PAIN

This trial investigates whether removing the chest tube during thoracoscopic lung surgery, instead of leaving it in place afterward, leads to less pain and faster recovery. Participants undergoing elective wedge resection are randomly assigned to have the tube removed during surg…

This study compared two pain medications—Ultracet (tramadol/acetaminophen) and Voltaren (diclofenac)—in people with ankylosing spondylitis who were already taking disease-modifying anti-rheumatic drugs (DMARDs). The goal was to see which one worked better for pain relief over 8 w…

This study tested whether D-cycloserine, a drug that affects brain signaling, could reduce pain in people with chronic low back pain that had not responded to other treatments. About 200 adults with at least 6 months of back pain and an average pain score of 4 or higher (on a 0–1…

This study looked at whether cancer patients already taking strong opioids (like morphine) still need paracetamol for pain control. Researchers planned to have 7 participants stop their regular paracetamol in a blinded way, but the trial was terminated early. The goal was to see …

This study tested whether a 3D ultrasound device (Accuro) helps anesthesiologists place epidural needles for pain relief during labor in women with a BMI of 40 or higher. The device was compared to the standard blind approach using touch. The trial was terminated early, so result…

This study tested an experimental drug called GSK3858279 in 147 adults with chronic nerve pain from diabetes. The goal was to see if it could reduce pain better than a placebo. However, the trial was terminated early, so we have less information than planned.

This early-stage trial tested whether taking ibuprofen (a pain reliever) and ondansetron (an anti-nausea drug) before a medical abortion could reduce side effects and improve patient satisfaction. The study enrolled 8 healthy women undergoing early medical abortion (up to 70 days…

This study tested an experimental drug called GSK3858279 in 314 adults with moderate to severe knee osteoarthritis pain. The goal was to find the best dose that reduces pain safely. However, the trial was stopped early, so we have less information than planned.

This study tested a virtual reality training program for maternity care providers, nurses, lactation consultants, and doulas. The goal was to improve teamwork and reduce pain disparities for birthing parents. The study enrolled 66 participants but was terminated early, so the res…

This study looked at 91 premature babies to see if measuring heart rate and skin sweat can help detect pain as well as a standard behavioral scale. Researchers recorded these body signals during routine medical procedures. The goal was to find a more objective way to assess pain …