University Of California, San Francisco

This study is testing a new gene therapy for a rare and life-threatening immune disorder in babies called Artemis-deficient SCID. Doctors take a child's own blood stem cells, use a virus to insert a healthy copy of the faulty gene, and then return the corrected cells. The goal is…

This study is for children and young adults (1-25 years old) with a specific type of slow-growing brain tumor that has a BRAF V600 gene mutation. The goal is to see if patients who have taken the drugs dabrafenib and trametinib successfully for 12-24 months can either stop the dr…

This study aims to find out if adding an antibiotic to standard nutritional therapy helps young children with severe, uncomplicated malnutrition recover faster. In Burkina Faso, 3000 children aged 6-59 months will receive either a single dose of azithromycin, a 7-day course of am…

This study aims to find out if a telehealth (remote) cardiac rehabilitation program works as well as the traditional in-person version. It will enroll over 500 adults with various heart conditions who are eligible for rehab. Researchers will compare how much participants improve …

This early-stage trial is testing the safety and best doses of two oral drugs, trametinib and everolimus, given together to children and young adults whose brain tumors have come back after prior treatment. The study aims to see if blocking two different tumor growth pathways at …

This study tests a program to help low-income patients with diabetes or high blood pressure use telehealth tools more effectively. It provides digital coaching to patients and support to clinics to overcome barriers like limited tech access or skills. The goal is to see if this a…

This study is testing whether clemastine, an older allergy medication, can help repair damaged nerve coatings in people with recent optic neuritis. Researchers will enroll 90 participants who developed optic neuritis within the past 3 weeks to receive either clemastine or a place…

This study is testing whether adding cyclosporine eye drops to the standard antifungal treatment helps people with fungal eye ulcers recover better vision. Researchers will compare two different strengths of cyclosporine against a placebo in 150 patients with confirmed fungal inf…

This study tests whether providing fruit and vegetable vouchers to families facing food insecurity can help improve fatty liver disease in children. Researchers will give vouchers to 48 California families with children who have the condition and track their food purchases, diet …

This study is creating and testing a new program to help pregnant women quit smoking, specifically designed for women who have experienced psychological trauma. Researchers are interviewing pregnant women and their healthcare providers to understand the challenges of quitting, th…

This study is testing a remote support program delivered through a smartphone app. It aims to help men living with HIV who use stimulants remember to take their daily medication more consistently. The goal is to keep their HIV viral load low and reduce stimulant use. The program …

This study is testing whether a motivational AI chatbot on your phone can help people quit smoking. Researchers will enroll 440 adult smokers to use the digital coach, which provides encouragement, education, and helps create a personalized quit plan. The main goal is to see if p…

This study is testing whether an online portal can help connect patients with support services. It's for people who speak English, Chinese, or Spanish and have been diagnosed with breast cancer or cardiovascular disease. The goal is to see if virtual patient navigation is a usefu…

This study is developing and testing a mobile phone app designed to help parents and caregivers manage their stress. The goal is to see if reducing this stress makes it easier for caregivers to support their teenagers who are leaving juvenile detention and need substance use trea…

This study is testing whether the medication letrozole can help control uterine fibroids. Researchers will compare letrozole to a placebo (inactive pill) in 140 premenopausal women with moderate to severe fibroid symptoms. The main goal is to see if the drug reduces symptom sever…

This early research study is testing whether a personalized brain stimulation device can help people with severe opioid addiction who haven't responded to standard treatments. Researchers will first map brain activity to identify craving signals, then use an implanted device to d…

This trial is testing new drug combinations for children and young adults with aggressive brain tumors called diffuse midline gliomas (DMGs), which currently have very few treatment options. It uses a flexible 'platform' design to test different drug combinations, including ONC20…

This study is testing if giving guaranteed cash payments to people living with HIV who are leaving jail helps them stay connected to medical care and keep their virus under control. Researchers will enroll 33 very low-income participants in San Francisco and give them money eithe…

This early-stage study is testing whether giving enzyme replacement therapy to fetuses still in the womb is safe and feasible. It aims to treat rare, severe genetic disorders that often cause life-threatening complications before or shortly after birth. The hope is that treating …

This study is testing a virtual peer support program designed to help Latinx teenagers with type 1 diabetes use helpful devices like insulin pumps and glucose monitors more often and confidently. The program, called DREAM, was created with input from families and healthcare teams…

This study is testing a new way to help patients who need dialysis after leaving the hospital for sudden kidney failure. Researchers will measure a patient's remaining kidney function at discharge and share that information with the patient and their kidney doctor. The goal is to…

This is a small pilot study to see if a new support program is practical and acceptable for people living with HIV who also use substances. The program aims to help participants stick to their HIV medication, manage substance use, and stay engaged with their healthcare. Researche…

This study is testing whether a new dental material called PILP is safe for treating cavities in adult teeth. Researchers will apply either PILP or a placebo to cavities before placing fillings, then monitor participants for six months to check for any problems. The goal is to se…

This study is testing if zinc supplements can help improve bone health in people with sickle cell disease. It will compare two different daily doses (25 mg vs. 40 mg) in 34 young adults to see which one is better tolerated and has a more positive effect on bone health markers. Th…

This study is testing a new combination treatment for men with advanced prostate cancer that has spread and is no longer responding to standard hormone therapies. It combines a targeted radiation drug that seeks out and destroys prostate cancer cells with an immunotherapy drug de…

This study is testing if an automated insulin delivery system (a wearable pump that adjusts insulin on its own) works better than the current standard of care (an insulin drip into a vein) for managing blood sugar during labor and delivery in pregnant people with type 1 diabetes.…

This study is testing whether combining two newer drugs, glofitamab and pirtobrutinib, is safe and effective for people with mantle cell lymphoma that has come back or stopped responding to previous treatments. The trial will enroll about 30 adults to see if this combination can …

This study is testing whether a longer, more intensive support program helps people experiencing homelessness quit smoking. It compares 6 months of coaching and nicotine patches to a standard 3-month program. The goal is to see which approach leads to more people successfully qui…

This study is testing a focused strategy to control a type of malaria in Peru. It will involve over 7,500 people across many villages. Researchers will compare giving preventive anti-malaria drugs to people living near recent cases against the current standard of care, which incl…

This study is testing if metformin, a common diabetes medication, can help control a rare and aggressive brain tumor called PFA ependymoma in children and young adults whose cancer has returned or worsened after standard treatment. The two-part study first checks if the drug affe…

This study is testing whether clemastine fumarate, an over-the-counter allergy medication, can repair the protective myelin coating around nerves in people with multiple sclerosis (MS). Researchers will use advanced MRI brain scans to measure changes in myelin in 74 participants …

This study tests whether training mothers to regularly measure their child's upper arm circumference at home can help catch malnutrition relapse sooner. It involves 2,400 children in Burkina Faso who recently recovered from severe malnutrition. Researchers will compare relapse ra…

This small pilot study is testing whether a higher dose of the common diabetes drug metformin works better for young people aged 10-21. Researchers think young bodies process the drug faster, so the standard adult dose might not be strong enough. The study will compare the standa…

This study is for people with advanced gastrointestinal cancers that have spread and have stopped responding to immunotherapy. Researchers want to see if giving a short, targeted course of radiation to one tumor can 'wake up' the body's immune system to attack all the cancer, inc…

This study is testing whether adding two new drugs, DB107-RRV and DB107-FC, to standard brain cancer treatment helps patients live longer without their cancer worsening. The trial will enroll 70 adults with newly diagnosed aggressive brain tumors who are having surgery. Researche…

This study is developing and testing a counseling program for couples in Malawi where the pregnant woman has HIV and depression. The goal is to see if working with both partners can help the woman manage her depression and better follow the HIV treatment plan during and after pre…

This study is testing a new interactive story app that uses artificial intelligence to help teenagers reduce risky alcohol use. The app, called CHANGEGRADIENTS, creates personalized stories where teens can explore the consequences of their choices in a virtual environment. Resear…

This study is testing a combination of chemotherapy and targeted radiation to try to control a rare and aggressive brain tumor in children, called ETMR. It will enroll about 70 children who have recently been diagnosed. The main goal is to see if this approach can keep the cancer…

This study is testing whether a 'smart' brain implant can safely help control movement and balance problems in people with spinocerebellar ataxia type 6. Five adults with this genetic condition will receive a device that listens to their brain signals and automatically adjusts it…

This study compares two approaches to prevent CMV infection in kidney transplant patients who receive an organ from a CMV-positive donor. One group takes daily antiviral medication for 200 days, while the other group gets weekly blood tests for 100 days and only takes medication …

This study is testing whether a combination of two existing cancer drugs, lenvatinib and pembrolizumab, can help control a rare and aggressive type of neuroendocrine tumor. It will enroll 29 adults with a specific, fast-growing tumor type that has spread or cannot be removed by s…

This study is testing a digital app called 'EmpowerMyCH' designed to help adults with congenital heart disease better manage their health. The app includes features like a digital medical record, health information, and community support. Researchers want to see if using the app …

This study is testing if a specially designed heart recovery program, offered in a community health setting, helps more people start and finish their rehab compared to the usual referral to an outside program. It will enroll 100 adults who have had a heart attack, surgery, or oth…

This trial is testing a personalized approach for children and young adults whose brain tumors (medulloblastoma or ependymoma) have come back. Doctors test tumor tissue from surgery in a lab to see which FDA-approved drugs work best against it, and a team of experts creates a cus…

This study is testing whether a gentle, focused ultrasound aimed at a specific brain area can help people with alcohol use disorder. Researchers want to see if this non-invasive procedure changes how the brain responds to alcohol cues and reduces cravings. They will use brain sca…

This is a first-in-human safety study for a new cell therapy called KIND T cells. It is for children and young adults (ages 2-25) with a specific, hard-to-treat brain tumor called H3.3K27M-mutated diffuse midline glioma. Doctors take a patient's own immune cells, genetically modi…

This study is testing whether a guided meditation app on a smartphone or tablet can help slow down memory and thinking problems in adults over 60. Researchers want to find the right amount of meditation needed to see benefits and understand which people it helps most. The goal is…

This study is testing if a drug called Maraviroc can prevent a dangerous complication called primary graft dysfunction (PGD) after a lung transplant. PGD is a major cause of early death and has no approved treatment. About 120 adult lung transplant patients at high risk for PGD w…

This study is testing if adding a small amount of urea (a natural waste product) to the dialysis fluid can prevent a dangerous brain swelling condition in kidney failure patients. These patients need urgent dialysis to fix life-threatening potassium or acid levels, but rapid trea…

This study is testing whether a new DNA sequencing method helps doctors treat drug-resistant tuberculosis more effectively. It will enroll 2,500 patients to see if this test helps doctors choose the right drugs faster, leading to better cure rates and fewer side effects. The goal…

This early-stage study aims to find a safe and effective dose for combining two cancer drugs, niraparib and irinotecan. It is for adults with advanced solid tumors (like certain breast, ovarian, or pancreatic cancers) that have spread and have specific mutations in genes like BRC…

This study is testing whether a 6-month, home-based exercise program can help slow down thinking and memory problems in people with Parkinson's disease. Researchers will enroll 32 participants to compare a supervised workout plan with a no-exercise group. They will measure change…

This study is testing if a common cholesterol drug, colesevelam, can help remove harmful PFAS chemicals from the body. It will involve 40 male firefighters from California who have high PFAS exposure. Participants will take the drug or a placebo for several months to see if it sa…

This study is testing whether playing specific memory-training games on a tablet at home can help improve long-term memory in older adults, including those with mild memory concerns. Researchers will compare two different game apps over 8 weeks to see if they boost memory perform…

This international trial is testing whether shorter antibiotic regimens (13-24 weeks) can work as well as the current standard 24-week treatment for drug-resistant tuberculosis. Researchers will enroll 400 participants with specific drug-resistant TB strains to compare different …

This study is observing whether existing anti-inflammatory drugs (anakinra or canakinumab) can help control severe FOP, a rare genetic disorder that causes muscle and soft tissues to turn into bone. Researchers will follow 11 patients, aged 6-30, who have very frequent painful fl…

This large study aims to find out which of two common blood pressure medications is better at preventing kidney and heart injuries after major surgery. It will involve 18,000 adults having long operations and compare the standard drugs norepinephrine and phenylephrine. The goal i…

This study is testing whether taking two pills, binimetinib and imatinib, can help control advanced melanoma that has a specific genetic change called a KIT mutation. The trial is for up to 25 adults whose cancer has spread or cannot be removed by surgery and who have already tri…

This study tests a free 10-week community exercise and education program designed to help low-income COPD patients improve their breathing and daily function. It compares the exercise program alone to the same program plus a 'health advocate' who helps address social barriers lik…

This study is testing a new mobile app program designed to help Veterans quit smoking before and after major elective surgery. Smoking around surgery greatly increases risks like infections, longer hospital stays, and even death. The program uses financial rewards to motivate par…

This study is testing a new combination of two cancer drugs (enfortumab vedotin and pembrolizumab) given alongside targeted radiation therapy. The goal is to see if this approach can effectively control muscle-invasive bladder cancer for patients who are not candidates for, or wh…

This study is testing whether a simple, brief red light therapy can slow the progression of nearsightedness in children. It will enroll 90 children aged 8-13 from African, Hispanic, and Caucasian backgrounds. The treatment involves looking into a special red light device for 3 mi…

This study is testing a more flexible way to provide HIV care for people who struggle to keep regular clinic appointments. It offers drop-in visits and mobile care to 400 participants in California who face barriers like homelessness or substance use. The goal is to see if this a…

This study is testing an artificial intelligence (AI) tool called Mirai that analyzes standard mammogram images to predict a woman's risk of developing breast cancer. Researchers want to see if women the AI flags as 'high-risk' benefit from getting an extra screening test—a breas…

This study is testing a new type of MRI scan that uses a special form of sugar (called hyperpolarized pyruvate) to create detailed pictures of prostate cancer cells. The goal is to see if this scan can help doctors better monitor 60 men with low-to-intermediate risk prostate canc…

This study aims to see if traditional healers in rural Uganda can successfully offer HIV testing to children aged 18 months to 5 years. Researchers want to know if parents are more likely to accept a test from a healer right away, compared to being referred to a health center. Th…

This study is testing whether wearable bladder monitoring devices can help track patients' progress during pelvic health physical therapy. Researchers want to see if these tools provide accurate measurements and are easy for patients and therapists to use. The study focuses on po…

This study aims to find better, faster, and cheaper ways to diagnose tuberculosis (TB) in children under 15. It will test new, simple diagnostic tools that don't rely on hard-to-get sputum samples, which are a major hurdle for diagnosing kids. The goal is to speed up diagnosis an…

This study aims to find better, faster, and less expensive ways to diagnose tuberculosis (TB) at local clinics. It will test new diagnostic tools on people with TB symptoms or risk factors in countries where TB is common. The goal is to see how accurate and easy-to-use these new …

This study aims to find and test new, simpler tools to diagnose tuberculosis (TB) faster and at a lower cost. It will involve over 26,000 people with TB symptoms or risk factors across 10 countries. Researchers will check how accurate and easy-to-use these new tests are compared …

This study is testing whether a tablet-based memory test helps primary care doctors identify early signs of dementia more effectively than usual care. It will involve about 180,000 patients across 26 clinics, where some clinics will use the tablet tool and others will continue th…

This study is testing a new, experimental type of MRI scan that looks at how a pancreatic tumor uses energy. The goal is to see if this scan can tell doctors earlier than current scans whether a patient's standard cancer treatment is working. About 70 adults with advanced pancrea…

This study aims to find the best hearing screening method for preschool children to catch hearing loss early. Researchers will compare a standard two-step test to a simpler one-step test in over 13,700 kids at community preschools. The goal is to identify which method is most eff…

This study tests whether community health worker counseling and text message reminders can help more Latino adults get the RSV vaccine. Researchers will work with 750 Latino adults in San Francisco and Daly City to see if these approaches increase vaccination rates among older ad…

This study is testing an educational program to help family child care home directors reduce pesticide exposure. About 30 directors will receive training, monthly consultations, and personalized reports showing pesticides found in their homes. The goal is to help them adopt safer…

This study aims to find the best low-cost methods to encourage people at higher risk for HIV to get tested again every few months. It will test up to 12 different strategies, like text message reminders, on 30,000-40,000 adults in rural Kenya and Uganda. The main goal is to see w…

This study tests whether a brief counseling session about alcohol use can help adults who drink heavily and are at high risk for HIV stay on their prevention medication (PrEP or PEP). It will involve 400 HIV-negative adults recruited from drinking venues in Kenya and Uganda. Rese…

This study is testing whether a farming support program can prevent food scarcity and improve health for pregnant women and their babies in Kenya. The program provides seeds, irrigation pumps, training, and access to a demonstration farm. Researchers will enroll 410 pregnant wome…

This study is testing a new program where trained peers help women at risk for HIV in Uganda. The goal is to see if this peer-led support makes it easier for women to choose and consistently use effective prevention methods, like PrEP. The program will be tested with about 60 wom…

This study is testing whether wearing a small, sticky patch on the forehead at night can help reduce ADHD symptoms in children who also have autism. The patch delivers gentle nerve stimulation. Researchers will measure changes in attention, social skills, repetitive behaviors, an…

This study is testing whether 12 weeks of group yoga practice can reduce symptoms of mild-to-moderate depression when used as the only treatment. Researchers will compare two types of yoga to an educational control group in 180 adults. The main goal is to see if yoga significantl…

This study is testing if a single dose of a drug called tranexamic acid (TXA), given by IV during surgery, can reduce bleeding and fluid buildup after gender-affirming mastectomy (top surgery). Researchers will compare 150 patients who receive the drug to those who do not, measur…

This study is testing three different methods to reduce mouth pain after a common surgery for urethral strictures in men. During this surgery, doctors take a small piece of tissue from the inside of the cheek to repair the urethra, which often causes significant mouth pain afterw…

This study is testing whether taking open-label placebo pills (sugar pills that patients know are placebos) alongside standard pain medication can help reduce opioid use after hip surgery. Researchers will enroll 64 teens and young adults undergoing a specific hip procedure and r…

This study is testing whether a live, online pelvic floor yoga program helps reduce chronic pelvic pain better than a general physical conditioning program. Researchers are recruiting 220 women with long-term pelvic pain to participate in a 4-month, fully remote program. The goal…

This study is testing whether a 24-week program of moderate exercise can improve symptoms and heart function in people with hypertrophic cardiomyopathy (HCM). About 70 participants will be randomly assigned to either follow the exercise program or continue with their usual physic…

This study is testing different ways to help adults with low-grade brain tumors who have trouble with memory, focus, and thinking after their cancer treatments. Researchers are trying out in-person therapy, a special iPad app, and daily supportive text messages to see if they can…

This study is testing whether a natural product called miracle fruit can help people with head and neck cancer who lose their sense of taste during radiation therapy. About 40 participants will take either a miracle fruit cube or a placebo cube three times a day before meals duri…

This study is testing if adding a warm sauna blanket to a standard digital sleep therapy program helps people with insomnia sleep better. All 40 adult participants will get the digital therapy, and half will also use the sauna blanket for 15-minute sessions over 9 weeks. The main…

This study is testing a medical device called Brijjit® to see if it can prevent thick, raised scars after gender-affirming chest surgery. Each participant will test the device on one side of their chest while using standard silicone tape on the other side for comparison. The goal…

This study is testing two non-surgical devices to help women manage urinary incontinence caused by obstetric fistula, a childbirth injury. The trial involves 100 women in Ghana, Kenya, and Uganda who are waiting for surgery or whose previous surgery failed. Researchers will compa…

This study aims to find the most effective starting dose of epidural medicine to relieve labor pain within the first 30 minutes. Researchers will test different amounts of a pain-relief mixture in 50 women in active labor to determine the dose that works for 90% of patients. The …

This study is testing whether a personalized meditation app can help improve sleep and reduce stress in older adults with mild memory problems. Researchers will enroll 90 participants to use the app and measure changes in sleep quality, stress levels, and attention. The goal is t…

This study is testing whether group-based treatments can help low-income patients better manage chronic pain. Researchers will compare group medical visits and group acupuncture to usual care in community health clinics. The goal is to see if these approaches reduce pain's impact…

This study tests whether taking a calming pill works as well as receiving sedation through an IV for older adults having cataract surgery. Researchers want to know which method is safer and helps people recover their thinking and memory faster after the procedure. Participants wi…

This study is testing whether using atropine eye drops after a specific eye surgery (vitrectomy) helps reduce pain and prevent certain complications. Researchers will compare patients who use the drops to those who do not, measuring pain levels, inflammation, and healing. The goa…

This study is testing if taking honest placebo pills—where patients know they are sugar pills—alongside standard pain treatment can help teens recover from scoliosis surgery. It will involve 64 teens aged 10-18 who are having surgery for idiopathic scoliosis. Researchers will com…

This study is testing a non-invasive, stick-on electrical patch designed to reduce chronic low back pain. Researchers will see if this patch, placed on the skin over the spine, can lower pain scores and improve how people move during simple tasks like standing up. The goal is to …

This study is testing whether a yoga program led by a trainer who shares the same racial background can improve quality of life and reduce symptoms for Black and African American cancer survivors. Researchers want to see if this culturally tailored approach makes the program more…

This study is testing whether two different wellness programs are practical and acceptable for breast cancer survivors who have finished their main treatment but still have a low quality of life. About 108 survivors will try either a multi-part program with yoga, nutrition advice…

This study is testing whether a personalized digital exercise program and online support group can help improve quality of life for people undergoing treatment for gynecologic cancers. Researchers will enroll 60 patients to see if the program is practical and acceptable, and whet…

This study is testing whether using a brain-training app on a tablet for 8 weeks can help improve memory and focus in older adults, including those experiencing mild memory problems. Researchers will compare two different training apps to see if they help. Participants will do al…

This study aims to understand why cancer patients feel extreme fatigue and nerve pain during standard chemotherapy and radiation treatment. Researchers will observe 125 patients with various cancers, collecting blood and stool samples to look for biological markers linked to thes…

This study aims to learn more about hidradenitis suppurativa (HS), a painful and poorly understood skin condition. Researchers will observe 1,000 people with HS and some healthy volunteers to track how the disease changes over time and look for biological clues. The goal is to ga…

This study is testing whether short videos people record at home on their smartphones can help doctors track multiple sclerosis symptoms as accurately as in-person visits. Researchers want to see if this low-cost, convenient method can monitor changes in walking, speech, and hand…

This study aims to find out if the common practice of packing a drained skin abscess with gauze is truly necessary. Researchers are comparing treatment outcomes for patients whose abscesses are packed versus those that are not packed after drainage. The goal is to see if skipping…

This study aims to learn more about a rare genetic condition called SPLIS by observing patients over time. Researchers will collect medical information and samples to understand how the disease progresses and affects different people. The goal is to build a patient registry and g…

This study aims to create prediction tools to forecast how lung function might change in people with sarcoidosis. Researchers will follow 200 adults with pulmonary sarcoidosis to see which information from a regular clinic visit—like symptoms, test results, and blood markers—best…

This study aims to understand if a single night of disrupted sleep can immediately increase irregular heartbeats in people with sleep apnea. Researchers will temporarily turn off participants' sleep apnea devices on some nights to disrupt sleep, while monitoring their heart rhyth…

This study is testing a blood test to see if it can find tiny leftover cancer cells after treatment for head and neck cancer. Researchers will follow 250 patients for two years to see if a positive blood test predicts if the cancer will return. The study is observational, meaning…

This study aims to understand if the natural bacteria (microbiome) in a person's gut and breast tissue can predict who gets an infection after breast reconstruction surgery. Researchers will compare patients who receive antibiotics after surgery to those who do not, tracking them…

This study aims to better understand hidradenitis suppurativa (HS), a painful and poorly understood skin condition. Researchers will collect health information and biological samples from 3,000 people with HS over time. The goal is to learn what causes HS, how it progresses, and …

This study is testing whether low-energy sound waves, aimed at a specific brain pathway, can cause a temporary reduction in hand tremor for people with essential tremor. Researchers will test different settings of the sound waves on 60 participants who are already scheduled for a…

This study aims to discover what proteins in the blood change after a person receives a platelet-rich plasma (PRP) injection for knee osteoarthritis. Researchers will compare these changes to a placebo (saltwater) injection in 60 participants aged 18-70. The main goal is to under…

This study aims to understand if short-term inflammation in the body changes how people process fear, which is a key problem in PTSD. Researchers will give some participants a typhoid vaccine to cause temporary inflammation and others a placebo, then measure their fear responses.…

This study aims to help veterans with advanced prostate cancer make better-informed decisions about genetic testing and personalized treatment options. Researchers are developing and testing a decision support tool to guide patients and their doctors through complex choices. The …

This study aims to settle a long-standing debate about which type of milk is better for heart health. For four months, 100 adults who regularly drink milk will switch between drinking whole milk and skim milk. Researchers will measure changes in blood sugar, cholesterol, and bloo…

This study is testing whether giving women clear, online information about their long-term birth control options helps them feel more informed and better able to get the method they truly want. Researchers are comparing a new educational website to an existing one to see which be…

This study is testing whether people with a common type of dry eye can successfully participate in research from home. Researchers will mail kits to 90 participants so they can complete surveys and collect their own tear samples twice, four weeks apart. The goal is to see if this…

This study aims to learn if a daily ketone drink can change the types of bacteria living in the gut. Researchers will enroll 20 healthy adults to take the drink for one week and collect stool samples before, during, and after. The goal is to see if the drink makes the gut microbi…

This study aims to understand how oxidative stress—a type of cellular damage—in both eggs and sperm affects the success of IVF treatments. Researchers will measure oxidative stress levels in 1,100 couples undergoing IVF and track how it relates to embryo development and pregnancy…

This study offers free genetic testing to people diagnosed with pancreatic neuroendocrine tumors to understand how often these cancers are linked to inherited genetic changes. Researchers at University of California medical centers will test 300 patients and track who completes t…

This study aims to understand why some prostate cancers become resistant to radiation-based treatments. Researchers will examine 125 patients already receiving PSMA-targeted radiation therapy to measure how much radiation reaches tumors and analyze cancer genetics. The goal is to…

This study aims to find out if drinking alcohol causes more episodes of an irregular heartbeat called atrial fibrillation (AFib) in people who already have it. For two weeks, 100 participants will be randomly told each day whether to drink or avoid alcohol while wearing several m…

This study is collecting information on a non-surgical treatment called histotripsy, which uses focused sound waves to break down soft tissue tumors. Researchers will follow 200 adult patients at UCSF for three years after they receive this treatment as part of their regular care…

This study aims to understand if certain genetic elements cause the immune system to age prematurely in people hospitalized with sepsis. Researchers will track 116 adult ICU patients with sepsis to see if these genetic markers are linked to higher risk of death or secondary infec…

This early-stage study aims to understand how a single dose of an existing medication (aripiprazole) affects brain activity related to speech in adults who stutter. Researchers will use brain scans to measure how participants' brains respond to hearing their own voice while speak…

This study aims to check how accurate common finger-clip oxygen monitors (pulse oximeters) are, especially for people with different skin colors. Researchers will temporarily lower oxygen levels in 10,000 healthy volunteers and compare the device readings to gold-standard blood t…

This study aims to learn what makes a common heart rhythm procedure (ablation for atrial fibrillation) more effective and safer in everyday practice. It will follow over 1,000 patients for one year after their procedure, collecting information about their lifestyle, symptoms, and…

This study aims to understand the long-term biological causes of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Researchers will observe and collect samples from 200 people, including those with ME/CFS and healthy volunteers, over time. The goal is to identify the b…

This study aims to understand how two common types of bladder control medications affect memory, thinking, and daily function in older women. Researchers will compare an older anticholinergic drug, a newer beta-3 agonist drug, and no medication over 9 months. The goal is to gathe…

This study aims to understand how racial discrimination affects alcohol and drug use among Black teenagers involved with the justice system. Researchers will conduct interviews with youth and focus groups with parents and community advocates to gather insights. The information wi…

This study aims to understand how being frail—more vulnerable to health stressors—affects the recovery and quality of life of people with gynecologic cancers like ovarian or uterine cancer. Researchers will observe 500 newly diagnosed patients for one year to see if frailty is li…

This study aims to find brain-based markers that could help predict how well someone with major depression will respond to a specific treatment called transcranial magnetic stimulation (TMS). Researchers will use brain scans and EEG recordings on 50 participants before, during, a…

This study is exploring whether applying common over-the-counter moisturizers can reduce body-wide inflammation in older adults with dry skin. Researchers will enroll 32 participants aged 70+ to apply either Vaseline or CeraVe cream daily for four weeks, comparing it to a period …

This study aims to understand and reduce pain, numbness, and taste changes that can happen after throat surgery. Researchers will measure the pressure placed on the tongue during surgery for 100 patients. For the second half of patients, surgeons will see these pressure readings …

This study is creating a patient registry to better understand metastatic lobular breast cancer, a specific type that can be harder to track. Researchers will follow about 12 patients over time, collecting information on their treatments, survival, and how the disease progresses.…

This study aims to find better ways to predict if tuberculosis (TB) will come back after a person finishes treatment. Researchers will follow 750 people who have completed standard TB treatment for one year, checking their blood and sputum for biological markers. The goal is to i…

This study aims to understand if nicotine made in a lab (synthetic) acts the same in the body as nicotine from tobacco. Researchers will have experienced e-cigarette users vape different types of nicotine. They will then measure how much nicotine gets into the blood, its effects …

This study aims to collect real-world information about how well FDA-approved antibody-drug conjugate (ADC) treatments work for people with advanced HER2-negative breast cancer. Researchers will follow 100 patients receiving these treatments as part of their regular care to under…

This study aims to understand and overcome barriers to genetic testing for Black men with advanced prostate cancer. Researchers are testing whether a community-based health coach, providing culturally tailored education, can improve knowledge and access to testing. The goal is to…

This study aims to understand the side effects that melanoma patients experience while receiving immunotherapy drugs. Researchers will follow 300 patients over time to track their symptoms, identify patterns, and learn what factors might make side effects worse. The goal is to ga…

This large study aims to find out if a personalized breast cancer screening schedule is as safe and effective as the standard annual mammogram. It will enroll up to 100,000 women aged 30-74 across the U.S. Participants can choose to either follow a personalized screening plan bas…

This is a national registry that connects people who have had a stroke with researchers. The goal is to build a large pool of potential participants to help scientists develop and test new treatments for stroke recovery. Anyone 18 or older who has had a stroke can join by complet…

This study aims to understand how not having reliable access to healthy food at home affects the severity of a common liver disease in children and teens. Researchers will look at 160 young patients in California who already have this liver condition. They will check if kids from…

This study aims to learn more about pancreatic cysts, which are fluid-filled sacs in the pancreas often found by accident on scans. Researchers will follow 4,000 adults with these cysts over time to see which ones stay harmless and which might develop into cancer. The goal is to …

This study is testing two different ways to help formerly homeless older adults plan for their future medical care while living in supportive housing. Researchers will compare whether group sessions or one-on-one meetings work better to help 650 participants document their health…

This study aims to understand if using cannabis with lower THC (the main psychoactive compound) can improve memory and thinking skills in young adults who use it frequently. Researchers will recruit 110 participants aged 21-25 in San Francisco, provide incentives for them to swit…

This study temporarily stops HIV medication in 40 volunteers to observe how the virus behaves in the earliest stages after treatment interruption. Participants will have frequent blood tests and will restart their medication within about three weeks, even if the virus hasn't retu…

This study aims to understand what happens in the body when people use marijuana and tobacco together. Researchers will measure drug levels in the blood and physical effects like heart rate in 48 healthy adults who regularly use both substances. The goal is to gather foundational…