University Health Network, Toronto

This study tests whether radiofrequency ablation (using heat) can safely cure small, low-risk thyroid cancers without surgery. Thirty adults who decline surgery or active monitoring will receive the treatment and be followed for a year. The goal is to see if the cancer is complet…

This study tests a two-dose pandemic H5N1 (bird flu) vaccine in 120 organ transplant recipients to see if it is safe and produces a strong immune response. Transplant patients are especially vulnerable to severe flu, and there is no data yet on how well this vaccine works in them…

This study explores whether growing miniature versions of a patient's own pancreatic tumor in the lab (called organoids) can help doctors choose the most effective drug for that individual. About 25 adults with advanced, inoperable pancreatic cancer will have their tumor organoid…

This phase 2 trial is testing whether giving two immunotherapy drugs, durvalumab and oleclumab, before surgery can boost the immune system's attack on pancreatic cancer. The study involves people with resectable pancreatic ductal adenocarcinoma (PDAC) who will receive the drugs i…

This phase 2 trial tests whether combining pembrolizumab (Keytruda) with bendamustine (Treanda) is safe and effective for people with Hodgkin lymphoma that has come back or is no longer responding to standard treatments. About 40 adults will receive the drug combination, and rese…

This study tests a new way to deliver high-dose radiation to prostate tumors using real-time MRI guidance. It includes two groups: men whose prostate cancer has returned after prior radiation, and men with advanced cancer receiving standard external beam radiation plus this boost…

This study tests whether taking pentoxifylline and vitamin E during chemoradiation can prevent lung injury (pneumonitis) in stage III non-small cell lung cancer patients. 150 participants will receive either the drug combo or a placebo for 6 months. The goal is to see if this red…

This phase 2 trial tests a new way to deliver radiation therapy for anal cancer using MRI guidance to adjust doses based on each patient's risk level. About 80 adults with anal squamous cell carcinoma will receive different radiation schedules depending on their tumor risk group.…

This phase 2 trial tests whether the chemotherapy pill capecitabine can eliminate tiny amounts of cancer DNA still present in the blood after standard treatment for early-stage ER+/HER2- breast cancer. About 15 patients whose blood tests show residual cancer DNA will take capecit…

This study tests a procedure called irreversible electroporation (IRE) using the NanoKnife system to treat intermediate-risk prostate cancer. The goal is to destroy cancer cells with fewer side effects than standard treatments like surgery or radiation. About 100 men over age 50 …

This early-phase study tests a new form of curcumin (the active ingredient in turmeric) that is wrapped in tiny fat particles to help the body absorb it better. The goal is to find the safest dose for people with multiple myeloma that has come back or stopped responding to standa…

This early-phase trial is testing a new cell therapy called TBI-2001 for people with certain blood cancers (B-cell lymphoma, CLL, SLL) that have come back or not responded to at least two prior treatments. The therapy uses a patient's own immune cells, modified to recognize and a…

This study tests whether a combination of two drugs, zanubrutinib and tislelizumab, along with standard care, can help people with large B-cell lymphoma whose cancer got worse after CAR-T cell therapy. About 76 adults will take part. The goal is to see if the treatment can shrink…

This study is testing a new way to give radiation for high-risk prostate cancer that has not spread. One hundred men will receive a shorter, stronger radiation boost to the prostate along with standard pelvic radiation. The goal is to see if this approach is safe and does not cau…

This study is for people with high-risk melanoma who have tiny bits of tumor DNA still in their blood after surgery. It compares a two-drug immunotherapy combo against a single drug to see which better clears these hidden cancer cells. About 54 participants will be randomly assig…

This study looks at men whose prostate cancer has spread to a few spots in the body (oligometastatic). It compares standard radiation and hormone therapy alone versus adding the drug abiraterone for 8-9 months. The goal is to see if the extra drug improves quality of life and del…

This phase 2 trial tests an experimental oral drug called ABSK043 in about 20 people with rare sarcomas (intimal sarcoma, head/neck angiosarcoma, or EHE). The drug blocks PD-L1, which may help the immune system recognize and kill cancer cells. The main goal is to see if tumors sh…

This study compares a precise radiation technique called SABR against standard treatments (like heat probes or chemo injections) for early-stage liver cancer. About 218 adults with a single tumor up to 8 cm will be randomly assigned to SABR or standard care. The main goal is to s…

This study is testing a non-invasive radiation treatment called SABR for people with kidney tumors who are not good candidates for surgery. The goal is to control the tumor while keeping the kidneys working well. About 90 participants will receive high-dose radiation and be follo…

This study tests a laser treatment guided by MRI to destroy early-stage prostate cancer in men aged 40-80 with low to intermediate risk. The goal is to control the cancer and avoid more aggressive treatments like surgery or radiation. Researchers will check results with follow-up…

This study tests a new way to give radiation for abdominal cancer. By having patients hold their breath at different points (inhale and exhale) during treatment, doctors aim to deliver a higher dose to the tumor while protecting nearby healthy organs. The study will enroll 15 adu…

This study tests whether a 1-week course of partial breast radiation is safe and effective for women who have had a breast cancer recurrence after prior whole-breast radiation. Participants will receive targeted radiation after breast-conserving surgery to remove the new tumor. T…

This study tests a precise radiation treatment (MR-guided high-dose-rate brachytherapy) for men whose prostate cancer has returned in the prostate bed after previous radiotherapy. About 20 participants will receive this targeted therapy to see if it can control the cancer with ac…

This pilot study is testing whether a 12-week combination of two common diabetes drugs—dapagliflozin (Farxiga) and semaglutide (Ozempic)—is safe and helpful for people who have received a kidney transplant. The 20 participants will take both drugs and be monitored for changes in …

This study tests whether a daily 25 mg dose of empagliflozin (a diabetes drug) is safe and helps preserve remaining kidney function in 20 adults on peritoneal dialysis. Participants must still produce at least 250 mL of urine daily. The trial measures changes in kidney filtration…

This phase 2 trial tests a new drug, GSK5764227, that delivers chemotherapy directly to cancer cells, either alone or with an immunotherapy called dostarlimab. The study enrolls 30 people with recurrent or metastatic head and neck cancer. Researchers will analyze tumor samples an…

This study tests a technique called in vivo lung perfusion (IVLP), where chemotherapy is delivered directly into one lung during surgery to remove lung tumors. The goal is to kill any remaining cancer cells while reducing side effects on the rest of the body. About 10 adults with…

This study tests whether adding belimumab to standard therapy can better control autoimmune hepatitis, a chronic liver disease. About 48 adults with active or stable disease will receive weekly injections for 72 weeks. The goal is to reduce liver inflammation and lower the need f…

This study tests a new way to treat diffuse large B-cell lymphoma (DLBCL) by using PET scans and blood DNA tests early in treatment to decide the best next steps. About 40 adults with untreated DLBCL will start standard chemo, then get either shorter chemo if tests show low risk,…

This phase 2 trial is testing whether high-dose radiation therapy, given after initial chemotherapy, can improve outcomes for people with locally advanced pancreatic cancer. About 43 participants whose tumors responded to chemotherapy will receive targeted radiation. Researchers …

This study tests a smarter way to give radiation to men whose prostate cancer has come back after surgery. Using advanced scans, doctors will give higher radiation doses to the spots where cancer is active and lower doses to healthy areas. The goal is to control the cancer while …

This trial tests whether giving radiation every other day (5 sessions total) is as safe as the standard daily schedule (20 sessions) for men who have had prostate cancer surgery. The study involves 204 participants across multiple centers. The main goal is to see if the shorter s…

This study tests a new type of radiation therapy for men with prostate cancer that has spread to lymph nodes in the abdomen or pelvis. The treatment uses daily CT scans to adjust the radiation beam precisely to the tumor and nearby at-risk areas. The goal is to control the cancer…

This early-stage study tests the safety of combining the drug talazoparib with low-dose chest radiation in people with extensive-stage small cell lung cancer that has not worsened after initial chemotherapy. About 24 participants will receive talazoparib pills daily during radiat…

This study tests whether a single, extremely high dose of radiation, guided by advanced MRI technology, can control liver tumors that have spread from other cancers better than the usual high dose. About 114 adults with up to 3 liver metastases will be randomly assigned to receiv…

This phase 2 study is testing stereotactic body radiation therapy (SBRT) for people with non-small cell lung cancer or other cancers that have spread to the lung. Instead of daily radiation for weeks, participants receive high doses in just 3 to 10 sessions over 1 to 2 weeks. The…

This study tests a single, precise dose of radiation to the heart to treat dangerous arrhythmias in 60 patients who haven't improved with medication or standard procedures. Researchers will monitor changes in heart rhythm events and medication use over 18 months. The goal is to s…

This study is for people with metastatic melanoma whose cancer has started growing in a few spots despite treatment. Researchers want to see if giving high-dose, precise radiation to those spots can delay further spread. About 52 adults will take part, and the main goal is to see…

This phase 2 study tests a drug called AZD2936 in people with high-risk head and neck cancer who still have traces of cancer DNA in their blood after completing standard treatment. The drug is designed to boost the immune system to find and destroy these remaining cancer cells. A…

This small pilot study tests whether implanting electrodes in the cerebellum—a brain area that controls coordination—can safely improve walking and balance in people with severe ataxia that hasn't responded to other treatments. Twelve adults aged 20 to 70 with primary ataxia will…

This study tests whether adding letermovir to standard antiviral treatment helps clear cytomegalovirus (CMV) infection faster in people who have received a lung transplant. About 40 participants will receive either letermovir or a placebo alongside their usual medication for 21 d…

This study tests whether giving iron through a vein (IV) after heart surgery helps people with iron-deficiency anemia recover better. About 60 adults having planned open-heart surgery will receive either IV iron or a placebo. The goal is to see if this treatment is practical and …

This study tests a new, less invasive way to treat intermediate-risk prostate cancer using a laser guided by micro-ultrasound. The goal is to see if the procedure is safe and can delay or avoid the need for more aggressive treatments like surgery or radiation. Seven men aged 40-8…

This study compares cold-stored platelets to standard room-temperature platelets for controlling bleeding in adults after heart surgery. About 150 patients will be randomly assigned to receive one type. The goal is to see if cold storage is a safe and effective option, and to pla…

This study tests whether combining two drugs, venetoclax and azacitidine, is safe and effective for people with a rare, advanced blood cancer called myeloproliferative neoplasm (MPN) that has worsened. About 40 participants will receive the combination therapy. The goal is to see…

This study looks at whether a simple blood test that finds cancer DNA can help doctors decide who needs extra treatment after lung cancer surgery. About 66 people who had their lung cancer removed will either get chemo-immunotherapy or just be watched. The goal is to see if the b…

This study tests whether robotic surgery can be the first treatment for stage IIA/B testicular seminoma, instead of chemotherapy or radiation. The surgery removes lymph nodes in the abdomen using a robot. The goal is to see if it prevents cancer from coming back. The trial will e…

This study offers people with advanced or rare cancers a personalized treatment plan based on their tumor's genetic profile. Each participant receives a unique therapy chosen by a team of experts. The goal is to see if these tailored treatments can shrink tumors and help more pat…

This study tests whether teclistamab, a drug for relapsed or refractory multiple myeloma, can be given safely outside the hospital. It involves 15 patients who have tried at least 3 prior treatments. The goal is to develop a clear process for outpatient care and measure how this …

This study is for adults with a type of blood cancer called diffuse large B-cell lymphoma (DLBCL) that has come back or not responded to treatment. Researchers want to find the safest and most effective way to prepare the body before giving standard CAR T cell therapy. They are t…

This study is testing whether combining internet-based cognitive behavioural therapy (i-CBT) with intravenous ketamine can quickly reduce suicidal thoughts and behaviors in people with treatment-resistant depression. All 110 participants will receive weekly i-CBT for 13 weeks, an…

This study tests a drug called cabozantinib in 20 adults whose liver cancer returned after a liver transplant. The goal is to see if the drug can control the cancer. Participants take the drug until it stops working or side effects become too bothersome.

This early-phase study tests a technique called in vivo lung perfusion (IVLP) that delivers chemotherapy directly into the lung during surgery to remove sarcoma tumors that have spread to the lungs. The goal is to kill any tiny cancer cells left behind that could cause the cancer…

This study tests whether a six-month program of supervised exercise, heart risk management, and online support can improve heart and lung fitness in young cancer survivors (ages 18-45) who have mild heart dysfunction. About 336 participants across Canada will be randomly assigned…

This study tests whether lungs from donors with hepatitis B can be safely given to people who do not have hepatitis B. The donated lungs are treated with UV light during a special preservation process, and recipients receive antiviral drugs and antibodies to prevent infection. Tw…

This phase 2 trial tests tarlatamab, a drug that helps immune cells attack tumor cells, in 44 adults with recurrent IDH-mutant gliomas (a type of brain tumor). The study aims to see if tarlatamab can increase immune cell activity in the tumor and potentially control the disease. …

This phase 2 trial tests whether giving focused radiation (SBRT) to a few growing prostate cancer spots, while staying on current therapy, can control the cancer better than switching to a new systemic therapy. About 75 men with castration-resistant prostate cancer that has a lim…

This study tests whether a special CT scan with contrast dye can give clearer images of tumors during radiation therapy. Twenty adults with advanced cancer will receive the extra scan alongside their standard treatment. The goal is to see if this approach is feasible and improves…

This study is testing whether a special type of PET/MRI scan, using a tracer called FAZA, can measure low oxygen levels (hypoxia) in tumors of patients with metastasized gastro-oesophageal cancer. The goal is to see if this scan can predict how well patients will respond to stand…

This study is testing whether a minimally invasive procedure called EBUS-TBNA is more accurate than standard CT/PET scans for checking if lung cancer has spread to lymph nodes in the chest. The goal is to better select patients for a precise type of radiation therapy (SBRT). Abou…

This study tests two different needles used during a lung ultrasound procedure to collect tissue samples from swollen lymph nodes. The goal is to see which needle gives better samples for diagnosing sarcoidosis, a disease that causes inflammation. About 128 adults with suspected …

This study is testing two new ways to find breast cancer in women at high risk: a blood test that looks for tumor DNA and a special mammogram that uses a low-dose radioactive tracer. About 100 women who already need a biopsy will get both tests first. The goal is to see if these …

This study is testing a new, smaller and mobile PET scanner called the Radialis PET Imager (RPI) to see if it can produce brain images as good as standard PET scanners for detecting amyloid plaques—a hallmark of Alzheimer's disease. Researchers will enroll 160 adults with cogniti…

This first-in-human trial is testing whether tiny particles called porphysomes can safely improve PET/CT imaging for women with advanced gynecological cancers. The study will enroll 24 participants to find the best dose and check for side effects. It is not a treatment, but a way…

This study tests whether a green dye called indocyanine green (ICG) can accurately find cancer that has spread to lymph nodes in breast cancer patients who have already had chemotherapy. About 100 adults will receive the dye along with standard methods during surgery. The goal is…

This study is testing a new blood test that looks for DNA fragments from tumors in people with hereditary cancer syndromes like Lynch syndrome or BRCA mutations. The goal is to see if the test can find cancers earlier than standard screening methods. Researchers will compare canc…

This large Phase 3 trial tests whether giving lidocaine (a numbing medicine) through an IV during breast cancer surgery can prevent persistent pain that often follows. Over 1,600 adults having lumpectomy or mastectomy will be randomly assigned to receive lidocaine or a placebo. T…

This study tests whether taking vitamin C around the time of knee replacement surgery can reduce long-term pain. About 400 adults having knee replacement will be randomly assigned to receive vitamin C or a placebo for 8 weeks. The main goal is to see if a larger study is possible…

This phase II trial tests whether a single high dose of psilocybin, given alongside specialized therapy, can help reduce distress in caregivers of people with advanced cancer. Fifteen caregivers in Ontario will receive the drug and be monitored for safety, feasibility, and change…

This study tests whether daily cannabis extracts (CBD or THC) can reduce pain interference in people with hip or knee osteoarthritis. One hundred adults aged 40-80 will take either CBD, THC, or a placebo capsule daily for 8 weeks and track their symptoms remotely. The goal is to …

This pilot study tests whether a new, faster radiation planning method can safely ease severe abdominal pain caused by advanced cancer. Instead of a separate planning session, doctors use existing scans to create a treatment plan on the spot. Only 5 people will take part, and the…

This study tests if a nerve block injection in the neck can reduce long-COVID symptoms like fatigue, brain fog, and heart palpitations. About 78 adults with post-COVID condition will get either the real block or a fake injection to see if it helps. The goal is to find a safe, eff…

This study tests whether a one-time high-dose intravenous ketamine infusion can reduce the number and intensity of headaches in people with chronic daily headaches. About 56 adults will receive either ketamine or a placebo (saline) and be followed for three months. The goal is to…

This study tests whether a 10-week virtual exercise program can reduce nerve pain and improve daily activities in cancer survivors who have persistent nerve damage from chemotherapy. About 240 participants will either receive the program or usual care. The program includes person…

This study tests if a newer, more precise type of radiation (adaptive SBRT) can cause fewer urinary problems than standard radiation for men with localized prostate cancer. About 320 men will be randomly assigned to one of the two radiation methods. The goal is to see if the newe…

This study looks at whether starting speech and swallowing therapy early — before and just after surgery — can help people with head and neck cancer recover better. Forty patients will either get early therapy sessions with a speech-language pathologist or the usual care. The mai…

This pilot study tests whether participating in the Lullaby Project—where pregnant women with epilepsy work with musicians to create a personal lullaby—can improve their quality of life and reduce anxiety, depression, and stress. Thirty first-time pregnant women with epilepsy wil…

This study tests whether putting tranexamic acid (a medicine that helps blood clot) into the surgical wound before closing it can reduce pain and the need for painkillers after wrist fracture surgery. About 90 adults having surgery for a broken wrist will be randomly assigned to …

This study tests a digital app that connects young adults (ages 18-40) who have finished treatment for lymphoma, breast cancer, testicular cancer, or sarcoma. The app pairs them with trained peer navigators to help with challenges like symptoms, school, work, and relationships. R…

This study tests a program called the Transitional Pain Service Program for adults who have chronic pain and take opioids before surgery. The program includes pain education, therapy, and a mobile app to help patients manage pain and safely reduce opioid use. Researchers will com…

This trial compares two ways to educate breast cancer patients before radiotherapy: a standard phone call versus a videoconference with a radiation therapist. The goal is to see if seeing a face on screen reduces patients' fears and anxiety more than a voice on the phone. About 1…

This study compares two approaches to early palliative care for people with advanced cancer. In one group, everyone gets a referral to palliative care. In the other, referrals happen only when patients report moderate-to-severe symptoms through an online screening tool. The goal …

This study tests whether doing special breathing exercises (inspiratory muscle training) before a lung transplant can help people recover more quickly after surgery. Researchers will enroll 90 adults with lung disease who are waiting for a transplant. The goal is to see if these …

This study follows 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep issues, anxiety, depression, or epilepsy. Researchers will track changes in symptoms using standard questionnaires over 24 weeks. The goal is to see how well medical cannabis work…

This study is for men with prostate cancer that has spread to other parts of the body. It compares two different schedules of radiation to the prostate: one given every other day for 2 weeks, and another given once a week for 6 weeks. The goal is to see if the shorter schedule ca…

This pilot study tests whether a mild electrical stimulation applied to the spinal cord, combined with balance training, can improve stability and reduce fall risk in people who had a stroke over a year ago. Sixteen community-dwelling adults will be randomly assigned to receive e…

This study tests whether adding mild electrical stimulation to leg muscles or the spinal cord during balance exercises can improve mobility and reduce falls in people with multiple sclerosis (MS). Up to 24 participants will be randomly assigned to balance training alone, with fun…

This phase II trial tests whether daily adaptive radiotherapy (DART) can better protect the submandibular glands during head and neck cancer treatment compared to standard image-guided radiation. About 50 participants will be randomly assigned to receive either standard or adapti…

This phase 3 trial compares lattice radiation therapy (LRT) to standard radiation for reducing pain from large solid tumors (at least 5 cm). About 148 adults whose tumors cannot be surgically removed will be randomly assigned to one of the two radiation approaches. The main goal …

This study tests if hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can ease lingering symptoms like brain fog and fatigue in people with Long COVID. Researchers will enroll 120 adults who had COVID-19 at least 3 months ago. The goal is to see if this t…

This study tests an 8-week virtual rehab program (CaRE@Home) for adults who finished cancer treatment for breast, colorectal, head and neck cancers, or lymphoma within the last two years. The goal is to see if the program reduces disability and improves physical function, anxiety…

This study tests whether a type of eye training called biofeedback can improve vision and quality of life in people with glaucoma. Glaucoma damages the optic nerve and can cause blind spots. The training teaches patients to move their eyes to use healthier parts of their retina. …

This study tests a new program designed to help people with brain metastases manage thinking and memory problems. About 140 patients will receive different levels of support based on their needs, from educational materials to one-on-one coaching. The goal is to see if the program…

This study compares two methods of using radiofrequency to treat chronic neck pain caused by arthritis in the small joints of the neck. About 72 adults with moderate to severe neck pain for at least 3 months will be randomly assigned to one of two needle techniques. The goal is t…

This study tests whether giving patients a fixed, evidence-based number of opioid pills after hand or forearm surgery leads to fewer unused pills while still controlling pain. About 292 adults having elective outpatient hand surgery at Toronto Western Hospital will be randomly as…

This study looks at whether a nerve block in the back of the head can temporarily relieve severe headaches caused by a spinal fluid leak. About 34 adults with this condition will receive the injection and be monitored for pain changes. The goal is to provide a safe, accessible br…

This study tests whether an artificial intelligence tool can help surgeons perform safer gallbladder removal surgery. About 70 patients having laparoscopic cholecystectomy will be randomly assigned to receive AI guidance or standard care. The goal is to see if AI helps surgeons a…

This small early-stage study tests whether a device that combines augmented reality (AR) with functional electrical stimulation (FES) is safe and usable for people with cervical spinal cord injury. Seven participants will attend 20 one-hour sessions over 10 weeks, using the syste…

This study tests whether injecting a person's own bone marrow cells or a mix of fat cells and platelet-rich plasma into the knee can reduce pain from osteoarthritis. About 148 adults with moderate knee arthritis will receive either the real treatment or a placebo (salt water) inj…

This study tests a short therapy program called CALM (Managing Cancer and Living Meaningfully) for people with advanced ovarian cancer. The goal is to see if it is practical and helpful for reducing stress and improving well-being. Fifty participants will attend 3 to 6 therapy se…

This study tests a talk therapy called EASE for parents whose child has cancer. The goal is to see if it reduces traumatic stress symptoms over six months. About 306 parents will take part, answering questionnaires at several points. The therapy is added to usual care and compare…

This study is testing SHAReClinic, a national virtual clinic that provides sexual health education and counselling to prostate cancer patients and their partners. Researchers will enroll 575 people across Canada to see if the program improves sexual function, reduces distress, an…

This study looks at whether adding early palliative care to standard treatment helps people with multiple myeloma or aggressive B-cell lymphoma feel better. About 144 patients and their caregivers will be randomly assigned to receive either usual care alone or usual care plus ear…

This study follows 104 breast cancer patients whose cancer has spread to the chest wall and who are having surgery to remove part of the chest wall. The goal is to see how the surgery affects their quality of life, pain, and survival. Researchers will track these outcomes over ti…

This study tests a device called Hi-OxSR that lets people rebreathe a small amount of their own carbon dioxide (CO2) to treat brain fog and fatigue from Long COVID. Researchers think CO2 may calm inflammation in the body. The trial will enroll 120 adults and compare different tre…

This study watches 3000 adults in hospitals worldwide to see what problems happen right after a breathing tube is removed. It looks for issues like very low oxygen, heart stopping, or needing to put the tube back in. The goal is to find better ways to keep patients safe during th…

This study investigates whether fragments of tumor DNA circulating in the blood can be used to detect and monitor soft tissue sarcoma. Researchers will collect blood and tumor tissue samples from 40 adults with high-risk sarcomas to see if this DNA can serve as a biomarker for ca…

This study is testing whether a program that includes virtual pulmonary rehabilitation, integrated care, and remote monitoring using a smartwatch and home spirometer is feasible for people with COPD after a recent flare-up. Researchers will enroll 100 patients and track how many …

This study looks at whether the natural variation in heartbeat timing (heart rate variability) can help doctors decide the right oxygen flow for patients with respiratory failure who are on a high-flow nasal cannula. Researchers will gradually lower the oxygen flow and monitor he…

This study looks at 100 people with advanced solid tumors whose cancer stopped responding to immunotherapy. Researchers will take a fresh tumor sample and blood tests to compare genetic and immune differences between those who never responded and those who initially improved but …

This study is trying to figure out what counts as a meaningful improvement in pain after major orthopedic surgeries like hip, knee, shoulder, or spine procedures. Researchers will ask 300 adults to rate their pain and recovery before and after surgery. The goal is to set clear be…

This pilot study is testing whether fecal microbiota transplantation (FMT) — giving processed stool from a healthy donor via enema — is safe and doable in 20 patients with lymphoma or leukemia who are receiving CAR-T therapy or stem cell transplants. The goal is to see if at leas…

This study is collecting detailed genetic and health information from 500 people with various cancers, including breast, lung, and leukemia. The goal is to create a shared database that helps researchers develop more personalized treatments. Participants provide samples and data,…

This study tests whether a new type of PET/MR scan using a tracer called FAZA can measure oxygen levels in leg tissues of people with critical limb ischemia, a severe form of peripheral artery disease. About 40 adults who are scheduled for a procedure to restore blood flow will g…

This study is testing whether a liquid biopsy (a blood test that looks for cancer DNA) can find tiny amounts of leftover cancer in people who have had surgery for early-stage non-small cell lung cancer. The goal is to see if this test can predict which patients might have their c…

This study is collecting stool and blood samples from 120 advanced cancer patients receiving immunotherapy combinations. Researchers want to see if the types of bacteria in the gut and certain immune markers can predict which patients will develop serious side effects. The goal i…

This study looks at how T cells (a type of immune cell) respond to liver cancer and cancers linked to Epstein-Barr virus (EBV) and human papillomavirus (HPV). About 105 participants will give blood and tissue samples once. Researchers will analyze these samples to identify cancer…

This study aims to collect and analyze tumor samples from 10,000 adults with advanced solid cancers (like breast, lung, or colon cancer) to create a province-wide gene database. The goal is to help doctors identify which targeted drugs or clinical trials might work best for each …

This study is testing whether a mobile phone app can help pregnant women at high risk for preeclampsia in Karachi, Pakistan, monitor their blood pressure and symptoms at home. Fifty women will use the app to send daily readings to their healthcare team, who can then respond if ne…

This study enrolls 7,000 people with various cancers who have had or will have treatment aimed at a cure. Researchers collect blood, tissue, urine, and saliva samples over time to look for tiny bits of cancer DNA left behind. The goal is to find any remaining cancer as early as p…

This study is building a registry of 300 people in Ontario who have had a rare type of thigh bone fracture called an atypical femur fracture. Researchers want to learn more about what causes these fractures, which have been linked to long-term use of osteoporosis drugs called bis…

This study is testing many different treatments for patients with severe breathing problems in the intensive care unit. It will include up to 6,250 participants and looks at various approaches like breathing machine settings, medications, and life support techniques. The goal is …

This study looks at whether a small sample taken from lung cancer patients during a routine biopsy (called EBUS-TBNA) can be used to analyze genes that predict how well treatments like chemotherapy or surgery might work. Researchers plan to enroll 400 adults with confirmed or sus…

This study looks at pregnant women with epilepsy to see how often doctors follow recommended care guidelines. Researchers will track pregnancy, delivery, and baby health, as well as epilepsy control. The goal is to understand if following guidelines leads to better outcomes for b…

This study takes tumor samples from people with triple-negative breast cancer, colorectal cancer, or ovarian cancer and grows them in mice. Researchers then test different drugs on these mouse tumors to see which ones might work best for each person. The goal is to provide person…

This study is testing whether a special type of cardiac MRI can find early signs of heart damage in people with Fabry disease. Researchers will follow 300 adults with Fabry disease over time, using MRI, ECG, and blood tests to see which patients later develop serious heart proble…

This pilot study tests two new technologies—HyperSight CBCT imaging and Ethos adaptive planning—in children receiving radiation for non-brain tumors. Twenty patients aged 18 or under will get extra scans twice a week to see if the radiation plan needs adjusting. The goal is to se…

This study is testing whether a special MRI scan and blood tests can predict if soft-tissue sarcoma will spread to other parts of the body. Researchers will look at markers of low oxygen levels in the tumor and blood. The goal is to help doctors personalize treatment for each pat…

This study explores whether using MRI scans before each radiation treatment is practical and helpful for people with liver or pancreatic cancer. About 30 participants will receive up to 5 extra MRIs alongside their standard radiation therapy. Researchers will measure patient sati…

This phase 2 trial is testing whether CT and MRI scans can act as biomarkers to predict how patients with brain metastases respond to radiation therapy. About 90 adults with brain metastases who are scheduled for radiation will get scans before and after treatment. The goal is to…

This study looks at fluid from the lungs of 70 people with soft-tissue sarcoma that has spread to the lungs. Researchers will check for specific inflammatory markers to see if they can predict how the disease will progress. The goal is to better understand the disease, not to tes…

This study is testing whether a special smart shirt, called Hexoskin, can help monitor side effects in 100 patients receiving palliative radiotherapy for cancer that has spread. The shirt tracks heart rate, breathing, and activity levels. The goal is to see if it's practical to u…

This study is testing whether repeated MRI scans during radiation therapy for head and neck cancer can help doctors see how the tumor is responding. About 173 people with newly diagnosed head and neck cancer will get extra MRI scans during their standard treatment. The goal is to…

This study looks at whether a special PET scan and a blood test for HPV can detect any remaining cervical cancer cells after standard chemoradiation. About 64 people with cervical cancer will be followed after their usual treatment. The goal is to see if these tests can predict i…

This study looks at how head and neck tumors change during treatment using special MRI scans and tissue samples. Sixty adults with newly diagnosed head and neck cancer will take a pill called pimonidazole, which highlights low-oxygen areas in tumors, and undergo repeat imaging. T…

This study is for people with neuroendocrine tumors who are about to receive or have already received peptide receptor radionuclide therapy (PRRT). Researchers want to find out if certain genetic changes in the blood can predict who might later develop myelodysplastic syndrome (M…

This study is testing whether a combined PET-MRI scan can help doctors plan radiation treatment more precisely for people with esophagogastric cancer. Fifteen participants will receive PET-MRI scans before, during, and after radiation therapy. The images will not be used for thei…

This study observes 100 adults with painful spinal metastases to see how doctors choose between two radiation types: standard palliative radiation (CRT) and a more precise, high-dose form (SBRT). Researchers will track pain relief, tumor control, and the reasons behind treatment …

This study is for people newly diagnosed with head and neck squamous cell carcinoma who are scheduled for curative surgery or radiation therapy. Researchers want to see how radiation changes MRI scans and immune-related markers in tumors. About 40 participants will be randomly as…

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse. Researchers will use brain recordings and movement tests to see if the ultra…

This study involves 30 men with advanced prostate cancer who will receive two different PET scans (PSMA and FDG) to see how their tumors behave at different stages and during treatment. The goal is not to treat the cancer directly, but to gather information that could help doctor…

This study looks at two types of spinal cord stimulation for people with long-term nerve pain after back surgery. One type causes a tingling sensation, while newer types do not. Researchers will use brain scans and pain questionnaires to figure out how each type works and which p…

This study is testing a new method for giving muscle relaxants to patients with severe breathing problems who are on a breathing machine. The goal is to see if this approach is safe and possible, and if it helps patients breathe on their own more easily. About 23 adults in the ho…

This study is looking for early signs of heart and lung damage in people receiving radiation for chest cancers. Researchers will use PET/MR scans and blood tests before and after treatment to see if they can predict who will develop problems like pulmonary hypertension. The goal …

This study aims to learn how gene and protein changes in gynecologic tumors affect cancer behavior and treatment response. Researchers will collect tumor tissue and blood samples from 1,000 people with ovarian, uterine, cervical, or other gynecologic cancers. The goal is to bette…

This study collects blood, tumor tissue, and other fluids from people with advanced ovarian cancer to find biological markers (biomarkers). Researchers will analyze these samples to understand why some patients live longer or respond better to treatment. Results may be shared wit…

This study is collecting information from 5,500 Canadian cancer patients whose tumors have rare genetic changes. Researchers want to see how well current targeted drugs work for these uncommon mutations. Participants are observed over time, and their treatment outcomes, side effe…

This study aims to create a large collection of blood samples from 2,500 people with or at high risk for cancer. Researchers will use these samples to study liquid biopsies, which are blood tests that may help detect cancer, track treatment response, and spot recurrence. Particip…

This study is looking for 500 people with early dementia or mild cognitive impairment to help develop a way to predict how their disease will progress. Researchers will use blood tests and other models to better understand each person's outlook. The goal is to give patients and d…

This study looks at how much waste is created during surgeries at Toronto Western Hospital, focusing on anesthesia-related trash. Researchers will sort through waste bins to see what can be recycled or reused, and how much is thrown away incorrectly. They will also test if teachi…