New eye drop combo could save sight from fungal infections

NCT ID NCT06658002

Recruiting now Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding cyclosporine A eye drops to standard natamycin treatment helps people with fungal keratitis (a serious eye infection). About 150 adults with confirmed fungal infection will receive either a low or high dose of cyclosporine A or a placebo for 4 weeks. The main goal is to see if this combination improves vision and reduces scarring.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cyclosporine A eye drops (0.1% or 2%) plus natamycin eye drops
What this could lead to: If it works, this could offer a better treatment for fungal eye infections, potentially improving vision and reducing scarring.
What could go wrong: This is a Phase 3 trial, but it is still testing two different doses against a placebo. The added benefit of cyclosporine A is not yet proven, and there may be side effects like eye irritation or increased risk of infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

corneal ulcer fungal keratitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORNEAL ULCER FUNGAL KERATITIS

Contacts and locations

Locations

Aravind Eye Institute
RECRUITING

Pondicherry, Tamil Nadu, 605 007, India
University of California, San Farncisco
NOT_YET_RECRUITING

San Francisco, California, 94143, United States

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