New drug cocktail aims to shrink Hard-to-Treat melanoma
NCT ID NCT04598009
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial is testing whether combining two drugs, binimetinib and imatinib, can shrink tumors in people with advanced KIT-mutant melanoma that cannot be removed by surgery. The study will enroll 25 participants with stage III or IV melanoma. The goal is to see how many patients respond to the treatment and to monitor side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- binimetinib and imatinib
- What this could lead to
- If it works, this combination could offer a new treatment option for people with advanced KIT-mutant melanoma that cannot be surgically removed.
- What could go wrong
- This is a small, early-phase trial with only 25 participants, so results may not apply to everyone. The drugs can cause side effects like nausea, fatigue, and skin issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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UC San Diego Moores Cancer Center
RECRUITINGLa Jolla, California, 92093, United States
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94143, United States
Contact Email: •••••@•••••
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