LUNG ADENOCARCINOMA

This study tests a new treatment for people with advanced lung cancer that cannot be removed by surgery. It combines a special type of radiation that targets only the center of the tumor with an immunotherapy drug that helps the immune system fight cancer. The goal is to see if t…

This early-phase trial tests a new treatment for people with advanced melanoma or other solid tumors that have spread. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. The goal is to find a safe dose and see if t…

This study tests whether adding an experimental drug called TRC102 to standard treatment (chemotherapy, radiation, and immunotherapy) can better shrink tumors and extend life in people with stage III non-squamous lung cancer. TRC102 blocks cancer cells from repairing damage, maki…

This study is for adults with advanced solid tumors that have a specific genetic change called STK11 mutation. The goal is to test a new drug, TNG260, given alone or with an immunotherapy drug (pembrolizumab). Researchers want to find the best dose, check safety, and see if the c…

This study tests two ways to treat lung cancer that has spread to the brain. One group gets focused radiation plus a drug called bevacizumab; the other gets whole-brain radiation that tries to protect the memory center. The goal is to see which approach better controls the brain …

This study tests whether the drug osimertinib can stop or shrink small, hazy spots (called ground-glass nodules) in the lungs of people who have already had surgery for a type of lung cancer with a specific gene change (EGFR mutation). About 59 adults aged 30–75 will take one pil…

This study tests the safety of dapagliflozin, a drug approved for diabetes and heart failure, when given before surgery to people with early-stage lung adenocarcinoma. The drug targets a protein found at high levels in these cancer cells. About 48 participants will receive the dr…

This study is testing whether a personalized care plan, which includes advanced genomic testing and immunotherapy, can help people with stage IV non-small cell lung cancer live longer and feel better. About 3,500 current or former smokers with this cancer will be followed to see …

This study tests whether adding a tumor-freezing procedure (cryoablation) to standard immunotherapy and chemotherapy helps people with advanced lung cancer live longer. About 214 adults with metastatic lung adenocarcinoma will be randomly assigned to receive either the standard d…

This study compares two types of lung surgery for people with small lung cancers (≤2 cm). One surgery removes only a part of the lung lobe (segmentectomy), while the other removes the entire lobe (lobectomy). The goal is to see if the smaller surgery works just as well at prevent…

This study tests an experimental drug called AZD5335, alone or with other cancer treatments, in people with advanced ovarian, lung, or endometrial cancers that have not responded to standard therapy. The main goals are to check safety and find the right dose. About 506 participan…

This study tests whether eating a low-sugar, high-fat (ketogenic) diet for 7 days before a PET scan can improve detection of a slow-growing lung cancer called lepidic-predominant adenocarcinoma. About 30 adults with a suspicious lung nodule will follow the diet and then have a PE…

This study is testing a new type of PET scan that uses a special sugar tracer (Me-4FDG) to find lung cancer earlier. The tracer is designed to highlight cancer cells that take up a lot of sugar. Researchers will check how safe and accurate this scan is in 60 adults who have a lun…

This study looks at whether giving veterans with lung cancer extra support can help them feel better day-to-day. Researchers will track quality of life, emergency room visits, and hospital stays over one year. The goal is to find simple ways to improve care for those who served.

This study looks at whether yoga and mindfulness can improve the social, emotional, and physical well-being of people who have had lung, colon, or non-Hodgkin's lymphoma cancer. Researchers will also check if these practices affect epigenetics—how our environment turns genes on o…

This study aims to create a decision aid for people with a type of lung cancer (lung adenocarcinoma) who have just had surgery. The tool will help patients and their doctors work together to decide whether to do molecular testing on the tumor. About 190 people, including patients…

This study looks for new molecular markers in the fluid that builds up around the lungs (pleural effusion) of people with lung adenocarcinoma. Researchers will compare these markers between cancerous and non-cancerous fluid samples from 100 patients. The goal is to find better wa…

This observational study aims to find how common inherited gene changes are in Mexican patients with lung adenocarcinoma. Researchers will collect blood samples from 332 participants to look for genetic variants linked to cancer. The goal is to better understand which patients ma…