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Can MRI reveal the Brain's response to deep brain stimulation?

NCT ID NCT03153670

Recruiting now Knowledge-focused Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This study uses advanced MRI (3T fMRI) to look at brain activity in people who have or will have deep brain stimulation (DBS) implants. DBS is a treatment for conditions like Parkinson's disease, tremor, and obsessive-compulsive disorder. The researchers will scan participants under different DBS settings to see which brain areas are activated, with the goal of helping doctors choose the most effective settings for each person. The study focuses on safety and understanding how DBS works in the brain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Functional magnetic resonance imaging (fMRI) scanning during deep brain stimulation (DBS) with different settings
What this could lead to
If successful, this could help doctors choose the best DBS settings for each patient, potentially improving treatment outcomes for movement and psychiatric disorders.
What could go wrong
This is an early imaging study, not a treatment trial. It may not directly improve patient outcomes, and MRI in DBS patients carries safety considerations.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease depressive disorder dystonic disorder epilepsy essential tremor neurodegenerative disease Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEURO-DEGENERATIVE DISEASE

Contacts and locations

Locations

  • Toronto Western Hospital

    RECRUITING

    Toronto, Ontario, M5T2S8, Canada

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