MELANOMA STAGE III
Clinical trials for MELANOMA STAGE III explained in plain language.
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New Alpha-Particle therapy shows promise for Tough-to-Treat melanoma
Disease control Recruiting nowThis study tests a new treatment called [212Pb]VMT01, which delivers targeted radiation to melanoma cells. It is for people with advanced melanoma that has not responded to prior therapies. The trial will evaluate safety and effectiveness when given alone or with the immunotherap…
Matched conditions: MELANOMA STAGE III
Phase: PHASE1, PHASE2 • Sponsor: Perspective Therapeutics • Aim: Disease control
Last updated May 17, 2026 01:46 UTC
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New drug combo targets tough skin cancer
Disease control Recruiting nowThis study tests whether two drugs, binimetinib and imatinib, can shrink tumors in people with advanced KIT-mutant melanoma that cannot be surgically removed. About 25 adults with stage III or IV melanoma will receive the combination. The goal is to control the disease by blockin…
Matched conditions: MELANOMA STAGE III
Phase: PHASE2 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated May 15, 2026 11:57 UTC
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New combo aims to revive immune attack in stubborn melanoma
Disease control Recruiting nowThis study tests whether adding a low-dose chemotherapy drug (cyclophosphamide) to an immunotherapy (pembrolizumab) can shrink tumors in people with advanced melanoma that no longer responds to standard immunotherapy. About 14 adults with stage III or IV melanoma will receive the…
Matched conditions: MELANOMA STAGE III
Phase: PHASE2 • Sponsor: University of California, Irvine • Aim: Disease control
Last updated May 15, 2026 11:56 UTC
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Could Pre-Surgery immunotherapy boost melanoma outcomes?
Disease control Recruiting nowThis study tests whether giving immunotherapy before and after surgery helps people with advanced melanoma (stage III or IV). About 90 participants will receive treatment based on their tumor's biomarkers. The goal is to see if this approach leads to a major or complete response …
Matched conditions: MELANOMA STAGE III
Phase: PHASE2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated May 15, 2026 11:55 UTC
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Can extra therapy after surgery keep melanoma from returning?
Disease control Recruiting nowThis study looks at whether giving extra treatment after surgery can lower the chance of melanoma coming back in people with advanced stage III or IV melanoma that has a BRAF V600 mutation. About 50 adults will receive a combination of two drugs (encorafenib and binimetinib) befo…
Matched conditions: MELANOMA STAGE III
Phase: EARLY_PHASE1 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated May 14, 2026 12:02 UTC
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New combo therapy aims to outsmart resistant melanoma
Disease control Recruiting nowThis study is for people with advanced melanoma (stage III or IV that cannot be removed by surgery) whose cancer has stopped responding to standard immunotherapy drugs like nivolumab or pembrolizumab. The trial tests a new sequence of three drugs: high-dose interleukin-2 (IL2) pl…
Matched conditions: MELANOMA STAGE III
Phase: PHASE2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated May 04, 2026 16:31 UTC
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Can a mushroom fiber boost melanoma immunotherapy?
Knowledge-focused Recruiting nowThis study looks at how beta-glucan, a natural fiber found in foods like oats and mushrooms, affects the immune system in people with stage III or IV melanoma who are already taking the immunotherapy drug pembrolizumab. Researchers will measure changes in immune cells from blood …
Matched conditions: MELANOMA STAGE III
Phase: NA • Sponsor: Kelly McMasters • Aim: Knowledge-focused
Last updated May 17, 2026 01:46 UTC
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Blood test and scan combo may predict melanoma treatment success
Knowledge-focused Recruiting nowThis study looks at whether combining a special PET/CT scan with a blood test for tumor DNA can help doctors predict which patients with advanced melanoma will respond to immunotherapy. Researchers will compare changes in the scan and blood test results from before treatment to a…
Matched conditions: MELANOMA STAGE III
Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated May 15, 2026 11:53 UTC
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CAR t patients monitored for years in new safety study
Knowledge-focused Recruiting nowThis study follows about 40 people who received a Miltenyi CAR T cell therapy at least one year ago. Researchers will track side effects, overall health, and any return of cancer over the long term. The goal is to better understand the lasting safety and effects of this treatment…
Matched conditions: MELANOMA STAGE III
Phase: NA • Sponsor: Miltenyi Biomedicine GmbH • Aim: Knowledge-focused
Last updated May 11, 2026 20:50 UTC