Can cannabis replace opioids for pain? new study investigates tolerance and withdrawal

NCT ID NCT04596644

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how daily cannabis smoking changes pain sensitivity and the risk of abuse in healthy adults who already use cannabis. Researchers will measure pain tolerance and withdrawal symptoms over 16 days in a controlled hospital setting. The goal is to understand if cannabis can be a safe, non-opioid option for chronic pain management.

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Conditions

The condition(s) this trial relates to.

cannabis dependence Hyperalgesia Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • New York State Psychiatric Institute

    New York, New York, 10032, United States

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