Radioactive 'Smart Bomb' targets melanoma in first human test

NCT ID NCT05655312

Recruiting now Disease control Sponsor: Perspective Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug, [212Pb]VMT01, that delivers a tiny dose of radiation directly to melanoma cells. It is being tested alone or with the immunotherapy nivolumab in 300 people with advanced melanoma that has worsened after prior treatment. The goal is to find safe doses and see if it shrinks tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: [212Pb]VMT01 (a radioactive drug that delivers alpha particles directly to melanoma cells) and nivolumab (an immunotherapy)
What this could lead to: If successful, this could offer a new treatment option for people with advanced melanoma that has stopped responding to other therapies.
What could go wrong: This is an early, first-in-human trial, so safety and effectiveness are not yet known. The radioactive treatment may cause serious side effects, and not all participants may benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cutaneous melanoma melanoma metastatic melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MELANOMA STAGE III MELANOMA STAGE IV METASTATIC MELANOMA RECURRENT MELANOMA (SKIN)

Contacts and locations

Locations

Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Mayo Clinic
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Nebraska Cancer Specialists
RECRUITING

Omaha, Nebraska, 68130, United States
Saint Louis University Hospital
RECRUITING

St Louis, Missouri, 63110, United States
Sarasota Memorial Hospital
RECRUITING

Sarasota, Florida, 34239, United States
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of California Irvine
RECRUITING

Orange, California, 92868, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kentucky
RECRUITING

Lexington, Kentucky, 40536, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of Wisconsin Carbone Cancer Center
ACTIVE_NOT_RECRUITING

Madison, Wisconsin, 53792, United States
Washington University of St. Louis
RECRUITING

St Louis, Missouri, 63110, United States

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