PAIN

This study is comparing three different material combinations used in hip replacement parts to see which causes the least bone wear over time. It involves 360 people with severe hip arthritis who need a total hip replacement. Researchers will track patients for up to 10 years to …

This study is testing if adding exercise and psychotherapy to standard drug treatment helps people with opioid addiction. It focuses on reducing drug cravings and managing chronic pain. The research involves 198 adults currently in a residential treatment program.

This study aims to find the best material for saving the living inner part (pulp) of children's immature back teeth that have deep cavities and are painful. It will compare three newer, putty-like dental materials over 12 months in 48 children aged 7-11. The goal is to see which …

This study is testing a simple, one-minute scoring tool to predict which patients will experience severe pain after going home from outpatient gynecologic surgery. Researchers will follow 207 patients to see if the tool accurately identifies high-risk individuals. If validated, t…

This study is developing an AI-powered system to measure pain objectively using body signals, rather than relying on patients' self-reporting. It involves 70 adults recovering from outpatient plastic surgery at home. Researchers hope this technology will help personalize pain med…

This study aims to validate a new self-report questionnaire designed to help diagnose Complex Regional Pain Syndrome (CRPS) remotely. Researchers will compare the new patient-completed survey against the current standard, which requires an in-person doctor's exam. The goal is to …

This study aimed to use advanced brain scanning to find the exact spots in the brain that cause seizures in people with hard-to-treat epilepsy. The goal was to create a better, non-invasive map to guide surgeons, potentially helping more people become seizure-free after surgery. …

This early-stage study is testing whether a cannabis compound called cannabigerol (CBG) can help with pain relief and increasing appetite, both alone and when combined with THC. Researchers are studying 20 healthy adults who occasionally use cannabis to measure how these compound…

This study is observing how well a new type of spinal cord stimulator works for people with long-term, hard-to-treat pain. The device, called evoke®, is already approved and being used in real-world patients. Researchers are tracking 25 adults with severe chronic pain to see how …

This small, early-stage study is testing a special bath that uses low-frequency sound waves to see if it is safe and might help with knee arthritis. The goal is to see if the device can ease pain and help with healing. Participants will soak their knee in the ultrasound bath ever…

This study is comparing two different nerve block injections for treating the severe pain of a hip fracture in the emergency department. It aims to see if a newer method (PENG block) works as well for pain relief as a common standard method (FIC block). The newer method is design…

This study is testing whether acupuncture can help manage the chronic pain experienced by people with sickle cell disease. Researchers are comparing traditional needle acupuncture to a needle-free laser version over 10 sessions. They will also use brain scans and other tests to t…

This study aims to understand how daily use of THC cannabis affects pain relief and the risk of developing dependence. It involves 16 healthy cannabis users who will take cannabis or a placebo daily in a controlled setting to see if pain relief decreases over time or if stopping …

This study is testing if a non-drug treatment using light and laser therapy can help manage pain and improve wound healing after a planned C-section. The goal is to see if this approach can reduce the need for strong pain medications, which can affect the baby. Researchers will c…

This study is exploring whether a single, one-hour art therapy session can help improve mood and reduce symptoms like pain and anxiety for adults receiving inpatient palliative care. Twenty participants will complete short questionnaires about their mood and symptoms before and a…

This study aimed to compare two different ways of giving a pain-blocking injection to patients having back surgery. It planned to enroll 50 adults scheduled for a specific spinal fusion procedure. The main goal was to see if giving the injection before surgery with ultrasound gui…

This study is testing if listening to music helps children feel less pain and fear when they get out of bed for the first time after abdominal surgery. Researchers will compare 74 children aged 4-6; one group will listen to their favorite music during this process, while the othe…

This study is testing whether a special light therapy device called MILTA can reduce pain from scars in the perineum (the area between the vagina and anus) after vaginal delivery. It will compare the MILTA treatment to a placebo (fake) treatment in 110 women who recently gave bir…

This study tested if showing a short educational video to children and their parents before a blood draw could make the experience less scary and painful. Researchers worked with 76 children aged 4-7, comparing those who watched the video to those who received standard care. The …

This study is testing whether a testosterone gel can help reduce pain and improve daily life for women over 60 who have chronic back pain and are using opioid painkillers. Researchers will compare the gel to a placebo (inactive substance) over three months to see if it helps with…

This study compares two methods for managing pain after gynecological surgery: a newer ultrasound-guided EXORA block and the standard epidural. Researchers will measure pain levels, recovery quality, and side effects like nausea in 60 patients. The goal is to see if the EXORA blo…

This study is testing whether simple distractions like showing cartoons or using finger puppets can help reduce pain and fear in young children (ages 3-6) when they need to have their blood drawn. Researchers are comparing these playful methods to see which one works better at ma…

This study is testing a web-based support program designed to help advanced cancer patients manage symptoms like depression, pain, and fatigue. It also aims to reduce stress and depression in their spouses or partners who are providing care. The program is intended to be accessib…

This small pilot study is testing whether a guided prayer and relaxation program can help adults with sickle cell disease manage their daily pain and stress. Researchers want to see if this non-drug approach, used alongside regular pain medication, can improve sleep and potential…

This small study is testing whether a mindfulness therapy program delivered over the phone can help patients who worry a lot about pain cope better before and after spine surgery. Researchers will first adapt the program with a small group, then offer four weekly sessions to 20 p…

This study aimed to see if a TENS device, which uses mild electrical pulses, could help reduce pain during IUD insertion. It planned to compare the real device to a fake one in women getting an IUD. The trial was withdrawn before any participants were enrolled.

This study is testing if using a simple stress ball can help men feel less pain and anxiety during a prostate biopsy. It will compare 66 men who use the ball during the procedure to those who do not. The goal is to find a low-cost, easy way to make this common medical test more c…

This study is testing if giving an intravenous steroid (hydrocortisone) right after a total knee replacement helps patients bend and straighten their knee better later on. It involves 132 patients who will be randomly assigned to receive either the steroid or a placebo (saltwater…

This study is testing if a form of acupuncture using mild electrical stimulation can help reduce pain from nerve damage caused by chemotherapy. It involves 255 cancer survivors who have finished treatment but still suffer from this painful side effect. Participants are randomly a…

This study is testing whether applying cold packs can help reduce pain and improve daily life for people with rheumatoid arthritis. It involves 90 participants who have had arthritis for at least six months and are currently experiencing pain. The goal is to see if this simple, l…

This study is testing if using patterned, colorful medical tape instead of plain tape can help reduce pain and stress for children who regularly get intravenous (IV) therapy. It involves 40 children, each of whom will try both the patterned and plain tape on different treatment d…

This study is exploring if a non-invasive brain stimulation treatment can improve symptoms like pain and discomfort in adults with Irritable Bowel Syndrome (IBS). Researchers will give participants 10 sessions of gentle magnetic pulses to the scalp over two weeks. They will also …

This study is testing whether a guided meditation can help people feel less anxious, experience less pain, and be more comfortable during an endoscopy. Researchers are enrolling 72 adults who are having their first endoscopy to see if listening to a meditation recording before an…

This study aimed to find out which of three nasal spray medications works best to reduce pain and anxiety in young children getting stitches in the emergency room. It planned to compare dexmedetomidine, fentanyl, and midazolam sprays in kids aged 2 to 6. The trial was withdrawn b…

This study is testing whether using virtual reality (VR) glasses can help reduce pain and anxiety for people recovering from colorectal surgery. Researchers will have 60 patients watch relaxing nature videos through VR headsets before and after their operation. They will compare …

This study is testing whether yoga can help reduce nerve pain caused by chemotherapy, a common side effect for cancer survivors. Researchers are comparing yoga classes to educational sessions and standard medical care to see which best improves pain, balance, and quality of life.…

This study is testing a new type of talk therapy called Pain Reprocessing Therapy (PRT) for people with chronic widespread pain, including fibromyalgia. It aims to see if this therapy can reduce pain levels and improve mood, sleep, and daily activities. The study is small, enroll…

This was a small pilot study to see if it's practical to prescribe lorazepam, a medication for anxiety, before an IUD insertion to help reduce pain and anxiety. It planned to enroll 25 adults and have them rate their pain and anxiety before and after the procedure. The main goal …

This study is testing whether combining two specific exercise approaches can help people with knee osteoarthritis feel less pain, move their knees more easily, and perform daily activities better. It will involve 40 participants aged 40-65 who have knee pain and stiffness. One gr…

This study is testing a video-based therapy program designed to help people with advanced cancer manage their pain. The program teaches coping skills and focuses on helping patients find meaning and purpose despite their illness. About 210 adults with advanced solid tumors and si…

This study is testing a special toolkit designed to help nursing home staff better manage residents' pain. Researchers will work with 40 residents who experience pain to see if the toolkit helps staff feel more confident in pain management and actually reduces residents' pain lev…

This study is testing if simple, non-drug methods can make tooth extractions less scary and painful for young children. Researchers are comparing the effects of letting kids watch videos and using gentle acupressure on their hands during the procedure. The goal is to see if these…

This study aims to see if a newer type of surgical screw, called the Bone Bolt®, provides better pain relief after surgery for a common pelvic fracture compared to standard screws. It will involve 100 adults with this specific injury. Researchers will measure pain levels after su…

This study is testing whether using virtual reality (VR) goggles during a medical procedure can help cancer patients feel less anxious and experience less pain. The procedure involves placing a special type of IV line called a PICC or a port, which is common for cancer treatment …

This study is testing whether laughter therapy can help improve breathing and reduce pain in people aged 60 and older. Researchers will enroll 64 members of a retirement club to see if attending 8 laughter sessions over 4 weeks makes a difference. The goal is to see if this enjoy…

This study is testing if wrapping cabbage leaves around the knee can help reduce pain and improve movement for people with knee osteoarthritis. Researchers will compare two methods of applying the leaves against standard care in 90 participants over 4 weeks. The goal is to see if…

This study is testing whether using immersive virtual reality (VR) can help reduce chronic jaw pain. Researchers are comparing real VR to a fake VR placebo to see how each affects the brain's natural pain control systems. They are working with about 260 adults who have had jaw pa…

This study is testing whether a non-surgical treatment using focused sound waves (MR-HIFU), either alone or combined with standard radiation therapy, can relieve pain from cancer that has spread to the bones faster and better than radiation alone. It involves about 216 adult pati…

This study is testing whether a vibrating device can help reduce pain and anxiety in children and teens during needle procedures like IV placement or blood draws. It involves about 1100 participants aged 4 and up. The goal is to see if this simple, non-drug method can make these …

This study is testing whether a combination of non-opioid pain medications (like ibuprofen and acetaminophen) can control pain just as well as opioid pills after a common outpatient hysterectomy surgery. Researchers want to see if this approach reduces the number of opioid pills …

This study is testing whether a non-invasive brain training technique called neurofeedback can help people manage chronic nerve pain caused by chemotherapy. Participants with breast cancer who have had this pain for at least three months will use a computer program that gives fee…

This study is testing if a simple, colorful walkway mat can make it easier for children to get moving after abdominal surgery. Researchers want to see if turning movement into a game reduces kids' pain and fear, and helps them take their first steps sooner. The study involves 74 …

This study is testing whether hearing a cracking sound during a spinal manipulation treatment affects how much pain relief people feel. It involves 38 adults with non-specific neck and upper back pain. One group receives a manipulation that makes an audible sound, while the other…

This study is testing whether a non-invasive brain training technique called neurofeedback can help reduce pain caused by chemotherapy nerve damage. 80 patients who have had chemotherapy and experience lasting nerve pain will be randomly assigned to either receive the brain train…

This study aims to discover biological and psychological markers that can predict whether a teenager with chronic musculoskeletal pain will recover after standard treatment or if their pain will persist. Researchers will collect brain scans, immune system data, and psychological …

This study aims to better understand sleep bruxism, the condition where people grind or clench their teeth during sleep. Researchers will observe 50 adults with bruxism to see how it connects to their sleep patterns, breathing, genetics, anxiety, and pain levels. The goal is to g…

This study aims to discover biological and psychological markers that can identify people with severe, disabling chronic pain and predict who is likely to recover or continue struggling. Researchers will follow 250 adults with chronic musculoskeletal pain, measuring brain functio…

This study aims to understand how best to measure pain and physical function in people with knee osteoarthritis. Researchers will enroll 100 participants with moderate knee arthritis to compare different questionnaires and physical tests. The goal is to gather information that co…

This study aims to better understand pain by collecting questionnaires from patients before and after orthopedic, thoracic, or gynecological surgery. Researchers will gather information about pain intensity, quality of life, and emotional factors to identify patterns and predict …

This study aims to understand and track shoulder pain, stiffness, and movement problems that can occur in people who have implanted heart devices like pacemakers. Researchers will follow 90 participants for two years, measuring their pain levels, shoulder motion, posture, and abi…

This UCLA study is testing whether specific cannabis compounds called terpenes affect pain relief and intoxication when used alone or with THC. Researchers are enrolling 45 regular cannabis users to measure pain responses and subjective feelings after inhaling vaporized compounds…

This study aimed to understand why some women develop long-term pain after breast cancer surgery while others don't. Researchers wanted to see if psychological traits or social factors could predict who might experience chronic pain. The study was withdrawn before it could be com…