New drug cocktail takes on rare adrenal cancer
NCT ID NCT06900595
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial tests whether adding the immunotherapy cemiplimab to the targeted drug cabozantinib works better than cabozantinib alone for advanced adrenocortical cancer. About 48 adolescents and adults whose cancer has spread or cannot be removed will take part. The study aims to see if the combination can delay cancer growth.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
cabozantinib and cemiplimab
What this could lead to
If successful, this combination could offer a new treatment option to slow or shrink advanced adrenocortical cancer when other therapies have failed.
What could go wrong
This is a small phase II trial, so results may not confirm benefit. The drugs can cause side effects like fatigue, high blood pressure, and immune-related reactions.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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BI-LO Charities Children's Cancer Center
RECRUITINGGreenville, South Carolina, 29605, United States
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Broadlawns Medical Center
RECRUITINGDes Moines, Iowa, 50314, United States
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Carle BroMenn Medical Center
RECRUITINGNormal, Illinois, 61761, United States
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Carle Cancer Center
RECRUITINGUrbana, Illinois, 61801, United States
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Carle Cancer Institute Normal
RECRUITINGNormal, Illinois, 61761, United States
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Carle Physician Group-Effingham
RECRUITINGEffingham, Illinois, 62401, United States
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Carle Physician Group-Mattoon/Charleston
RECRUITINGMattoon, Illinois, 61938, United States
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Carle at The Riverfront
RECRUITINGDanville, Illinois, 61832, United States
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Children's Hospital of Pittsburgh of UPMC
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
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Children's Hospital of San Antonio
RECRUITINGSan Antonio, Texas, 78207, United States
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Children's Mercy Hospitals and Clinics
RECRUITINGKansas City, Missouri, 64108, United States
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CoxHealth South Hospital
RECRUITINGSpringfield, Missouri, 65807, United States
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Dell Children's Medical Center of Central Texas
RECRUITINGAustin, Texas, 78723, United States
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Duke Cancer Center Cary
RECRUITINGCary, North Carolina, 27518, United States
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Duke Cancer Center Raleigh
RECRUITINGRaleigh, North Carolina, 27609, United States
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27710, United States
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Iowa Methodist Medical Center
RECRUITINGDes Moines, Iowa, 50309, United States
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Lurie Children's Hospital-Chicago
RECRUITINGChicago, Illinois, 60611, United States
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Memorial Hospital East
RECRUITINGShiloh, Illinois, 62269, United States
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Memorial Sloan Kettering Basking Ridge
RECRUITINGBasking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen
RECRUITINGMontvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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Memorial Sloan Kettering Commack
RECRUITINGCommack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth
RECRUITINGMiddletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau
RECRUITINGUniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester
RECRUITINGHarrison, New York, 10604, United States
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Mercy Medical Center - Des Moines
RECRUITINGDes Moines, Iowa, 50314, United States
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Nebraska Medicine-Bellevue
RECRUITINGBellevue, Nebraska, 68123, United States
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Nebraska Medicine-Village Pointe
RECRUITINGOmaha, Nebraska, 68118, United States
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Northwestern Medicine Cancer Center Delnor
RECRUITINGGeneva, Illinois, 60134, United States
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Northwestern Medicine Cancer Center Kishwaukee
RECRUITINGDeKalb, Illinois, 60115, United States
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Northwestern Medicine Cancer Center Warrenville
RECRUITINGWarrenville, Illinois, 60555, United States
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Northwestern Medicine Glenview Outpatient Center
RECRUITINGGlenview, Illinois, 60026, United States
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Northwestern Medicine Grayslake Outpatient Center
RECRUITINGGrayslake, Illinois, 60030, United States
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Northwestern Medicine Lake Forest Hospital
RECRUITINGLake Forest, Illinois, 60045, United States
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Northwestern Medicine Oak Brook
RECRUITINGOak Brook, Illinois, 60523, United States
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Northwestern Medicine Orland Park
RECRUITINGOrland Park, Illinois, 60462, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
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Prisma Health Cancer Institute - Butternut
RECRUITINGGreenville, South Carolina, 29605, United States
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Prisma Health Cancer Institute - Easley
RECRUITINGEasley, South Carolina, 29640, United States
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Prisma Health Cancer Institute - Eastside
RECRUITINGGreenville, South Carolina, 29615, United States
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Prisma Health Cancer Institute - Faris
RECRUITINGGreenville, South Carolina, 29605, United States
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Prisma Health Cancer Institute - Greer
RECRUITINGGreer, South Carolina, 29650, United States
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Prisma Health Cancer Institute - Seneca
RECRUITINGSeneca, South Carolina, 29672, United States
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Prisma Health Cancer Institute - Spartanburg
RECRUITINGBoiling Springs, South Carolina, 29316, United States
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Prisma Health Richland Hospital
RECRUITINGColumbia, South Carolina, 29203, United States
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Saint Anthony Regional Hospital
RECRUITINGCarroll, Iowa, 51401, United States
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Saint Jude Children's Research Hospital
RECRUITINGMemphis, Tennessee, 38105, United States
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Siteman Cancer Center at Christian Hospital
RECRUITINGSt Louis, Missouri, 63136, United States
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Siteman Cancer Center at Saint Peters Hospital
RECRUITINGCity of Saint Peters, Missouri, 63376, United States
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Siteman Cancer Center at West County Hospital
RECRUITINGCreve Coeur, Missouri, 63141, United States
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Siteman Cancer Center-South County
RECRUITINGSt Louis, Missouri, 63129, United States
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UC San Diego Moores Cancer Center
RECRUITINGLa Jolla, California, 92093, United States
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UCHealth University of Colorado Hospital
RECRUITINGAurora, Colorado, 80045, United States
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UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITINGAnkeny, Iowa, 50023, United States
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UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITINGDes Moines, Iowa, 50309, United States
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UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITINGDes Moines, Iowa, 50314, United States
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UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITINGWaukee, Iowa, 50263, United States
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UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITINGClive, Iowa, 50325, United States
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UI Healthcare Mission Cancer and Blood - Fort Dodge
RECRUITINGFort Dodge, Iowa, 50501, United States
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University of Michigan Rogel Cancer Center
RECRUITINGAnn Arbor, Michigan, 48109, United States
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University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68198, United States
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University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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University of Texas Health Science Center at San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
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VCU Massey Cancer Center at Stony Point
RECRUITINGRichmond, Virginia, 23235, United States
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VCU Massey Comprehensive Cancer Center
RECRUITINGRichmond, Virginia, 23298, United States
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
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