Can a common amino acid make TMS work better for depression?
NCT ID NCT06876129
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether taking D-serine (an amino acid) before transcranial magnetic stimulation (TMS) can improve depression symptoms more than TMS alone. Sixty adults with major depressive disorder will receive either D-serine or a placebo before TMS sessions for six weeks. The goal is to see if the combination leads to greater mood improvement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
D-serine
What this could lead to
If it works, this could point toward a more effective way to treat depression by combining a brain-stimulation therapy with a drug that boosts brain plasticity.
What could go wrong
This is a very early Phase 1 trial with only 60 people, so results may not apply to everyone. The drug may cause side effects or not improve depression beyond standard TMS.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for DEPRESSION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
McLean Hospital
RECRUITINGBelmont, Massachusetts, 02478, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••