DEPRESSION

This study investigates whether ketamine, given as four intravenous infusions over two weeks, can reduce depression and alcohol cravings in adults who have both conditions. Participants are already in inpatient addiction therapy and are randomly assigned to receive either ketamin…

This study tests a talk therapy called CETA for 300 mothers in a low-income area of Lima, Peru. The therapy aims to reduce depression, anxiety, and stress, and improve parenting and children's well-being. Another 300 mothers receive standard support. Researchers will follow famil…

This study tests a short counseling program (about 4 sessions) designed to help pregnant and postpartum women in Cape Town, South Africa, keep taking their daily HIV-prevention pill (PrEP). Many women stop PrEP due to depression or trauma from violence. The program uses cognitive…

This pilot study is testing whether combining cognitive behavioral therapy (CBT) with guided exercise can improve blood sugar control, reduce depression, and boost quality of life in Black men with type 2 diabetes. Eighty participants will receive 8 sessions of CBT, with half als…

This study tests a program called iCHART, designed to help teens aged 12-18 who have depression or suicidal thoughts. The program connects them to mental health care and safety planning. Researchers hope it will reduce suicide-related events by 50% compared to usual care.

This trial tests a program called WeCare, which combines problem-solving therapy with support for taking HIV medication. It is designed for men who have sex with men (MSM) in South Africa. The study will enroll 60 participants to see if the program reduces depression and anxiety,…

This study tests whether screening for social needs like housing and food access, combined with referrals to community resources, can improve chronic disease outcomes for patients of color. Researchers will track blood pressure, cholesterol, blood sugar, depression, and asthma co…

This study tests a combined therapy for mothers with PTSD who are already receiving child welfare prevention services. The treatment blends skills to manage emotions and trauma with parent-child interaction coaching. Researchers will track changes in PTSD, depression, parenting b…

This study compares methotrexate alone versus methotrexate plus the antidepressant escitalopram in 40 adults with moderate to severe psoriasis and depression or anxiety. Over six months, researchers will measure skin improvement and mental health changes to see if the combination…

This study tests a program called Enhanced Friendship Bench that combines problem-solving therapy with HIV support for pregnant women in Malawi who have HIV and depression. About 400 women will take part to see if the program reduces depression symptoms and helps them stay in HIV…

This study tests a 9-session program called MILAP for young married women (ages 15-24) in Nepal who have experienced intimate partner violence. The program involves the woman, her husband, and her mother-in-law, aiming to reduce depression, violence, and PTSD. 900 participants wi…

This global study tests whether applying a sunlight-reflecting coating to roofs can lower indoor temperatures and improve health. Researchers will enroll 3,200 households in five hot cities across Africa, Asia, Latin America, and the Pacific. They will measure heart rate, blood s…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study tests whether a trauma-focused group therapy (CPT-CJ) given in prison can reduce drug use, PTSD symptoms, and re-arrest after release. 640 incarcerated adults from about 10 prisons will either receive the group therapy or a self-help workbook. Researchers will also mea…

This study is testing whether a computer-delivered cognitive behavioral therapy (CBT) program can help people who have both an anxiety disorder and alcohol use disorder. The program teaches skills like breathing control and problem solving to break the cycle of negative feelings …

This study looks at whether a non-invasive brain stimulation technique called iTBS can help prevent depression from returning. 60 adults who already improved with iTBS will receive maintenance sessions, either once a day for a week or all in one day. The goal is to see which sche…

This study tests simple methods to help adults with depression take their antidepressant medication regularly. Researchers will use electronic pill bottles to track adherence and measure depression symptoms over 12 weeks. The goal is to find practical ways to improve both medicat…

This study tests whether community health workers can help adults with chronic illnesses get up-to-date on COVID-19 and flu vaccines. Participants receive up to three counseling sessions in English or Spanish to address their vaccine concerns. The goal is to reduce health dispari…

This study tests a parenting program designed to help Hispanic teens who are gay, lesbian, or bisexual. The goal is to see if the program can prevent or reduce drug use and symptoms of depression by improving family support and reducing stress. About 306 teens and their parents w…

This study tests a therapy called Positive Affect Treatment (PAT) to see if it can prevent depression in teenagers aged 12-16 who have experienced two or more adverse childhood events. The therapy involves 15 weekly sessions focused on building positive emotions and coping skills…

This study tests a new way to train mentors and their supervisors to deliver a proven depression prevention program to teens in rural communities. The training uses online modules, live coaching, and a buddy system where new mentors learn from experienced ones. About 96 teens age…

This study looks at whether cognitive-behavioral therapy (CBT), exercise training, or both can help prevent type 2 diabetes in teenage girls who are at risk. The researchers want to see if these approaches lower stress, improve mood, boost physical activity, and reduce insulin re…

This study tests whether a mindfulness-based sleep program for pregnant women with insomnia can prevent depression during and after pregnancy. Researchers will enroll 500 women and compare the program to standard care. The goal is to improve sleep and reduce the risk of perinatal…

This study tests a six-session program called SER Familia for Latino immigrant families with a parent and a child aged 12-17. The program, led by community health workers, aims to reduce stress from adapting to a new culture and build resilience. The goal is to prevent substance …

This study tests two school-based programs designed to help teenagers aged 13-19 sleep better. The goal is to see if improving sleep can prevent depression, anxiety, and daytime sleepiness. About 3000 students in Swedish high schools will take part, and their results will be comp…

This study tests whether a virtual reality (VR) game can help children aged 10 to 16 improve their emotional regulation and reduce symptoms of anxiety and depression. Half of the 160 participants will play VR cognitive training games, while the other half will do VR relaxation ex…

This study tests whether a mobile app with short weekly exercises can help first-time parents manage emotions and reduce depression during pregnancy. About 572 expectant mothers and fathers in Singapore will use the app or receive standard care. Participants will also wear a Fitb…

This Phase 3 study tests whether CYB003, a psilocin analog (related to the active ingredient in magic mushrooms), can safely reduce depression symptoms in 330 adults with major depressive disorder. Participants receive either one of two doses of CYB003 or a placebo, along with ps…

This study tests whether clemastine, a common antihistamine, can improve brain white matter and make antidepressants work better for adults over 60 with depression. Eighty participants will receive either clemastine or a placebo alongside their antidepressant. The goal is to see …

This study tests whether wearing a headset that delivers a flickering 60Hz white light for 30 minutes a day can help ease depression symptoms. Adults with major depressive disorder will use the device at home for three weeks. Researchers will measure how well people stick with th…

This study tests whether a noninvasive brain stimulation technique called tDCS can reduce depression in people with multiple sclerosis. Participants use a headband-like device at home for 30 minutes a day over 30 days, while listening to mindfulness meditation. Half receive real …

This study tests whether cariprazine (Vraylar) can safely ease depressive episodes in teens aged 10-17 with bipolar I disorder. Around 380 participants will receive either the drug or a placebo for 6 weeks, with dose adjustments based on response. The goal is to see if the drug i…

This study tests whether a chatbot that uses motivational interviewing can help college students with anhedonia (loss of interest or pleasure) feel more emotional arousal. Eighty participants will interact with the chatbot or a control version, and their brain activity will be sc…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with talk therapy can safely help cancer survivors with depression or anxiety. Twenty adults who have finished cancer treatment and have no brain involvement will receive a single dose of psil…

This study tests whether a chatbot that uses motivational interviewing can help college students with anhedonia (loss of interest or pleasure) update their beliefs in a more positive way. 80 participants will interact with the chatbot or a control version over several sessions. T…

This study tests whether a chatbot that uses motivational interviewing can improve how people with anhedonia (loss of interest or pleasure) respond to social rewards. Eighty college students with elevated depression and anhedonia will interact with the chatbot regularly over a pe…

This study tests a program called ACT Together for parents of children with disabilities. The program includes six online lessons and weekly phone coaching sessions with a trained therapist. It teaches skills to handle stress and difficult emotions. Researchers want to see if the…

This study tests whether using a genetic test to guide antidepressant dosing helps teens aged 12-17 with anxiety or depression. About 452 teens will be randomly assigned to either gene-guided dosing or standard dosing. The goal is to see if the genetic approach leads to more remi…

This study tests whether a type of talk therapy called behavioral activation (BA) can help treat depression in older adults who have survived cancer. Participants will receive BA or supportive psychotherapy remotely via video or phone over 10 weeks. The goal is to see if BA reduc…

This study tests an internet-based cognitive behavioural therapy (ICBT) program designed specifically for Canadian public safety personnel (like police, firefighters, and paramedics) who have symptoms of depression, anxiety, or posttraumatic stress. Participants choose their leve…

This study tests a behavioral program called InSTILL for nursing home residents who feel stressed or depressed. Twenty participants will attend six sessions to learn life management and emotion regulation skills. The main goal is to see if the program is practical and well-liked,…

This pilot study tests whether adding brief guided mindfulness exercises (via a smartphone app) between sessions of accelerated brain stimulation (aiTBS) is feasible and acceptable for people with major depression. Twenty adults already receiving aiTBS as standard care will pract…

This study tests a program called Parenting STAIR Modular (PSTAIR-M) for military-connected mothers who have experienced trauma and have young children aged 2-10. The program helps mothers manage PTSD and depression symptoms while improving their parenting skills. Researchers wil…

This study tests a 10-session LGBTQ-affirmative cognitive behavioral therapy (CBT) delivered via telehealth to sexual minority women who drink heavily and have anxiety or depression. Researchers will compare it to standard LGBTQ-affirmative therapy to see if it better reduces hea…

This Phase 1 study is testing the safety and brain effects of DMT, a psychedelic drug, in 60 adults with depression and healthy volunteers. Participants receive low or medium doses of DMT, THC, or a placebo, and researchers monitor mood, anxiety, and brain activity. The goal is t…

This study tests whether a new drug called HNK can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with their depression …

This study tests whether adding poverty alleviation (like financial support) to group talk therapy helps low-income rural women in Bangladesh with depression more than therapy alone. Six hundred women aged 18-45 with depression and economic hardship will be randomly assigned to e…

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This study compares two ways to treat depression in cancer survivors: a mobile app called Moodivate that tracks activities and mood, and 8 sessions of telehealth therapy with a mental health provider. About 45 adults who have had cancer and currently feel depressed will take part…

This study is testing whether a yoga program can help ease depression symptoms in teenagers, compared to group cognitive-behavioral therapy (CBT). Researchers will recruit 96 teens aged 12-18 with elevated depressive symptoms across two sites in Boston and Columbus. Participants …

This study tests whether hemp-derived CBD (with or without THC) can help older adults (60+) who use cannabis for pain, anxiety, depression, or sleep problems. Over 8 weeks, 385 participants will take either CBD+THC, CBD alone, or a placebo. The goal is to see if CBD can reduce sy…

This study tests a smartphone app designed to help teenagers aged 14-18 who self-harm and are not currently in therapy. The app teaches coping skills and connects them with support through a friendly chatbot. The goal is to see if the app is easy to use and helps reduce self-inju…

This study tests whether vortioxetine, an antidepressant known to boost thinking skills, can reduce the mental fogginess caused by the lung cancer drug lorlatinib. About 24 adults with advanced ALK-positive lung cancer who are already taking lorlatinib will receive vortioxetine. …

This study tests whether a coaching program combined with a decision aid can help Black patients with long-term muscle and joint pain and depression use non-drug treatments like physical therapy or counseling. 304 patients will be randomly assigned to either the coaching program …

This study tests a sleep-focused program (TranS-C) plus bright light therapy in 90 teens aged 12-18 with moderate to severe depression and sleep problems. Half get the full program with a sleep therapist and light glasses; the other half just track their sleep. The goal is to see…

This study tests if reading a personal narrative book, in addition to standard care, can help women of childbearing age manage anxiety, depression, and negative thinking before a hysterectomy. About 156 women will either receive standard information or also read a book. The goal …

This study tests a workplace-based program designed to help low-wage hospital service workers manage depression and become more physically active. Ten participants will receive remote counseling, work coaching, social needs support, and text message encouragement. The goal is to …

This Phase 2 trial tests whether TNX-102 SL, a tablet taken under the tongue at bedtime, can improve depression symptoms in adults with moderate to severe major depressive disorder. About 360 participants will receive either the drug or a placebo nightly for 6 weeks. Researchers …

This study compares group-based Acceptance and Commitment Therapy (ACT) to standard individual therapy for young people aged 16-25 with depression, anxiety, or stress. About 212 participants will be randomly assigned to either group ACT or individual therapy. The goal is to see i…

This study tests whether a single dose of psilocybin, given with psychological support, can improve depression in people with Parkinson's disease. Sixty adults aged 40 to 80 with mild to moderate Parkinson's and depressive symptoms will receive either a low or high dose of psiloc…

This study tests whether brief cognitive behavioral therapy (CBT) can help people hospitalized for depression or anxiety. About 204 patients will receive CBT sessions during their stay. The goal is to see if this therapy reduces symptoms and improves daily functioning.

This study tests two digital mindfulness programs—one live over Zoom and one self-paced app—to see if they can reduce depression in younger breast cancer survivors. It includes 402 women diagnosed at or before age 50 who finished cancer treatment at least 6 months ago and have el…

This study tests a program called CAPABLE Transplant, where an occupational therapist, nurse, and handy worker visit people at home over 4 months. The goal is to help kidney transplant candidates who are currently inactive on the waitlist become active again, and to improve their…

This study tests a telemedicine-delivered cognitive behavioral program (RxWell) to help adults with anxiety or depression use fewer opioids after knee or hip replacement. About 150 participants will be enrolled. The program aims to improve mood and reduce painkiller use by provid…

This study tests whether an 8-week virtual reality adventure exergaming program can improve physical activity, mood, and thinking in women veterans aged 18-45. Participants will play VR games that involve movement, and researchers will track changes in depression, anxiety, and PT…

This study looks at how Behavioral Activation (BA) therapy affects the brains of depressed teenagers. 136 teens aged 15-17 with depression will receive up to 16 therapy sessions focused on increasing rewarding activities. Researchers will use brain scans (fMRI) to see if BA thera…

This study looks at whether riding a stationary bike while using virtual reality can improve mood and thinking skills. Researchers will compare the effects in 200 adults (ages 18-65) who are inactive, with or without depression symptoms. Participants will exercise on a cycle ergo…

Researchers at Yale University are testing whether a smartphone app called Caravan Wellness can improve quality of life, reduce stress, and ease symptoms of anxiety and depression. The app offers short mindfulness and light exercise modules like yoga and meditation. The study wil…

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely reduce anxiety and depression in people with incurable cancer. Participants will receive a pharmaceutical-grade psilocybin along with guided discussions to help them ga…

This study tests a culturally adapted cognitive-behavioral therapy (CBT) program for Venezuelan migrants in Lima, Peru, who struggle with anxiety, depression, or PTSD. The intervention is delivered remotely by trained lay providers over 6 to 12 weekly sessions. The goal is to see…

This pilot study tests a mobile game called Change My Story, designed to help young people (ages 16-24) living with HIV who also have depression. The game uses a choose-your-own-adventure format to teach coping skills, and is combined with problem-solving therapy. Researchers wil…

This study tests two behavioral treatments—cognitive behavioral therapy (CBT) and mindfulness—to help people with traumatic brain injury (TBI) sleep better and feel less stressed. 360 veterans and service members with mild to moderate TBI, insomnia, and PTSD symptoms will receive…

This study tests an accelerated version of a brain stimulation treatment called iTBS for depression. Instead of daily sessions over weeks, patients receive 30 short sessions in just 5 to 14 days. Researchers will track mood changes over six months to see if this faster approach w…

This study tests a noninvasive device that gently stimulates a nerve in the ear to help people wake up faster after surgery. Researchers will also see if it reduces confusion and depression after the operation. The study involves 40 adults having lumbar spine surgery.

This study tests a smartphone app called Matter Neuroscience that uses neurofeedback from brain scans to help people with mild to moderate depression better understand positive emotions. Researchers will enroll 240 adults to see if the app is safe and effective at reducing depres…

This study looks at whether adding a peer support program (WoVeN) to a self-help version of Cognitive Processing Therapy (CPT) helps women veterans with PTSD feel better and improve their mental well-being. About 100 women who have served in the U.S. military and have PTSD sympto…

This study tests whether using a smartphone meditation app (Healthy Minds Program) for 8 weeks can reduce depression symptoms in teens aged 14-19. 200 participants with elevated depression scores will be randomly assigned to either the meditation app or a hydration tracking app. …

This study compares a standard mobile cognitive behavioral therapy (CBT) program to a personalized version that teaches skills faster. About 100 adults aged 18-25 with anxiety, depression, or bipolar disorder will use the Maya app for 20 minutes, twice a week, for six weeks. The …

This study looks at whether orthopaedic surgeons can safely screen for depression in patients recovering from a broken bone and offer treatment with common antidepressants like Prozac or Cymbalta. About 100 adults who score at least 5 on a depression questionnaire will be offered…

This study tests a communication coaching program for adolescent and young adult cancer survivors (ages 18-35) who have finished treatment at least a year ago. Participants complete online sessions and AI coaching to improve how they talk with peers. The goal is to see if the pro…

This study is testing a mobile app called MAYA that teaches cognitive behavioral therapy (CBT) skills to help older adults manage anxiety and depression. About 60 participants aged 40 and older with an anxiety or depressive disorder will use the app for at least 20 minutes, twice…

This study tests a mobile app called Moodivate that helps people with incurable cancer track their daily activities and mood, and suggests new activities to improve their mood. About 279 participants will be randomly assigned to use the app or receive usual care for 8 weeks, with…

This study tests whether watching augmented reality (AR) health education videos can help reduce anxiety and depression in women after breast cancer surgery. 60 female patients will be randomly assigned to receive either standard education alone or standard education plus AR vide…

This study tests whether using a mindfulness app for 15 minutes a day over two weeks, plus a storytelling workshop, can improve wellbeing in STEM graduate students at the University of Wisconsin-Madison. Researchers will measure changes in depression, anxiety, stress, sleep, and …

This study compares two brain areas for treating depression with a gentle electrical current (tDCS). Fifty adults with depression will receive stimulation to either the DLPFC or DMPFC. Researchers will measure changes in mood and emotional regulation to see which target works bet…

This study compares two behavioral approaches to see which works better for improving mood, sleep, and reducing suicide risk in adults aged 55 and older with depression. Participants will complete interviews, questionnaires, and wear a sleep tracker for 8 weeks. The goal is to fi…

This study is testing whether adding small amounts of human coaching, email reminders, or text messages to a meditation app can help people with depression and anxiety feel better. About 688 adults with elevated symptoms will use the Healthy Minds Program app for four weeks. Rese…

This study tests whether a structured emotional intelligence (EI) training program can improve mental health and reduce anxiety and depression among secondary school teachers and students in Dhaka, Bangladesh. The program teaches skills like self-awareness, self-management, socia…

This study tests whether taking D-serine (an amino acid) before transcranial magnetic stimulation (TMS) can improve depression symptoms more than TMS alone. Sixty adults with major depressive disorder will receive either D-serine or a placebo before TMS sessions for six weeks. Th…

This study tests a 100% remote education program for adults with moderate depression who recently started antidepressants. The program aims to help them stick with their medication and improve their symptoms. Researchers will compare the program to usual care in 220 participants …

This study tests whether a mobile app delivering cognitive behavioral therapy can help U.S. military veterans who have both insomnia and depression. 1,200 participants will receive either therapy for insomnia, depression, or both in sequence. The goal is to see which approach wor…

This study looks at people with depression that hasn't improved with other treatments. If they don't get better after four sessions of one type of ECT (right unilateral), they will either continue with that type or switch to another type (bitemporal). The goal is to see which app…

This study looks at whether the antidepressant vortioxetine can help people who suffer from both depression and migraine. Researchers will track 31 adults over 12 weeks to see if their mood and headache symptoms improve. The goal is to find a treatment that works for both conditi…

This study tests whether a mushroom supplement called Ganoderma lucidum spore powder can reduce depression in women who have had thyroid cancer surgery. Three hundred participants will take either the supplement or a placebo daily for three months. Researchers will measure change…

This study explores whether teaching people emotion regulation skills tailored to their individual needs works better than a one-size-fits-all approach. Researchers will enroll 390 adults with emotional difficulties, such as depression, anxiety, or PTSD, and assign them to practi…

This study tests whether a virtual reality training program can help people with depression and low positive affect feel more joy and motivation. 80 adults will be randomly assigned to either a reward-focused VR training or a neutral memory VR training for 7 weeks. The goal is to…

This study tests whether a daily probiotic supplement can help treat depression in people with Parkinson's disease. Sixty adults with mild to moderate Parkinson's and depression will take either the probiotic or a placebo for 12 weeks. Researchers will measure changes in mood and…

This study tests a non-invasive device that sends mild electrical pulses to the ear to stimulate the vagus nerve. Researchers want to see if it can improve attention and memory in 30 veterans with traumatic brain injury, depression, or PTSD. Participants will try both the real st…

This study is testing whether an online, self-guided dialectical behavior therapy (DBT) course is practical and helpful for adults with mild-to-moderate depression or anxiety. Up to 40 participants will take the 8-week course, which teaches skills like mindfulness and emotion reg…

This study compares two forms of ketamine for people with depression that hasn't improved with other treatments. One is given through an IV drip, the other as a nasal spray. Researchers want to see which works better, is more acceptable to patients, and has fewer side effects. Ab…

This study tests an online psychological program called MY-CHOICE for adults with ischemic heart disease who also have anxiety or depression. The program offers personalized online modules and therapist calls over 6-12 weeks. Researchers want to see if patients find it acceptable…

This study tests three versions of internet-delivered cognitive behaviour therapy (ICBT) for post-secondary students with depression or anxiety: a fast-track option, a 5-week course, and an 8-week course. About 200 students will choose their preferred option and receive optional …

This study tests a new approach for people with depression that hasn't improved with standard treatments. It combines a type of brain stimulation called iTBS with digital mindfulness training to help improve mood and thinking skills. About 120 adults with moderate to severe depre…

This study tests a digital program called BSHAPE designed to help immigrant women who have experienced violence and suffer from PTSD or depression. The program includes education, skill-building, and mindfulness exercises. Researchers will compare it to a general wellness program…

This small pilot study tests whether a combination of buspirone (an anxiety medication) and melatonin (a sleep aid) can improve depression and thinking problems in people who have had a traumatic brain injury. Ten adults with mild or moderate TBI and depression will take the comb…

This study is testing a self-help workbook designed to help people in prison manage anxiety and depression. About 96 adults with moderate to severe symptoms will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is practical, acce…

This study tests a new approach for treating depression in people who have had a mild traumatic brain injury (concussion). Participants will receive a personalized cognitive training program combined with either real or sham brain stimulation over 4 weeks. The goal is to see if t…

This study aims to help families with food insecurity and mothers with depression by providing resources like food, rent help, and mental health support. Researchers will enroll 2,000 caregivers of young children in the hospital to see if these services improve mother-child bondi…

This study tests an internet-based sleep course for adults who have trouble falling or staying asleep. The course teaches skills to improve sleep and reduce daytime distress. Researchers will check if the course is easy to use and helpful for people in Saskatchewan. About 56 adul…

This study tests whether taking high-dose vitamin B6 can reduce symptoms of anxiety and depression by changing brain activity. Researchers will measure brain waves with EEG and track mood changes in 44 adults who have mild to moderate symptoms. Participants will take either vitam…

This study tests two types of online cognitive behavioural therapy (CBT) for Canadian public safety personnel (like police, firefighters, and paramedics) who have symptoms of PTSD, anxiety, or depression. Participants can choose between a therapy focused on PTSD or one that cover…

This study tests whether estradiol patches can improve anhedonia (loss of pleasure) and psychosis symptoms that start during perimenopause. About 100 women aged 44-55 will receive either estradiol or a placebo patch for three weeks, plus a short course of progesterone. Researcher…

This study tests whether low or moderate doses of LSD can reduce anxiety, pain, and depression in people with advanced or terminal illnesses. Sixty participants will receive either two moderate doses or two very low (placebo-like) doses of LSD in a double-blind setup. The goal is…

This study tests whether adding special content about loneliness to an internet-based cognitive behavioral therapy (ICBT) program helps people with depression and anxiety feel better. About 494 adults in Saskatchewan who report feeling lonely will take part. Some will get the sta…

This study tests whether an 8-week virtual Mindfulness-Based Stress Reduction (MBSR) program can reduce fatigue, anxiety, and depression in 100 adults with sarcoidosis. One group takes MBSR; the other joins a monthly virtual support group. Researchers will compare which approach …

This study tests whether a type of talk therapy called narrative therapy can reduce depression in people aged 60 and older. 110 participants with mild to moderate depression will be randomly assigned to either 8 weekly group therapy sessions or a waitlist. The therapy helps peopl…

This study tests a 7-session therapeutic song-writing program for young people aged 13 to 24 with mild to moderate depression. Participants are randomly assigned to either the song-writing program or a waitlist group. The goal is to see if the program improves depressive symptoms…

This study tests a new digital therapy program designed to help people with anxiety or depression return to work. The program combines mental health support with practical work-focused strategies. Researchers will enroll 400 adults in Norway who are on sick leave and receiving me…

This study tests whether a digital program on an iPad, combined with learning thinking strategies, can improve mood and mental skills in people who have had a stroke. The study will include 70 adults who had a first stroke at least 6 months ago and now have depression and trouble…

This study tests a new, single-session therapy called PATH-SS for people struggling with PTSD or depression after a sexual assault. Researchers want to see if this brief treatment reduces distress and is helpful to participants. The study involves 45 adults in Ohio who experience…

This study tests whether a proven sleep therapy (CBT-I) can improve how the brain regulates emotions, helping treat depression and anxiety. Researchers will use brain scans to see changes in emotion networks. 120 adults with insomnia and depression will participate. The goal is t…

This study tests whether a keto-like supplement, taken as a drink three times daily for 8 weeks, changes brain activity in people with moderate to severe depression. Researchers will use brain scans to compare the supplement to a placebo in 75 adults. The goal is to see if the su…

This study tests a program called PATH-Pain in 100 older adults (60+) who have mild cognitive impairment or early Alzheimer's, along with chronic pain and depression. The program teaches problem-solving and uses memory aids like checklists and a tablet app to help manage emotions…

This study tests an internet-delivered cognitive behaviour therapy (ICBT) course designed specifically for public safety personnel (like police, firefighters, paramedics) who experience anxiety, depression, or PTSD. The 164 participants will be randomly assigned to different ways…

This study aims to see if college students can effectively deliver cognitive-behavioral therapy (CBT) to high school students in rural Pennsylvania to reduce symptoms of depression, anxiety, and stress. About 40 teens aged 13-18 with mild to moderate symptoms will participate. Th…

This study compares a 3-session couples program (Brief Relationship Checkup) to standard individual care for 360 veterans and their partners who have relationship and mental health concerns. The goal is to see which approach better reduces suicide risk factors by improving relati…

This early-stage trial tests whether a single low-dose injection of ketamine is safe and practical for adults who come to the emergency department with severe suicidal thoughts. Researchers will monitor side effects and ask staff about their experience. If successful, it could of…

This study tests whether a sleep health program can help U.S. Marines sleep better and feel mentally healthier. About 860 Marines will be randomly assigned to one of five groups to receive different versions of the program. Researchers will use surveys and wearable sleep trackers…

This study tests an 8-week group mindfulness program designed for African American adults who have both high blood pressure and depression. Researchers want to see if the program improves mood and blood pressure, and if it works well in a community setting. Participants will lear…

This study tests whether a type of talk therapy called Interpersonal Psychotherapy (IPT), delivered in groups by trained non-specialists, can reduce depressive symptoms in young adults aged 18-24 in Porto Alegre, Brazil. Half of the 50 participants will receive the 8-week group t…

This study tests whether sexual counseling during pregnancy can improve sexual function, marital adjustment, and emotional health. About 70 pregnant women will receive either counseling or standard care. Researchers will measure changes before delivery and three months after birt…

This study aims to find the best dose of a safe, non-invasive brain stimulation technique called accelerated TMS to improve both depression and thinking skills in people aged 60-85 with mild cognitive impairment and depression. About 60 participants will receive different doses o…

This pilot study at Mayo Clinic is testing whether a single 20-30 minute virtual reality session can safely reduce anxiety, depression, and fatigue in cancer patients. 24 adults undergoing chemotherapy or bone marrow transplant will try calming VR experiences like nature walks or…

This study tests whether a smartphone app called SilverCloud, which teaches cognitive behavioral therapy (CBT) skills, can help reduce anxiety and depression in high school students. About 120 teens who screen positive for symptoms will either use the app with a clinician's guida…

This study compares two group therapies for university students aged 18-28 who have moderate anxiety and depression. One group receives Acceptance and Commitment Therapy (ACT), which teaches skills to accept difficult emotions and live according to personal values. The other grou…

This study follows 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep issues, anxiety, depression, or epilepsy. Researchers will track changes in symptoms using standard questionnaires over 24 weeks. The goal is to see how well medical cannabis work…

This study tests whether a 9-week therapy called Engage & Connect can improve brain function related to social reward and reduce suicidal thoughts in older adults with depression. Researchers will use brain scans to measure changes in key brain networks. The study involves 128 pe…

This study is testing a mobile app called MAYA that provides cognitive behavioral therapy (CBT) to help adults who have had a stroke manage anxiety and depression. About 10 participants aged 40-79 will use the app and provide feedback on how easy and helpful it is. The goal is to…

This study tests whether a single dose of ketamine given during surgery can help adults with serious orthopedic trauma recover better. Researchers want to see if it reduces pain, lowers the need for opioids, and improves symptoms of depression and PTSD. Ninety participants will b…

This study tests Mom-Net, an online cognitive behavioral therapy program with coaching, for low-income mothers with depression whose children are in Head Start. About 960 mothers will be assigned to Mom-Net or usual care, with coaching provided by Head Start staff. The goal is to…

This study tests a brief group therapy that teaches people to better understand their own and others' thoughts and feelings (called mentalization). One hundred adults with anxiety or depression will be randomly assigned to this new therapy or to standard group therapy. Researcher…

This study is testing whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) applied to the cerebellum can improve cognitive deficits and mood in people with schizophrenia, autism, bipolar disorder, depression, or Parkinson's…

This study is testing a type of talk therapy called Emotion Regulation Therapy (ERT) delivered over video for people in New York who struggle with worry, overthinking, or being hard on themselves. The goal is to see if the therapy helps people better manage their emotions and fee…

This study tests whether a smartphone app that tracks daily mood and symptoms can help doctors treat depression more effectively. 200 adults with depression will use the app for 6 weeks, while a comparison group receives standard care. The goal is to see if the app improves treat…

This pilot study is testing whether psilocybin, the active ingredient in magic mushrooms, can safely help depression in people with mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive one or two doses under supportive conditions. Researchers w…

This study tests a brief guided self-help program called Self-Help Plus for university students who are behind on at least three exams and feeling distressed. The program teaches coping skills based on acceptance and commitment therapy. Researchers will measure changes in distres…

This early-phase study tests whether a non-invasive brain stimulation technique called rTMS can improve pain and depression in people with knee osteoarthritis. Thirty adults aged 50 and older with chronic knee pain and moderate to severe depression will receive rTMS while also ta…

This study tests whether Tui Jing therapy, a deeper form of Gua Sha from traditional Chinese medicine, can help ease depression symptoms. Researchers will compare real therapy to a sham ultrasound in 64 adults with depression. They will measure mood, sleep, heart rate, and brain …

This study tests whether guanfacine, a medication typically used for blood pressure, can improve brain network function and reduce cognitive problems in people with depression. Researchers will enroll 162 adults aged 18-60 who are currently experiencing a major depressive episode…

This study is testing a safe, non-invasive treatment called rTMS (repetitive transcranial magnetic stimulation) for depression in people with spinal cord injury. Fourteen adults with a spinal cord injury and major depression will receive daily rTMS sessions for four weeks. The go…

This study tests a mobile app called Blueprint that teaches coping skills to people who survived a serious illness in the ICU. Many survivors face anxiety, depression, and PTSD, but mental health care is hard to access. The app aims to help them manage these symptoms on their own…

This study tests a simple tool called iHeart DepCare to help people with heart disease who also feel depressed. About 200 adults will either get usual care or extra support and guidance to start depression treatment. The goal is to see if the tool helps more patients get the ment…

This study tests a brief behavioral sleep program for depressed teens aged 12-18 who sleep less than 7 hours or have irregular sleep. The program uses two sessions and smartphone tools to help teens set sleep goals. Researchers will compare it to a simple sleep education session …

This study tests whether a 24-week collaborative care program can improve quality of life for adults with epilepsy who also have anxiety or depression. The program includes regular check-in calls and expert recommendations from a psychiatrist and neurologist. Researchers will com…

This study tests if an AI avatar-led mental health program can help employees with depression. About 50-80 UK adults will either use the program right away or wait. They will fill out questionnaires on mood, anxiety, and work performance. The goal is to see if this self-guided to…

This study tests a new, faster version of a brain stimulation treatment called TMS for people with depression or OCD. Instead of daily sessions for weeks, participants get 10 hours of TMS each day for just 5 days. The goal is to see if this quick approach can improve symptoms and…

This study tests whether advancing sleep timing (going to bed and waking up earlier) can improve depression symptoms. 150 adults with moderate to severe depression, recently discharged from a psychiatric ward, will either receive usual care or a psychotherapeutic program focused …

This study is testing whether listening to specially chosen music every day for 4 weeks can help reduce anxiety and depression in people who have recently had a stroke. About 132 participants will either receive the music therapy plus standard care, or standard care alone. The go…

This study tests a personalized, noninvasive brain stimulation technique called TMS for people aged 18–65 with chronic symptoms after a mild concussion or traumatic brain injury. Symptoms like headache, dizziness, brain fog, and anxiety can last for months. Participants will rece…

This study tests whether a short-term therapy called Enhanced Brief Interpersonal Psychotherapy (IPT-B) can reduce depression in mothers of children with asthma. Sixty Black mothers who have mild to moderate depression and a child with asthma will either receive the therapy or us…

This pilot study tests a new 12-week group therapy program called BEAR-SI for women aged 18-75 who have experienced interpersonal trauma and currently have suicidal thoughts. The program combines psychological skills, education about trauma, and physical self-defense training. Th…

This study is testing two online cognitive behavioral therapy (CBT) courses for veterans who are at risk for suicide or have depression. One course focuses on depression symptoms, and the other on suicidal thoughts and behaviors. The goal is to see if veterans find these self-gui…

This study looks at whether using the Calm meditation app for 10 minutes a day can help blood cancer patients who have trouble sleeping. Researchers will track sleep, mood, and inflammation in 276 participants over 20 weeks. The goal is to find a simple, drug-free way to improve …

This study tests whether a culturally adapted skills training program called START NOW can reduce depression and anxiety in teen refugees. About 80 participants aged 14-18 will be randomly assigned to either the training or standard care. The goal is to see if the program helps t…

This study tests an online, 9-week program designed to help parents and caregivers of LGBTQ+ youth of color become more supportive and accepting. Researchers will enroll 180 youth (ages 14-25) and their caregivers to see if the program reduces depression, anxiety, drug use, and o…

This study compares music-backed mindfulness meditation to meditation alone for reducing stress and anxiety in people of African descent. 70 participants with anxiety or depression will join virtual sessions. The goal is to see if adding music makes stress management more effecti…

This study explores whether using a virtual reality headset to experience nature scenes can help reduce depression in people with progressive multiple sclerosis. About 40 participants will use the Apple Vision Pro at home for short sessions over 8 weeks. The goal is to see if thi…

This study enrolls 1,000 community college students aged 18-40 who have depression or anxiety. Participants are randomly assigned to one of two decision-making methods that determine their level of care: self-guided online prevention, coach-guided online therapy, or clinician-del…

This study tests whether an online parenting program, called Incredible Years, can help Filipino families in California. 500 parents and their children aged 8-12 will take part. Half will get the program, and half will receive standard handouts. The goal is to see if the program …

Depression is common among cancer survivors, but many don't get help. This pilot study tests a text-based referral platform that sends tailored messages and a video to encourage survivors to take up a mental health referral. The study will enroll 60 cancer survivors with depressi…

This phase 2 trial tests an experimental drug called TJ0113 for people with depression. About 150 adults aged 18 to 65 will take either 200 mg or 400 mg of TJ0113 or a placebo daily for 8 weeks. Researchers will measure changes in depression symptoms using a standard rating scale…

This study looks at whether mindfulness meditation can help first-generation college students feel less anxious or depressed and stay in school. About 53 students will be randomly assigned to either mindfulness meditation or a general mental health education group. Researchers wi…

This study tests whether L-DOPA, a drug used for Parkinson's, can improve anhedonia (loss of interest or pleasure) in people with depression who also have high inflammation. Seventy adults aged 25-55 will receive either L-DOPA or a placebo for 8 weeks. Researchers will measure ch…

This study is for teenagers aged 13 to 18 with depression that hasn't gotten better after their first treatment. It will test different common antidepressants to find which one works best next. The goal is to help teens feel better and provide doctors with clear evidence on what …

This study is testing whether transcranial magnetic stimulation (TMS) can reduce anxiety and depression in children and teens aged 6 to 18. About 120 participants will receive TMS treatment, and researchers will track symptom changes using questionnaires. The goal is to see if th…

This study tests whether adjusting the electrical amplitude of ECT (electroconvulsive therapy) to each person can better treat depression and reduce memory problems. Researchers will compare a personalized amplitude approach to the standard fixed 800 mA setting in 50 older adults…

This study tests a new type of talk therapy called Identity-Based Transdiagnostic Therapy (IBTT) for young adults with anxiety or depression. It compares IBTT to a well-known therapy called the Unified Protocol (CBT-based). The goal is to see if IBTT is more engaging and effectiv…

This study tests a 6-week program called Emotion Focused Family Therapy (EFFT) for parents of children aged 7-15 with anxiety, depression, or behavioral challenges. The program teaches parents how to coach their child through difficult emotions and improve their relationship. Res…

This study tests whether a smartphone app called Safe Haven can help college students feel less depressed, anxious, or stressed. About 68 undergraduates will either use the app plus standard campus care, or just standard care alone. The app includes daily mood tracking, weekly ch…

This study is for people with spinal cord injury who also have depression. It tests a new method to dose a brain stimulation treatment called rTMS, which is already approved for depression but usually requires a thumb movement to set the dose. Since many with spinal cord injury h…

This study tests a two-week smartphone program designed to help people who struggle to feel pleasure (anhedonia) and also have high depression, anxiety, or stress. Participants do three short audio-guided exercises each day, focusing on gratitude, savoring positive moments, and f…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via home-based telehealth, can improve social functioning and mood in veterans recently discharged from the hospital for a heart condition. About 132 veterans with depression will receive eith…

This study tests whether adding a low dose of esketamine (a fast-acting anesthetic) to standard electroconvulsive therapy (ECT) can improve depression outcomes in adolescents aged 13-17 with severe depression. About 220 participants will be randomly assigned to receive either esk…

This study tests whether a probiotic called Clostridium butyricum can help reduce anxiety and depression in people with functional dyspepsia (a common stomach disorder). 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard stomach medication. …

This study tests a digital program designed to help teens and young adults who have survived cancer manage symptoms of depression. The program includes educational content and four evidence-based tools. Researchers want to find out which parts of the program work best to reduce d…

This study tests whether a nutritional supplement called 'Think Tank' can improve thinking and memory in middle-aged women after they experience stress. Forty healthy women aged 40-60 will take either the supplement or a placebo and then complete cognitive tests. The goal is to s…

This study tests whether a probiotic called Bacillus coagulans can reduce anxiety and depression in people with functional dyspepsia, a common stomach disorder. 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard treatment. The main goal is t…

This study tests whether dance-movement therapy can reduce depression in teenagers. 140 adolescents with moderate to severe depression will attend 12 group dance therapy sessions. Researchers will measure changes in depressive symptoms using questionnaires and interviews. The goa…

This study tests whether electroacupuncture, a type of acupuncture with mild electrical pulses, can safely reduce depression in people with cancer. Researchers will enroll 86 adults with cancer-related depression and give them electroacupuncture sessions targeting specific points…

This pilot study is testing whether ketamine infusions, combined with a brief counseling session, can help veterans who have both chronic low back pain and depression. About 44 veterans will receive four ketamine infusions over two weeks, and some will also get a short behavioral…

This study tests whether listening to music before and after electroconvulsive therapy (ECT) can reduce postictal agitation—a common side effect where patients become restless or confused after treatment. Researchers will enroll 92 adults with severe depression undergoing ECT. Ha…

This study tests whether internet-based cognitive behavioral therapy (CBT) can reduce depression and slow cognitive decline in older adults who survived an ICU stay. About 300 participants aged 50+ with depressive symptoms will receive either online CBT or standard depression edu…

This study tests whether using a person's own brain scan to guide a non-invasive treatment called iTBS works better than the standard one-size-fits-all approach. About 210 adults with major depression will receive 6 weeks of iTBS, with the treatment spot chosen either by standard…

This study is testing a mobile app that uses cognitive behavioral therapy (CBT) to help people with depression. Over 8 weeks, participants use the app for weekly AI-guided lessons and homework. The goal is to see if the app reduces depression symptoms and to explore how it affect…

This study tests a free 6-week online coaching program for NSU undergraduate students. The program aims to reduce anxiety, depression, and stress while improving quality of life and coping skills. About 160 students will participate, and the study measures changes using standard …

This study tests a 10-week online group program for adults with spina bifida to improve self-esteem, quality of life, and reduce anxiety and depression. Participants join weekly video sessions with 6-7 others, plus two follow-ups. The goal is to strengthen social skills and emoti…

This study compares three ways to treat moderate depression in adults aged 18-65: usual care from a general practitioner, behavioral therapy from a psychologist, or a structured step-by-step treatment plan from a GP. The goal is to see if the structured plan works better at easin…

This study tests whether personalizing the Healthy Minds Program app can improve well-being in people with mild depression. About 1500 participants will use the app for 4 weeks, with some getting personalized features like tailored module order or supportive text messages. The go…

This study tests whether a free online program from the World Health Organization, called 'Doing What Matters in Times of Stress,' can help reduce anxiety and depression in employees of small and medium-sized Dutch companies. About 518 workers with elevated stress levels will eit…

This study tests whether repetitive transcranial magnetic stimulation (rTMS) can safely and effectively treat depression in adults with autism spectrum disorder. Twenty-five participants will receive 20 sessions of rTMS over five days. The main goal is to see if mood improves aft…

This study is for adults aged 22-65 with major depression that hasn't improved with other treatments. Researchers want to see if giving psilocybin (the active ingredient in magic mushrooms) followed by a quick, focused brain stimulation technique is safe and can help reduce depre…

This study tests whether heart rate data can help guide a non-invasive brain stimulation technique called tDCS for people with mild to moderate depression. One hundred participants will receive either real or sham tDCS at home over 10 sessions. Researchers will monitor heart rate…

This study tests whether cognitive behavioral therapy (CBT) and group activities can reduce depression and improve daily functioning in elderly women in India. About 5,370 women aged 55 and older will take part. Some will receive CBT at home, some will join group activities, some…

This study looks at whether combining two common therapy techniques—changing negative thoughts and practicing detached mindfulness—works better than using them alone for people with anxiety or depression. Researchers will compare the effects of each technique and their order. The…

This study tests whether dapagliflozin, a drug normally used for diabetes, can help reduce depression symptoms when added to standard antidepressant treatment. Sixty adults with moderate to severe depression will receive either dapagliflozin plus fluoxetine or fluoxetine alone. T…

This study tests a virtual platform called MOVIN that helps pregnant and postpartum people with depression or anxiety. Participants get a care coordinator who recommends online treatments and works with their doctor. The goal is to see if this approach reduces symptoms better tha…

This study tests an online self-help program called Empower@Home for older adults with depression who have trouble walking. The program includes 9 online sessions, a workbook, and phone coaching from a trained staff member. Researchers will compare it to usual care in 64 particip…

This study tests an online, therapist-guided program to help cancer survivors who have anxiety, depression, or fear of cancer returning. About 400 adults in Sweden who finished cancer treatment at least 6 months ago will take part. The goal is to see which parts of the 10-week on…

This study is testing a digital mental health program called Empower@Home for homebound older adults (age 50+) with depression. The program includes online self-help sessions, a workbook, and phone coaching from trained staff. Researchers will compare it to usual care in 256 part…

This study tests an 8-week online cognitive behavioral therapy course designed for new and expecting parents struggling with anxiety or depression. Researchers will enroll 60 parents (including non-birthing partners) to see if the program reduces symptoms and is practical for rou…

This study tests whether a single session of whole-body heat therapy (using an infrared sauna) with or without a cold water plunge can reduce depression symptoms. Researchers will enroll 162 adults with depressive symptoms and track their mood changes over two weeks. The goal is …

This study compares heated yoga, sauna sessions, and a mindfulness app to see which best reduces symptoms of depression. Researchers at Massachusetts General Hospital are recruiting 120 adults aged 18-65 with moderate to severe depression. Participants will attend twice-weekly se…

This study looks at whether doing heated or non-heated yoga can reduce symptoms of depression. Researchers will enroll 120 adults with moderate depression. Participants will practice yoga and report their mood changes over time.

This study tests a behavioral health program called InSTILL for nursing home residents who feel depressed and their main support person (like a family member or friend). The program aims to help them cope with stress and transitions. About 100 pairs (resident and caregiver) will …

This study tests whether adding bright light therapy, a stimulant (methylphenidate), or melatonin to cognitive behavior therapy can improve sleep and related symptoms like fatigue, anxiety, and depression in 188 adults with advanced cancer. Participants will receive one of these …

This study tests a mobile app called WellPATH-PREVENT for adults aged 50-90 who were recently hospitalized for suicidal thoughts or a suicide attempt. The app teaches emotion regulation skills to help reduce suicide risk. Researchers will measure changes in brain activity, self-r…

This study tests whether a low or moderate dose of propofol, a sleep-inducing drug, combined with brief behavioral therapy for insomnia, can improve sleep and depression symptoms in adults aged 60 and older with treatment-resistant depression. Seventy participants will receive tw…

This study tests a computer program called COGENT, designed to improve thinking skills like memory and attention in people with anxiety, depression, or PTSD. 128 adults will be randomly assigned to either the COGENT training or a sham program. Researchers will compare changes in …

This study tests two mind-body programs designed to reduce anxiety, depression, and emotional distress in cardiac arrest survivors and their caregivers. About 84 pairs (survivor and a family member or friend who helps them) will participate. The goal is to see if the programs are…

This study tests whether a 12-week program called Mindful Moms, which includes gentle yoga and mindfulness, can reduce depressive symptoms in pregnant women. About 200 pregnant women with mild to moderate depression will be randomly assigned to either Mindful Moms or standard pre…

This study explores whether music therapy can help children with depression build resilience and ease symptoms. Twenty children will attend 11 music therapy sessions, with some also attending recitals to discuss performance anxiety and self-expression. The goal is to see if these…

This study looks at how psilocybin (the active ingredient in magic mushrooms) affects mood and pain in people with both chronic low back pain and depression. About 40 adults will receive either a single high dose of psilocybin or a control drug. Researchers will track changes in …

This study tests whether cognitive analytic therapy guided self-help (CAT-GSH) works as well as the standard cognitive behavioural therapy guided self-help (CBT-GSH) for people with anxiety or depression who are returning to NHS talking therapy services. About 100 participants wi…

This pilot study tests a mindfulness-based program called Quiet Focus, adapted for older Black adults (age 50+) who have both chronic pain and mild depression. Researchers want to see if it's feasible and acceptable, and whether it can improve quality of life and reduce pain inte…

This study tests whether doing five simple actions each day, with daily text reminders, can reduce symptoms of anxiety and depression. 410 adults in Norway with mild to moderate symptoms will be randomly assigned to the five-actions group, a gratitude group, or a waiting list. Th…

This study tests a new depression treatment that combines cognitive behavioral therapy with faith-based principles, delivered by therapists and pastors in church settings. It aims to reduce depressive symptoms in African American adults. The trial will enroll 50 participants and …

This study tests a 10-session group therapy designed to help teens aged 15-18 with autism who also have anxiety or depression. The therapy focuses on changing how they think about their own thoughts. Researchers want to see if the therapy is practical, acceptable, and shows promi…

This study tests a single injection of apimostinel, a fast-acting antidepressant, in 150 adults with major depression. Half also receive digital cognitive training sessions to see if it extends the drug's effects. The trial is placebo-controlled and double-blind, meaning neither …

This study tests a program called M-O-M-S on the Bayou, which pairs pregnant women with experienced mothers for support and classes. The goal is to reduce anxiety and depression in women living in areas hit by natural disasters. Researchers will recruit 240 pregnant women and tra…

This study is testing a digital cognitive behavioral therapy program (SilverCloud) in Spanish, with added support from a peer coach, for Latino adults in San Francisco with depression or anxiety. 213 participants will either use the program on their own or with weekly check-ins f…

This study looks at a telephone-based program called SUSTAIN that helps older adults (65+) manage depression, anxiety, and chronic pain. Participants receive brief phone assessments and care management over 12 weeks. Researchers want to see what factors influence treatment succes…

This study is testing whether a focused muscle contraction exercise program called the GH Method can improve body composition, physical abilities, and overall well-being in U.S. veterans. Twenty-five veterans with pain, fatigue, or low energy will do 90 exercise sessions over 18 …

This study tests whether adding a motivational lifestyle program—focusing on diet, exercise, and stress management—to usual care helps adults with depression recover better. About 210 participants from primary care will receive the lifestyle coaching or usual care alone. The goal…

This study tests whether adding metformin, a common diabetes drug, to standard antidepressants can better improve depression symptoms in obese patients. Researchers will compare two groups of 140 newly diagnosed depressed adults with a BMI over 25: one gets metformin, the other a…

This study compares two well-known therapies—cognitive-behavioral therapy (CBT) and mindfulness-based therapy (MBT)—to see which works better for autistic adults with depression and anxiety. About 300 participants from North Carolina and Virginia will receive therapy via teleheal…

This study is testing whether an 8-week mindfulness program can help hospital staff and older adults sleep better and feel less depressed. Researchers will measure changes in sleep quality, depressive symptoms, and well-being using questionnaires and overnight sleep tests. The go…

This study compares two types of computer-based attention training for adults with depression symptoms. One is a traditional version, the other is gamified to be more engaging. Researchers will enroll 600 participants to see which approach works better at reducing depression symp…

This pilot study tests a virtual reality (VR) therapy session guided by an AI-powered virtual therapist to help reduce depression symptoms. Sixty Chinese young adults with mild to severe depression will either receive the VR therapy or join a waitlist. The goal is to see if this …

This study tests whether the JoyPop app can help 110 Canadian youth aged 12-17 better manage their emotions while on a waitlist for mental health services. Participants use the app at least twice daily alongside usual care. The goal is to see if the app improves emotion regulatio…

This study tests whether the JoyPop app can help 18-25 year olds in Northwestern Ontario better manage their emotions and reduce stress while they wait for mental health services. Participants will use the app at least twice daily and be compared to those receiving usual care. Th…

This study tests whether a web-app based lifestyle physical activity program can improve depressive symptoms in midlife Korean American women. The program includes online coaching, peer support, and educational sessions in English and Korean. Researchers will enroll 300 sedentary…

This study tests whether a 5-session online program teaching positive thinking skills can help people with HIV who use stimulants. Researchers want to see if it reduces stimulant use and depression by changing brain and immune function. 189 participants will be followed for 3 mon…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can help reduce depression, anxiety, and stress in adults whose parents survived genocide. One hundred participants will receive a single 25mg dose under supervision, followed by …

This study tests whether adding social cognitive training—like learning to understand another person's point of view—to standard cognitive behavioral therapy (CBT) helps teens with depression feel better. Researchers will compare two groups of 82 teens aged 13-17: one gets CBT pl…

This pilot study tests whether giving brain stimulation three times a day (accelerated) works better than the standard once-daily schedule for teenagers aged 16-19 with treatment-resistant depression. Ten participants will receive fMRI-guided theta burst stimulation, a non-invasi…

This study tests whether the JoyPop app can help Indigenous youth aged 18-25 in Northwestern Ontario manage their emotions and reduce stress while they wait for mental health services. Participants will use the app at least twice daily and be compared to those receiving usual car…

This study tests a program called FOREST that teaches positive emotion skills to staff working in gun violence prevention. The goal is to reduce burnout, anxiety, and depression, and improve well-being and job retention. One hundred employees from UCAN in Chicago will take part o…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use brain scans, sleep monitoring, blood tests, and questionnaires to compare four groups: people with recent suicidal thoughts or attempts, those with past sui…

This study aims to create a risk score that uses information from electronic medical records to predict the chance of developing dementia within 5, 9, or 13 years in older adults with depression. Researchers will analyze data from 44 participants aged 50 and older who have a depr…

This study investigates how depression and cannabis use together affect brain circuits involved in reward and pain in young people living with HIV. Researchers will use MRI scans and questionnaires to measure brain activity, mood, and substance use. The goal is to understand why …

This study gives 25 depressed individuals aged 15-25 a fake version of accelerated transcranial magnetic stimulation (no real brain stimulation). The goal is to see how their beliefs and expectations about treatment change over time and whether those expectations influence mood, …

This NIH study aims to understand what causes depression in teenagers and how the brain changes with the condition. Researchers will compare depressed teens with healthy ones using interviews, computer tasks, and brain scans. Eligible participants may also receive free talk thera…

This study at the National Institute of Mental Health screens up to 16,000 people with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies. Participants undergo evaluations like psychiatric interviews, brain scans, and lab test…

This study investigates why some adolescents act impulsively when experiencing negative emotions, a trait called negative urgency. Researchers will measure brain cell communication using transcranial magnetic stimulation and EEG in teens aged 13-21 with depression and suicidal th…

This study compares two sets of strategies to help HIV clinics in Cape Town, South Africa, treat depression and improve medication adherence. Ten clinics will be randomly assigned to receive either basic support or enhanced training and supervision. Researchers will track how man…

This study uses PET scans to measure levels of COX-1 and COX-2, enzymes linked to inflammation, in the brains of people with major depressive disorder (MDD) during a depressive episode. Researchers will compare these levels between MDD participants and healthy volunteers. The goa…

This study aims to see if people with major depressive disorder have lower levels of an enzyme called PDE4B in their brains compared to healthy volunteers. Researchers will use PET and MRI scans along with an experimental radioactive tracer to measure this enzyme. The study invol…

This study looks at how loneliness impacts recovery from depression in 200 hospitalized patients. Researchers will track symptoms, social support, and collect blood, saliva, and stool samples at three points: start of treatment, discharge, and three months later. The goal is to u…

This research study examines how brain activity changes during emotional and thinking tasks in people with depression and healthy volunteers. Using brain scans (EEG, fMRI) and mild brain stimulation (TMS), researchers aim to understand the brain circuits involved in mood and suic…

This study investigates how the gut and brain communicate in people with Irritable Bowel Syndrome (IBS) who also experience anxiety or depression. Researchers will compare 100 IBS patients with anxiety or depression to 100 healthy volunteers using brain scans, stool samples, and …

This study looks at how ketamine affects the brain in people with major depression and healthy volunteers. Researchers use brain scans, blood tests, and other measures to understand why a single dose works quickly but briefly. The goal is to find biomarkers that could lead to bet…

This study looks at how ketamine, a fast-acting antidepressant, affects the brain. Researchers want to understand if a specific brain receptor (AMPA) is key to its effects. Seventy adults with treatment-resistant depression will take part, receiving ketamine and a drug that block…

This study looks at how depression and very early (preclinical) Alzheimer's disease affect driving habits in adults aged 65 and older who still drive regularly. Participants will have their driving tracked with a GPS device and undergo brain scans to measure Alzheimer-related pro…

This study tests whether a gentle brain stimulation technique called tDCS, done at home, can improve sleep quality in adults with moderate depression. Researchers will track sleep changes and see if better sleep leads to better mood. The study involves 35 participants and aims to…

This study looks at whether inflammation in the brain causes symptoms like loss of interest and slow movement in depressed people with HIV. Sixty participants will receive either the anti-inflammatory drug baricitinib or a placebo for 10 weeks. Researchers will use brain scans an…

This study looks at how cannabis ads that claim to help with anxiety or depression affect what people buy. About 2,000 light-to-moderate cannabis users with mild to severe anxiety or depression will shop in a realistic online store. Some see ads with mental health claims, others …

This study tests three types of non-invasive brain stimulation (intermittent, continuous, and sham) in 200 adults with major depression. Participants receive each type in separate sessions while undergoing MRI scans and mood assessments. The goal is to understand how different st…

This study looks at why people with depression sometimes get stuck in rigid thinking patterns. Researchers will use online tests to measure cognitive flexibility in 2,500 adults. The goal is to better understand how these thinking habits relate to depression symptoms, not to prov…

This study tests a community-wide program in Harlem that trains health workers and coordinates services to help Black and Latino adults with depression or anxiety. About 700 participants from low-income housing or primary care clinics will be involved. The goal is to see if this …

This study looks at how a natural brain chemical called allopregnanolone affects mood and thinking in women going through menopause. Researchers want to understand why some women feel depressed during this time. The study involves 80 healthy women aged 40 to 60 who have depressiv…

This study will test if cameras, microphones, and wearable sensors can help doctors measure how severe a person's depression is. About 300 adults hospitalized for severe depression will be recorded during interviews and while wearing devices that track movement, heart rate, and b…

This study aims to create a more realistic brain-scan task that mimics social media interactions, like getting likes or comments. Researchers will scan the brains of 60 teens with depressive symptoms while they receive virtual peer feedback. The goal is to see how brain activity …

This study is testing a mobile app called Wysa for Chronic Pain, designed to support people aged 45 and older who have chronic pain along with depression or anxiety. Researchers want to see if personalized in-app notifications can encourage people to use the app more often. Parti…

This study uses smartphone tracking and brain scans to see how your daily emotions, thoughts, and actions are linked. About 100 adults will answer quick surveys and share location data for four months. The goal is to better understand patterns in mood and thinking, not to test a …

This study follows 415 people with difficult-to-treat depression for 5 years after they joined an earlier genetics study. Researchers will review medical records and registry data to see how patients' depression changes over time, including suicide attempts and treatment response…

This study records brain activity from epilepsy patients who already have electrodes implanted for seizure monitoring. While they perform thinking tasks like memory and attention games, researchers watch how different brain areas talk to each other. The goal is to better understa…

This study looks at how stress impacts pain, hormone levels, and mood in 120 people with and without HIV, cannabis use disorder, and depression. Participants will complete two sessions of a pain stress task and provide blood samples to measure cortisol and other stress hormones. …

This study aims to reduce the number of people with depression who do not receive treatment. It compares two approaches: one where people only get a brief psychological therapy at a health center, and another where they also receive community support to encourage them to seek and…

This study looks at how cannabis use changes brain function in teenagers who also have depression. About 280 teens will have brain scans (fMRI) and answer questionnaires at the start and again one year later, with a second year of follow-up. The goal is to understand the connecti…

This online registry is studying the safety and effectiveness of the CEFALY device, a non-invasive nerve stimulator worn on the forehead, for treating migraines during and after pregnancy. Pregnant women aged 18-44 with migraines can join, regardless of whether they use the devic…

This study looks at medical records from over 150,000 people who received NeuroStar TMS (a non-invasive brain stimulation treatment) for depression, OCD, or anxiety. Researchers want to find out which patient traits and treatment settings lead to the best results. No new treatmen…

This study looks back at the treatment records of about 12,000 people with depression, OCD, or anxiety. Researchers will compare how well two treatments—NeuroStar TMS and Esketamine—reduce symptoms. The goal is to learn which approach works better in real-world settings.

This study aims to understand why some people get stuck in repetitive negative thinking, common in depression and anxiety. Researchers will compare brain activity in 50 patients and 50 healthy volunteers using a harmless brain-imaging device during emotion tasks. The goal is to u…

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This study looks at how the brain, nerves, and blood vessels interact in 80 adults having heart surgery. Researchers will measure brain activity, blood flow, and heart reflexes to better understand the link between heart disease and depression. The goal is to develop new tools fo…

This study looks at how transcranial magnetic stimulation (TMS) changes brain activity in healthy adults and people with depression. Participants will have brain scans while receiving single and repeated magnetic pulses. The goal is to understand the brain mechanisms behind TMS, …

This study aims to better understand how brain activity relates to mood in people with depression or epilepsy. Researchers will record brain signals directly from electrodes placed inside the skull while participants complete mood assessments and tasks. The goal is to use explain…

This study aims to see if it is possible to measure brain activity patterns related to thinking and attention in people with chronic pain or depression, compared to healthy volunteers. Researchers will use non-invasive brain stimulation and computer tasks to record brain signals.…

This observational study seeks to define a new concept called 'visual frailty' in people aged 60 and older with advanced age-related macular degeneration (AMD). Researchers will measure vision, reading ability, mental health, and daily function in 20 participants to develop a vis…

This study follows 200 teens aged 12-18 who use cannabis daily or near-daily and have some depression symptoms. Using smartphone surveys several times a day, researchers track cannabis use, mood, and suicidal thoughts to see how they change over time. The goal is to learn when an…

This study looks at whether adjusting sleep timing and using bright light therapy can improve mood and sleep in perimenopausal women with depression. Researchers will have 120 women either advance or delay their sleep for one night, then use a light box for 30 minutes daily for t…

This study at the University of Oxford is testing how the antidepressant fluoxetine (Prozac) influences the way healthy young people process anger. Eighty participants aged 18-24 will take either fluoxetine or a placebo for 7 days and complete tasks involving angry faces, words, …

This study tests a 9-session program called Changing Lives and Changing Outcomes-9 for people with serious mental illness who have been involved with the legal system. The program is designed to help participants understand their mental health better and reduce their chances of f…

This study tests a program called FRAME that helps heart failure patients discuss stress, anxiety, and depression with their doctors and loved ones. About 7,300 patients in Ontario, Canada will take surveys before and after using the tool. The goal is to see if the program makes …

This study explores whether people who seek help for both their allergies and their mental health (like anxiety or depression) have better control over their symptoms. Researchers will look at health records from 200,000 adults over several years. The goal is to understand if com…

This study looks at whether Parent-Child Interaction Therapy (PCIT) can help parents and children dealing with anxiety, depression, and stress. About 80 parents of children aged 2-7 will complete surveys and provide saliva samples to measure oxytocin levels. The goal is to unders…

This study tracks 300 adults who developed a surgical site infection after orthopedic surgery on their limbs or spine. Researchers will use questionnaires to measure how often depression and malnutrition occur over one year. The goal is to better understand these complications so…

This study looks at how a type of talk therapy for depression changes the gut microbiome, immune system, and brain function in people living with HIV. Researchers will enroll 150 adults with HIV and depression to understand these connections. The goal is to learn more about how t…

This study looks at how adults with depression respond to heat stress compared to those without depression. Researchers will measure skin blood flow, sweating, and core temperature during passive heating. The goal is to understand if depression or antidepressant medications like …

This study tests whether teaching mothers with depression to encourage positive emotions in their young children (ages 4-6) can increase the child's brain response to rewards. 180 mother-child pairs will be randomly assigned to either a parent-coaching program or general parentin…

This pilot study is testing a program called Tiwahe Tewichaglapi, which adapts the Family Acceptance Project for Lakota 2SLGBTQ+ youth and their caregivers. The goal is to see if the program is acceptable, safe, and feasible, and to check if it helps reduce depression, anxiety, a…

This study looks at how thinking skills (like memory and focus) are linked to sick leave in people with depression or anxiety. Researchers will give metacognitive therapy with a work focus to 200 patients at risk of sick leave. They want to see if the therapy improves symptoms an…

This study tests whether teaching mindfulness and meditation to mothers with babies in the neonatal ICU can increase breastmilk volume and reduce stress. Forty mothers will be split into two groups: one gets standard care, the other adds mindfulness training. Researchers will mea…

Latino teens are less likely to get depression treatment than their peers. This study asks teens, parents, and doctors which of three strategies—peer support groups, parent-teen training, or care navigation—they prefer. Researchers will interview 15 teens, 15 parents, and 5 healt…

This study looks at why people with bipolar disorder may think about or attempt suicide, focusing on life experiences and biology. Researchers will test a 6-week group program to help reduce these behaviors and improve quality of life. About 130 English-speaking adults with bipol…

This study looks at how a new, non-invasive brain stimulation technique called temporal interference (TI) affects social reward processing in people with depression. Researchers will use brain scans and tests to see if TI can change brain activity linked to social function. The g…

This study looks at why depression and heart disease often occur together in women going through menopause. Researchers will measure stress-related chemicals and heart rate in 30 women aged 44-55. The goal is to find clues that could lead to better ways to reduce heart disease ri…

This study tests whether a choice-driven, interactive storytelling web app can help Latinas with anxiety or depression start mental health treatment. Seven hundred participants in Los Angeles and Orange County will either use the story-based app or a control webpage with standard…

This study explores whether teachers can be trained to deliver mental health support to teenagers in rural India. About 216 students from 60 low-cost private schools will take part. The goal is to see if this approach is practical and effective for improving teen mental health.

This study looks at whether the brain activity of a therapist and a client can become synchronized during a therapy session for mild to moderate depression. Researchers will measure brain waves using EEG while students receive either behavioral activation therapy or education abo…

This study tests whether cognitive remediation—brain exercises with coaching—can improve thinking skills and reduce aggression in 30 forensic inpatients with conditions like psychosis, ADHD, or substance use. Participants will do exercises and be compared to an active control gro…

This study uses brain imaging to explore how severe childhood stress may cause chemical changes in the brain that increase depression risk. Researchers will scan the brains of 160 women aged 20-32, some with a history of childhood adversity and some without. The goal is to unders…

This study aims to understand how depression affects decision-making, especially when choices are difficult. Researchers will use brain stimulation techniques (TMS and TI) on 500 participants with depression and healthy controls while they perform game-like tasks. The goal is to …

This study explores whether a new system using ultrasound and light sensors can remotely monitor brain blood flow in people who have had a stroke. Researchers will test the technology in 140 participants, including healthy older adults and those with stroke, dementia, depression,…

This study follows 1000 adults who previously took part in mood disorder research at NIH. Participants complete online surveys and optional phone interviews about their current symptoms, treatments, and well-being. The goal is to learn how depression, bipolar disorder, and suicid…

This study works with clinics in Massachusetts to help people in underserved communities manage weight, get cancer screenings, and improve mental health. It includes 3,600 adults who speak English or Spanish and have obesity, are due for colorectal or cervical cancer screening, o…

This study looks at whether doulas with extra training in mental health support can help pregnant women in rural Montana feel more confident and less depressed. About 75 pregnant women will be split into three groups: one with a specially trained doula, one with a regular doula, …

This study looks at whether mindfulness-based cognitive therapy (MBCT) can improve how the brain controls emotions in people with mild depression symptoms. 76 adults with depression in remission will be randomly assigned to either MBCT or a wellness program. Researchers will use …

This study uses brain imaging and a single dose of the anti-anxiety drug lorazepam to understand how people with both depression and anxiety disorders process threats differently than those with depression alone. About 165 adults will complete two sessions involving startle tests…

This study uses MRI scans to observe how the brain changes in people with depression during a 5-day accelerated transcranial magnetic stimulation (TMS) treatment. Researchers aim to see if a new imaging method called INSCAPE can track individual recovery patterns. Twenty adults w…

This study looks at how a device that stimulates the vagus nerve (used for depression or epilepsy) affects stomach emptying and digestion. Researchers will compare stomach function in 16 people who already have the device to healthy controls. The goal is to understand the connect…

This study is testing whether brain scans can predict how well people respond to internet-based cognitive behavioral therapy (iCBT) for depression, insomnia, and social anxiety. Researchers will scan the brains of 150 participants before they start 12 weeks of online therapy. The…

This study looks at whether thinking about death can increase feelings of depression and anxiety. Researchers will ask 128 adults to write about their thoughts on death or dental pain (as a control) and then measure their mood. The goal is to understand if fear of death plays a r…

This study is testing a program called Coffee and Family Education and Support (CAFES2) for refugee families from Arabic-speaking countries who have recently moved to Chicago. The program is led by trained peers and aims to improve mental health and family relationships. Research…

This study aims to find out how often sexual dysfunction occurs in women with relapsing-remitting multiple sclerosis and how it connects to fatigue, depression, anxiety, overactive bladder, and thinking problems. Researchers will use questionnaires and tests to measure these fact…

This study is testing a mobile app called TrueBlue that automatically measures mood in pregnant women and new mothers. Researchers want to see if the app is safe, easy to use, and agrees with standard depression questionnaires. About 125 participants in Nottinghamshire, UK, will …

This study aims to uncover why physical activity reduces depression symptoms. Researchers will compare aerobic exercise with stretching in 250 adults with moderate depression, measuring changes in brain activity, immune markers, and motivation. The goal is to understand the under…

This study tests a web-based app called PST-Aid that helps clinicians guide patients through problem-solving therapy for depression. About 410 clinicians and their patients from community health centers will take part. The goal is to see if the app makes it easier for clinicians …

This study looks at whether the quality and function of HDL (often called 'good' cholesterol) is different in people with depression compared to healthy controls. Researchers will analyze blood samples from 90 adults with moderate to severe depression and a control group. The goa…

This study follows 540 adults with solid cancers to see how their anxiety and depression levels change over six months. Participants fill out questionnaires about their mood, coping, and quality of life at the start, 3 months, and 6 months. No drugs or treatments are given—the go…

This study tests a stepped care program called the Trauma Resilience and Recovery Program (TRRP) for people hospitalized after a traumatic injury. It includes education, symptom tracking, and referrals to mental health services. Researchers will follow 350 participants for 12 mon…

This study follows 5,000 children in a Miami-Dade park-based after-school program called Fit2Play. The program includes daily physical activity and nutrition lessons. Researchers will track changes in weight, fitness, blood pressure, and mental health over time to see if the prog…