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New drug combo aims to shrink lung tumors better

NCT ID NCT05198830

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 12 times

Summary

This study tests whether adding the experimental drug TRC102 to standard treatment (chemotherapy, radiation, and immunotherapy) can help shrink tumors and extend survival in people with stage III non-squamous lung cancer. TRC102 blocks cancer cells from repairing damage, making them more vulnerable to treatment. About 42 adults with newly diagnosed stage III disease will be enrolled.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma of Lung lung adenocarcinoma lung cancer lung large cell carcinoma lung neoplasm non-small cell lung carcinoma non-small cell squamous lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG ADENOCARCINOMA LUNG LARGE CELL CARCINOMA LUNG NON-SQUAMOUS NON-SMALL CELL CARCINOMA STAGE III LUNG CANCER AJCC V8

Contacts and locations

Locations

  • Case Western Reserve University

    RECRUITING

    Cleveland, Ohio, 44106, United States

    Contact Email: •••••@•••••

  • City of Hope Antelope Valley

    RECRUITING

    Lancaster, California, 93534, United States

    Contact Email: •••••@•••••

  • City of Hope Comprehensive Cancer Center

    RECRUITING

    Duarte, California, 91010, United States

    Contact Email: •••••@•••••

  • City of Hope South Pasadena

    RECRUITING

    South Pasadena, California, 91030, United States

    Contact Email: •••••@•••••

  • City of Hope Upland

    RECRUITING

    Upland, California, 91786, United States

    Contact Email: •••••@•••••

  • City of Hope at Irvine Lennar

    RECRUITING

    Irvine, California, 92618, United States

  • Community Medical Center

    RECRUITING

    Toms River, New Jersey, 08755, United States

  • Cooperman Barnabas Medical Center

    RECRUITING

    Livingston, New Jersey, 07039, United States

  • Jersey City Medical Center

    RECRUITING

    Jersey City, New Jersey, 07302, United States

  • Keck Medicine of USC Buena Park

    RECRUITING

    Buena Park, California, 90621, United States

  • Los Angeles General Medical Center

    RECRUITING

    Los Angeles, California, 90033, United States

    Contact Email: •••••@•••••

  • MetroHealth Medical Center

    RECRUITING

    Cleveland, Ohio, 44109, United States

  • Monmouth Medical Center

    RECRUITING

    Long Branch, New Jersey, 07740, United States

  • Montefiore Medical Center - Moses Campus

    ACTIVE_NOT_RECRUITING

    The Bronx, New York, 10467, United States

  • Montefiore Medical Center-Einstein Campus

    ACTIVE_NOT_RECRUITING

    The Bronx, New York, 10461, United States

  • Newark Beth Israel Medical Center

    RECRUITING

    Newark, New Jersey, 07112, United States

  • Robert Wood Johnson University Hospital Somerset

    RECRUITING

    Somerville, New Jersey, 08876, United States

  • Rutgers Cancer Institute of New Jersey

    RECRUITING

    New Brunswick, New Jersey, 08903, United States

  • UC Comprehensive Cancer Center at Silver Cross

    RECRUITING

    New Lenox, Illinois, 60451, United States

    Contact Email: •••••@•••••

  • UChicago Medicine Northwest Indiana

    RECRUITING

    Crown Point, Indiana, 46307, United States

    Contact Email: •••••@•••••

  • UF Health Cancer Institute - Gainesville

    RECRUITING

    Gainesville, Florida, 32610, United States

    Contact Email: •••••@•••••

  • UM Sylvester Comprehensive Cancer Center at Coral Gables

    RECRUITING

    Coral Gables, Florida, 33146, United States

  • UM Sylvester Comprehensive Cancer Center at Deerfield Beach

    RECRUITING

    Deerfield Beach, Florida, 33442, United States

  • UM Sylvester Comprehensive Cancer Center at Kendall

    RECRUITING

    Miami, Florida, 33176, United States

  • UM Sylvester Comprehensive Cancer Center at Plantation

    RECRUITING

    Plantation, Florida, 33324, United States

  • UPMC Hillman Cancer Center

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • USC / Norris Comprehensive Cancer Center

    RECRUITING

    Los Angeles, California, 90033, United States

  • USC Norris Oncology/Hematology-Newport Beach

    RECRUITING

    Newport Beach, California, 92663, United States

  • University of California Davis Comprehensive Cancer Center

    ACTIVE_NOT_RECRUITING

    Sacramento, California, 95817, United States

  • University of Chicago Comprehensive Cancer Center

    RECRUITING

    Chicago, Illinois, 60637, United States

    Contact Email: •••••@•••••

  • University of Chicago Medicine-Orland Park

    RECRUITING

    Orland Park, Illinois, 60462, United States

    Contact Email: •••••@•••••

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    RECRUITING

    Miami, Florida, 33136, United States

  • University of Texas Medical Branch

    SUSPENDED

    Galveston, Texas, 77555-0565, United States

  • Wake Forest University Health Sciences

    RECRUITING

    Winston-Salem, North Carolina, 27157, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.