Cannabis spray could boost chemo for deadly brain tumors
NCT ID NCT05629702
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial tests whether adding a cannabis-based mouth spray (nabiximols) to standard chemotherapy helps people with recurrent glioblastoma live longer. About 120 adults whose brain tumor has returned after initial treatment will receive either the cannabis spray or a placebo, alongside chemo. The study is double-blind, meaning neither patients nor doctors know who gets the real spray, to ensure fair results.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Nabiximols (cannabinoid spray, also known as Sativex) plus temozolomide chemotherapy
What this could lead to
If it works, this could point toward a new way to extend survival for people with recurrent glioblastoma, a type of brain cancer with very few options.
What could go wrong
This is a mid-stage trial with only 120 patients, so results may not be conclusive. Cannabinoids can cause side effects like dizziness or nausea, and the added benefit over standard chemo alone is unproven.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Aberdeen Royal Infirmary, NHS Grampian
RECRUITINGAberdeen, AB25 2ZN, United Kingdom
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Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust
RECRUITINGCambridge, CB2 0QQ, United Kingdom
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Beatson West of Scotland Cancer Centre, NHS Greater Glasgow & Clyde
WITHDRAWNGlasgow, G12 0YN, United Kingdom
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Belfast City Hospital, Belfast Health and Social Care Trust
WITHDRAWNBelfast, BT9 7AB, United Kingdom
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Bristol Haematology & Oncology Centre, University Hospitals Bristol & Weston NHS Foundation Trust
ACTIVE_NOT_RECRUITINGBristol, BS2 8ED, United Kingdom
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Castle Hill Hospital, Hull University Teaching Hospitals NHS Trust
RECRUITINGHull, HU16 5JQ, United Kingdom
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Charing Cross Hospital, Imperial College Healthcare NHS Trust
RECRUITINGLondon, W6 8RF, United Kingdom
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Churchill Hospital, Oxford University Hospitals NHS Foundation Trust
RECRUITINGOxford, OX3 9DU, United Kingdom
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City Hospital, Nottingham University Hospitals NHS Trust
RECRUITINGNottingham, NG5 1PB, United Kingdom
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Clatterbridge Cancer Centre, The Clatterbridge Cancer Centre NHS Foundation Trust
RECRUITINGMetropolitan Borough of Wirral, CH63 4JY, United Kingdom
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Derriford Hospital, University Hospitals Plymouth NHS Trust
RECRUITINGPlymouth, PL6 8DH, United Kingdom
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Glan Clwyd Hospital
WITHDRAWNBodelwyddan, Denbighshire, LL18 5UJ, United Kingdom
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Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust
RECRUITINGLondon, SE1 9RT, United Kingdom
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Maidstone Hospital, Maidstone and Tunbridge Wells NHS Trust
RECRUITINGMaidstone, ME16 9QQ, United Kingdom
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Mount Vernon Hospital, The Hillingdon Hospitals NHS Foundation Trust
RECRUITINGNorthwood, Middlesex, HA6 2RN, United Kingdom
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Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust
RECRUITINGBirmingham, B15 2TH, United Kingdom
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Southampton General Hospital, University Hospital Southampton NHS Foundation Trust
WITHDRAWNSouthampton, SO16 6YD, United Kingdom
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St Bartholomew's Hospital, Barts Health NHS Trust
RECRUITINGLondon, EC1A 7BE, United Kingdom
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St James's University Hospital, Leeds Teaching Hospitals NHS Trust
RECRUITINGLeeds, LS9 7TF, United Kingdom
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The Christie Hospital, The Christie NHS Foundation Trust
RECRUITINGManchester, M20 4BX, United Kingdom
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Velindre Cancer Centre, Velindre University NHS Trust
RECRUITINGCardiff, CF15 7QZ, United Kingdom
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Western General Hospital, NHS Lothian
WITHDRAWNEdinburgh, EH4 2XU, United Kingdom