Scientists track families to unlock secrets of inherited kidney cancer

NCT ID NCT00001238

Recruiting now Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 6 times

Summary

This study follows families with a history of inherited kidney cancer to learn more about the disease's genetic causes and how it progresses. Researchers will collect blood, tissue, and urine samples from affected individuals and their relatives. The goal is to identify new genes linked to these cancers and improve future diagnosis and management. No experimental treatments are being tested.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to better understanding of inherited kidney cancers and help identify new genetic targets for future treatments.
What could go wrong: This is an observational study, not a treatment trial. It may not directly benefit participants, and results may take many years to translate into therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Birt-Hogg-Dube syndrome chromophobe renal cell carcinoma clear cell renal carcinoma hereditary clear cell renal cell carcinoma hereditary kidney oncocytoma hereditary leiomyomatosis and renal cell cancer hereditary papillary renal cell carcinoma hereditary renal cell carcinoma kidney cancer kidney oncocytoma malignant urinary system neoplasm pheochromocytoma renal cell carcinoma von Hippel-Lindau disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLEAR CELL RENAL CANCER FAMILIAL RENAL CANCER (FRC) KIDNEY CANCER RENAL CELL CARCINOMA UROLOGIC MALIGNANT DISORDERS

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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