KIDNEY CANCER

This study looks at whether removing the kidney after successful immunotherapy can help patients with metastatic kidney cancer stop all treatment and stay cancer-free. About 60 adults whose tumors have shrunk significantly with immunotherapy will be randomly assigned to either ha…

This study tests whether giving two drugs (pembrolizumab and axitinib) before surgery can shrink tumor-related blood clots in the main vein of people with kidney cancer. The goal is to make surgery easier and safer, and to improve long-term outcomes. About 17 adults with clear ce…

This trial tests a personalized cancer vaccine made from tumor cells grown in a lab. The cells are modified to boost the immune system, then killed and injected into the patient. The goal is to help people with metastatic melanoma, breast, ovarian, colorectal, gastric, lung, or k…

This study tests whether the drug casdatifan, alone or with zimberelimab, can safely shrink kidney tumors before surgery. It involves 32 adults with clear cell renal cell carcinoma who are scheduled for kidney removal. The goal is to see if these drugs reduce tumor size and are s…

This study tests a daily pill called olaparib in people with advanced kidney cancer that has certain gene mutations (like BAP-1 or BRCA). The goal is to see if the drug can shrink tumors or keep them stable for at least six months. About 20 adults who have already tried other tre…

This study tests an experimental oral drug called Alintegimod combined with standard immunotherapies (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, or liver cancer who have already tried other treatments. The goal is to see if the com…

This study looks at whether removing the kidney tumor after initial immunotherapy can help people with advanced kidney cancer that has spread. About 400 participants will either have surgery or not after starting treatment. The goal is to see which approach leads to longer surviv…

This early-phase study tests a new experimental treatment called VET3-TGI, a virus designed to attack cancer cells. It is given alone or with an immunotherapy drug (atezolizumab) to about 60 adults with advanced solid tumors that have not responded to standard treatments. The mai…

This study looks at how older adults (70+) with advanced kidney cancer handle a combination of two drugs, cabozantinib and nivolumab. Researchers want to see what doses work best and how often side effects cause treatment breaks. The goal is to improve treatment for this age grou…

This study tests a new treatment called EBNK-001, which uses donor natural killer (NK) cells to fight advanced solid tumors. About 83 adults with cancers like lung, breast, or colorectal cancer that have not responded to standard treatments will receive the NK cells along with ch…

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, breast, and kidney cancers) that have not responded to standard therapy. The treatment uses specially engineered immune cells designed to kill cancer cells while protectin…

This early-phase study tests whether adding an experimental drug (HC-7366) to standard immunotherapy (nivolumab, with or without ipilimumab) can help control advanced clear cell kidney cancer. About 35 adults with stage IV disease will participate. The main goal is to check safet…

This study is testing whether a combination of three drugs—sasanlimab, palbociclib, and axitinib—can shrink or control advanced kidney cancer that has spread. About 25 adults with clear cell or translocation renal cell carcinoma will receive the drugs and be monitored for tumor r…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study tests whether fecal microbiota transplantation (FMT) capsules can help people with diarrhea and colitis caused by immune checkpoint inhibitors, a common side effect of cancer treatment. Twenty adults with melanoma or kidney cancer will receive either FMT or placebo cap…

This study tests whether non-steroidal anti-inflammatory drugs (NSAIDs) can effectively control pain after robotic kidney cancer surgery, reducing the need for stronger opioid painkillers. About 110 adults undergoing this surgery will be randomly assigned to receive either NSAIDs…

This study tracks drug levels in the blood of 200 people with advanced kidney cancer to see if monitoring can improve how well the drugs work and reduce side effects. Researchers will also look at how genetics and immune responses affect treatment. No new drugs are being tested—t…

This study looks at how well different imaging methods can measure the stiffness of kidney tumors and healthy kidney tissue. Researchers will compare MRI-based elasticity measurements with CT scans to build a model that predicts tissue stiffness. The goal is to help surgeons crea…

This study follows 50 adults with localized kidney cancer who have laparoscopic nephrectomy as an outpatient procedure. Researchers track any complications that happen within one month after surgery, such as infections or bleeding. The goal is to understand how often these proble…

This study looks at whether giving cancer patients more personalized help (high-intensity navigation) makes them more likely to join a clinical trial compared to standard help (low-intensity navigation). About 90 adults with prostate or kidney cancer will take part. The goal is t…

This study collects live tumor tissue from 2,000 people with various cancers to understand why some respond to immunotherapy and others don't. Participants give a biopsy as part of their normal care, and researchers analyze the samples in the lab. The goal is to develop better wa…

This study is building a large French database of up to 30,000 kidney cancer patients. Researchers will collect medical information and biological samples over time to better understand the disease and improve care. The goal is to create a powerful research tool, not to test a ne…

This study tests whether visual decision aids help urologists better discuss risks and benefits of surgery with patients who have prostate or kidney cancer. About 20 doctors and 200 patient visits will be recorded and analyzed. The goal is to see if these tools improve communicat…

This study looks at how kidney and bladder cancers use nutrients like sugar and fat to grow. About 600 adults having surgery or a biopsy will receive a special nutrient tracer through an IV. Blood and tissue samples are then analyzed to see how the cancer uses these fuels. Partic…

This study is testing whether a simple blood test that looks for cancer DNA can detect if kidney cancer has come back after surgery, possibly earlier than standard imaging scans. Researchers will follow 450 people who have just been diagnosed with kidney cancer and are having sur…

This study aims to learn more about the genetic causes of Birt-Hogg-Dube (BHD) syndrome, a rare condition that raises the risk of kidney cancer, lung cysts, and benign skin bumps. Researchers will study up to 950 people with known or suspected BHD and their family members. Partic…

This study collects blood, urine, saliva, and tissue samples from people who have or may have cancer, as well as their blood relatives. The goal is to help researchers learn more about the genetic and molecular causes of cancer. No direct treatment is given, but the samples may l…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer, along with their medical information. The samples will be stored and used by researchers to develop better ways to detect, monitor, and understand cancer over time…

This study aims to find the genetic changes that cause hereditary leiomyomatosis renal cell cancer (HLRCC), a condition that can lead to kidney tumors, painful skin bumps, and uterine fibroids. Researchers will study people with known or suspected HLRCC and their family members t…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…

This study aims to better understand inherited forms of kidney and urinary tract cancers, like Von Hippel-Lindau disease. Researchers will observe families with these conditions over time to learn how the diseases develop, what symptoms they cause, and how specific genetic change…