Can a common amino acid make TMS work better for depression?
NCT ID NCT06876129
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether taking D-serine (an amino acid) before transcranial magnetic stimulation (TMS) can improve depression symptoms more than TMS alone. Sixty adults with major depressive disorder will receive either D-serine or a placebo before TMS sessions for six weeks. The goal is to see if the combination leads to greater mood improvement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- D-serine
- What this could lead to
- If it works, this could point toward a more effective way to treat depression by combining a brain-stimulation therapy with a drug that boosts brain plasticity.
- What could go wrong
- This is a very early Phase 1 trial with only 60 people, so results may not apply to everyone. The drug may cause side effects or not improve depression beyond standard TMS.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
McLean Hospital
RECRUITINGBelmont, Massachusetts, 02478, United States
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