CANNABIS

This study tests whether adding a cannabis-based mouth spray (Nabiximols) to standard chemotherapy can help people with a returning, aggressive brain tumor (glioblastoma) live longer. About 120 adults whose tumor has returned after initial treatment will be randomly assigned to r…

This study tests whether a cannabis extract containing THC and CBD can reduce sudden nerve-related back pain and the need for strong painkillers. About 200 adults with acute radicular pain will receive either the cannabis oil or a placebo, and their pain and opioid use will be tr…

This study tests whether dronabinol, a synthetic THC (the active ingredient in cannabis), can reduce severe breathlessness in people with advanced COPD. About 30 participants will receive both the drug and a placebo at different times to compare effects. The goal is to see if it …

This study looks at whether cannabidiol (CBD) can reduce the mind-altering effects of THC, the main psychoactive ingredient in cannabis. Healthy adults who use cannabis occasionally will receive different combinations of CBD and THC in a controlled setting. Researchers will measu…

This study looks at how the active ingredient in cannabis, THC, affects men and women differently. Researchers want to understand why some people feel more 'high' or have memory changes. They are looking for 100 healthy volunteers who have used cannabis at least once. Participant…

This study aims to understand if a woman's menstrual cycle changes how she responds to cannabis. Researchers will give cannabis to 21 women at different points in their cycle and measure their feelings, thinking, and blood THC levels. The goal is to learn more about how natural h…

This study looks at how taking cannabidiol (CBD) repeatedly changes the way people experience cannabis, including how much they like it and how it relieves pain. Healthy adults who use cannabis but are not seeking treatment will take CBD and then rate their drug liking and pain s…

This study looks at how chronic marijuana use impacts brain inflammation and thinking skills in people with HIV. Researchers will use brain scans and cognitive tests to compare marijuana users and non-users. The goal is to understand whether marijuana helps or harms brain health …

This study looks at how cannabis and tobacco affect the body when used together. Researchers will measure levels of THC and nicotine in the blood of 48 adults who regularly use both substances. The goal is to understand the combined health effects and inform public health policie…

This study looks at how cannabis affects driving in younger (19-25) versus middle-aged (35-45) adults. Half of the 128 participants will be occasional users, and half will be frequent users. They will use a driving simulator to measure weaving and speed after using cannabis.

This study looks at how cannabis ingredients (CBD and THC) impact inflammation and brain health in people with HIV. Researchers will give 90 participants both compounds in different orders over 6 weeks, then measure blood markers and brain barriers. The goal is to understand how …