National Cancer Institute (nci)

This study tests a drug called abemaciclib, currently used for breast cancer, to see if it can safely treat Kaposi sarcoma (KS) in people with or without HIV. About 86 adults with KS will take the drug daily in 28-day cycles. Researchers will monitor for side effects and check if…

This study is testing whether a combination of two drugs, sacituzumab govitecan and berzosertib, can help shrink tumors in people with aggressive cancers that have stopped responding to standard treatments. It is for adults with specific cancers, including small cell lung cancer …

This large, late-stage trial is testing whether adding newer, faster-to-administer targeted drugs to standard chemotherapy is better at controlling a specific, aggressive type of uterine cancer (HER2-positive). It will involve 360 patients who have recently been diagnosed and hav…

This study is testing a combination of two targeted drugs, inotuzumab ozogamicin and blinatumomab, for adults with a specific type of acute lymphoblastic leukemia (ALL). It is for older adults newly diagnosed with this cancer or adults whose cancer has come back or hasn't respond…

This study follows people with inherited changes in the BAP1 gene and other cancer-related genes to learn how mesothelioma and other cancers develop. Participants include both people with mesothelioma and their family members. Researchers collect medical history, saliva, blood, a…

This study aims to better understand inherited forms of kidney and urinary tract cancers, like Von Hippel-Lindau disease. Researchers will observe families with these conditions over time to learn how the diseases develop, what symptoms they cause, and how specific genetic change…