DEPRESSION

This study tests whether magnetic brain stimulation can help prevent depression from returning in people who initially responded well to the treatment. Researchers will compare two different schedules of stimulation—one spread over a week and another compressed into a single day—…

This study is testing whether using a person's own brain scan to guide magnetic stimulation treatment works better than the standard approach for major depression. Researchers will enroll 210 adults with depression who haven't responded well to medication. Participants will recei…

This study tests an online platform called MOVIN that provides mental health support to pregnant and postpartum people experiencing depression or anxiety. Participants work with a care coordinator through a website to create personalized treatment plans and track their progress. …

This study tests a new approach to address the youth mental health crisis in rural India by training teachers to provide mental health support to their students. Teachers in 60 low-cost private schools will learn to weave evidence-based therapeutic techniques into their daily int…

This study is testing whether a new drug called CYB003 helps reduce depression symptoms when added to a person's current antidepressant medication. It will involve 330 adults with moderate to severe depression who are already taking a stable dose of antidepressants. Participants …

This study is testing whether combining psilocybin (a psychedelic compound) therapy with a rapid form of non-invasive brain stimulation is safe and more effective for treating severe depression that hasn't responded to other treatments. One hundred adults will receive either a hi…

This study is testing whether adding the diabetes medication metformin to standard antidepressant treatment helps reduce depression symptoms in obese adults who don't have diabetes. Researchers will compare 140 participants who receive either metformin or a placebo pill alongside…

This study is testing whether a smartphone app called Matter Neuroscience can help people with mild to moderate depression. The app works with brain scans (fMRI) to give users feedback about their brain activity related to positive emotions. Researchers want to see if this neurof…

This study aims to understand how ketamine, a drug with rapid antidepressant effects, works in the brain. Researchers are enrolling 150 adults with major depression and healthy volunteers to receive repeated ketamine infusions while undergoing brain scans and other tests. The goa…

This study is testing whether dapagliflozin, a medication typically used for diabetes, can help treat depression. It will involve 60 adults with depression who haven't responded well to standard treatments. Researchers will measure changes in depression symptoms and quality of li…

This study compares two forms of ketamine treatment for people with depression that hasn't responded to standard antidepressants. Researchers will test whether an IV ketamine drip works as well as the FDA-approved nasal spray Spravato®. The trial will measure how much depression …

This study is testing a new system to match community college students with anxiety or depression to the right level of mental health care. It will compare a standard method based on symptoms to a more personalized method that also considers life stress, background, and other fac…

This study is testing a new way to adjust the electrical dose used in Electroconvulsive Therapy (ECT) for severe depression. Researchers want to see if customizing the dose for each person can improve depression relief while causing fewer memory and thinking problems compared to …

This study is testing whether helping with both depression and poverty works better than treating depression alone for low-income women in rural Bangladesh. It will compare two groups: one gets depression treatment plus poverty aid, and the other gets only depression treatment. R…

This study is testing an online, 9-week family program designed to help parents and caregivers of LGBTQ+ youth of color become more supportive and accepting. The goal is to see if improving family relationships can reduce the youth's depression, anxiety, and other health risks li…

This study is testing whether providing a short, focused talk therapy to mothers experiencing depression can improve their mental health and, in turn, help them better manage their child's asthma. The research will involve about 60 Black mothers of children with asthma who report…

This study is testing if adding guided exercise to a standard talk therapy program helps Black men with type 2 diabetes better control their blood sugar and feel better mentally. It will involve 80 men over 7 months, with sessions held online. The goal is to see if this combined …

This study is testing whether adding a dietary supplement called D-serine to standard magnetic brain stimulation (TMS) therapy works better for treating depression than TMS alone. Researchers will compare depression symptoms in about 60 adults receiving either the combination or …

This UCLA study is testing a personalized, non-invasive brain stimulation treatment for people who still have symptoms like headaches, dizziness, fatigue, and brain fog months after a concussion. Researchers will use MRI scans to map each person's brain and then apply magnetic pu…

This study is testing a new, fast-acting medication called apimostinel for treating major depression. Researchers want to see if it works better than a placebo and if adding a digital brain training program helps the benefits last longer. The trial will involve 150 adults with de…

This small pilot study is testing whether a faster schedule of a non-invasive brain stimulation treatment works better for teenagers with depression that hasn't improved with medication. Researchers are comparing a new, accelerated schedule (three treatments per day for two weeks…

This study is testing whether a low-dose anesthetic drug (propofol), given as an IV infusion, can help treat depression in adults aged 60 and older. The idea is that the drug may boost deep, restorative sleep, which is often disrupted in depression. All 70 participants will also …

This study is testing if a non-invasive brain stimulation treatment called TMS can help reduce symptoms of anxiety and depression in children and teenagers. It will involve 120 young people aged 6 to 18 who have been diagnosed with these conditions. The goal is to see if this dru…

This study is testing whether a simple text-message system can help cancer survivors who have symptoms of depression get connected to mental health care. The goal is to see if this approach is easy to use and helpful for patients. Researchers will enroll 60 adult cancer survivors…

This study is testing a flexible therapy approach called FIRST that teaches children and teens skills to manage difficult emotions like anxiety, sadness, and anger. Researchers will compare FIRST to standard therapy for 212 youth ages 7-15 who are struggling with mental health ch…

This study is evaluating a telephone support program called SUSTAIN, designed to help manage depression, anxiety, and chronic pain in older adults. The program provides check-in calls, education, and care coordination for 4,000 seniors in Pennsylvania. Researchers want to see how…

This study is testing if a medication called cariprazine can help control the depressive episodes in teenagers (ages 10-17) who have bipolar I disorder. About 380 teens will be randomly assigned to receive either the study drug or a placebo for 6 weeks, followed by safety checks.…

This study is testing if a new therapy that helps people shift their sleep schedule to an earlier time can improve depression. It involves 150 people with moderate to severe depression who have recently left the hospital. One group will receive this new sleep-focused therapy, whi…

This study is testing a step-by-step support program called TRRP to help people get mental health care after a serious physical injury. It will involve 350 patients at a Washington D.C. hospital who are at risk for PTSD or depression. The program provides education, check-ins via…

This study is testing a new method to deliver brain stimulation therapy for depression in people with spinal cord injuries. Many people with these injuries can't use the standard treatment because it requires hand movement to set the dose. Researchers are testing a computer model…

This study is testing whether a computer-delivered therapy program can help people who have both alcohol use disorder and an anxiety disorder. Researchers want to see if this accessible, online version of a proven therapy works as well as when delivered by a therapist. The goal i…

This study is testing a special mobile app designed for Black pregnant women. The app provides culturally relevant tools to build self-advocacy skills, improve communication with doctors, and create a support network. Researchers want to see if using the app can help reduce depre…

This study aims to improve depression care in India by testing whether a simple talk therapy or a common antidepressant medication works better for different people. It will enroll 1500 adults with moderate to severe depression to receive one of these treatments. The main goal is…

This study is testing whether a new, fast-acting drug called (2R,6R)-HNK can help people with major depression who haven't gotten better with standard treatments. Fifty participants will receive intravenous infusions of either the study drug or a placebo over several weeks to see…

This study is testing if a special pill bottle that tracks when it's opened can help adults with depression take their medication more consistently. Researchers will follow 525 participants for 12 weeks to see if better medication habits lead to improved mood and quality of life.…

This study tests a new support program for low-income patients with chronic diseases like diabetes and heart problems after they leave the hospital. It provides free medications, delivers them to the bedside and then to the home, and offers a coach to help with follow-up care. Re…

This study is exploring whether a non-invasive brain stimulation technique can improve thinking problems and mood in people with several brain-based conditions. Researchers will use a magnetic coil placed on the head to stimulate a part of the brain called the cerebellum in 200 p…

This study is testing a 9-session group program for adults hospitalized with serious mental illness (like depression, bipolar, or psychotic disorders) who are also involved with the legal system. The program aims to help participants better understand their mental health and redu…

This study tests whether group therapy for trauma (PTSD) given in prisons can help people after release. It compares group therapy to a self-help workbook to see which better reduces drug use, mental health symptoms, and repeat offenses. The research involves 640 incarcerated peo…

This study is testing different medication combinations for teenagers with depression who don't get better with their first treatment. Researchers will follow 520 teens aged 13-18 over 16 weeks, trying different approaches if the initial treatment doesn't work. The goal is to fin…

This study is testing a smartphone app designed to help doctors and patients better understand and manage depression day by day. It will compare 200 adults with depression who use the app to track symptoms and medication with those receiving standard care. The goal is to see if u…

This study tests whether a structured, step-by-step treatment plan for depression works better than standard care. 171 adults with moderate depression will receive either standard GP treatment, psychologist therapy, or the structured medication plan for 12 weeks. Researchers will…

This study is testing if adding social skills training to standard depression therapy works better for teenagers. Researchers are enrolling 82 teens (ages 13-17) with depression. They will compare a therapy that teaches social skills, like understanding others' perspectives, to s…

This study is testing whether a computer-based brain training program can help people in forensic mental health care. The training aims to improve thinking skills like planning and problem-solving, which are often impaired. Researchers hope better thinking skills will lead to few…

This study is testing a special therapy program for mothers who have PTSD and are involved with child welfare services. It aims to help mothers manage their trauma symptoms and improve their parenting skills, with the goal of reducing the risk of future child maltreatment. The st…

This study is testing if adding the medication guanfacine to a standard antidepressant (sertraline) can help people with depression, especially those who also have trouble with thinking and focus. Researchers will use brain scans and cognitive tests to see how the treatment affec…

This study is testing whether a special computer-based brain training program can help people with anxiety, depression, or PTSD. Participants will be randomly assigned to use either the active training program or a less effective 'sham' version. Researchers will measure changes i…

This study is testing a new, faster version of an approved brain stimulation treatment for depression and obsessive-compulsive disorder (OCD). The goal is to see if delivering the treatment over just 5 days can quickly improve symptoms. Researchers will also use brain scans to tr…

This study is testing if a new clinic program can help control chronic diseases like high blood pressure, diabetes, and asthma. The program screens patients for social needs like housing or food insecurity and works to reduce racial bias in care. Researchers will enroll 68,000 ad…

This study is testing a home-based support program for people waiting for a kidney transplant who are currently 'inactive' on the official waitlist. A team of a nurse, an occupational therapist, and a handyman will visit participants at home over four months to help them tackle p…

This study is testing if adding a low dose of the medication esketamine to standard electroconvulsive therapy (ECT) is more effective for treating severe depression in teenagers. Researchers will compare two groups of 110 adolescents each: one receiving esketamine with ECT and on…

This study is testing a 12-week tablet-based coaching program called WellPATH-PREVENT for adults aged 50-90 who were recently hospitalized for suicidal thoughts or an attempt. The program teaches skills to manage difficult emotions and aims to reduce suicide risk after people lea…

This study is testing how well two common therapy techniques work when used together for anxiety and depression. Researchers want to see if combining 'cognitive restructuring' (changing unhelpful thoughts) with 'detached mindfulness' (observing thoughts without judgment) is more …

This study is testing a program for parents of Hispanic LGBTQ+ teenagers. The goal is to see if teaching parents how to be more supportive can help prevent or reduce depression and drug use in their teens. Researchers will work with about 300 families in South Florida to see if i…

This global study is testing whether painting roofs with special reflective coatings can keep homes cooler and prevent heat-related health problems. Researchers are working with 3,200 people in five hot climate regions where housing conditions make residents especially vulnerable…

This study is testing whether an online parenting program can improve family wellness and help prevent mental health issues in children. Researchers are enrolling 500 Filipino families in California, where half will take the online parenting course and half will receive standard …

This study is testing a new online training method for mentors in rural communities. The goal is to help mentors learn how to deliver a proven program that prevents depression and anxiety in teenagers. Researchers will compare this new 'just-in-time' training to usual training me…

This study is testing whether a fun, game-like virtual reality (VR) program can help children and teenagers learn to better manage their emotions. Researchers want to see if this training can prevent anxiety and depression. About 160 kids aged 10-16 will use the VR games for five…

This study is testing two different school-based programs designed to help teenagers get better sleep. It involves 3,000 students aged 13-19 in Sweden. The goal is to see if improving sleep can prevent future symptoms of depression and anxiety while also boosting school performan…

This study tests a family program designed to prevent multiple health problems common in Latino immigrant families. The six-session program, led by community health workers, helps families manage stress, build resilience, and access community resources. Researchers want to see if…

This study is testing a special online therapy program called Empower@Home, designed for older adults who have trouble leaving home due to mobility issues and are feeling depressed. The program uses videos and interactive exercises to teach coping skills, with weekly support call…

This study is testing two different telehealth programs to help veterans with mild to moderate traumatic brain injury sleep better. Researchers will compare a structured sleep coaching program (CBT-I) with a mindfulness-based approach (MBTI), both delivered in six video sessions.…

This study is testing whether a program that helps people improve multiple lifestyle habits—like diet, exercise, and stress management—can support recovery from depression. It will involve 210 adults starting treatment for depression at a primary care clinic. Researchers will mea…

This study is testing whether a smartphone app called JoyPop can help young adults (ages 18-25) manage difficult emotions, stress, anxiety, and depression while they are on a waitlist for professional mental health services. Researchers in Northwestern Ontario will compare the ap…

This study is testing a coaching program designed to help Black patients who have both long-term pain and depression. The program uses four coaching sessions to help people learn about and stick with non-drug treatments, like physical therapy or mindfulness, and to talk more effe…

This study is testing a smartphone app designed to help people with depression, bipolar disorder, or other mood conditions. About 325 participants will use the app for 8 weeks, completing AI-guided therapy sessions and homework. The main goal is to see if this digital form of cog…

This study is testing an online group support program designed to help adults with spina bifida. Over 10 weekly video sessions, participants will work on improving their self-esteem, social skills, and overall psychological well-being. The goal is to see if this accessible, remot…

This study is testing whether psilocybin (a compound found in 'magic mushrooms'), combined with psychotherapy, can help reduce depression and anxiety in people who have survived cancer. It will involve about 20 participants and aims to check if the treatment is safe and practical…

This study is testing whether a new virtual reality training program can help improve mood and reduce symptoms in people with depression and low positive feelings. Researchers will compare two different VR programs over 7 weeks with 80 adult participants. The goal is to see if gu…

This study is testing whether a self-guided mental health program led by an artificial intelligence (AI) avatar can help employees who are experiencing symptoms of depression. About 50-80 adults in the UK will be randomly assigned to either try the online program immediately or w…

This study is testing a behavioral health program designed to help nursing home residents experiencing depression and their primary caregivers. The program focuses on building resilience and coping skills during the transition to nursing home care. Researchers will compare this p…

This small, early-stage study is testing whether a non-invasive brain stimulation technique called rTMS can boost the benefits of Tai Chi for people with knee arthritis and depression. Researchers will compare two different rTMS stimulation patterns in 30 participants to see if t…

This study is testing a special online parenting program designed to help military-connected mothers who have experienced trauma. The program aims to help mothers manage difficult emotions like PTSD and depression, and improve their parenting skills and connection with their youn…

This study is testing whether an online therapy program can help older adults who have survived a serious hospital stay in the Intensive Care Unit (ICU). The goal is to see if treating depression with this accessible therapy can also slow down feelings of memory and thinking prob…

This small pilot study is testing whether using virtual reality (VR) is a safe and helpful way to improve the mental well-being of cancer patients during treatment. Researchers want to see if relaxing VR experiences, like walking through a forest or swimming with dolphins, can re…

This study is testing whether psilocybin-assisted therapy can help adult children of genocide survivors who struggle with depression and anxiety. Researchers will give 100 participants two doses of psilocybin alongside therapy sessions to see if it reduces symptoms and improves r…

This study aims to see if combining talk therapy (CBT) with light therapy, medication, or melatonin can help improve sleep quality, fatigue, anxiety, and depression in people with advanced cancer. Researchers will compare these active treatments against placebo (inactive) treatme…

This study is testing whether a nutritional drink called 'Think Tank' can help improve mental sharpness and well-being after someone experiences stress. Researchers will recruit 40 healthy women aged 40-60 to see if the drink helps with memory, focus, and mood better than a place…

This study is testing a short-term group talk therapy designed to help people with anxiety or depression. It will compare this new therapy to a standard group therapy to see which is more effective at reducing symptoms. The study aims to enroll 100 adults from community mental he…

This study is testing whether a new program called FRAME helps people with heart failure talk about and get support for mental health issues like stress, anxiety, and depression. About 7,300 patients at clinics in Ontario, Canada, will use the FRAME tool and answer surveys before…

This study is testing whether a single session of whole-body heat therapy, with or without a follow-up cold water plunge, can help reduce symptoms of depression. It will involve about 112 adults currently experiencing depression, who will be randomly assigned to one of the two tr…

This study tests whether a team-based care program can improve emotional well-being for adults with epilepsy who also experience anxiety or depression. Researchers will compare the new program against standard neurology care in 60 participants over 24 weeks. The program involves …

This study is testing whether two simple programs can help reduce depression in elderly women in India. Over 5,000 women aged 55 and older will receive either one-on-one talk therapy, group social activities, both, or neither. The goal is to see if these community-led programs ca…

This study is testing whether dance-movement therapy can help reduce depression symptoms in teenagers. Researchers will enroll 140 teens (ages 13-17) with moderate to severe depression and randomly assign them to either receive 12 weeks of dance therapy or continue with their usu…

This study is testing whether an 8-week online mindfulness program can help reduce the severe fatigue often experienced by people with sarcoidosis. It will also see if the program improves symptoms of anxiety and depression. Researchers will compare the mindfulness group to a mon…

This study is testing whether an 8-week group therapy program can help reduce feelings of depression in older adults. Researchers will compare the therapy group to a waitlist group to see if participants report fewer depressive symptoms and improved well-being. The therapy focuse…

This study is testing whether a special web app program can help reduce feelings of depression in midlife Korean American women. The program provides information and coaching to help participants become more physically active in their daily lives. Researchers want to see if incre…

This pilot study is testing a culturally adapted mindfulness program called 'Quiet Focus' for older Black adults who experience both chronic pain and depression. The research aims to see if this tailored therapy is a practical and acceptable approach for this community. The main …

This study is testing whether a faith-based group therapy program can help reduce depression symptoms in African American adults. The program combines cognitive behavioral therapy techniques with spiritual support and is delivered through church groups. Researchers want to see if…

This study is testing whether a smartphone app called Safe Haven can help reduce depression, anxiety, and stress in college students. Researchers will compare students using the app alongside regular campus mental health services to students receiving only standard campus care. T…

This study is testing whether mindfulness meditation can help first-generation college students who experience anxiety or depression. Researchers will compare a 4-week mindfulness program to an educational program to see which better improves students' well-being and their intent…

This study is testing whether using the Calm meditation app for 10 minutes a day can help people with blood cancers who have trouble sleeping. Researchers will enroll 276 patients to see if the app improves sleep quality, reduces fatigue and anxiety, and lowers body inflammation …

This study is testing whether a specific probiotic (Clostridium butyricum) can help reduce feelings of anxiety and depression in people who have functional dyspepsia, a common condition causing ongoing stomach pain or discomfort. The trial will involve 180 adults who will take ei…

This study is testing whether a guided smartphone app therapy program can help reduce depression and anxiety symptoms in high school students. Researchers will compare the app-based program to the usual school mental health services. The goal is to see if this digital tool is a p…

This study is testing whether a free, 5-week online stress-management program from the World Health Organization (WHO) can improve mental health for employees at small and medium-sized companies in the Netherlands. Researchers will compare two groups: one that gets the program pl…

This study is testing whether a traditional Chinese massage therapy called Tui Jing can help reduce symptoms of depression. Researchers will compare the real therapy against a fake, placebo treatment in 64 adults with depression. They will measure changes in mood, sleep quality, …

This study is testing an investigational capsule called TJ0113 to see if it can safely reduce symptoms of depression. About 150 adults with moderate to severe depression will take either TJ0113 at one of two doses or a placebo pill daily for 8 weeks. Researchers will measure chan…

This early-stage study from Johns Hopkins University is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' can help people who suffer from both chronic lower back pain and depression. Forty participants will receive either psilocybin or a stimu…

This study is testing a non-invasive brain stimulation technique called rTMS to see if it can help reduce depression in adults with autism spectrum disorder (ASD). It will involve 25 participants who have both ASD and depression. Researchers will measure changes in mood, irritabi…

This study is testing whether a prenatal yoga app can improve the well-being of first-time Black and African American pregnant women. Researchers want to see if using the app for 12 weeks is practical and helps with stress, mood, and physical health. The study also aims to learn …

This study is testing a mobile app called Blueprint, designed to help people manage depression, anxiety, and PTSD after surviving a serious heart or lung condition in the hospital. Researchers will enroll 400 people from four hospitals and randomly assign them to use either the B…

This study is testing a new smartphone app designed to help adolescent and young adult cancer survivors manage symptoms of depression. Researchers want to find out which parts of the app, or which combination of parts, are most helpful in reducing these symptoms. The study will i…

This study is testing whether a smartphone app called JoyPop can help Indigenous young adults (ages 18-25) manage difficult emotions like stress, anxiety, and depression while they wait for formal mental health services. Researchers will compare the app's effects to usual waitlis…

This study is testing whether group therapy focused on improving relationships can help reduce depression symptoms in young adults. The therapy will be delivered by trained university students and doctors to groups of up to 10 participants over eight weekly sessions. Researchers …

This study is testing whether heated yoga or regular yoga is more effective at reducing symptoms of moderate depression. Researchers will enroll 120 adults who don't regularly practice yoga or meditation and have them attend in-person classes with certified instructors. The goal …

This study is testing whether a daily probiotic supplement can help reduce depression in people who have Parkinson's disease. About 60 participants with mild to moderate Parkinson's and depression will take either the probiotic or a placebo pill for 12 weeks. Researchers will mea…

This study is testing a 9-month wellness program designed to help staff who work to prevent gun violence. The program teaches skills to manage emotions, reduce burnout, and improve mental health. It aims to see if this support helps workers feel better and stay in their jobs long…

This study is testing a 10-week online psychological treatment program for cancer survivors who are struggling with anxiety, depression, or fear of their cancer returning. It will enroll 400 survivors in Sweden to figure out which parts of the online therapy are most helpful. The…

This study is testing whether a smartphone app called JoyPop can help teenagers manage difficult emotions, stress, anxiety, and depression while they wait to start formal mental health therapy. Researchers will compare 110 teens aged 12-17 who use the app to those who receive usu…

This study is exploring whether a therapy program for parents and young children can reduce parental stress, anxiety, and depression while improving the parent-child relationship. Researchers will enroll 80 parents of children aged 2-7 and measure stress levels, a bonding hormone…

This study is testing if giving a single dose of ketamine during surgery helps adults with serious bone injuries recover better. Researchers want to see if ketamine reduces pain after surgery, lowers the need for strong opioid painkillers, and improves symptoms of depression and …

This study is testing a 6-part online therapy program called Emotion Regulation Therapy (ERT) for adults in New York who struggle with excessive worry, rumination, or self-criticism. The goal is to see if learning specific emotional regulation skills can reduce symptoms of anxiet…

This study is testing a program that connects pregnant women in disaster-affected areas with experienced mothers as mentors. The goal is to see if group meetings and peer support can reduce anxiety and depression during pregnancy. Researchers will recruit 240 women to participate…

This study is testing whether a specific probiotic supplement (Bacillus coagulans) can help reduce feelings of anxiety and depression in people who also have chronic stomach discomfort (functional dyspepsia). About 180 adults will take either the probiotic or a placebo (dummy pil…

This study aims to see if a game-like mobile app treatment works as well as a standard version for reducing depression symptoms. It will involve 600 adults with elevated depression symptoms who will use one of the apps or a placebo version. Researchers will measure changes in dep…

This study is testing whether a personalized mobile therapy app is as good as a standard version at helping young adults with anxiety, depression, or bipolar disorder. About 100 participants will use one of two versions of the 'Maya' app for six weeks. Researchers will compare ho…

This study is testing whether electroacupuncture—a form of acupuncture that uses mild electrical stimulation—can safely help reduce depression in people with cancer. Researchers will compare the treatment to a control group in 86 participants to see if it improves mood and qualit…

This study tests whether a specific talk therapy for depression, delivered via video calls to veterans at home, can help them get back to their normal activities and improve their mood after being hospitalized for a heart condition. It will compare 12 sessions of this home-based …

This study is testing two different mind-body programs designed to help cardiac arrest survivors and their caregivers manage emotional distress like anxiety and depression. The programs involve weekly sessions that teach mindfulness and resilience skills, starting in the hospital…

This study is testing two self-guided online therapy courses designed to help veterans. One course focuses on reducing suicidal thoughts, while the other helps manage depression symptoms. Researchers want to see if these free, accessible online programs are practical, safe, and h…

This study aims to find out which of two common talk therapies works better for autistic adults struggling with depression or anxiety. Researchers will compare Cognitive-Behavioral Therapy (CBT) and Mindfulness-Based Therapy (MBT), both delivered online, in 300 adults from North …

This study is testing a two-part treatment for veterans who have both chronic low back pain and depression. The goal is to see if giving ketamine infusions followed by a brief therapy program is safe, practical, and acceptable to participants. Researchers will measure if this app…

This study is testing whether an online therapy program called Mom-Net can be successfully offered through Head Start agencies to help low-income mothers manage depression. The program includes online lessons and live coaching. Researchers want to see if it reduces mothers' depre…

This study aims to find out if heated yoga, regular sauna use, or a mindfulness app can help reduce symptoms of depression. Researchers will enroll 120 adults with moderate depression and assign them to one of these three activities for 12 weeks. They will measure changes in depr…

This study is testing a new online program designed to help parents of children with disabilities manage stress, anxiety, and depression. Parents will complete six online modules and receive brief weekly phone coaching from a trained occupational therapist. The research aims to s…

This study is testing whether a smartphone meditation app called the Healthy Minds Program can help reduce depression symptoms in teenagers. Researchers will enroll 200 teens with elevated depression scores to use the app for 8 weeks, comparing it to a control group using a diffe…

This study is testing a new type of talk therapy for young adults struggling with anxiety or depression. The therapy uses virtual reality to help people explore their sense of self and is designed to be more engaging for young people. Researchers will compare this new approach to…

This study is testing whether listening to personalized music daily can help reduce anxiety and depression in people recovering from a recent stroke. About 132 participants will be randomly assigned to either receive standard care plus four weeks of daily music listening sessions…

This study is testing whether a culturally adapted skills training program called START NOW is better than usual care at reducing depression and anxiety in adolescent refugees. Researchers will enroll 80 young migrants in Switzerland and randomly assign them to either the new tra…

This study is testing whether music therapy can help children with depression. Twenty children will receive 11 weekly music therapy sessions. Half of the group will also attend special recitals to observe performers and discuss how sharing creativity affects their feelings and re…

This study is testing a specially adapted self-help workbook to see if it can help reduce symptoms of anxiety and depression for people in prison. About 96 participants will work through the 8-week workbook on their own, with researchers checking in to see if it's helpful and pra…

This study is testing whether mindfulness training can help reduce stress, depression, and sleep problems in two groups: hospital staff and older adults. Forty participants will take part in two four-month mindfulness courses. Researchers will use brain scans and wearable devices…

This study is testing whether an 8-week virtual reality exercise program can help improve physical and mental health for women veterans. Researchers will compare 40 veterans who use the VR adventure games to a control group, measuring changes in activity levels, mood, stress, and…

This small, early-stage study from Johns Hopkins University is testing whether the psychedelic compound psilocybin, given in a controlled setting with support, can safely reduce depression in people with mild cognitive impairment or early Alzheimer's disease. Up to 20 participant…

This study is testing if a smartphone app called 'Moodivate' can help reduce depression in people living with incurable cancer. About 279 participants will be randomly chosen to either use the app or not for 12 weeks. The goal is to see if this easy-to-access digital tool can imp…

This study is testing if a medication called L-DOPA can help people with depression who also have high inflammation and a specific symptom called anhedonia, which is the inability to feel pleasure. Seventy adults with depression will take either L-DOPA or a placebo for eight week…

This study is testing a special online therapy program called Empower@Home, designed to help homebound older adults who are feeling depressed. The program uses interactive lessons based on cognitive-behavioral therapy (CBT) and is supported by weekly check-in calls from trained c…

This study is developing and testing a culturally adapted family support program for Lakota LGBTQ2S+ youth and their caregivers. The 8-week group program aims to reduce family rejection, improve mental health, and decrease risks like depression and substance use. Researchers are …

This study is testing whether a 12-week prenatal yoga program called 'Mindful Moms' can help reduce depression symptoms in pregnant women, compared to standard prenatal education classes. It will enroll 200 pregnant women who are experiencing depressive symptoms, with a focus on …

This study is testing whether a non-invasive brain stimulation treatment called rTMS is safe and helpful for reducing depression in people with spinal cord injuries. Fourteen participants with depression and cervical or thoracic spinal cord injuries will receive magnetic stimulat…

This study is testing whether using virtual reality (VR) to experience nature walks at home can help reduce depression in people with progressive multiple sclerosis (MS). Researchers will give 40 participants a VR headset to use for short sessions several times a week over 8 week…

This study is testing a two-week smartphone app program designed to help people who struggle to feel pleasure (anhedonia) and experience high stress, anxiety, or depression. Participants are randomly assigned to use an app with daily audio exercises focused on gratitude, positive…

This study is testing a new program where college students are trained to provide therapy to high schoolers in rural Pennsylvania. The goal is to see if this approach can effectively reduce symptoms of depression, anxiety, and stress in teens who often have limited access to ment…

This study is testing a short, online self-help program designed to help university students who are feeling significant distress and are behind on their coursework. The program, developed by the World Health Organization, teaches skills for managing stress and improving well-bei…

This study is testing two different ways to deliver mindfulness training to help younger breast cancer survivors who are feeling depressed or fatigued after finishing their main cancer treatments. It will compare a live, instructor-led class over Zoom with a self-paced smartphone…

This study is testing a new, single-session therapy designed to help college students who are struggling emotionally after experiencing a sexual assault. Researchers want to see if this 2-hour therapy session can reduce symptoms of PTSD and depression. The study will enroll 45 Oh…

This study is testing whether a newer type of guided self-help therapy (CAT-GSH) works as well as the standard one (CBT-GSH) for people who are returning to NHS mental health services for anxiety or depression. It involves 100 participants who will choose their preferred therapy …

This study is testing a family support program designed to help refugee families cope with stress, trauma, and mental health challenges. The program brings families together in groups led by fellow refugees to build community support and improve family relationships. Researchers …

This is a small pilot study to see if a culturally adapted talk therapy is practical and acceptable for people living with HIV who also have depression and anxiety in Pakistan. Fifty participants will be randomly assigned to either receive six sessions of this special therapy or …

This study is testing a smartphone app designed to help people recover from knee or hip replacement surgery. The app uses digital therapy techniques and coach support to help patients manage anxiety, depression, and pain. Researchers want to see if using the app can help patients…

This study is testing whether a specific, long-term exercise program can help U.S. veterans feel better. It will see if the workouts improve body composition, physical strength, and reduce symptoms of pain, fatigue, depression, and PTSD. Over 18 months, 25 participants will atten…

This study is testing a digital program designed to help immigrant women who have experienced violence and are dealing with PTSD or depression. The program aims to teach coping skills, reduce stress, and improve safety and mental health. It will involve about 676 participants and…

This study is testing a new 12-week group therapy program for women who have experienced interpersonal trauma (like physical or sexual abuse) and are currently having suicidal thoughts. The program combines psychological counseling with physical self-defense training, aiming to b…

This study is testing a 6-week group therapy program for parents of children with anxiety, depression, or behavioral problems. The program teaches parents skills to better support their child's emotions and behaviors. Researchers will compare families who receive the therapy imme…

This study is testing whether a 7-week therapeutic song-writing program can help young people with mild to moderate depression. Researchers will compare 120 participants, aged 13-24, who either join the program immediately or are placed on a waitlist. The goal is to see if the pr…

This study is testing a free, 6-week online coaching program designed to help Nova Southeastern University undergraduate students manage anxiety, depression, and stress. About 160 students will be randomly assigned to either start the program immediately or be placed on a waitlis…

This study aims to see if mood and sleep problems during menopause can be improved by resetting the body's internal clock. Researchers will test whether one night of specific sleep timing followed by two weeks of daily bright light exposure helps. They are recruiting 120 perimeno…

This study is testing an 8-week online therapy course designed to help new and expecting parents in Saskatchewan who are struggling with anxiety or depression. The course provides educational materials and therapist support through a secure website. Researchers want to see if thi…

This study aims to understand if making people think about their own death increases symptoms of anxiety and depression. Researchers will compare two groups: one group writes about death, while a control group writes about dental pain. The goal is to learn more about the role of …

This study aims to understand the long-term course of depression, bipolar disorder, and suicide risk by re-contacting over 1,000 people who participated in past research. Participants complete online surveys and optional phone interviews about their current symptoms and treatment…

This study aims to understand the immediate relationship between cannabis use, withdrawal, and mental health in teenagers. Researchers will follow 200 adolescents (ages 12-18) who use cannabis frequently and have depression symptoms. Using smartphone surveys throughout the day, t…

This pilot study is testing whether adults experiencing acute mental health crises like severe anxiety, depression, or psychosis can safely receive hospital-level care at home instead of in a traditional hospital. Researchers will enroll 45 carefully screened, lower-risk patients…

This research aims to understand how specific brain areas influence difficult decision-making in people with depression. Researchers will recruit 500 participants, including people with depression and healthy volunteers, to play game-like tasks while receiving safe, non-invasive …

This study aims to understand how severe stress in childhood affects the brain and increases the risk for depression later in life. Researchers will use brain scans and other tests on 160 young women to look for specific chemical and functional changes linked to past trauma. The …

This study follows 540 cancer patients for 6 months to understand how anxiety and depression change during cancer treatment. Researchers will track patients' emotional symptoms and identify factors that might predict who needs more support. The goal is to learn how to better help…

This study aims to understand how chronic stress affects brain activity and immune system function in people living with HIV who also use stimulants like methamphetamine or cocaine. Researchers will test whether a 5-session online program focused on positive emotions can reduce s…

This study aims to understand how cognitive-behavioral therapy (a type of talk therapy) for depression affects the gut microbiome, immune system, and brain function in people living with HIV. Researchers will enroll 150 adults with HIV and depression to measure changes in their g…

This study aims to understand how brain activity relates to mood, particularly in depression. Researchers will record brain signals directly from 58 participants who are already undergoing monitoring for epilepsy or treatment for severe depression. Using advanced computer analysi…

This study aims to collect detailed information from 4,500 patients before and after various brain and spine surgeries. The goal is to identify which factors best predict a patient's recovery and quality of life after their operation. By standardizing how outcomes are measured ac…

This study is testing a web-based app called PST-Aid, which is designed to help therapists learn and consistently use a specific talk therapy for depression called Problem-Solving Treatment (PST). The researchers want to see if using this app helps therapists adopt the treatment …

This study aims to understand how a specific type of non-invasive brain stimulation affects the brain's 'social reward' system in people with depression. Researchers will use brain scans and behavioral tests to see how stimulation of deep brain areas changes activity and connecti…

This study aims to understand if a therapist's and a client's brain activity sync up during a therapy session for depression. Researchers will measure brain waves in 45 students with mild to moderate depression and their therapists during a single session of either behavioral act…

This study aims to understand if teaching mothers with depression how to encourage their child's positive emotions can improve the child's brain response to rewards. Researchers will work with 180 mothers and their 4- to 6-year-old children, randomly assigning them to either a sp…

This study aims to understand if depression or common antidepressant medications affect how the body cools itself down when overheated. Researchers will compare skin blood flow and sweating in four groups: healthy adults, adults with untreated depression, and adults with depressi…

This study aims to understand how common sexual dysfunction is in women living with multiple sclerosis (MS). Researchers will enroll 140 women with MS to complete surveys about their sexual health, fatigue, mood, and other symptoms. The goal is to identify connections between sex…

This study aims to understand how ketamine, a drug known to relieve depression symptoms within hours, works in the brain. Researchers will test whether blocking a specific brain receptor (called AMPA) reduces ketamine's antidepressant effects. About 70 adults with major depressio…

This study is not a treatment trial. Its main purpose is to screen a large number of people—including those with mood or anxiety disorders and healthy volunteers—to understand these conditions better and to find suitable participants for future research studies. Participants unde…

This University of Oxford study aims to understand how the antidepressant fluoxetine (Prozac) affects how healthy young people process anger. 80 participants aged 18-24 will take either a 20mg fluoxetine pill or a placebo daily for one week and complete tasks designed to measure …

This study aims to understand if brain inflammation is linked to major depression. Researchers will use special PET brain scans to measure levels of two inflammation-related enzymes (COX-1 and COX-2) in 64 adults with depression and healthy volunteers. The goal is to gather knowl…

This study aims to discover exactly how physical activity helps reduce depression symptoms. Researchers will compare an 8-week aerobic exercise program to a stretching program in 250 adults with moderate depression. They will measure changes in brain activity, body chemistry, and…

This study is testing a mobile app called TrueBlue that aims to monitor signs of depression and anxiety in pregnant women and new mothers. For 12 weeks, 125 participants in the UK will use the app weekly, reading or speaking while it records their face and voice to generate mood …

This study aims to understand why people with bipolar disorder are at such high risk for suicide. Researchers will look at how factors like childhood trauma, drug use, and aggressive impulses might lead to suicidal thoughts and actions. They are also testing a 6-week group therap…

This study aims to understand why women going through menopause who experience depression may have a higher risk of developing heart disease. Researchers will enroll 30 women to measure their body's stress responses during a brief social stress test. The goal is to gather knowled…

This study aims to understand how supporting mothers of hospitalized infants affects family wellbeing. Researchers will connect mothers experiencing depression, anxiety, or food insecurity with helpful resources and emotional support. They want to see if this assistance improves …

This study aims to understand why people with depression have a higher risk of heart disease. Researchers will analyze blood samples from 90 adults, comparing those with depression to those without, focusing on specific fats and proteins. The goal is to uncover biological clues t…

This study aims to understand how often depression and malnutrition occur in patients who develop infections after orthopedic surgery. Researchers will follow 300 patients for three years to track their mental health, nutrition, and recovery. The goal is to gather information tha…

This study aims to define a new concept called 'visual frailty' and create a tool to measure it. Researchers will gather information from 20 Scottish adults aged 60+ with advanced age-related macular degeneration (AMD). They will look at vision, reading ability, daily function, m…

This study aims to understand how two different programs—Mindfulness-Based Cognitive Therapy and a general Wellness class—affect specific thinking skills related to emotions in people with mild to moderate depression symptoms. Researchers will measure how well participants can ma…

This study aims to understand how a non-invasive brain stimulation technique works in the brain. Researchers will use MRI scans while applying magnetic pulses to the brains of healthy adults and people with depression. The goal is to see how the brain responds and if these respon…

This study is investigating whether taking a high dose of Vitamin B6 changes brain activity in people with mild to moderate anxiety or depression. Researchers will use EEG brain scans to measure neural activity and compare results between people taking Vitamin B6 and those taking…

This study aims to understand how a vagus nerve stimulator (VNS), a device used to treat severe depression or epilepsy, affects how the stomach works. Researchers will measure how quickly the stomach empties and how much it expands after a meal in 16 people who already have the V…

This study aims to see if brain scans can better predict how well a person will respond to online therapy for depression, social anxiety, or insomnia, compared to just asking them. Researchers will scan the brains of 150 people before they start a 12-week online therapy program. …

This study is trying to understand how a natural hormone might be connected to depression in women going through menopause. Researchers will give some participants a dietary supplement (pregnenolone) and others a placebo to see if it changes certain brain activities and repetitiv…

This study aims to find out if a person's heart rate can be used as a signal to predict who will benefit from a specific depression treatment. Researchers will enroll 100 adults with mild to moderate depression to use a home-based, non-invasive brain stimulation device for 10 day…

This study aims to understand how the brain processes fear and threat in people with depression, anxiety, or both. Researchers will give 165 participants a single dose of an anxiety medication (or a placebo) and use brain scans and eye-blink tests to measure their fear responses.…

This study aims to test if new brain scanning and stimulation methods can find common markers for thinking problems in people with chronic pain or depression. It will involve 45 people, including healthy volunteers, to see if the research procedures are practical. The goal is to …

This early-stage study aims to understand if an investigational drug called SP-624 changes brain activity patterns in healthy adults and people with major depression. Researchers will use a special cap to measure brain waves and AI software to analyze them. The study will also ch…

This study is testing whether a special web app that uses interactive stories and a relatable character can help Latinas with anxiety or depression take the first step to get professional help. It will compare this story-based app to a standard app with informational videos and r…

This study is observing whether a free, daily after-school program in community parks improves children's health. Researchers will analyze data from about 5,000 kids aged 6-14 who participate in the program, which includes sports, games, and nutrition lessons. The goal is to see …

This study aims to understand how a fast-acting depression treatment called accelerated TMS affects brain activity. Researchers will use MRI scans to track brain changes in 20 people with depression before and after one week of treatment. The goal is to see if brain imaging can s…

This study aims to learn more about how a type of talk therapy called schema therapy might help people with depression that hasn't improved with standard treatments. It will closely follow three patients as they receive about 30 therapy sessions over a year. The goal is to unders…

This large research study aims to better understand what causes depression in teenagers and to test effective treatments. It will enroll 4,100 participants, including teens with depression and healthy volunteers, to observe them for up to two years using interviews, computer task…

This study aims to understand the biology of major depression by using a special brain scan (PET scan) to measure levels of an enzyme called PDE4B. Researchers want to see if people experiencing a depressive episode have lower levels of this enzyme in their brains compared to hea…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will compare brain scans, sleep patterns, and blood tests from people with different levels of suicidal thoughts to healthy volunteers. Some participants currently i…

This study is testing whether a new wearable device and computer software can safely and effectively monitor brain blood flow in people at home. It will involve 140 people, including healthy older adults and those who have had a stroke, dementia, depression, or delirium. The main…

This study is testing whether support from a doula—a trained birth companion—can improve mental health and wellness for pregnant people. Researchers will enroll 75 pregnant participants from rural Montana to compare different types of doula care to standard care. The main goal is…

This study aims to find out what support methods work best to help Latino teenagers attend therapy for depression. Researchers will interview teens, their parents, and healthcare providers to learn their preferences. The goal is to identify the most promising strategies to connec…

This Mayo Clinic study is exploring whether teaching mindfulness and meditation techniques to mothers can help them while they pump breastmilk for their premature babies in the Neonatal Intensive Care Unit (NICU). Researchers will measure if these relaxation practices are linked …