Experimental virus therapy takes on advanced cancers in first human trial
NCT ID NCT06444815
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial is testing a new treatment called VET3-TGI, a virus designed to infect and destroy cancer cells. It is being given alone or with the immunotherapy drug atezolizumab to 60 people with advanced solid tumors that have not responded to standard treatments. The main goals are to find a safe dose and check for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- VET3-TGI (a modified virus that targets and kills cancer cells) and atezolizumab (an immunotherapy drug)
- What this could lead to
- If successful, this could lead to a new treatment option for advanced solid tumors that have not responded to other therapies.
- What could go wrong
- This is a very early (Phase 1) first-in-human trial with only 60 participants, so safety and effectiveness are not yet known. The virus may cause side effects or not work as expected.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Community Health Network
RECRUITINGIndianapolis, Indiana, 46250, United States
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Mary Crowley Cancer Research
RECRUITINGDallas, Texas, 75230, United States
Contact Email: •••••@•••••
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UC Irvine Health
RECRUITINGOrange, California, 92868, United States
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UPMC- Hillman Cancer Center
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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USC/Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
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University of Miami
RECRUITINGMiami, Florida, 33136, United States
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University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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