PAIN

This study follows 4,800 adults who use a Boston Scientific neurostimulation system for pain. It aims to see how well the device works in everyday life over the long term. The study does not test a new treatment but observes real-world outcomes and costs.

This study tests whether a combined PET/MRI scan using a sugar tracer (FDG) can pinpoint the exact source of chronic pain that lingers after joint surgery. About 128 adults with persistent pain or no pain will be scanned and followed for up to a year. If successful, the method co…

This study tests if artificial intelligence can analyze facial expressions to recognize pain in people with fibromyalgia, a condition causing widespread body pain. Researchers will also check saliva for biological markers of pain. 61 fibromyalgia patients and 61 healthy volunteer…

This study tests whether the oral medication venlafaxine can prevent postherpetic neuralgia, a chronic pain condition that often follows shingles. Researchers will enroll 832 adults with active shingles and moderate to severe pain. The goal is to see if early treatment with venla…

This study tests whether using a stress ball can lower pain, anxiety, and changes in heart rate and blood pressure during chest tube removal after open heart surgery. About 46 adults who have one chest tube after surgery will be split into two groups: one group will squeeze a str…

This study looks at whether a numbing injection near the cheekbone before nose surgery can lower the amount of strong pain medicine needed during the operation and improve recovery. About 90 adults having septorhinoplasty will either get the nerve block plus general anesthesia or…

This study tests two approaches for adults with chronic pain who take long-term opioids: a mindfulness program called MORE and patient-centered pain management visits. The goal is to see if these methods can reduce pain, improve quality of life, and lower the risk of opioid misus…

This study tests a prenatal education program designed to reduce fear of childbirth, improve beliefs about pain, and increase confidence for a normal delivery. It involves 126 first-time pregnant women in Turkey who are between 20 and 32 weeks pregnant with a low-risk pregnancy. …

This study looks at whether special mental imagery exercises or task-focused training can improve shoulder pain and movement better than standard physical therapy. About 66 adults with shoulder impingement will be split into three groups and treated for 6 weeks. The goal is to fi…

This study tests whether a digital cognitive behavioral therapy (CBT) program, with or without personalized peer support, can reduce pain, opioid use, and hospital visits in 470 teens and young adults (ages 16–30) with sickle cell disease and chronic pain. Participants will be ra…

This study compares two ways to manage pain in children aged 3-17 having tonsil surgery. One uses standard opioids, the other uses a non-opioid drug combo. The goal is to see if the opioid-free approach controls pain just as well while reducing side effects like nausea and agitat…

This study looks at whether the BETY exercise program, which combines physical exercises with emotional and social support, can reduce pain and improve quality of life in people with knee osteoarthritis. Participants must have received a knee injection in the past month. The goal…

This study looks at whether giving parents extra information about what to expect and how to manage pain after surgery helps children feel better. About 900 children ages 1 to 6 having day surgery will take part. Researchers will compare pain levels and satisfaction between famil…

This early-phase study tests whether adding oxytocin (a natural hormone) to the opioid oxycodone can reduce its abuse potential while improving pain relief. Researchers will give 45 older adults different combinations of the drugs across six sessions and measure pain, subjective …

This study tests whether listening to a short mindfulness audio while waiting for an orthopedic appointment can reduce pain. About 400 adults will be randomly assigned to either the mindfulness exercise or a standard injury management talk. The goal is to see if this simple, no-d…

This study tests whether a small electrical device (TENS) can reduce pain during an outpatient procedure for stress urinary incontinence. About 100 women will be randomly assigned to receive either real TENS or a placebo device during the procedure. Researchers will measure pain …

This study tests a new way to manage pain from broken ribs by freezing the nerves that cause pain. It involves 24 adults with rib fractures who will receive either standard pain care plus the freezing treatment or standard care alone. The goal is to see if this approach is practi…

This study follows 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep, anxiety, depression, or epilepsy. Researchers will track changes in symptoms and quality of life over 24 weeks using standard questionnaires. The goal is to understand how effect…

This study tests whether using virtual reality (VR) during a heart device implantation procedure can make patients more comfortable. 150 adults having a new device or battery change under local anesthesia will either use VR or receive standard care. Researchers will measure pain,…

This study tests whether injecting a low-dose painkiller (flurbiprofen) and a numbing drug (ropivacaine) into the scalp before brain surgery can reduce the need for strong opioid pain medicine afterward. About 216 adults having craniotomy will take part. The goal is to see if thi…

This study tests whether a long-acting opioid (methadone) works better than short-acting opioids (fentanyl/hydromorphone) for pain control after cleft palate repair in infants and young children aged 6 months to 4 years. The goal is to reduce the total amount of opioids needed an…

This study looks at whether dronabinol, a drug similar to THC in cannabis, can reduce pain sensitivity and improve thinking and mood in people being treated for opioid use disorder. About 36 adults on stable methadone or buprenorphine will receive either dronabinol or a placebo b…

This study tests whether a medicated patch (loxoprofen sodium) can safely reduce pain from shingles. About 750 adults with moderate to severe shingles pain will use the patch and report their pain levels. The goal is to find a topical option that works well with fewer side effect…

This study compares two medications, pregabalin and mirogabalin, to see which works better for easing pain in people with fibromyalgia, a condition causing widespread pain and fatigue. About 674 adults with moderate to severe fibromyalgia who haven't tried these drugs before will…

This study tests whether using a ShotBlocker device, a cold needle, or both together can reduce pain and improve satisfaction for people getting a vitamin B12 shot. About 132 adults will take part, and their pain and satisfaction will be measured right after the injection. The go…

This study tests a device called NeuroCuple™ that uses no medication to manage pain after cesarean delivery. About 180 women will be randomly assigned to receive the device, a sham device, or standard care. The goal is to see if the device reduces pain and the need for opioid pai…

This study tests whether the antidepressant desvenlafaxine can safely reduce pain in people with shingles. Researchers will enroll 750 adults who have had a shingles rash for less than 90 days and are experiencing moderate to severe pain. The goal is to see if this medication off…

This study tests whether using a virtual reality headset (REALICA) can help reduce pain and anxiety in people undergoing common outpatient urology procedures like prostate biopsy, cystoscopy, or circumcision. About 56 adults will use the VR device during their procedure and repor…

This study tests whether aromatherapy (lavender and orange oils) and a digital anesthesia device can reduce pain and anxiety in children aged 6-12 during tooth extraction. About 132 kids will be assigned to different groups to compare these methods with traditional anesthesia. Th…

This study tests whether adding a newer pain medication called mirogabalin to standard shingles treatment provides better pain relief than standard treatment alone. The trial will enroll 750 adults with shingles rash for less than 30 days and moderate to severe pain. Mirogabalin …

This study looks at whether adding kinesiotaping (a special elastic tape) to prenatal stretching exercises can reduce low back pain, improve movement, and enhance quality of life in pregnant women. About 34 women between 20-34 weeks pregnant and aged 18-35 will take part. They wi…

This study tests whether a numbing injection placed near the spine can reduce pain after lower back fusion surgery. About 32 adults will receive the injection before surgery, and researchers will track their pain scores and recovery for four days. The goal is to see if this appro…

This study looks at whether therapeutic cuddling (like kangaroo care or comfort holding) can help reduce pain, agitation, and delirium in children in the pediatric intensive care unit (PICU). About 112 kids expected to stay more than 48 hours will be randomly assigned to receive …

This study tests whether listening to music during a first-trimester abortion procedure can lower pain and anxiety. About 176 women will be randomly assigned to either listen to their favorite songs through headphones or receive standard care. Researchers will measure pain and an…

This study compares adhesive and elastic band devices for securing urinary catheters in critically ill patients. The goal is to see which type causes fewer injuries, less pain, and fewer infections. About 188 adults in intensive care will be randomly assigned to one device and mo…

This study tests whether a single, short mindfulness session before endometriosis surgery can help reduce pain and the need for painkillers afterward. About 20 adults with endometriosis will either receive the mindfulness training or standard education before their operation. Res…

This study tests whether playing pop or rock music during a colonoscopy can lower the pain people feel. About 1,042 adults will be randomly assigned to have music or not during their procedure. Afterward, they will rate their pain on a 0–10 scale. If music helps, it could be a si…

This study looks at whether patients recovering from shoulder surgery can safely and effectively give themselves liquid acetaminophen (a common pain reliever) instead of waiting for a nurse to bring pills. About 24 adults will be enrolled to test how well this patient-controlled …

This study looks at whether wearing a lumbar brace for 4 weeks after an ER visit for low back pain can lower pain, improve spine function, and reduce the need for painkillers. About 152 adults aged 18-65 in Edmonton will be enrolled. The goal is to find a safer, non-drug option f…

This study looks at whether listening to live or recorded music can help lower stress, pain, and improve mood in people about to have brain surgery. Researchers will check things like heart rate, stress hormones, and how patients feel using simple questionnaires. The goal is to f…

This study tests whether a special, soothing way of talking called hypnotic communication can help patients feel less anxious and stressed during a heart catheterization. About 306 adults will be randomly assigned to receive either this calming talk plus usual care, or usual care…

This study tests whether watching a calming video before and during a thyroid biopsy can reduce pain, anxiety, and increase comfort. About 68 adults will take part, with half watching the video and half receiving standard care. The goal is to see if a simple, drug-free method can…

This study compares pregabalin alone versus pregabalin plus venlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The trial will enroll 750 adults with moder…

This study looks at whether using a kaleidoscope or watching cartoons can lower pain, fear, and anxiety in children aged 7 to 12 when they get a numbing shot at the dentist. About 126 kids will be split into three groups: one uses a kaleidoscope, one watches cartoons, and one get…

This study tests if a small electrical device (TENS) placed inside the mouth can reduce pain after getting braces. About 150 teens and adults will have the device used on one side of their mouth and a fake device on the other side. They will rate their pain over three days to see…

This study looks at whether classical massage can reduce pain and improve daily life in people with myofascial pain syndrome, a condition that causes muscle tenderness and pain. Researchers will compare massage alone versus massage combined with standard physical therapy in 60 ad…

This study tests whether adding nerve exercises (neural mobilization) to standard balance training can reduce pain, improve balance, and boost quality of life in people with diabetic neuropathy. About 32 adults aged 50-75 with type 2 diabetes and mild to moderate nerve pain will …

This study looks at whether a relaxing therapy called Reiki can help adults with cancer who feel very tired from immunotherapy. Twelve people will either get six weekly Reiki sessions right away or wait six weeks before starting. Researchers will track changes in fatigue, pain, a…

This study tests a mouth rinse called MucoLock to see if it can reduce mouth pain or burning. About 25 adults with severe mouth burning will use the rinse three times a day for 28 days. The goal is to find a simple, well-tolerated treatment for this uncomfortable condition.

This study tests whether the muscle relaxant baclofen can safely reduce pain from shingles (herpes zoster). Researchers will enroll 750 adults with moderate to severe pain who have had a shingles rash for less than 90 days. Participants will take baclofen or a placebo, and pain l…

This study tests a special gel and mouthwash (XCM-OM118) in 63 head and neck cancer patients getting radiation, with or without chemo. The goal is to see if it lowers the chance of severe mouth sores (grade 3-4) and improves quality of life. Patients use the product during radiat…

This study explores whether immersive virtual reality-based exercise therapy can reduce pain, improve shoulder function, sleep, and thinking skills in people with mild-to-moderate frozen shoulder (Grade 1-2 adhesive capsulitis). Researchers will enroll 36 adults aged 18-64 who ar…

This study tests a special adhesive made with zinc oxide to hold catheters (thin tubes placed in veins) in place for hospitalized adults. The goal is to see if this device reduces complications like the catheter moving, skin irritation, vein inflammation, and pain. About 400 pati…

This study tests two medications, pregabalin and a newer drug called crisugabalin, to see which works better for fibromyalgia pain. About 1,100 adults with moderate to severe fibromyalgia will take one of the drugs and report their pain levels. The goal is to find a more effectiv…

This study tests whether using a standardized method for giving blood thinner injections can reduce bruising and pain in heart patients. Researchers will compare the new approach to usual care in 180 adults in cardiac units in Hong Kong. The goal is to improve patient comfort and…

This study trains psychotherapists to give personalized talk therapy to cancer patients and their caregivers who are feeling very distressed. Therapists learn to use proven methods like cognitive behavioral therapy and mindfulness to help with anxiety, depression, pain, fatigue, …

This study tests whether adding a non-opioid painkiller (ketorolac) to standard opioid pain medicine can reduce the amount of opioids needed after preventive thigh bone surgery. The surgery is for patients with cancer that has spread to the thigh bone but who do not have a broken…

This early-stage study tests a new drug, TT5, to see if it is safe and how the body processes it. About 94 healthy adults and people recovering from surgery will receive either TT5 or a placebo. The goal is to find the right dose and check for side effects, with the hope of devel…

This study looks at whether a traveling team of pain specialists can help children and young adults (up to age 25) with moderate to severe intellectual disabilities, autism, or multiple disabilities feel better. The team visits patients at home or in care facilities to assess and…

This study compares virtual reality (VR) and music relaxation to standard care for reducing anxiety and pain in 600 women undergoing breast biopsies. Participants will be randomly assigned to one of three groups. The goal is to see if these simple, drug-free techniques make the p…

This study looks at whether teaching people about their pain before doing specific exercises can help reduce fear of movement, pain intensity, and negative thoughts about pain. Researchers will compare three groups: exercise plus pain education, exercise alone, and a placebo. The…

This study tests a new pain medicine called suzetrigine in 210 adults having hip replacement surgery. Half will get the drug and half a placebo for 7 days, starting before surgery. The main goal is to see if it lowers the amount of opioids needed in the first 48 hours after surge…

This study tests whether a handheld device called Grasp can reduce pain and distress in children and adolescents aged 8-15 during needle procedures like blood draws or injections. Participants will either use the device or receive standard care, then report their pain and distres…

This study compares taking pregabalin alone versus pregabalin combined with desvenlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The study will involve 3…

This study is testing a new pain treatment for people having total knee replacement surgery. The goal is to see if it can help them avoid or use fewer opioid painkillers after the operation. The study will involve 60 adults who are scheduled for knee replacement and will compare …

This study tests a training program that helps family caregivers assist their loved ones with mild to moderate dementia in managing chronic pain. The program teaches coping skills to reduce pain interference and improve quality of life. Researchers will enroll 60 participants (30…

This study tests if dry needling—inserting thin needles into muscles—can help people with chronic low back pain feel better and improve their quality of life. Researchers will compare three different dry needling sessions in 42 adults aged 18 to 65. The goal is to see if the appr…

This study tests a device called NOVABLOC to see if it can reduce pain and the need for strong painkillers after knee replacement surgery. About 120 adults having a first knee replacement will be randomly assigned to get the real device or a sham version. The main goal is to meas…

This study tests whether training the leg's reflexes can reduce nerve pain in people with spinal cord injury. Researchers will enroll 15 adults who have had a spinal cord injury for at least a year and have nerve pain in their lower leg. The study lasts about 6.5 months and invol…

This study tests a therapy called PATH-Pain for 100 older adults with mild memory problems, chronic pain, and depression. The therapy helps people cope with pain and mood issues to improve thinking and daily function. Participants are compared to those receiving usual care.

This study tests whether moderate to high doses of LSD can reduce anxiety, depression, and pain in people with advanced, life-limiting illnesses. Sixty participants with a life expectancy of 12 weeks to 2 years will receive either two doses of LSD or a very low dose as a placebo.…

This study tests whether acupuncture can reduce pain in people with sickle cell disease. Researchers will use brain scans and other tests to understand how acupuncture works. The study involves 120 participants aged 14 to 80 who have chronic pain or recent pain crises. It aims to…

This study looks at whether warm sacral massage using cherry pits or taking a shower with partner support can lower pain during labor and improve the overall birth experience. About 150 first-time mothers giving birth vaginally will be split into three groups: massage, shower, or…

This study tests whether a simple breathing technique called box breathing can help reduce anxiety, pain, and nausea in adults undergoing a medical procedure called ERCP. About 70 participants will be randomly assigned to either receive standard care plus box breathing training o…

This study tests whether using virtual reality (VR) can help people use fewer opioid painkillers after heart or chest surgery. 60 patients will be split into three groups: one using interactive VR games, one watching relaxing 360-degree videos, and one receiving standard care. Th…

This study looks at whether listening to music for 10 minutes during labor can lower anxiety and pain levels for women giving birth. About 106 participants will either listen to music or have no music, then answer questions about their anxiety, pain, and satisfaction. The goal is…

This study looks at whether adding a simple nerve stimulation technique (using deep breathing to activate the vagus nerve) to standard manual therapy can better reduce pain and improve jaw movement in people with temporomandibular disorders (TMD). Sixty adults with jaw muscle pai…

This study looks at whether using a stress ball during cataract surgery can lower patients' pain and fear and increase their satisfaction. About 60 adults having their first cataract surgery will be asked to squeeze a stress ball during the procedure. Researchers will then measur…

This study compares the pain-relieving effects of pregabalin alone versus pregabalin combined with toludesvenlafaxine in people with fibromyalgia. Fibromyalgia causes widespread pain, fatigue, and mood issues, and current treatments often provide only modest relief. The study wil…

This early-stage study tests an experimental pain drug called HRS-6257 in 80 healthy volunteers aged 18-55. The main goal is to check safety and side effects, and to see how the body processes the drug with and without food. Participants will receive either the drug or a placebo,…

This study helps Veterans with long-term muscle or joint pain find ways to manage it without medication. Participants work with a coach to explore personal goals and non-drug options like exercise or relaxation. The goal is to reduce how much pain interferes with daily life.

This study tests whether a very short (7-minute) mindfulness exercise can help reduce pain and anxiety in adults undergoing kyphoplasty or radiofrequency ablation for back pain. About 80 participants will be randomly assigned to receive the mindfulness intervention or standard ca…

This study tests whether applying a special mud (peloid) to the jaw and cheek muscles can reduce pain and improve chewing and speaking in people with temporomandibular joint (TMJ) disorders. Forty adults with jaw pain for at least 4 weeks will receive 20-minute mud treatments fiv…

This study looks at whether playing with a special toy doll before getting a shot can lower fear, anxiety, and pain in children ages 4 to 6. About 80 kids will be split into two groups: one group plays with the doll first, and the other gets the shot the usual way. Researchers wi…

This study looks at whether combining pain education with therapeutic exercise can reduce pain, improve quality of life, and lower pain-related distress in women with endometriosis. Researchers will track how well participants stick with the program and any side effects like incr…

This study looks at whether a physiotherapist-supervised online exercise program can ease pain and boost physical function in remote white-collar workers. About 33 adults who work from home and have back or neck pain will take part. They will follow guided exercises online, and r…

This study tests whether using a virtual reality headset during interventional radiology procedures can lower pain and anxiety in children ages 8 and older. About 500 participants will use VR while getting their procedure, and researchers will compare their pain and anxiety level…

This study tests whether using a virtual reality (VR) headset with a guided meditation program during a vasectomy can lower pain, anxiety, and discomfort. About 90 adult men will be randomly assigned to either use VR or receive standard care. The goal is to see if VR can make the…

This study tests whether using a virtual reality headset showing calming scenes (like puppies in a meadow) can reduce pain and discomfort for older adults in long-term care during wound dressing changes. About 20 residents will use VR during routine wound care for two weeks, with…

This study is testing a mobile app designed to help cancer survivors manage pain and other symptoms after finishing treatment. About 25 adults who have completed cancer treatment and still have pain will use the app for several weeks. The goal is to see if the app is easy to use …

This study tests whether adding crisugabalin, a newer pain medicine, to usual treatment provides better pain relief for people with shingles. About 750 adults with moderate to severe shingles pain will receive either standard care alone or standard care plus crisugabalin. The goa…

This study tests whether an oral medication called tulodsesvenlafaxine can safely reduce pain in people with shingles (herpes zoster). Shingles causes a painful rash and can lead to long-term nerve pain. The drug works by affecting brain chemicals that control pain. The trial wil…

This study looks at whether giving children a nerve block in the arm before elbow fracture surgery can reduce pain and the need for opioid painkillers afterward. About 90 children with closed elbow fractures will be randomly assigned to receive either the nerve block or standard …

This study tests whether wearing a virtual reality headset during a common kidney stone procedure (ESWL) can lower pain and anxiety. About 72 adults will be randomly assigned to either standard care or standard care plus VR. The goal is to see if VR can distract patients enough t…

This study tests whether a small electrical device (TENS) can reduce pain when an IUD is placed. About 86 women will get either real TENS or a fake device during the procedure. Researchers will compare pain scores to see if TENS helps.

This study tests whether a flurbiprofen patch can safely reduce pain from shingles (herpes zoster). The patch delivers pain relief directly to the skin, aiming to avoid side effects from oral painkillers. Researchers will enroll 750 adults with moderate to severe shingles pain to…

This study looks at whether coloring can help adults feel less pain and anxiety while they wait in the emergency room. About 168 people with moderate pain or anxiety will be given nature or geometric coloring sheets to use. Researchers will measure changes in their self-reported …

This study looks at whether standing in the shower to urinate, instead of sitting on a toilet, can reduce pain and help women empty their bladder more fully after having a urinary catheter removed following vaginal surgery. About 100 adult women will be randomly assigned to one o…

This study is testing whether testosterone replacement therapy can improve pain, energy, sexual function, and overall quality of life in men. It focuses on men with chronic back pain who have been taking opioid painkillers for at least six months and have developed low testostero…

This study uses brain scans (fMRI) to understand how low doses of nitrous oxide (laughing gas) affect the way the brain processes pain and forms memories. Healthy volunteers will have their brain activity measured while receiving mild pain stimulation, both with and without the g…

This study looks at whether cannabis affects pain relief and the risk of abuse differently in men and women. Researchers will give cannabis to 160 people who already use it and measure their pain response, drug effects, and blood levels. The goal is to understand sex-based differ…

This study aims to create an objective method to measure pain and how well pain treatments work, especially for children and others who cannot easily describe their pain. Researchers will use a device that tracks changes in the eye's pupil in response to pain and pain relief. The…

This study aims to understand how cancer therapies cause nerve pain by testing how patients feel heat, cold, and touch. Researchers will also take small skin samples to see if nerve endings have pulled back. The goal is to learn more about this type of pain, not to treat it. Adul…

This study tests whether an augmented reality (AR) system can help doctors guide needles during MRI scans. About 25 people aged 3 to 21 who need a needle procedure will try the AR system. The goal is to see if it is safe and works well, not to treat a disease.

This study aims to better understand pain by testing how people with and without pain disorders respond to different sensations like heat, cold, and pressure. Researchers will also use questionnaires, medical history, and brain scans to gather information. The goal is to learn mo…

This study tests whether adding oxytocin (the 'love hormone') to oxycodone can reduce pain while lowering the risk of addiction. Researchers will give 45 recreational opioid users different combinations of the two drugs and measure pain relief, subjective effects, and brain activ…

This study tests a new drug that blocks a specific nerve channel (NaV1.8) to see which types of pain it reduces. Healthy volunteers receive tiny, safe doses injected into the skin and undergo brief pain tests like heat, cold, and pressure. The goal is to understand pain better an…

This study looks at how hormones like testosterone and estradiol influence pain sensitivity in cisgender and transgender individuals. Researchers will recruit 120 participants across six groups and use heat, cold, and pressure tests to measure pain responses. Blood samples will a…

This study looks at why some stroke survivors develop long-term pain, called central poststroke pain (CPP). Researchers will use brain scans to see how brain connections change in people with this pain. The goal is to better understand the condition, which currently has no effect…

This study looks at how the body processes ketamine after a C-section to help with pain and postpartum depression. Researchers will compare results in new mothers, non-pregnant women, and men. The goal is to better understand how ketamine works in the body after pregnancy, not to…

This study looks at whether core stability (strength in your midsection) is linked to reaction time, hand-eye coordination, pain, and daily function in people with rotator cuff injuries. Researchers will compare 52 adults with these injuries to healthy individuals using tests lik…

This study looks at how short-term pain, created with a capsaicin heat patch, changes the way older adults (ages 55-90) learn and remember new walking patterns. Researchers will measure how well participants adjust their step symmetry on a split-belt treadmill and whether they re…

This study looks at how CBD (a non-psychoactive cannabis compound) changes the effects of THC (the part that makes you high). Researchers will give both substances to 30 regular cannabis users (ages 21-55) who are not seeking treatment. They will measure drug effects, pain relief…

This study looks at how brief periods of walking affect pain in older adults who have muscle or joint pain. Researchers will measure pain responses during simple tasks like standing up from a chair. The goal is to better understand how the body adapts to pain with movement. 40 pa…

This study looks at how the angle of your knee bones, seen on an X-ray, relates to pain, fear of moving, and quality of life in people with knee osteoarthritis. Researchers will measure pain, function, and fear of movement in 100 adults using questionnaires and compare these to t…

This study looks at how a single session of exercise can temporarily reduce sensitivity to pain in both healthy adults and stroke survivors who do not currently have pain. Researchers will measure pain thresholds before and after a cardiovascular workout to understand the body's …

This study aims to understand how psychological factors, such as expectations and emotions, influence the way we perceive pain. Healthy volunteers aged 18-50 will undergo brain scans (MRI) and pain tests (heat or electric shocks) while their heart rate, breathing, and other respo…

This study looks at why migraine is more common in people with autoimmune diseases like multiple sclerosis or rheumatoid arthritis. Researchers will measure immune cells and inflammatory markers in 396 women with and without migraine, including those with autoimmune conditions. T…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1,800 veterans who recently left service and have a back, neck, knee, or shoulder condition will take part. The program includes s…

This study looks at whether children aged 6-12 with a specific learning disorder that affects written expression have different touch sensitivity, pain thresholds, and hand or finger strength compared to children without the disorder. Researchers will measure fingertip touch, han…

This study looks at why over 60% of people with ADPKD (a kidney disease) experience pain, often in the belly, side, or back. Researchers will use simple touch tests and questionnaires to measure pain and quality of life in 150 patients and compare them to healthy volunteers. The …

This study looks at how body composition and diet affect pain and inflammation in people with chronic spinal cord injury. Researchers will measure pain sensitivity and blood markers of inflammation after participants eat a high-fat or moderate-fat meal. The goal is to understand …

This study looks at how a person's age and sex affect their response to THC, the main active ingredient in cannabis. Researchers will give THC by smoking or by mouth to 103 adults aged 18-65 who already use cannabis weekly or monthly. The goal is to measure pain relief, feelings …

This study looks at how two common anesthesia drugs, ketamine and propofol, change brain activity related to memory and pain. Researchers will use MRI and EEG to scan the brains of 60 healthy adults while they receive the drugs alone or together. The goal is to understand how the…

This study will follow about 200 gender minority adults, some starting gender-affirming hormone therapy and some not, to see how chronic pain changes over a year. Participants will fill out surveys, and some will also have pain sensitivity tests, brain MRIs, and interviews. The g…

This study is a small test to see if a larger trial comparing two pain management plans after major orthopedic surgery is possible. One plan uses only non-opioid pain relievers, while the other includes opioids as usual. The study will enroll 100 adults to check if patients can b…

This study is building a large collection of information and biological samples (blood and saliva) from 300 people with pain who are eligible for military healthcare. Researchers will use surveys and lab tests to learn more about pain and how it affects people. This is an observa…

This study looks at how smoking high-potency cannabis affects pain relief and feelings of being high. Researchers will test 30 near-daily cannabis users who are not trying to quit. They will compare results when people smoke as usual and after a short break from cannabis.

This study looks at whether giving ICU staff real-time feedback and having a dedicated nurse facilitator can increase the use of a set of proven practices (the ABCDEF bundle) for adults on breathing machines. About 8,100 patients across multiple ICUs will take part. The goal is t…

This study looks at how the body processes anesthetics and painkillers in children and teenagers up to age 18. By measuring drug levels in the blood, researchers hope to find the right doses for safer and more effective pain control. The study is currently recruiting 500 particip…

This study looks at whether swelling (edema) after knee replacement surgery affects how a TENS machine needs to be adjusted for pain relief. Researchers will test three different TENS modes on 125 patients before and after surgery, comparing the affected leg to the healthy one. T…

This study looks at whether Native American adults who smoke can lower their risk of long-term pain by quitting smoking for 4 weeks. Participants will get help to stop smoking and then have pain tests, like cold water and mild electric shocks, to see how their body handles pain. …

This study follows 260 adults newly diagnosed with cancer who have no prior sleep problems. Researchers will track insomnia symptoms over the first year using questionnaires. The goal is to understand when and why sleep issues start and what factors—like treatment type or emotion…

This study looks at how brain activity changes when people feel pain. Researchers will use brain scans (fMRI, EEG) and mild brain stimulation to understand pain signals. 60 healthy adults will take part. The goal is to learn more about pain, not to test a new treatment.

This study uses brain scans (fMRI) to understand how the sedative remimazolam affects memory, pain perception, and brain activity. About 60 healthy adults will receive the drug and then perform memory tasks while experiencing mild pain. The goal is to learn more about how the dru…

This study aims to see if it is possible to measure brain activity patterns related to thinking and attention in people with chronic pain or depression, compared to healthy volunteers. Participants will complete computer tasks while their brain activity is recorded. No treatment …

This study looks at how stress and pain affect hormones and mood in 120 people with or without HIV, cannabis use disorder, and depression. Participants will do a pain stress task and give blood samples to measure stress chemicals. The goal is to understand these connections, not …

This study looks at how negative feelings like stress, pain, or hunger change the way people make decisions. Healthy adults aged 18 to 55 will experience different emotional triggers (like watching a sad video or putting a hand in ice water) and then perform computer tasks. Some …

This study looks at how nerve blocks work for people who donate part of their liver. Researchers will map where the blocks stop feeling and track pain levels in 20 donors. The goal is to learn exactly how these blocks cover pain after surgery, so doctors can improve care for futu…

This study looks at how much of the pain medicine suzetrigine and its breakdown product enter breast milk. Twelve healthy women who are breastfeeding will take a single dose and provide milk samples. The goal is to estimate the dose a nursing baby might receive and check for any …

This study aims to see if low-dose buprenorphine (a partial opioid) can provide pain relief similar to oxycodone but with less risk of abuse. Healthy volunteers will receive different doses of buprenorphine, oxycodone, or a placebo in separate sessions. Researchers will measure p…

This study looks at how metabolic factors like insulin resistance and body measurements relate to pain and nerve sensitivity in women with lipedema. Researchers will measure pain levels and central sensitization (a condition where the nervous system is overly sensitive to pain) i…

This study aims to learn more about how people feel pain and itch, especially on the face. Thirty healthy adults will take part in three sessions where they receive different substances (like histamine or capsaicin) and rate their sensations. The goal is to better understand thes…

This study looks at how a placebo (fake) cream can change the way your brain feels pain. Researchers will apply heat to eight spots on the body and use brain scans to see if the cream lowers pain unpleasantness and intensity. About 150 healthy adults will take part. The goal is t…

This study looks at how the pain medicine remifentanil behaves in low-weight intensive care patients who need a breathing machine. Researchers will measure drug levels in the blood and check blood pressure changes. The goal is to find the right dose for this group to improve safe…

This study looks at how people feel during a screening colonoscopy for colorectal cancer and whether that experience influences their decision to come back for future screenings. Researchers will ask 8,000 participants about pain, discomfort, and other feelings right after the pr…

This early-stage study tests a new oral drug called SBS-147 in 80 healthy adults to see if it is safe and how the body handles it. Some participants get the drug, others get a placebo. The study has two parts: a single-dose group and a 7-day multiple-dose group. It does not aim t…

This study looks at pain in patients who survive a cardiac arrest and are treated in the intensive care unit (ICU). Researchers want to understand how pain is measured and managed, and how it affects recovery, including the risk of delirium. The goal is to improve pain care and h…

This study looks at how immersive virtual reality changes the way the brain processes chronic pain, compared to a placebo effect. Researchers will measure brain activity and pain tolerance in 78 adults with temporomandibular disorder (jaw pain) lasting at least 3 months. The goal…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already taking these drugs as part of their regular care, or have had a recent CO…

This study looks at whether a 3-month virtual program called Choose to Move Replacement Ready is practical for people waiting for hip or knee replacement surgery due to osteoarthritis. About 60 participants will answer surveys and interviews about their activity, pain, and well-b…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and how different types of moderate exercise—strength training versus aerobic exercise—affect their pain. Participants will complete three sessions: baseline tests, a …

This study aims to find out how often nerve pain (neuropathic pain) occurs in people aged 80 and older. Researchers will also see how nerve pain relates to overall health in this age group. About 450 participants will answer pain questionnaires and undergo physical exams. The goa…

This study tests a program called PAIN-CPG-EIT, which helps nursing home staff better assess and manage pain in residents with dementia. About 300 residents from 12 nursing homes will take part. Half of the homes will get the full program with coaching and support, while the othe…

This study looks at how keeping a consistent sleep schedule affects heart health and metabolism in healthy adults aged 18-40, and also in people with chronic pain. Over 12 weeks, researchers will track sleep patterns and measure things like blood pressure, heart rate, and blood s…

This study looks at how a person's background—like race or ethnicity—affects how they feel and show pain, and how others judge that pain. Researchers will measure pain responses in healthy volunteers and then test if people can learn to assess pain more accurately. The goal is to…

This study follows 50 people over age 50 who had arthroscopic rotator cuff repair. Researchers will measure shoulder disability, pain (at rest, during movement, and at night), and sleep quality over time. The goal is to better understand recovery patterns and help create clearer …