Green light and pink dye take on tough eye infections

NCT ID NCT05110001

Completed Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding a light-activated dye (rose bengal) to standard antibiotic or antifungal eye drops could improve vision in people with severe corneal infections. About 330 adults in India and Brazil with fungal or amoeba infections received either standard drops alone or drops plus the dye-and-light treatment. The main goal was to see which group had better eyesight after six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Rose Bengal dye activated by green light (photodynamic therapy)
What this could lead to: If successful, this could offer a new way to treat stubborn corneal infections and reduce vision loss without needing stronger drugs.
What could go wrong: This is an early-phase trial with 330 participants; the added light therapy may not improve outcomes over standard drugs alone, and risks include eye irritation or scarring.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ACANTHAMOEBA KERATITIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Acanthamoeba keratitis corneal ulcer fungal keratitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACANTHAMOEBA KERATITIS FUNGAL KERATITIS

Contacts and locations

Locations

Aravind Eye Care System

Madurai, Tamil Nadu, India
Federal University of São Paulo

São Paulo, Brazil

More trials for these conditions

Other studies related to the condition(s) this trial covers.