MELANOMA STAGE III
Clinical trials for MELANOMA STAGE III explained in plain language.
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Radioactive 'Smart Bomb' targets melanoma in first human test
Disease control Recruiting nowThis study tests a new drug, [212Pb]VMT01, that delivers a tiny dose of radiation directly to melanoma cells. It is being tested alone or with the immunotherapy nivolumab in 300 people with advanced melanoma that has worsened after prior treatment. The goal is to find safe doses …
Matched conditions: MELANOMA STAGE III
Phase: PHASE1, PHASE2 • Sponsor: Perspective Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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New drug cocktail aims to shrink Hard-to-Treat melanoma
Disease control Recruiting nowThis phase II trial is testing whether combining two drugs, binimetinib and imatinib, can shrink tumors in people with advanced KIT-mutant melanoma that cannot be removed by surgery. The study will enroll 25 participants with stage III or IV melanoma. The goal is to see how many …
Matched conditions: MELANOMA STAGE III
Phase: PHASE2 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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New triple-drug attack aims to revive immune response in hard-to-treat melanoma
Disease control Recruiting nowThis phase 2 trial tests whether combining high-dose interleukin-2 with low-dose ipilimumab, followed by nivolumab, can shrink tumors in people with advanced melanoma that has stopped responding to prior immunotherapy. About 29 participants with inoperable stage III or IV melanom…
Matched conditions: MELANOMA STAGE III
Phase: PHASE2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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Personalized immunotherapy shows promise for advanced melanoma in new trial
Disease control Recruiting nowThis phase 2 trial tests the immunotherapy drug nivolumab (Opdivo) given before and after surgery for people with stage III or IV melanoma. The goal is to see if tailoring treatment based on tumor biomarkers leads to better outcomes. About 90 participants will be enrolled at a si…
Matched conditions: MELANOMA STAGE III
Phase: PHASE2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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Last-resort melanoma combo shows early promise in small trial
Disease control Recruiting nowThis study tests whether adding a low-dose chemotherapy drug (cyclophosphamide) to an immunotherapy (pembrolizumab) can shrink tumors in people with advanced melanoma that has stopped responding to standard immunotherapy. About 14 adults with stage III or IV melanoma that cannot …
Matched conditions: MELANOMA STAGE III
Phase: PHASE2 • Sponsor: University of California, Irvine • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Can tailored drugs after surgery keep melanoma from coming back?
Disease control Recruiting nowThis early-phase trial tests whether giving different drug combinations after surgery, based on how well the tumor responded to initial treatment, can reduce the risk of melanoma returning. About 50 adults with stage III or IV BRAF-mutant melanoma will receive encorafenib, binime…
Matched conditions: MELANOMA STAGE III
Phase: EARLY_PHASE1 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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CAR t cell therapy: how safe is it years later?
Disease control Recruiting nowThis study follows 40 people who received Miltenyi CAR T cell therapy at least one year ago for cancers like melanoma, lymphoma, or leukemia. Researchers will track side effects, cancer return, and overall health for years. The goal is to understand the long-term safety and effec…
Matched conditions: MELANOMA STAGE III
Phase: NA • Sponsor: Miltenyi Biomedicine GmbH • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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New study: simple scan and blood test may reveal who benefits from melanoma immunotherapy
Knowledge-focused Recruiting nowThis study looks at 24 people with advanced melanoma who are starting immunotherapy. Researchers will do a special PET/CT scan and a blood test for tumor DNA about 3-4 weeks after the first treatment. The goal is to see if these early tests can predict whether the immunotherapy i…
Matched conditions: MELANOMA STAGE III
Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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Yeast fiber may boost cancer immunotherapy in melanoma patients
Knowledge-focused Recruiting nowThis study looks at whether beta-glucan, a natural fiber from yeast, can improve the immune response to the immunotherapy drug pembrolizumab in people with stage III or IV melanoma. Researchers will measure changes in immune cells from blood samples. The goal is to understand how…
Matched conditions: MELANOMA STAGE III
Phase: NA • Sponsor: Kelly McMasters • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC