Can a Tumor's genetic blueprint guide better treatment for kids with brain cancer?
NCT ID NCT03739372
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This pilot trial explores whether using a tumor's molecular profile—its gene expression and DNA sequencing—can help doctors choose a personalized treatment plan for children and young adults with high-grade glioma (a type of brain cancer). Participants receive a recommendation from a specialized tumor board, which may include up to four FDA-approved drugs based on the tumor's unique characteristics. The study aims to see if this tailored approach can improve progression-free survival and overall survival at 12 months, while also monitoring safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Individualized treatment plan based on molecular profiling, with up to four FDA-approved drugs selected by a specialized tumor board
- What this could lead to
- If successful, this approach could show that tailoring treatment to each tumor's genetic makeup improves survival in children with high-grade glioma.
- What could go wrong
- This is a small pilot study, so results may not be conclusive. The approach depends on the accuracy of molecular profiling and the availability of effective drugs.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ASTROCYTOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
-
Children's Hospitals and Clinics of Minneapolis
Minneapolis, Minnesota, 55404, United States
-
Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
-
Johns Hopkins University
Baltimore, Maryland, 21218, United States
-
Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
-
Seattle Children's Hospital
Seattle, Washington, 98105, United States
-
The Children's Hospital Of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
-
University of California, San Diego Rady Children's Hospital
San Diego, California, 92123, United States
-
University of California, San Francisco
San Francisco, California, 94158, United States
-
University of Florida
Gainesville, Florida, 32611, United States
-
University of Utah
Salt Lake City, Utah, 84112, United States
-
Washington University
St Louis, Missouri, 63110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A good Night's sleep: could a simple program ease Cancer's toll on rest?
- Could sitting up make radiation therapy more comfortable?
- Can we predict dangerous side effects when combining radiation and immunotherapy?
- Can trained immune cells outsmart brain tumors?
- Family history as a shield: can culturally tailored guidance cut cancer risk?
- A simple screening program could transform cancer aftercare