New eye drop combo could save sight from fungal infections
NCT ID NCT06658002
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding cyclosporine A eye drops to standard natamycin treatment helps people with fungal keratitis (a serious eye infection). About 150 adults with confirmed fungal infection will receive either a low or high dose of cyclosporine A or a placebo for 4 weeks. The main goal is to see if this combination improves vision and reduces scarring.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cyclosporine A eye drops (0.1% or 2%) plus natamycin eye drops
What this could lead to
If it works, this could offer a better treatment for fungal eye infections, potentially improving vision and reducing scarring.
What could go wrong
This is a Phase 3 trial, but it is still testing two different doses against a placebo. The added benefit of cyclosporine A is not yet proven, and there may be side effects like eye irritation or increased risk of infection.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Aravind Eye Institute
RECRUITINGPondicherry, Tamil Nadu, 605 007, India
Contact Email: •••••@•••••
Contact
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University of California, San Farncisco
NOT_YET_RECRUITINGSan Francisco, California, 94143, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••