New Pill-and-Immunotherapy combo aims to shrink melanoma before surgery

NCT ID NCT07565285

Recruiting now Disease control Sponsor: Primmune Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 4 times

Summary

This phase 2 trial tests whether adding an experimental immune-boosting pill (PRTX007) to standard immunotherapy (pembrolizumab) before surgery can improve outcomes for people with stage III melanoma. About 48 adults with resectable melanoma will take the combination for 9 weeks before surgery. The main goal is to see how many patients have a major reduction in tumor cells after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PRTX007 (an immune-boosting pill) combined with pembrolizumab (an immunotherapy drug)
What this could lead to: If successful, this combination could improve the chance of eliminating or shrinking melanoma tumors before surgery, potentially leading to better long-term outcomes.
What could go wrong: This is an early phase 2 study with only 48 participants, so results may not apply to everyone. The combination may cause significant immune-related side effects, and it is not yet known if it works better than standard treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cutaneous melanoma melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MELANOMA STAGE III

Contacts and locations

Locations

Calvary Mater Newcastle
RECRUITING

Waratah, New South Wales, 2298, Australia
Gallipoli Medical Research
NOT_YET_RECRUITING

Greenslopes, Queensland, 4120, Australia
One Clinical Research Pty Ltd
NOT_YET_RECRUITING

Nedlands, Western Australia, 6009, Australia
Peter MacCallum Cancer Centre
NOT_YET_RECRUITING

Melbourne, Victoria, 3000, Australia
Princess Alexandra Hospital
NOT_YET_RECRUITING

Woolloongabba, Queensland, 4102, Australia

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