Antidepressant may ease brain fog from lung cancer drug

NCT ID NCT07633626

Recruiting now Symptom relief Sponsor: Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether vortioxetine, an antidepressant known to boost thinking skills, can reduce the mental fogginess caused by the lung cancer drug lorlatinib. About 24 adults with advanced ALK-positive lung cancer who are already taking lorlatinib will receive vortioxetine. Researchers will track changes in memory, attention, and mood over six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vortioxetine (an antidepressant)
What this could lead to: If it works, this could point toward a way to manage cognitive side effects from lorlatinib, helping patients think more clearly during treatment.
What could go wrong: This is a small, early observational study with only 24 people, so results may not apply to everyone. It is not a controlled trial, so improvements could be due to other factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma of Lung carcinoma cognitive disorder Cognitive Dysfunction Depression depressive disorder lung adenocarcinoma non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED ALK/ROS1-POSITIVE NSCLC ALK-POSITIVE NON-SMALL CELL LUNG CANCER (NSCLC) CARCINOMA, NON-SMALL-CELL LUNG (NSCLC) COGNITIVE DYSFUNCTION DEPRESSION LUNG ADENOCARCINOMA

Contacts and locations

Locations

Centro de Tratamiento e Investigación sobre Cáncer Luis Carlos Sarmiento Angulo CTIC
RECRUITING

Bogotá, 110131, Colombia

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