Can zinc strengthen bones in sickle cell disease? new study seeks answers

NCT ID NCT06260891

Recruiting now Knowledge-focused Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests two daily doses of zinc (25 mg and 40 mg) in 34 adults with sickle cell disease to see which dose works best for bone health. Participants take zinc for 12 weeks, and researchers measure changes in bone formation and breakdown markers. The goal is to pick the right dose for a future larger trial on zinc and bone health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zinc (as zinc gluconate)
What this could lead to: If successful, this study could determine the best zinc dose for a larger trial aiming to improve bone health in people with sickle cell disease.
What could go wrong: This is a small, early-phase study focused on finding the right dose and measuring bone markers, not on treating the disease itself. Results may not lead to a proven treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SICKLE CELL DISEASE

Contacts and locations

Locations

Baylor College of Medicine
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Children's Hospital of Philadelphia
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Cincinnati Children's Hospital
NOT_YET_RECRUITING

Cincinnati, Ohio, 45229, United States
Duke University Medical Center
NOT_YET_RECRUITING

Durham, North Carolina, 27710, United States
Thomas Jefferson University Hospital
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19107, United States
UCSF Benioff Children's Hospital Oakland
RECRUITING

Oakland, California, 94609, United States

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