart patients. Researchers will compare the new protocol to usual care in 180 adults in cardiac units. The goal is to improve patient comfort …

This study looks at whether teaching people about the science of their pain, combined with tailored exercises, can reduce fear of movement, pain intensity, and negative thoughts about pain in adults with non-specific neck pain. Researchers will compare three groups: education plu…

This study tests a numbing injection (erector spinae plane block) given before lumbar spine fusion surgery. About 32 adults will receive the injection, which includes a numbing medicine and a non-narcotic pain reliever, plus a dye to see where it spreads. Researchers will measure…

This study tests two medications, pregabalin and a newer drug called crisugabalin, to see which works better for fibromyalgia pain. Fibromyalgia causes long-lasting pain, tiredness, and mood issues. The trial will include over 1,100 adults with moderate to severe pain who haven't…

This study tests whether a small electrical device (TENS) can reduce pain during an outpatient procedure for stress urinary incontinence in women. One hundred women will be randomly assigned to receive either real TENS or a placebo device during the procedure. The goal is to see …

This study tests whether injecting a low-dose anti-inflammatory drug (flurbiprofen) together with a numbing agent (ropivacaine) into the scalp before brain surgery can reduce pain afterward. About 216 adults having a craniotomy will take part. The goal is to see if this approach …

This study tests whether adding a newer pain medication called mirogabalin to standard shingles treatment provides better pain relief than standard treatment alone. The trial will enroll 750 adults with moderate to severe shingles pain that started within the last 30 days. Resear…

This study looks at whether a traveling team of pain specialists can help children and young adults (up to age 25) with moderate to severe intellectual disabilities, autism, or multiple disabilities who are in pain. The team visits patients at home or in their care setting to ass…

This study tests whether watching a calming video before and during a thyroid biopsy can reduce pain, anxiety, and improve comfort. About 68 adults will take part, with half watching the video and half receiving standard care. Researchers will measure pain, anxiety, and comfort l…

This study tests whether aromatherapy (lavender and orange oils) and digital anesthesia can reduce pain and anxiety in children during tooth extraction. About 132 kids aged 6-12 will receive one of these methods or standard care. The goal is to find a more comfortable, child-frie…

This study tests a special gel and mouthwash (XCM-OM118) to see if it can lower the chance of severe mouth sores in head and neck cancer patients getting radiation therapy. About 63 adults will use the product during and after treatment. The goal is to reduce pain and improve qua…

This study looks at whether Reiki, a non-invasive therapy where a practitioner lightly places hands near the body, can help adults with cancer who feel very tired from immunotherapy. Twelve participants will either receive six weekly Reiki sessions or wait, then switch. Researche…

This study trains psychotherapists to give personalized talk therapies to cancer patients and their caregivers who are feeling high levels of distress. Therapists will choose from proven treatments like cognitive behavioral therapy or mindfulness to address issues such as anxiety…

This pilot study tests whether patients recovering from shoulder surgery can safely and effectively give themselves liquid acetaminophen (Tylenol) instead of relying on nurses for pills. About 24 adults will try the patient-controlled liquid method, and researchers will measure h…

This study tests whether using a virtual reality (VR) meditation program during a vasectomy can lower pain, anxiety, and discomfort compared to standard care alone. About 90 adult men will be randomly assigned to either use a VR headset or receive usual care. The goal is to see i…

This study tests two medications, pregabalin and mirogabalin, to see which one better reduces pain in people with fibromyalgia, a condition causing widespread pain and fatigue. About 674 adults with moderate to severe fibromyalgia will take one of the drugs and report their pain …

This study looks at whether therapeutic cuddling (like kangaroo care or comfort holding) can help reduce pain, agitation, and delirium in children in the pediatric intensive care unit (PICU). About 112 children expected to stay in the PICU for more than 48 hours will be randomly …

This study tests a new pain medicine called suzetrigine in 210 adults having hip replacement surgery. Half will get the drug and half a placebo for 7 days, starting before surgery. The main goal is to see if it lowers the amount of opioids needed in the first 48 hours after surge…

This study tests whether a single mindfulness session before endometriosis surgery can help reduce pain and the need for painkillers afterward. About 20 adults with endometriosis will either receive the mindfulness training or standard education before their operation. Researcher…

This study tests whether listening to music during an early abortion procedure (manual vacuum aspiration) can help reduce pain and anxiety. About 176 women will be randomly assigned to either listen to their favorite songs through headphones or receive standard care. Researchers …

This study tests a special adhesive made with zinc oxide to secure catheters (thin tubes placed in veins) in hospitalized adults. The goal is to see if it reduces complications like the catheter moving, skin irritation, vein inflammation, and pain. About 400 participants who need…

This study tests whether extra support for case managers helps more veterans get a pain care program that combines counseling and non-drug treatments. The goal is to reduce pain, improve quality of life, and lower risky substance use. About 1800 veterans who recently left the mil…

This study looks at whether combining manual therapy (hands-on physical therapy) with vagus nerve stimulation (a technique using deep breathing) works better than manual therapy alone for people with jaw pain and limited movement. About 60 adults with myogenic temporomandibular d…

This study helps Veterans with chronic pain learn non-medication ways to manage it, like exercise or relaxation. Participants work with a coach to find approaches that fit their personal goals and values. The goal is to reduce how much pain interferes with daily life.

This study looks at whether giving children a nerve block in the arm before elbow fracture surgery helps control pain afterward. About 90 children with a specific type of elbow fracture will be randomly assigned to receive either the nerve block or standard care. Researchers will…

This study tests whether classical massage can reduce pain and improve daily life in people with myofascial pain syndrome, a condition causing persistent muscle knots and pain. Researchers will compare massage alone versus massage combined with standard physical therapy in 60 adu…

This study looks at whether giving parents extra information about what to expect and how to manage pain after surgery helps children feel better. About 900 children ages 1 to 6 having day surgery will take part. Researchers will compare pain levels and satisfaction between famil…

This study tests whether listening to a short mindfulness audio while waiting for an orthopedic appointment can reduce pain. About 400 adults will be randomly assigned to either the mindfulness exercise or a standard injury management talk. The goal is to see if this simple, no-d…

This study tests a new way to manage pain from broken ribs by freezing the nerves that cause pain. It involves 24 adults with rib fractures who will receive either standard pain care plus the freezing treatment or standard care alone. The goal is to see if this approach is practi…

This study follows 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep, anxiety, depression, or epilepsy. Researchers will track changes in symptoms and quality of life over 24 weeks using standard questionnaires. The goal is to understand how effect…

This study tests whether using virtual reality (VR) during a heart device implantation procedure can make patients more comfortable. 150 adults having a new device or battery change under local anesthesia will either use VR or receive standard care. Researchers will measure pain,…

This study looks at whether dronabinol, a drug similar to THC in cannabis, can reduce pain sensitivity and improve thinking and mood in people being treated for opioid use disorder. About 36 adults on stable methadone or buprenorphine will receive either dronabinol or a placebo b…

This study tests whether a medicated patch (loxoprofen sodium) can safely reduce pain from shingles. About 750 adults with moderate to severe shingles pain will use the patch and report their pain levels. The goal is to find a topical option that works well with fewer side effect…

This study tests whether using a ShotBlocker device, a cold needle, or both together can reduce pain and improve satisfaction for people getting a vitamin B12 shot. About 132 adults will take part, and their pain and satisfaction will be measured right after the injection. The go…

This study tests a device called NeuroCuple™ that uses no medication to manage pain after cesarean delivery. About 180 women will be randomly assigned to receive the device, a sham device, or standard care. The goal is to see if the device reduces pain and the need for opioid pai…

This study tests whether the antidepressant desvenlafaxine can safely reduce pain in people with shingles. Researchers will enroll 750 adults who have had a shingles rash for less than 90 days and are experiencing moderate to severe pain. The goal is to see if this medication off…

This study compares adhesive and elastic band devices for securing urinary catheters in critically ill patients. The goal is to see which type causes fewer injuries, less pain, and fewer infections. About 188 adults in intensive care will be randomly assigned to one device and mo…

This study tests whether playing pop or rock music during a colonoscopy can lower the pain people feel. About 1,042 adults will be randomly assigned to have music or not during their procedure. Afterward, they will rate their pain on a 0–10 scale. If music helps, it could be a si…

This study looks at whether combining pain education with therapeutic exercise can reduce pain and improve quality of life in women with endometriosis. Researchers will track how well participants stick with the program and measure changes in pain, negative thoughts about pain, a…

This study explores whether immersive virtual reality-based exercise therapy can reduce pain, improve shoulder function, sleep, and cognitive abilities in people with mild to moderate frozen shoulder (grade 1-2). Researchers will compare standard care plus VR exercise to standard…

This study tests whether adding a new pain drug called crisugabalin to standard treatment provides better pain relief for people with shingles. About 750 adults with moderate to severe shingles pain will receive either standard care alone or standard care plus crisugabalin. The g…

This early-stage study tests a new drug called HRS-6257 in 80 healthy adults to see if it is safe and how the body processes it. Researchers will also check if food changes how the drug works. The goal is to gather basic safety information before testing it in people with pain.

This study looks at whether listening to music for 10 minutes while in labor can lower anxiety and pain and boost satisfaction. About 106 women will either listen to music or have no music, then rate their feelings. The goal is to find a simple, drug-free way to improve the birth…

This study tests if a mouth rinse called MucoLock can safely reduce mouth pain or burning. About 25 adults with severe mouth discomfort will use it like a mouthwash three times a day for 28 days. The goal is to see if pain scores and quality of life improve.

This study tests whether a small electrical device (TENS) can reduce pain when an IUD is placed. About 86 women will either get real TENS or a fake device during the procedure. Researchers will compare pain scores to see if TENS helps.

This study tests two approaches for adults with chronic pain who take long-term opioids: a mindfulness program called MORE and patient-centered pain management visits. The goal is to see if these methods can reduce pain, improve quality of life, and lower the risk of opioid misus…

This study tests a prenatal education program designed to reduce fear of childbirth, improve beliefs about pain, and increase confidence for a normal delivery. It involves 126 first-time pregnant women in Turkey who are between 20 and 32 weeks pregnant with a low-risk pregnancy. …

This study looks at whether special mental imagery exercises or task-focused training can improve shoulder pain and movement better than standard physical therapy. About 66 adults with shoulder impingement will be split into three groups and treated for 6 weeks. The goal is to fi…

This study tests whether a digital cognitive behavioral therapy (CBT) program, with or without personalized peer support, can reduce pain, opioid use, and hospital visits in 470 teens and young adults (ages 16–30) with sickle cell disease and chronic pain. Participants will be ra…

This study compares two ways to manage pain in children aged 3-17 having tonsil surgery. One uses standard opioids, the other uses a non-opioid drug combo. The goal is to see if the opioid-free approach controls pain just as well while reducing side effects like nausea and agitat…

This study looks at whether wearing a lumbar brace for 4 weeks after an ER visit for low back pain can lower pain, improve spine function, and reduce the need for painkillers. About 152 adults aged 18-65 in Edmonton will be enrolled. The goal is to find a safer, non-drug option f…

This study tests whether a special, soothing way of talking called hypnotic communication can help patients feel less anxious and stressed during a heart catheterization. About 306 adults will be randomly assigned to receive either this calming talk plus usual care, or usual care…

This study compares pregabalin alone versus pregabalin plus venlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The trial will enroll 750 adults with moder…

This study looks at whether using a kaleidoscope or watching cartoons can lower pain, fear, and anxiety in children aged 7 to 12 when they get a numbing shot at the dentist. About 126 kids will be split into three groups: one uses a kaleidoscope, one watches cartoons, and one get…

This study tests if a small electrical device (TENS) placed inside the mouth can reduce pain after getting braces. About 150 teens and adults will have the device used on one side of their mouth and a fake device on the other side. They will rate their pain over three days to see…

This study tests whether adding nerve exercises (neural mobilization) to standard balance training can reduce pain, improve balance, and boost quality of life in people with diabetic neuropathy. About 32 adults aged 50-75 with type 2 diabetes and mild to moderate nerve pain will …

This study tests whether the muscle relaxant baclofen can safely reduce pain from shingles (herpes zoster). Researchers will enroll 750 adults with moderate to severe pain who have had a shingles rash for less than 90 days. Participants will take baclofen or a placebo, and pain l…

This study tests whether adding a non-opioid painkiller (ketorolac) to standard opioid pain medicine can reduce the amount of opioids needed after preventive thigh bone surgery. The surgery is for patients with cancer that has spread to the thigh bone but who do not have a broken…

This study compares virtual reality (VR) and music relaxation to standard care for reducing anxiety and pain in 600 women undergoing breast biopsies. Participants will be randomly assigned to one of three groups. The goal is to see if these simple, drug-free techniques make the p…

This study tests whether a handheld device called Grasp can reduce pain and distress in children and adolescents aged 8-15 during needle procedures like blood draws or injections. Participants will either use the device or receive standard care, then report their pain and distres…

This study compares taking pregabalin alone versus pregabalin combined with desvenlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The study will involve 3…

This study is testing a new pain treatment for people having total knee replacement surgery. The goal is to see if it can help them avoid or use fewer opioid painkillers after the operation. The study will involve 60 adults who are scheduled for knee replacement and will compare …

This study tests if dry needling—inserting thin needles into muscles—can help people with chronic low back pain feel better and improve their quality of life. Researchers will compare three different dry needling sessions in 42 adults aged 18 to 65. The goal is to see if the appr…

This study tests a device called NOVABLOC to see if it can reduce pain and the need for strong painkillers after knee replacement surgery. About 120 adults having a first knee replacement will be randomly assigned to get the real device or a sham version. The main goal is to meas…

This study tests a therapy called PATH-Pain for 100 older adults with mild memory problems, chronic pain, and depression. The therapy helps people cope with pain and mood issues to improve thinking and daily function. Participants are compared to those receiving usual care.

This study tests whether acupuncture can reduce pain in people with sickle cell disease. Researchers will use brain scans and other tests to understand how acupuncture works. The study involves 120 participants aged 14 to 80 who have chronic pain or recent pain crises. It aims to…

This study looks at whether warm sacral massage using cherry pits or taking a shower with partner support can lower pain during labor and improve the overall birth experience. About 150 first-time mothers giving birth vaginally will be split into three groups: massage, shower, or…

This study tests whether using virtual reality (VR) can help people use fewer opioid painkillers after heart or chest surgery. 60 patients will be split into three groups: one using interactive VR games, one watching relaxing 360-degree videos, and one receiving standard care. Th…

This study compares the pain-relieving effects of pregabalin alone versus pregabalin combined with toludesvenlafaxine in people with fibromyalgia. Fibromyalgia causes widespread pain, fatigue, and mood issues, and current treatments often provide only modest relief. The study wil…

This study tests whether a very short (7-minute) mindfulness exercise can help reduce pain and anxiety in adults undergoing kyphoplasty or radiofrequency ablation for back pain. About 80 participants will be randomly assigned to receive the mindfulness intervention or standard ca…

This study looks at whether playing with a special toy doll before getting a shot can lower fear, anxiety, and pain in children ages 4 to 6. About 80 kids will be split into two groups: one group plays with the doll first, and the other gets the shot the usual way. Researchers wi…

This study tests whether using a virtual reality headset during interventional radiology procedures can lower pain and anxiety in children ages 8 and older. About 500 participants will use VR while getting their procedure, and researchers will compare their pain and anxiety level…

This study tests whether using a virtual reality headset showing calming scenes (like puppies in a meadow) can reduce pain and discomfort for older adults in long-term care during wound dressing changes. About 20 residents will use VR during routine wound care for two weeks, with…

This study tests whether an oral medication called tulodsesvenlafaxine can safely reduce pain in people with shingles (herpes zoster). Shingles causes a painful rash and can lead to long-term nerve pain. The drug works by affecting brain chemicals that control pain. The trial wil…

This study tests whether wearing a virtual reality headset during a common kidney stone procedure (ESWL) can lower pain and anxiety. About 72 adults will be randomly assigned to either standard care or standard care plus VR. The goal is to see if VR can distract patients enough t…

This study looks at whether coloring can help adults feel less pain and anxiety while they wait in the emergency room. About 168 people with moderate pain or anxiety will be given nature or geometric coloring sheets to use. Researchers will measure changes in their self-reported …

This study is testing whether testosterone replacement therapy can improve pain, energy, sexual function, and overall quality of life in men. It focuses on men with chronic back pain who have been taking opioid painkillers for at least six months and have developed low testostero…

This study aims to learn more about how people feel pain and itch on their face. Thirty healthy adults will have their skin tested with different substances like histamine and capsaicin to see how their body reacts. The goal is to better understand these sensations, not to treat …

This study looks at how social and cultural factors affect how people express pain and how others judge that pain. Researchers will measure pain responses in healthy volunteers and then test whether observers can accurately estimate someone else's pain. The goal is to understand …

This study looks at how short walks affect pain in older adults who have muscle or joint pain. Researchers will have 40 participants do brief walking and chair-stand tests, then measure their pain levels. The goal is to understand how movement changes pain in daily life.

This study follows 8,000 adults in Denmark who are getting a screening colonoscopy for colorectal cancer. Researchers want to know how much pain or discomfort people feel during the procedure and whether that experience affects their decision to get screened again two years later…

This study looks at how two common anesthesia drugs, ketamine and propofol, change brain activity and brain waves. Researchers will give these drugs to 60 healthy adults and use MRI and EEG to measure effects on memory and pain perception. The goal is to understand how these drug…

This study aims to better understand pain by examining people with and without pain disorders. Researchers will expose participants to pleasant and unpleasant sensations, like heat, cold, or pressure, and collect health information through exams, questionnaires, and MRI scans. Th…

This study looks at how immune cells and inflammation might play a role in migraine. Researchers will compare 396 women with and without migraine, some of whom also have autoimmune diseases like multiple sclerosis or rheumatoid arthritis. The goal is to measure levels of certain …

This study looks at how cannabis affects pain relief and the risk of abuse differently in men and women. Researchers will measure pain tolerance, drug effects, and THC levels in 160 regular cannabis users aged 21-55. The goal is to understand sex-based differences, not to treat a…

This study looks at how cancer treatments cause nerve pain. Researchers will use simple tests like heat, cold, and touch to measure pain, and take small skin samples to see if nerve endings are damaged. The goal is to better understand this pain, not to treat it. Adults with adva…

This study tests a program called PAIN-CPG-EIT, which helps nursing home staff better assess and manage pain in residents with dementia. Researchers will compare this program to standard education alone in 12 nursing homes, involving 300 residents aged 60 and older. The goal is t…

This study looks at how brain activity changes when people feel pain. Researchers will use brain scans (fMRI, EEG) and mild brain stimulation (tACS, tRNS) to measure these changes. 60 healthy adults will take part. The goal is to better understand pain, not to treat it.

This study is testing whether giving patients pain medicine without opioids after major bone surgery is possible and works well. About 100 adults who had orthopedic surgery will either get the usual opioid prescription or an opioid-free plan. The main goal is to see if a larger s…

This study tests whether adding oxytocin (a natural hormone) to oxycodone can reduce the drug's addictive potential while improving pain relief. Researchers will give 45 healthy volunteers who have used opioids recreationally different combinations of oxytocin and oxycodone in a …

This study looks at how metabolic factors like insulin resistance and body measurements relate to pain and central sensitization in women with lipedema. Researchers will measure pain levels and other symptoms in 59 women to find connections. No treatments are given—this is an obs…

This study is building a large collection of surveys, blood, and saliva from 300 people with pain who are eligible for military healthcare. Researchers will follow participants over time to learn more about pain and how it affects daily life. No new treatments are being tested; t…

This study follows 260 adults newly diagnosed with cancer who had no sleep problems at the start. Researchers will track how insomnia develops over the first year, using questionnaires to measure sleep quality and severity. They also look at factors like cancer treatments, pain, …

This study looks at how the angle of your knee joint (seen on an X-ray) relates to pain, daily function, quality of life, and fear of moving. Researchers will measure these factors in 100 adults with knee osteoarthritis using questionnaires and X-ray readings. The goal is to bett…

This study looks at how a stroke can lead to long-term pain, called central poststroke pain (CPP). Researchers will use brain scans (MRI) to see if certain brain connections are linked to pain. The goal is to better understand why some stroke survivors develop this hard-to-treat …

This study aims to compare how likely low-dose buprenorphine is to be abused versus a standard dose of oxycodone, while also checking if they provide similar pain relief. About 120 healthy adults will receive different doses of buprenorphine, oxycodone, or a placebo in separate s…

This study looks at how much pain people experience after a cardiac arrest while they are in the intensive care unit. Researchers will track pain in 300 adults who are unconscious or sedated using special pain scales. The goal is to see how early pain relates to later problems li…

This study looks at how a single session of exercise can temporarily reduce sensitivity to pain in both healthy adults and stroke survivors who do not currently have pain. Researchers will measure pain thresholds before and after exercise to understand the body's natural pain-blo…

This study looks at how a low dose of nitrous oxide (laughing gas) changes the way the brain handles pain and memory. Healthy volunteers will have brain scans while feeling brief pain, with and without the gas. The goal is to understand which brain areas are involved, not to trea…

This study looks at how ketamine is processed in the body after a C-section and how it affects pain and mood. It involves 50 adults who have had a C-section, plus a control group of non-pregnant women and men. The goal is to better understand ketamine's effects in the postpartum …

This study tests whether an augmented reality (AR) system can safely help doctors guide needles during MRI scans. About 25 people aged 3 to 21 who need a needle procedure will try the AR system. The goal is to see if it works well and does not cause extra side effects.

This study looks at how nerve blocks help control pain in people who donate part of their liver. Researchers will map where the blocks work on the skin and track pain levels for the first 24 hours after surgery. The goal is to learn exactly how these blocks provide relief, so doc…

This study follows 50 people over age 50 who had arthroscopic rotator cuff repair. Researchers will measure shoulder disability, pain at rest and during movement, and sleep quality over the recovery period. The goal is to gather data to help create clearer rehab guidelines, since…

This study looks at how core stability (strength in the midsection) relates to reaction time, hand-eye coordination, pain, and daily function in people with rotator cuff tears. Researchers will compare 52 adults with rotator cuff lesions to healthy individuals using physical test…

This study looks at how smoking high-potency cannabis affects pain relief, feelings of being high, and drug levels in the blood. Researchers will test 30 near-daily cannabis users who are not trying to quit. Participants will be studied during their normal use and after a short b…

This study looks at whether children diagnosed with a specific learning disorder that affects written expression have differences in fingertip touch, hand grip strength, and pain sensitivity compared to healthy children. Researchers will measure these sensations using simple tool…

This study aims to see if it is possible to measure brain activity patterns related to thinking and attention in people with chronic pain or depression, compared to healthy volunteers. Participants will complete computer tasks while their brain activity is recorded, and receive m…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already receiving these drugs as part of their normal care. No new treatments are…

This study looks at how stress, pain, and the immune system interact in people living with HIV who also have cannabis use disorder and depression. Researchers will measure stress hormones, pain levels, and heart rate during a pain stress task. The goal is to better understand the…

This study tests a new drug that blocks a specific nerve channel (NaV1.8) to see which types of pain it reduces. Healthy volunteers receive tiny, safe doses injected into the skin and undergo brief pain tests like heat, cold, and pressure. The goal is to understand pain better an…

This study looks at how hormones like testosterone and estradiol influence pain sensitivity in cisgender and transgender individuals. Researchers will recruit 120 participants across six groups and use heat, cold, and pressure tests to measure pain responses. Blood samples will a…

This study looks at how short-term pain, created with a capsaicin heat patch, changes the way older adults (ages 55-90) learn and remember new walking patterns. Researchers will measure how well participants adjust their step symmetry on a split-belt treadmill and whether they re…

This study looks at how CBD (a non-psychoactive cannabis compound) changes the effects of THC (the part that makes you high). Researchers will give both substances to 30 regular cannabis users (ages 21-55) who are not seeking treatment. They will measure drug effects, pain relief…

This study aims to understand how psychological factors, such as expectations and emotions, influence the way we perceive pain. Healthy volunteers aged 18-50 will undergo brain scans (MRI) and pain tests (heat or electric shocks) while their heart rate, breathing, and other respo…

This study looks at how a placebo (fake) cream can change the way the brain processes pain. About 150 healthy adults will receive mild heat pulses on different body spots, with and without the cream. Researchers will use brain scans to see if the cream reduces pain-related brain …

This study looks at how age and sex influence the effects of smoked and oral THC (the main psychoactive ingredient in cannabis). Researchers will measure pain relief, intoxication, and risk of abuse in 103 adults aged 18-65 who already use cannabis weekly to monthly. The goal is …

This study looks at how the pain medicine remifentanil behaves in underweight intensive care patients who need a breathing machine. Researchers will measure drug levels in the blood and check vital signs like blood pressure. The goal is to find the right dose for this vulnerable …

This study aims to create an objective method to measure pain and how well pain treatments work, especially for children and others who cannot easily describe their pain. Researchers will use a device that tracks changes in the eye's pupil in response to pain and pain relief. The…

This study looks at why over 60% of people with ADPKD (a kidney disease) experience pain, often in the belly, side, or back. Researchers will use simple touch tests and questionnaires to measure pain and quality of life in 150 patients and compare them to healthy volunteers. The …

This study looks at how body composition and diet affect pain and inflammation in people with chronic spinal cord injury. Researchers will measure pain sensitivity and blood markers of inflammation after participants eat a high-fat or moderate-fat meal. The goal is to understand …

This study will follow about 200 gender minority adults, some starting gender-affirming hormone therapy and some not, to see how chronic pain changes over a year. Participants will fill out surveys, and some will also have pain sensitivity tests, brain MRIs, and interviews. The g…

This study looks at whether giving ICU staff real-time feedback and having a dedicated nurse facilitator can increase the use of a set of proven practices (the ABCDEF bundle) for adults on breathing machines. About 8,100 patients across multiple ICUs will take part. The goal is t…

This study looks at how the body processes anesthetics and painkillers in children and teenagers up to age 18. By measuring drug levels in the blood, researchers hope to find the right doses for safer and more effective pain control. The study is currently recruiting 500 particip…

This study looks at whether swelling (edema) after knee replacement surgery affects how a TENS machine needs to be adjusted for pain relief. Researchers will test three different TENS modes on 125 patients before and after surgery, comparing the affected leg to the healthy one. T…

This study looks at whether Native American adults who smoke can lower their risk of long-term pain by quitting smoking for 4 weeks. Participants will get help to stop smoking and then have pain tests, like cold water and mild electric shocks, to see how their body handles pain. …

This study uses brain scans (fMRI) to understand how the sedative remimazolam affects memory, pain perception, and brain activity. About 60 healthy adults will receive the drug and then perform memory tasks while experiencing mild pain. The goal is to learn more about how the dru…

This study looks at how negative feelings like stress, pain, or hunger change the way people make decisions. Healthy adults aged 18 to 55 will experience different emotional triggers (like watching a sad video or putting a hand in ice water) and then perform computer tasks. Some …

This study looks at how much of the pain medicine suzetrigine and its breakdown product enter breast milk. Twelve healthy women who are breastfeeding will take a single dose and provide milk samples. The goal is to estimate the dose a nursing baby might receive and check for any …

This early-stage study tests a new oral drug called SBS-147 in 80 healthy adults to see if it is safe and how the body handles it. Some participants get the drug, others get a placebo. The study has two parts: a single-dose group and a 7-day multiple-dose group. It does not aim t…

This study looks at how immersive virtual reality changes the way the brain processes chronic pain, compared to a placebo effect. Researchers will measure brain activity and pain tolerance in 78 adults with temporomandibular disorder (jaw pain) lasting at least 3 months. The goal…

This study looks at whether a 3-month virtual program called Choose to Move Replacement Ready is practical for people waiting for hip or knee replacement surgery due to osteoarthritis. About 60 participants will answer surveys and interviews about their activity, pain, and well-b…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and how different types of moderate exercise—strength training versus aerobic exercise—affect their pain. Participants will complete three sessions: baseline tests, a …

This study aims to find out how often nerve pain (neuropathic pain) occurs in people aged 80 and older. Researchers will also see how nerve pain relates to overall health in this age group. About 450 participants will answer pain questionnaires and undergo physical exams. The goa…

This study looks at how keeping a consistent sleep schedule affects heart health and metabolism in healthy adults aged 18-40, and also in people with chronic pain. Over 12 weeks, researchers will track sleep patterns and measure things like blood pressure, heart rate, and blood s…