PAIN

This study looks at three different dental materials used to treat deep cavities in children's permanent molars. The goal is to keep the tooth nerve alive so the root can finish growing normally. About 48 children aged 7 to 11 with deep cavities will be treated and followed for 1…

This study compares three types of hip replacement parts in 360 adults aged 18-75 with osteoarthritis. The goal is to see which option causes less bone loss around the implant and gives better pain relief and function over 5 years. Participants receive a G7 acetabular cup and Ech…

This study aims to validate a new self-report questionnaire that people with Complex Regional Pain Syndrome (CRPS) can fill out at home to measure their symptom severity. Researchers will compare the self-report results with in-person clinical exams to see if the questionnaire is…

This study tests whether a low-cost, colorful walkway (like a game mat) can help children aged 4-10 feel less pain and fear when they first get up after abdominal surgery. The walkway is meant to distract kids and make moving feel more like play. Researchers will measure pain, fe…

This study looks at whether hearing a popping sound during a spinal manipulation changes how much pain and disability people feel. 38 adults with non-specific neck and upper back pain will be split into two groups: those who hear an audible sound and those who don't. Their pain, …

This study tests whether a short, phone-delivered mindfulness program can help people who are very worried about pain before spine surgery. About 25 participants will take part in weekly sessions before their operation and be followed for two weeks after. The goal is to see if th…

This study looks at whether combining two types of gentle exercises—Feldenkrais and active release—can help people with knee osteoarthritis feel less pain and move better. Forty adults aged 40-60 with mild to moderate knee pain took part. The goal is to see if these exercises imp…

This study tests whether neurofeedback training can help people with chemotherapy-induced peripheral neuropathy change their own brain waves to reduce pain and improve quality of life. About 91 adults with moderate to severe nerve pain will be randomly assigned to active, deactiv…

This study planned to compare three different nose sprays (dexmedetomidine, fentanyl, and midazolam) for reducing pain and anxiety in young children (ages 2-6) getting stitches in the emergency room. The goal was to see which spray worked best and was safest. However, the study w…

This study looks at how well a closed-loop spinal cord stimulator works for people with long-term pain. Researchers will track pain levels and quality of life in 25 adults who have had pain for at least 6 months. The device automatically adjusts stimulation to help reduce pain.

This study tests a device called MILTA, which uses light and a magnetic field, to see if it can reduce pain from perineal scars after giving birth. About 110 women with painful scars will receive either MILTA or a fake treatment. The goal is to find a drug-free way to help with t…

This study looks at whether using patterned (decorated) tape instead of plain tape to hold an IV in place can reduce pain and improve heart rate and oxygen levels in children. Forty children aged 3 to 12 who get regular IV therapy for chronic conditions will try both types of tap…

This study tests whether a 2-minute perineal massage before a pessary check can reduce pain and improve comfort. About 68 women with prolapse or stress incontinence will try both massage and a gel-only method at separate visits. The goal is to find a simple, drug-free way to make…

This study compares two types of nerve blocks to treat pain from hip fractures in the emergency department. The standard fascia iliaca compartment (FIC) block is compared to the newer pericapsular nerve group (PENG) block. About 80 adults with isolated hip fractures and significa…

This study looked at whether showing cartoons or using finger puppets before a blood draw can lower pain and fear in children aged 3 to 6. About 120 children took part, and their pain and fear levels were measured using special scales. The goal is to find simple, non-medical ways…

This study tests if using focused ultrasound (MR-HIFU) alone or with standard radiation can better relieve bone pain caused by cancer that has spread to the bones. About 216 adults with painful bone metastases will receive either ultrasound, ultrasound plus radiation, or radiatio…

This study tests whether a non-invasive therapy called neurofeedback can help people with nerve pain caused by chemotherapy. Participants learn to change their own brain waves to reduce pain and improve quality of life. The trial involves 80 adults with moderate to severe pain, a…

This study tests a light and laser device (photo-biomodulation therapy) used on the C-section wound twice a day to see if it reduces pain right after surgery and long-term pain. 180 women having planned C-sections will take part. The goal is to find a drug-free way to manage pain…

This study tests a small vibrating device (like a buzzer) to see if it can reduce pain and anxiety during needle sticks. Researchers will compare how children and adults feel with and without the device. The goal is to find a simple, drug-free way to make procedures like blood dr…

This study looks at whether prescribing fewer opioid painkillers after laparoscopic hysterectomy still keeps patients comfortable. About 120 adults having this surgery for non-cancer reasons will be randomly assigned to get a standard or reduced opioid prescription. The goal is t…

This study looks at whether laughter therapy can improve lung function and reduce pain in people aged 60 and older. Researchers will measure breathing and pain levels in 64 participants before and after a 4-week laughter program. The goal is to see if a fun, non-drug activity can…

This study looks at whether a single art therapy session can improve mood and reduce symptoms like pain and anxiety in adults receiving palliative care. Twenty patients in a Canadian hospital will complete short questionnaires before and after a 30-60 minute art session. The goal…

This study looks at two ways to manage pain after gynecologic surgery: the EXORA block and epidural analgesia. Researchers want to see which method helps patients recover better and feel less pain. About 60 adults having planned gynecologic surgery will take part, and their recov…

This study looks at whether using a stress ball during a prostate biopsy can help lower anxiety and pain. About 66 adults having their first prostate biopsy will be asked to squeeze a stress ball during the procedure. Researchers will measure pain, anxiety, and vital signs to see…

This study tested whether showing a video to parents and children before a blood draw can reduce pain, fear, and anxiety in kids aged 4-7. 76 children participated. The video explained what would happen during the procedure. Researchers measured pain, fear, and anxiety using stan…

This study tests whether a new low frequency ultrasound bath device is safe and can help heal knee osteoarthritis. Ten adults aged 40 and older with chronic knee pain will use the device and report their pain and any side effects. The goal is to see if this experimental treatment…

This study tests whether watching calming nature videos with virtual reality (VR) glasses can lower pain and anxiety in people recovering from colorectal surgery. Sixty adults will be split into two groups: one group uses VR glasses for 10-15 minutes before and after surgery, whi…

This study tests whether combining exercise (cycling) with psychotherapy can reduce drug cravings, depression, and anxiety in adults with opioid use disorder and chronic pain. About 198 people in residential treatment will take part. The goal is to find better ways to manage both…

This study tests whether acupuncture can reduce pain in people with sickle cell disease. Researchers will use brain scans and other tests to understand how acupuncture works. The study involves 60 participants aged 14 to 80 who have chronic pain or recent pain crises.

This study tests whether yoga can reduce nerve pain (peripheral neuropathy) caused by chemotherapy. About 227 cancer survivors will either take yoga classes, attend educational sessions, or continue their usual care. Researchers will measure pain levels, balance, fall risk, and q…

This study aimed to see if a TENS device could reduce pain during IUD insertion. It planned to compare active TENS to a placebo in about 100 women. However, the trial was withdrawn before enrolling anyone, so no results are available.

This study planned to test whether taking lorazepam, a medicine for anxiety, before getting an IUD could reduce pain and worry during the procedure. It aimed to enroll 25 adults at a family medicine clinic. However, the study was withdrawn before any participants joined, so no re…

This early-stage study looks at whether cannabigerol (CBG), a compound from cannabis, can reduce pain and increase appetite when taken alone or with THC. Twenty healthy adults who use cannabis occasionally will take part. Researchers will measure pain tolerance, hunger levels, an…

This study aimed to compare two methods of giving a TLIP nerve block to control pain after spinal fusion surgery. One method used ultrasound before surgery, the other did not use ultrasound during surgery. The study was withdrawn before enrolling any participants, so no results a…

This study tested two gels—ozone oil-based and CHX—on 100 people having lower wisdom teeth removed. Each person received both treatments in separate sessions. The goal was to see which gel better reduces pain and prevents dry socket, a painful complication. Pain was measured usin…

This study tests whether placing cabbage leaves on the knee can reduce pain and improve movement and quality of life in people with knee osteoarthritis. Ninety adults with knee pain for at least 6 months will be split into three groups: two groups get different cabbage leaf treat…

This study tests Pain Reprocessing Therapy (PRT), a type of talk therapy that teaches people to reinterpret pain signals, for chronic widespread pain and fibromyalgia. Fifteen adults will track their pain, mood, sleep, and activity multiple times daily during a baseline period an…

This study tests whether a new type of screw (Bone Bolt) works better than standard screws for fixing a specific kind of pelvic fracture (LC-1). The main goal is to see if patients have less pain after surgery. About 100 adults aged 18-80 who need surgery for this injury will tak…

This study tests whether a simple visualized meditation technique can help patients feel less anxious, experience less pain, and be more comfortable during an endoscopy. About 72 adults having their first endoscopy will be guided through meditation before the procedure. Researche…

This study tests if a non-invasive magnetic brain treatment (TMS) can reduce IBS symptoms like stomach pain and bloating. About 160 adults with IBS will receive 10 TMS sessions over two weeks. Researchers will use brain scans and stool samples to understand how TMS affects the br…

This study tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can reduce nerve pain caused by chemotherapy in cancer survivors. About 255 people who have finished chemo and still have pain, numbness, or tingling in their hands or feet will receive …

This study tests a program called Meaning-Centered Pain Coping Skills Training (MCPC) for people with advanced solid tumor cancer who have pain. The program teaches skills to manage pain and its impact on daily life. About 211 participants will either receive MCPC or standard car…

This study tests whether using a virtual reality headset during PICC or PICC-PORT placement can reduce anxiety and pain in cancer patients. About 120 adults will be randomly assigned to either receive VR plus standard care or standard care alone. The goal is to see if VR can impr…

This study is testing a pain management toolkit in a nursing home to help staff better understand and treat pain. About 40 residents with pain will take part. Researchers will check if the toolkit improves staff confidence, pain treatments, and residents' pain levels and quality …

This study looks at whether watching a video or using acupressure can lower anxiety and pain in children having a tooth pulled. About 69 healthy kids aged 5-8 will take part. Their heart rate and self-reported fear and pain will be measured to see which method works best.

This study looks at whether giving the steroid hydrocortisone through a vein can improve how much people can bend and straighten their new knee after total knee replacement surgery. About 132 adults with knee arthritis who are having their first knee replacement will take part. S…

This study looks at whether letting children aged 4 to 6 listen to their favorite music when they first get up after abdominal surgery can lower their pain and fear. Half of the 74 children will hear music, while the other half gets usual care. Researchers will measure pain and f…

This study looks at how natural compounds called terpenes, found in cannabis, affect pain and drug effects when taken alone or with THC. About 45 adults who use cannabis regularly will take part. The goal is to understand these effects better, not to treat any condition.

This study tests whether a wearable skin sensor can tell how much pain a person is feeling. Thirty-seven adults with cancer or COPD will wear the device for up to a week and rate their pain. The goal is to create an algorithm that automatically detects rising pain levels and aler…

This study trains school nurses and mental health professionals in Michigan to help children manage pain using cognitive behavioral therapy techniques. About 68 school staff will learn and use these strategies, then report on how well they work. The goal is to see if the program …

This study aims to teach artificial intelligence to measure pain by looking at body signals like heart rate and voice. Researchers will track 70 people recovering from minor plastic surgery to see if the AI can accurately tell how much pain they are in. The goal is to create a sy…

This study aimed to find out if certain psychological and social factors make women more likely to develop long-term pain after breast cancer surgery. Researchers planned to follow women having a mastectomy or lumpectomy and measure their pain levels. However, the study was withd…

This study was designed to collect information about pain in people having orthopedic, chest, or gynecological surgery. Researchers planned to use questionnaires to understand pain and find out who might be at risk for long-term pain. However, the study was withdrawn before any p…

This study aimed to create a database of high-frequency brain signals to better understand epilepsy, migraines, and other brain conditions. It planned to use advanced software to map brain functions in healthy volunteers. However, the study was withdrawn before enrolling anyone, …

This study tested two different laser settings against the standard method for removing ceramic braces. Ten healthy adults who had finished orthodontic treatment took part. The goal was to see which approach best protects the tooth's surface and keeps the inside of the tooth from…

This study looks at 50 adults with sleep bruxism (teeth grinding during sleep) to understand how it affects sleep, pain, anxiety, and overall health. Researchers will measure brain waves during sleep, check blood markers, and look at genetic factors. The goal is to find better wa…

This study tests a simple idea: giving doctors a short summary of each patient's work-related challenges before their appointment. The goal is to help people with muscle pain, anxiety, depression, or stress return to work faster. About 1180 adults in Norway will take part, and re…

This study looks at how knee osteoarthritis (KOA) impacts daily life by using both patient surveys and physical tests like walking and stair climbing. Researchers will enroll 100 adults aged 45-75 with moderate knee arthritis. The goal is to better understand function from both t…

This study looks at how immersive virtual reality changes the way people with chronic jaw pain (temporomandibular disorder) experience pain. Researchers compare VR to a placebo to understand its effects. About 259 adults aged 18-88 will take part. The goal is to find new, low-ris…

This study follows 275 teens aged 11-18 with chronic muscle or joint pain to find clues that predict whether they will get better or continue to struggle. Researchers measure pain levels and daily function over time to identify biological and behavioral markers. The goal is to be…

This study follows 90 adults with implantable cardiac devices (like pacemakers) for two years to track shoulder pain, movement, posture, and daily function. Researchers will compare different device types and look for factors that make pain worse. The goal is to better understand…

This study aims to find biological markers that can tell if a person with long-term muscle or joint pain will get better or keep having severe pain. Researchers will follow 250 adults to track pain levels and look for patterns in their bodies. The goal is to improve diagnosis and…

This study looks at how daily cannabis smoking changes pain sensitivity and the risk of becoming dependent. Researchers will test 16 healthy cannabis users in a controlled hospital setting, measuring pain responses and withdrawal symptoms. The goal is to understand if cannabis ca…

This study watches 166 teens (ages 10-18) having knee surgery to see if their sleep quality before the operation changes how much pain and pain medicine they need afterward. Researchers will ask about sleep habits and track painkiller use for two weeks using a smart pill bottle. …

This study looks at whether the Norwegian Sickness Absence Clinic (NSAC) helps people with common mental health issues or muscle pain return to work faster. About 2500 adults will be split into three groups: one gets treatment within 4 weeks, another after 10-14 weeks, and a thir…

This study looks at whether a person's insurance status affects how well their epidural works during a C-section. Researchers will review records from 2,500 pregnant adults at one hospital. The goal is to find out if there are unfair differences in pain relief based on insurance …