University Of California, San Francisco

This study tests a combination of two drugs (enfortumab vedotin and pembrolizumab) plus radiation therapy for people with muscle invasive bladder cancer. The goal is to destroy the tumor without removing the bladder, offering an alternative to standard surgery. About 47 adults wi…

This study looks at whether anti-IL1 medications (like anakinra or canakinumab) can reduce flare-ups and prevent extra bone growth in people with fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder where soft tissues turn into bone. About 11 participants with sev…

This study tests whether a shorter, personalized treatment plan (called BPaLM) works as well as the standard longer treatment for people with a type of drug-resistant tuberculosis (TB). About 400 adults with fluoroquinolone-susceptible multidrug-resistant TB will be randomly assi…

This study tests a combination of two drugs (lenvatinib and pembrolizumab) in people with a rare, aggressive type of neuroendocrine tumor called well-differentiated grade 3 (WD G3 NET). The goal is to see if the treatment can shrink or control the tumors. About 29 adults with adv…

This study tests a remote mobile health program designed to help men living with HIV who use stimulants remember to take their HIV medications. The goal is to improve medication adherence and reduce the amount of virus in their blood (viral load). The program uses a smartphone ap…

This early-stage trial tests a combination of two drugs, niraparib and irinotecan, in people with advanced solid tumors that have mutations in DNA repair genes like BRCA, ATM, or PALB2. The main goal is to find a safe dose and understand side effects. About 24 adults with cancers…

This study is for people with oral cavity squamous cell carcinoma (a type of mouth cancer) who are scheduled for surgery. Researchers want to see if taking nisin, a natural food preservative, is safe and can change the bacteria in the mouth in a helpful way. About 40 participants…

This study is a registry that will follow about 200 adults with soft tissue tumors who receive a treatment called histotripsy. Histotripsy uses focused ultrasound waves to break down tumors into liquid without surgery. The goal is to gather information on how well it works and ho…

This study tests a program called Smokefree Family Living (SFL) to help Chinese American smokers quit and reduce harmful smoke residue that lingers on surfaces. About 760 smokers and their non-smoking family members will take part. The program combines quitting support with educa…

This study tests whether giving guaranteed income to people with HIV recently released from jail helps them stay in HIV care and keep the virus under control. 33 participants will receive money as a lump sum, monthly payments, or choose their preference. Researchers will measure …

This study tests whether two drugs, binimetinib and imatinib, can shrink tumors in people with advanced KIT-mutant melanoma that cannot be surgically removed. About 25 adults with stage III or IV melanoma will receive the combination. The goal is to control the disease by blockin…

This study is for children newly diagnosed with a very rare and aggressive brain tumor called ETMR. It tests a treatment plan that uses strong chemotherapy drugs and focused radiation to try to stop the tumor from growing. The goal is to see if this approach can help children liv…

This study tests whether combining the drug ONC201 with other new agents can help children and young adults with diffuse midline gliomas (DMGs), including DIPG. The trial uses an adaptive design, meaning new drug combinations can be added as research evolves. About 360 participan…

This study tests whether combining a targeted radiation drug (177Lu-PSMA-617) with liver-directed therapy is safe for men with advanced prostate cancer that has spread to the liver. About 30 participants will receive both treatments to see how well they tolerate the combination a…

This study tests a gene therapy for Artemis-deficient SCID, a severe immune disorder where babies cannot fight infections. Doctors take the child's own blood stem cells, add a working copy of the faulty gene, and return them to the body after mild chemotherapy. The goal is to bui…

This study tests whether giving pregnant women farming tools, seeds, and training can reduce food shortages and improve health for them and their babies. About 410 pregnant women in Kenya will join, half of whom are living with HIV. Participants will either get the farming suppor…

This study tests a program called Mlambe for married couples in Malawi where one partner drinks heavily and both are affected by HIV. The program offers savings accounts, money management lessons, and relationship skills training to help couples reduce alcohol use and improve com…

This study tests a smartphone-based reward program to help 36 veteran smokers quit before major elective surgery. Participants earn rewards for verified smoke-free days. The goal is to see if this approach is practical and helps reduce surgical risks.

This study tests whether clemastine fumarate, an old allergy medicine, can help repair the protective coating (myelin) around nerves in people with multiple sclerosis (MS). About 74 adults with relapsing-remitting MS will receive either the drug or a placebo, and advanced MRI sca…

This study tests whether azithromycin, an antibiotic, helps children aged 6-59 months with severe acute malnutrition gain weight and recover better than the current standard treatment (amoxicillin) or a placebo. About 3,000 children in Burkina Faso will be randomly assigned to on…

This study tests whether adding cyclosporine A eye drops to the usual natamycin treatment can improve vision in people with fungal keratitis, a serious eye infection. About 150 adults with a confirmed fungal corneal ulcer will receive either standard care alone or standard care p…

This study tests a laser treatment called LITT for children, teens, and young adults whose low-grade brain tumors have come back or worsened after prior therapy. The goal is to stop tumor growth for at least 15 months. About 40 participants will receive the laser procedure, which…

This study looks at whether a specially designed cardiac rehabilitation program for people treated at safety net hospitals helps more patients attend rehab sessions compared to standard care. About 100 adults who have had a heart attack, heart surgery, or other heart conditions w…

This study tests whether Maraviroc, a drug already approved for HIV, can prevent a serious lung injury called primary graft dysfunction (PGD) after a lung transplant. About 120 adults at high risk for PGD will receive either Maraviroc or a placebo every 12 hours for 3 days after …

This study tests a new way to provide HIV care for people who have trouble keeping regular doctor appointments. It offers drop-in visits and mobile care at convenient locations, including a needle exchange site and community health centers. The goal is to help 400 participants st…

This study tests a program to improve telehealth access for 600 low-income adults with diabetes or high blood pressure. Participants will get digital health coaching and clinic support. The goal is to see if this helps lower blood sugar levels and increase use of online patient p…

This study looks at whether giving fruit and vegetable vouchers to families with food insecurity can improve liver health in children with MASLD (fatty liver disease). About 48 children aged 6 to 17 with high BMI and elevated liver enzymes will receive vouchers for 6 months. Rese…

This study tests whether metformin, a common diabetes medicine, can help children and young adults with a rare brain tumor called PFA ependymoma that has come back or grown after standard treatments. About 30 participants will receive metformin to see if it can slow tumor growth …

This study tests whether adding urea to dialysis fluid can prevent dialysis disequilibrium syndrome—a set of brain-related side effects like headache, confusion, or seizures—in kidney failure patients who need fast dialysis to correct dangerously high potassium or acid levels. Ab…

This study looks at whether people with a slow-growing brain tumor (low-grade glioma) that has a specific gene change (BRAF V600) can safely stop or lower their dose of two targeted drugs (dabrafenib and trametinib) after taking them for 12-24 months. About 96 participants will e…

This study tests a 10-week community-based pulmonary rehabilitation program (COPD Wellness) combined with social navigation (Health Advocates) to help vulnerable COPD patients improve their walking ability and quality of life. About 387 adults aged 40-90 with confirmed COPD who s…

This study looks at whether automated insulin delivery (AID) systems can safely manage blood sugar during labor and delivery for pregnant people with type 1 diabetes. Researchers will compare AID to standard IV insulin in 150 participants. The goal is to improve newborn blood sug…

This study tests whether giving enzyme replacement therapy to fetuses with certain lysosomal storage diseases (like MPS disorders, Gaucher, or Pompe) before birth is safe and possible. About 10 pregnant participants will receive the drug through the fetal umbilical vein. The goal…

This study tests a new approach to control myopia (nearsightedness) in children. 90 non-Chinese kids aged 8-13 will use a low-level red-light device for 3 minutes, twice a day. The goal is to see if this treatment can slow the worsening of their eyesight over one year.

This study tests whether bicalutamide, a drug that blocks male hormones, can improve liver health in women with both PCOS and fatty liver disease. About 50 women aged 18-42 will receive either the drug or a placebo for a short time. The goal is to see if it reduces liver fat and …

This study looks at whether training mothers to measure their child's upper arm with a simple tape can help catch malnutrition early and prevent relapse. About 2,400 children who recovered from severe acute malnutrition will take part. Some mothers will check their child's arm we…

This study looks at how two types of bladder medication affect thinking, memory, and daily life in women aged 60 and older who have sudden, strong urges to urinate. Participants will be randomly assigned to take one of two drugs or a placebo for 6 to 9 months. The goal is to see …

This study tests whether personalized deep brain stimulation (DBS) is safe and can reduce cravings and opioid use in people with severe, treatment-resistant opioid use disorder. Six adults aged 22–75 who have used opioids for over 5 years will undergo brain mapping to identify cr…

This study looks at whether giving lower doses of radiation after a good response to initial chemotherapy can control EBV-associated nasopharyngeal cancer as well as standard radiation. About 66 people with stage III or IVA disease will receive either reduced or standard radiatio…

This study tests whether a new genetic sequencing method can help doctors choose the right drugs for people with drug-resistant tuberculosis (TB). Researchers will compare standard care to the new approach in 2,500 participants across multiple clinics. The goal is to improve cure…

This study is for people with advanced gastrointestinal cancers that are spreading and no longer responding to immunotherapy. Researchers want to see if adding targeted radiation to one tumor can help the immune system fight cancer throughout the body. About 28 participants will …

This study tests whether adding two experimental drugs, DB107-RRV and DB107-FC, to standard treatment (radiation and chemotherapy) can help people with newly diagnosed high grade glioma, a fast-growing brain cancer. About 70 adults aged 18-75 will receive the drugs during and aft…

This pilot study tests whether a program that teaches coping skills and supports HIV care engagement is practical and helpful for people living with HIV who also use substances. The study will enroll 50 adults and measure satisfaction, retention, and medication adherence. The goa…

This study tests if a group program for newly married women, their husbands, and mothers-in-law can reduce anemia and improve nutrition. The program includes education on health and gender norms, plus micronutrient supplements. 2,100 people across 140 villages in Nepal will take …

This study is testing whether a higher-than-normal dose of metformin (1350 mg twice a day) is acceptable and feasible for young people aged 10-21 with type 2 diabetes. Researchers will compare this higher dose to the standard dose (1000 mg twice a day) and monitor blood sugar con…

This study tests whether combining two drugs—glofitamab and pirtobrutinib—can safely and effectively treat mantle cell lymphoma that has returned or not responded to prior therapy. About 30 adults will receive the combination. The goal is to see if the drugs work together to shri…

This study tests whether clemastine fumarate, a common allergy medication, can help repair the protective coating around nerves in people with optic neuritis (inflammation of the optic nerve). About 90 participants will receive either clemastine or a placebo for 9 months. The goa…

This study tests a program to help homeless people stop smoking. It offers coaching sessions and nicotine replacement therapy (like patches) to 150 adults in San Francisco and Los Angeles. The goal is to see if this support helps them quit and stay smoke-free for at least 6 month…

This study tests whether combining two drugs—pembrolizumab (an immunotherapy) and 177Lu-PSMA-617 (a targeted radiation therapy)—can slow or stop the growth of advanced prostate cancer that has spread and no longer responds to hormone therapy. About 48 men with this type of cancer…

This study tests a new program for pregnant women with HIV and their male partners in Malawi. The program teaches couples problem-solving and communication skills to help the woman manage depression and stick to her HIV treatment, which prevents passing the virus to her baby. The…

This early study tests whether placing a deep brain stimulator in the cerebellum and using it to automatically adjust electrical pulses can safely improve movement and balance in people with spinocerebellar ataxia type 6. Five adults who still have some walking ability will recei…

This study will compare two hearing screening methods in about 14,000 preschool children to see which one works better at finding hearing loss early. Early detection can help prevent speech and language delays. The goal is to identify the most effective screening approach for com…

This study is testing whether an artificial intelligence (AI) model called Mirai can accurately identify women at high risk for breast cancer. 400 women aged 40-89 who are flagged as high-risk by the AI will receive an additional MRI screening. The goal is to see if this approach…

This study tests whether using telehealth tools like eye scans and pressure checks can find undiagnosed glaucoma earlier than just giving people information. Researchers will enroll 2,000 high-risk adults—including Black people 50+, Hispanic people 65+, and people with diabetes 5…

This study tests a new type of MRI scan that uses a special contrast agent (hyperpolarized carbon-13 pyruvate) to see how pancreatic tumors process nutrients. The goal is to predict whether treatment is working earlier than standard scans. The study involves 70 adults with advanc…

This study aims to find better, faster, and cheaper ways to diagnose tuberculosis (TB), a disease that kills over a million people each year. Researchers will test new diagnostic tools on over 26,000 adults in 10 countries who have a cough lasting two weeks or more, or who have r…

This study aims to find better ways to diagnose tuberculosis (TB) in children under 15. Every year, about 230,000 children die from TB, often because current tests are slow or hard to use. Researchers will test new, faster, and simpler diagnostic tools on 2,100 children with TB s…

Every year, over 3 million people with TB go undiagnosed and 1 million die. This study tests new, faster, and cheaper TB tests that can be used at a clinic or bedside. About 1350 adults with a cough lasting 2 weeks or TB risk factors will take part to see if these tests work bett…

This study tests two different approaches to prevent cytomegalovirus (CMV) disease in adults who have received a kidney from a CMV-positive donor but are themselves CMV-negative. One group will take daily antiviral medication for 200 days, while the other will have weekly blood t…

This study tests whether a program led by peers (trained community members) can help women at high risk for HIV use prevention methods like PrEP more consistently. About 60 HIV-negative women in Uganda will receive the program and be followed for 6 months. The goal is to see if t…

This study tests whether a program that provides farming tools, training, and family support can reduce sexually transmitted infections (STIs) and improve mental health in 900 teen girls (ages 15-19) in Kenya. The program aims to reduce food insecurity and poverty, which are link…

This study tests whether a monthly injection of naltrexone can prevent fentanyl overdose deaths in people who use stimulants like cocaine or methamphetamine but do not intentionally use opioids. About 100 participants will either receive the shot or standard harm reduction care f…

This study compares two common blood pressure medications, norepinephrine and phenylephrine, given during major surgery to prevent kidney injury afterward. About 18,000 adults having non-cardiac surgery lasting at least two hours will be included. Hospitals will switch between th…

This study tests several low-cost, easy-to-use strategies to encourage people at higher risk for HIV to get retested. Researchers will enroll 40,000 adults in Kenya and Uganda who have access to a mobile phone. The goal is to see which approaches work best to increase repeat HIV …

This study tests a program for low-income Latino families with babies. It provides health coaching and text messages during doctor visits to encourage healthy feeding, sleep, and limited screen time. Half of the 576 families get this program, while the other half get safety and l…

This study tests whether giving anti-malarial drugs to everyone in a village can reduce new cases of vivax malaria. Over 7,500 people in Peru will take part. Some villages will get the drugs, while others will only receive standard care like bed nets and testing. The goal is to s…

This study tests whether a brief alcohol counseling program helps heavy drinkers at high risk for HIV stay on their prevention medications (PrEP or PEP). Researchers will enroll 400 adults in Kenya and Uganda who visit bars or drinking venues. The goal is to see if the counseling…

This study aims to increase RSV vaccination among Latino adults aged 50 and older in San Francisco. Researchers will test if community health workers and text message reminders help more people get the vaccine. The study also looks at whether younger adults can encourage their ol…

This study tests if a remote, video-based pelvic floor yoga program can reduce chronic pelvic pain in women better than a general physical conditioning program. About 220 women with pelvic pain for at least 6 months will participate from home. The goal is to see if yoga offers a …

This study tests whether practicing yoga for 12 weeks can reduce symptoms of mild-to-moderate depression without using antidepressant medication. Researchers will compare a yoga program to an education class in 180 adults diagnosed with depression. Participants must not currently…

This study looks at whether packing a skin abscess after draining it is really needed. About 196 adults who need an abscess drained will be checked to see if skipping packing leads to more infections or extra doctor visits. The goal is to find out if the usual practice of packing…

This study looks at whether giving children a placebo pill, along with their usual pain treatment, can reduce the amount of opioids they need after scoliosis surgery. About 64 teenagers will be split into two groups: one gets the placebo plus standard care, the other gets standar…

This study aims to help caregivers of justice-involved youth (ages 12-17) who are in detention or group homes. Researchers are developing and testing a mobile health app to reduce parenting stress, which often keeps youth from getting substance use treatment. About 60 caregivers …

This study tests whether a personalized digital meditation program (MediTrain) can improve sleep, reduce stress, and boost thinking skills in older adults with mild cognitive impairment (MCI). Researchers will enroll 90 participants aged 60-85, comparing those with MCI to healthy…

This study tests whether a home-based, virtually-supervised exercise program combining high-intensity endurance and resistance training is safe and feasible for people with Parkinson's disease. Researchers will also measure if the exercise improves cognitive function and motor sy…

This study is testing whether a personalized digital exercise program and virtual support group can help people with gynecologic cancer feel better during treatment. About 60 patients will participate. The goal is to see if the program is practical and helpful for improving well-…

This study tests a digital coach, called a chatbot, that uses motivational interviewing to help people quit smoking. The chatbot provides education, builds motivation, and creates a personalized quit plan. 440 adult smokers will use the chatbot and be followed for 6 months to see…

This study tests whether a special injection called an erector spinae plane block (ESPB) can reduce pain and the need for pain medicine in children having scoliosis surgery. About 42 children with adolescent idiopathic or neuromuscular scoliosis will either get the block plus sta…

This study tests whether atropine eyedrops help reduce pain and inflammation after a type of eye surgery called vitrectomy. About 62 adults who are having this surgery will receive atropine or a placebo. Researchers will measure pain levels and signs of eye swelling to see if the…

This study compares three different numbing methods to reduce pain in the mouth after a surgery that uses a cheek graft to repair the urethra. Sixty men will be randomly assigned to one of the methods, and their pain levels and painkiller use will be tracked. The goal is to find …

This study tests whether applying mild electrical stimulation to the skin over the spine, starting just 3 days after a spinal cord injury, is safe and might help patients regain movement. Researchers will monitor 15 participants for side effects and measure changes in muscle stre…

This study tests whether letrozole, a drug currently used for breast cancer, can reduce symptoms like heavy bleeding and pelvic pain caused by uterine fibroids. About 140 premenopausal women will receive either letrozole or a placebo for 12 weeks. The goal is to see if the drug i…

This study tests whether a digital intervention can improve working memory and inhibitory control in older adults, including those with mild cognitive impairment. Participants will complete cognitive tests and surveys before and after up to 8 weeks of at-home training, with a fol…

This study explores whether a six-week creative writing program can help teens and young adults (ages 16-25) with anorexia nervosa express themselves and build emotional strength. Participants will read stories, write their own, and share in group discussions. The goal is to see …

This study aims to find the most effective dose of epidural medicine to relieve labor pain within 30 minutes. About 50 women in active labor will receive a specific epidural technique, and researchers will measure pain scores and side effects. The goal is to improve comfort and s…

This study compares a targeted nerve block injection to usual pain treatments for people with sudden sciatica in the emergency room. About 100 adults with severe leg and back pain will be randomly assigned to get either the injection or standard care. Researchers will measure pai…

This study tests whether low-intensity focused ultrasound (LIFU) can temporarily reduce tremors in people with essential tremor. Researchers will aim sound waves at specific brain areas in 60 participants who are already scheduled for a related procedure. The goal is to see if LI…

This study is testing a less invasive method to collect brain signals from people with Parkinson's disease who are already getting deep brain stimulation (DBS). Researchers will place small electrodes under the scalp to see if they can detect signals related to movement and sleep…

This study is testing if a non-invasive device that sends mild electrical pulses through the skin to the spinal cord can help people with chronic low back pain. The goal is to see if it can reduce pain and improve movement, like standing up from a chair. The study will enroll 50 …

This study is testing a trilingual smartphone app and telehealth coaching program to help Black, Chinese, and Latinx adults in the San Francisco Bay Area manage chronic pain without medication. About 586 people with long-term pain will be randomly assigned to use the app plus coa…

This study looks at whether giving fluoride varnish during regular cancer follow-up visits can help improve oral health for head and neck cancer patients who have had radiation and lack easy access to dental care. About 120 uninsured or underinsured adults will take part. Researc…

This study tests a device that gently stimulates a nerve in the forehead (eTNS) to see if it reduces ADHD symptoms in 60 autistic children. Kids wear a small sticky patch on their forehead each night for 8-12 weeks. The goal is to learn if this safe, non-drug approach can improve…

This study tests whether group-based pain management can help low-income adults with chronic pain feel better and more supported. About 360 participants will join group sessions that address pain, stigma, and social isolation. The goal is to reduce pain's impact on daily life and…

This study tests whether taking placebo pills along with standard pain medication can reduce opioid use and pain in 64 teens and young adults (ages 13-40) after hip surgery. Participants are randomly assigned to receive either placebo pills plus usual care or usual care alone. Th…

This study tests whether low-intensity focused ultrasound (LIFU) can change brain activity linked to alcohol cravings in 25 adults with alcohol use disorder. Participants will receive LIFU and have brain scans to see if it reduces their response to alcohol-related cues. The goal …

This pilot study tests whether weekly sauna visits can help reduce loneliness in adults aged 19-22. Participants will visit a sauna in San Francisco once a week for 2 hours, either alone or with a friend, for 8 weeks. The study focuses on whether people find the program acceptabl…

This study looks at whether moderate exercise training can improve symptoms and heart function in people with hypertrophic cardiomyopathy, a condition where the heart muscle is thickened. About 70 adults aged 18 to 80 will be randomly assigned to either a moderate exercise progra…

This study looks at whether special brain exercises can help adults with low-grade glioma improve memory, attention, and thinking skills that often get worse after surgery, radiation, or chemo. About 97 people will try three different rehab methods—in-person, app-based, or text m…

This study tests a device called Brijjit® to see if it can prevent thick, raised scars (hypertrophic scars) after gender-affirming double incision mastectomy. About 78 people will take part, and each person will use the device on one side of their chest while the other side serve…

This study tests whether giving a drug called tranexamic acid (TXA) through an IV during gender affirming mastectomy (top surgery) can lower the risk of hematomas (blood collections) and seromas (fluid collections). About 150 adults having top surgery at UCSF will be randomly ass…

This study tests whether a special fruit cube (miraculin) can improve taste problems in head and neck cancer patients undergoing radiation therapy. About 40 participants will receive either the fruit cube or a placebo during the first half of treatment. The goal is to help patien…

This study tests whether playing a digital navigation game can improve long-term memory in healthy older adults and those with mild cognitive impairment. About 150 participants will play either the navigation game or a control game for up to 8 weeks at home. Memory and thinking s…

This study tests whether a liquid called PILP is safe to use when treating cavities in adults. 30 adults with at least one cavity will get either PILP or a placebo before a filling. Researchers will check tooth health, pain, and gum condition over six months to see if PILP is a s…

This study tests whether adding passive body heating (using a sauna blanket) to digital cognitive behavioral therapy for insomnia (CBT-I) helps improve sleep. 40 adults with insomnia will receive CBT-I, and half will also use a sauna blanket for 15 minutes per session over 9 week…

This study tests a social media program called the Quit the Hit Toolkit to help teens and young adults stop vaping. Researchers will train coaches to lead 5-week online support groups for 60 participants aged 13-21. The goal is to see if the program is practical and well-liked in…

This study tests two non-surgical devices to help women with obstetric fistula manage urine leakage. One is a vaginal cup that collects urine, and the other is the cup attached to a leg bag for more capacity. The trial includes 100 women awaiting surgery or whose surgery failed, …

This study is testing whether a yoga program led by trainers who share the same racial background as participants can improve quality of life and reduce symptoms for Black and African American cancer survivors. The research focuses on 50 adults in California who have had cancer t…

This study looks at whether short-term changes in the immune system affect how people with PTSD process fear. Participants will receive either a typhoid vaccine or a placebo, then have their body responses measured while listening to sounds. The goal is to better understand the l…

This study looks at why some prostate cancers do not respond to a type of targeted radiation therapy called PSMA radioligand therapy. Researchers will use scans and tumor samples from 125 people to measure radiation doses and check gene activity. The goal is to learn more about r…

This study is testing a computer program that uses interactive stories and artificial intelligence to help teenagers aged 15-17 who already drink alcohol make healthier choices. About 200 teens will use the program during their regular clinic visits. The goal is to see if the pro…

This study looks at whether drinking alcohol increases the chance of atrial fibrillation (AFib) episodes in people with a come-and-go form of the condition. One hundred participants will be randomly assigned to drink or avoid alcohol on different days while wearing heart monitors…

This study looks at how oxidative stress (a type of cell damage) in the fluid around eggs and in sperm affects embryo quality and pregnancy outcomes in couples undergoing IVF. Researchers will measure stress levels in both partners and link them to how well embryos develop and im…

This study will test if a mobile app that provides health education and social support can improve the health of new mothers and their babies in India. About 2100 pregnant women will either get the app plus standard care or standard care alone. Researchers will measure breastfeed…

This study looks at cells from the airways of 24 adults (some with asthma, some without) to understand why mucus is overproduced in asthma. Researchers will compare gene activity in these cells using advanced sequencing. The goal is to learn more about asthma, not to test a new t…

This study aims to improve alcohol and drug treatment for Black teenagers on probation by making it more culturally relevant. Researchers will interview teens and hold focus groups with parents and community advocates to understand how racial discrimination affects substance use.…

This study looks at ways to help formerly homeless older adults living in supportive housing make plans for their future medical care. Researchers will compare group sessions versus one-on-one coaching to see which better helps people share their healthcare wishes. The goal is to…

This study is for adults with sarcoidosis, a disease that can affect the lungs. Researchers want to create models that predict how the lungs will change over time using simple blood tests and clinic data. The goal is to help doctors better understand and manage the disease. About…

This study aims to find biological signs in the brain that can help doctors diagnose major depression and predict how well a person will respond to treatment. Researchers will use brain imaging and EEG to track changes in 50 adults with depression as they undergo transcranial mag…

This study looks at the forces placed on the tongue and throat during laryngeal surgery. Researchers want to see if these forces cause pain, numbness, or other problems after surgery. The study involves 100 adults having throat surgery. In the first 50 patients, forces are measur…

This study is creating a large registry of 3000 people with hidradenitis suppurativa (HS), a painful and poorly understood skin condition. Researchers will collect medical information and blood samples over time to learn what causes HS and how it progresses. The goal is to develo…

This study looks at whether certain genetic elements, called transposable elements, can prematurely age the immune system of people with sepsis in the ICU. Researchers will take blood samples from 116 adult patients to see if these elements are linked to higher death rates or mor…

This study follows 1,125 adults who have had or will have a heart procedure called catheter ablation for atrial fibrillation (AFib). Over one year, participants use a mobile app to answer surveys about their lifestyle, symptoms, and quality of life. The goal is to find out what f…

This study collects information from up to 250 people with lysosomal storage diseases (like certain forms of MPS, Pompe, Gaucher, and Wolman disease) to learn how these conditions develop and how they appear before birth. Researchers will review medical records and test samples t…

This study tests two imaging methods—central microperimetry and radial OCT—to see if they can more accurately measure the progression of geographic atrophy, a form of age-related macular degeneration that can lead to vision loss. Researchers will follow 80 participants aged 55 an…

This study aims to uncover the long-term biological drivers of ME/CFS by observing 200 volunteers, including both people with the condition and healthy controls. Researchers will track infections, inflammation, and other factors over time to better understand what causes this deb…

This study tests whether watching short educational videos can help people with diabetes better understand their eye disease and return for follow-up visits. About 150 patients at Zuckerberg San Francisco General Hospital will take part. The goal is to see if videos improve knowl…

This study looks at how the body handles different types of nicotine in e-cigarettes. Eighteen experienced vapers will try three forms: natural, synthetic, and a mix. Researchers will measure nicotine levels in the blood, heart effects, and how much people vape, as well as cravin…

This study compares a newer MRI-based scan (DWI) with the standard FDG PET scan to see how well each finds cancer spread in people with metastatic cancer. About 30 adults with cancer that has spread will get both scans, and researchers will compare the results. The goal is to see…

This study follows 500 adults with newly diagnosed gynecologic cancer to understand how frailty—being more vulnerable to stress—affects their recovery and quality of life. Researchers will measure physical frailty using five criteria like weight loss and slow walking. The goal is…

This study aims to create a smoking cessation program for pregnant women who have experienced trauma. Researchers will interview healthcare workers and pregnant women to understand their needs. The goal is to combine trauma-informed care with standard smoking cessation advice. Th…

This study enrolls 750 people who have completed standard TB treatment to find blood or sputum markers that predict whether TB will return within a year. Researchers will test how accurately these markers identify recurrence risk. The goal is to make future TB treatment trials fa…

This study looks at whether watching a short educational video after prostate surgery (HoLEP) helps patients manage their recovery at home and reduces the need for extra phone calls, clinic visits, or emergency care. About 114 adults having the procedure will be randomly assigned…

This study looks at how not having enough healthy food at home affects liver disease in children with MASLD (a fatty liver condition). Researchers will track 160 children from California liver and weight clinics to see if food insecurity leads to worse liver damage. The goal is t…

This study looks at why African American men with prostate cancer often miss out on genetic testing and whether a community-based health coach can help. About 72 men will receive tailored education to improve their knowledge and decision-making. The goal is to learn how to make g…

This study tests a computer system called CirrhosisRx that helps doctors make decisions for hospitalized patients with cirrhosis. About 2,100 adults with cirrhosis will be included, and the system will be compared to usual care. The goal is to see if the tool helps doctors follow…

This study is building a large registry of people who have had a stroke and still have symptoms. The goal is to connect them with researchers working on new ways to improve recovery. Anyone 18 or older with a past stroke and ongoing symptoms can join.

This study is creating and testing a simple, patient-friendly tool to help Black or African American men with metastatic prostate cancer understand genetic testing for their tumors. Researchers want to see if the tool makes it easier for patients to learn about testing options an…

This study enrolls 100 people with HIV to donate large numbers of white blood cells through a process called leukapheresis. Researchers will measure HIV DNA and RNA in these cells to better understand how the virus persists despite treatment. The goal is to gather knowledge that …

This study is looking at how antibiotics change the bacteria in the gut and breast after a mastectomy with implant reconstruction. Researchers want to see if certain bacteria make infections more likely. About 200 women with breast cancer or a high genetic risk will provide sampl…

This study is creating a registry (a database) for people with a rare type of breast cancer called invasive lobular carcinoma that has spread. Researchers will collect information from about 12 participants to develop a tool that better measures how the disease responds to treatm…

This study aims to see if doing dry eye research from home works well. Researchers will ask 90 adults with evaporative dry eye disease to fill out surveys and collect eye samples at home. The goal is to learn how to run bigger, more inclusive studies in the future.

This study compares two approaches to breast cancer screening: the standard annual mammogram starting at age 40 versus a personalized schedule based on each woman's individual risk. Researchers will enroll 100,000 women aged 30-74 across the U.S. to see if personalized screening …

This study looks for inherited gene changes in 300 people diagnosed with pancreatic neuroendocrine tumors. Researchers want to learn how often these gene changes occur and what types are most common. The goal is to better understand genetic risks and improve future care for patie…

This study looks at how whole milk versus skim milk affects blood sugar and cholesterol in adults. Researchers will ask 100 people who drink at least one cup of milk daily to switch between whole and skim milk for a set time. The goal is to see which type of milk is better for he…

This study follows 300 adults with stage IIB to IV melanoma who are receiving immune checkpoint inhibitors. Researchers will track 53 different symptoms over time to identify which are most common, severe, and distressing. The goal is to find risk factors linked to worse symptoms…

This study aims to find the best amount of a digital meditation program to improve thinking skills and reduce stress in older adults. Researchers will enroll 4,000 people aged 60 and older who own a smartphone or tablet. Participants will use a meditation app, and their cognitive…

This study looks at how androgens (a type of sex hormone) might affect fatty liver disease in young women. Researchers will compare women with PCOS (who often have high androgen levels) to those without PCOS. The goal is to understand changes in liver fat and stiffness over time.…

This study is testing a smartphone app called Empower My Congenital Health (EmpowerMyCH) designed to help adults with congenital heart disease feel more confident managing their health. Researchers will enroll 1000 adults aged 18 and older to use the app and provide feedback on i…

This study follows 4,000 adults aged 30 and older who have at least one pancreatic cyst. The goal is to track which cysts turn into cancer and which stay harmless. By collecting data over time, researchers hope to create better guidelines to avoid unnecessary surgeries while catc…

This study tests a program called CONNECTing to LungCare that helps smokers and their doctors have better conversations about quitting smoking and getting screened for lung cancer. The program gives patients information and a summary to share with their doctor. The study will see…

This study looks at whether menopause and HIV together increase the risk of heart disease in women. Researchers will examine blood markers and body scans from 90 women with HIV to understand how inflammation and weight changes play a role. The goal is to fill a knowledge gap, not…

This study is testing a special MRI scan that uses a substance called hyperpolarized pyruvate to see how well it can monitor prostate cancer in men who have chosen active surveillance (no immediate treatment). The goal is to see if this scan can detect changes in tumor cells more…

This study is testing whether step counts from wearable activity trackers can help predict when cancer patients undergoing radiation therapy might need to go to the emergency room or be hospitalized. Researchers will collect step data from 260 adults with cancer before, during, a…

This study aims to learn more about hidradenitis suppurativa (HS), a painful and poorly understood skin condition. Researchers will follow 1,000 people with HS to track their symptoms, genetics, and other health markers. No new treatments are being tested; instead, the goal is to…

This study looks at how zinc supplements affect bone health in people with sickle cell disease. About 34 participants aged 15 to 40 will take either 25 or 40 mg of zinc daily for 12 weeks. The goal is to find which dose works best and is safe, so it can be used in a larger future…

This study explores whether short selfie videos taken on a smartphone can reliably measure walking and speech changes in people with multiple sclerosis (MS). Researchers will compare video data with standard in-person tests to see if remote monitoring is accurate and practical. A…

This study looks at whether traditional healers in rural Uganda can offer HIV tests to children aged 18 months to 5 years. Researchers want to see if parents accept testing from a healer versus being referred to a clinic. About 400 children will take part, and the goal is to find…

This study pauses HIV medication in 40 volunteers to closely watch how the virus and body interact early on. Participants stop their antiretroviral therapy for up to three weeks and have frequent check-ups. Most will restart treatment within three weeks, even if the virus stays u…

This study looks at why the antibiotic doxycycline, when taken after sex, prevents bacterial STIs in some people but not others. Researchers will measure doxycycline levels in hair, blood, and urine from 48 healthy volunteers who take the drug on different schedules. The goal is …

This study looks at how platelet-rich plasma (PRP) injections change proteins in the blood of people with knee osteoarthritis. About 60 adults aged 18-70 will receive either a PRP injection or a saltwater placebo, and researchers will track protein changes over 26 weeks. The goal…

This study looks at how the drug aripiprazole affects brain activity in adults who stutter. Researchers will use brain scans to measure how the brain processes sound before and during speech. The goal is to better understand what causes stuttering, not to test a new treatment.

This study follows 100 people with HER2-negative metastatic breast cancer who are receiving antibody-drug conjugates (ADCs) as part of their normal care. Researchers want to see how long these treatments control the cancer in real-world settings. The goal is to gather information…

This study looks at whether giving extra information to patients and their kidney doctors after a hospital stay can help manage recovery from acute kidney injury that needed dialysis. About 40 adults who still need dialysis after leaving the hospital will have their remaining kid…

This study looks at why cancer patients feel very tired during chemotherapy and radiation. Researchers will collect blood and stool samples from 125 adults with different cancers before, during, and after treatment. They aim to find links between fatigue and changes in genes and …

This study collects blood samples from 2,000 people, both with and without HIV, to provide researchers with specimens for collaborative studies. Participants must have good vein access and be able to consent. No treatment is given; the goal is to advance scientific understanding …

This study looks at whether a simple tablet-based test can help primary care doctors detect cognitive impairment, including dementia, in older adults during regular visits. The test is designed to be easy to use and automatically scores results. Researchers will compare detection…

This study looks at how cannabis and tobacco affect the body when used together. Researchers will measure levels of THC and nicotine in the blood of 48 adults who regularly use both substances. The goal is to understand the combined health effects and inform public health policie…

This study looks at whether a night of poor sleep can trigger heart rhythm problems like atrial fibrillation (AFib) in people with sleep apnea. About 100 adults with a sleep apnea device will wear a heart monitor for 14 days. Researchers will compare days after good sleep versus …

This study compares two ways of delivering cardiac rehabilitation: in-person sessions at a clinic and telehealth sessions done from home. Researchers want to see if both methods produce similar improvements in walking ability and quality of life for people with heart conditions. …

This study looks at whether doing extra genetic testing (genomic sequencing) on fluid from the womb can find important genetic changes in fetuses that appear perfectly normal on ultrasound. Researchers will enroll 1,000 pregnant people who are already having standard genetic test…

This study tests whether a drug called colesevelam, which binds to bile acids, can help lower levels of PFAS (forever chemicals) in the blood of male firefighters with high exposure. The trial involves 50 participants and will measure how well people stick with the treatment and …

This study looks at how to help veterans with advanced prostate cancer make informed decisions about precision oncology tests, which use genetic information to guide treatment. Researchers will develop and test a decision support tool to reduce confusion and improve understanding…

This study looks at whether daily use of simple moisturizers like Vaseline or CeraVe can lower inflammation in older adults with dry skin. Researchers will measure skin barrier function, blood markers of inflammation, and skin microbes. The goal is to see if a larger trial is pos…

This study tests if different breath-holding methods, with or without extra oxygen, can make liver MRI images clearer by reducing blurring from breathing. Ten healthy adults aged 18-75 will have one MRI scan using two breath-hold techniques. The goal is to find a simple way to im…

This study is testing a virtual patient navigation program for 260 underserved adults who speak English, Chinese, or Spanish and have breast cancer or heart disease. The program uses a phone-based portal to connect patients with navigators who can help them manage their care. The…

This study explores whether wearable bladder monitors and exercisers can help track and improve bladder health in postpartum women and men after prostate surgery. Researchers will compare these devices to standard clinic tests and ask patients and therapists about their experienc…

This study looks at different ways to help people with age-related macular degeneration, diabetic retinopathy, or glaucoma get to their eye hospital appointment after a screening. About 3,000 participants will be split into three groups: some get text reminders, some get calls fr…

This study looks at whether measuring body fat before and after breast reconstruction surgery can help predict outcomes. About 40 women having a mastectomy followed by immediate reconstruction will take part. The goal is to see if these measurements are easy to collect and if the…

This observational study tests whether a ketone ester drink, taken daily for a week, can improve the gut microbiome in 20 healthy adults aged 18-40. Participants will provide stool samples before, during, and after the drink period, and track their ketone levels and any symptoms.…

This study looks at how getting abortion care through telehealth (online) compares to in-person visits. Researchers will survey 2,000 people seeking medication abortion to see how telehealth affects timing, costs, and follow-up care. The goal is to understand what patients want a…

This study looks at whether a blood test that finds tiny bits of tumor DNA (called ctDNA) can tell if head and neck cancer has returned after successful treatment. Researchers will follow 250 adults who have finished curative surgery or radiation. The goal is to see if a positive…

This study collects medical and genetic information from people with SPLIS, a rare enzyme deficiency, to better understand the disease. No treatments or interventions are given. Participants of all ages, including family members and healthy volunteers, can join. The goal is to tr…

This study is testing a new approach for children and young adults whose medulloblastoma or ependymoma has come back. After surgery, the tumor is quickly tested in the lab and its genes are analyzed to find the most effective and least toxic drugs for that specific patient. A spe…

This study looks at whether giving women clear, easy-to-understand information about tubal sterilization and long-acting birth control helps them feel they have better access to these options. About 650 women who speak English or Spanish and strongly want to avoid pregnancy will …

This study aims to check how accurately common pulse oximeters measure blood oxygen levels in healthy people. Researchers will temporarily lower participants' oxygen levels in a controlled setting and compare the device readings to precise blood tests. The study will include 10,0…