University Health Network, Toronto

This study is testing a new pandemic flu vaccine specifically for people who have had an organ transplant. It will check if the vaccine is safe and if it triggers a strong immune response in these patients, who are at high risk for severe flu. About 120 stable transplant patients…

This study is testing whether a surgical brain stimulation device can help people with severe, untreatable ataxia—a condition that causes unsteady walking and poor coordination. Researchers will implant a 'deep brain stimulation' device in the cerebellum, the brain's coordination…

This study is testing whether the drug tarlatamab can help control the growth of specific types of recurrent brain tumors (gliomas) that have an IDH gene mutation. It will involve about 44 adults whose tumors have returned or stopped responding to prior treatments. The research w…

This study is testing whether a gentle, focused ultrasound beam can safely calm overactive brain areas in people with movement disorders like Parkinson's or essential tremor, and conditions like epilepsy or addiction. Researchers will measure changes in brain activity and symptom…

This pilot study is testing whether platelets (blood cells that help clotting) stored in the cold work as well as standard room-temperature ones to control bleeding in adults undergoing heart surgery. The main goal is to see if a larger future trial is feasible by checking if eno…

This study aims to develop a safe process for giving the drug teclistamab to patients with advanced multiple myeloma in an outpatient or home setting, rather than requiring a hospital stay. It will enroll 15 patients who have tried at least three other treatments, along with thei…

This study is testing whether a shorter, less frequent radiation schedule works as well as the standard daily treatment for controlling prostate cancer after surgery. Researchers will compare side effects and quality of life in men receiving either 5 treatments over 10 days or 20…

This study aims to understand if a major surgery to remove breast cancer that has grown into the chest wall improves patients' quality of life and controls the disease. It will follow 104 patients who undergo this surgery, tracking their pain, daily function, and whether the canc…

This study is for people with high-risk melanoma who have had surgery to remove their cancer. Researchers are testing if a combination of two immunotherapy drugs works better than the current standard single drug at preventing the cancer from returning. They will use a special bl…

This study is testing whether an artificial intelligence (AI) tool can help surgeons perform safer gallbladder removal surgery. The AI provides real-time guidance during the operation to help surgeons see critical anatomy and avoid injuries. Researchers will compare outcomes from…

This study is testing a minimally invasive laser procedure for men with intermediate-risk prostate cancer. Doctors use a special, high-resolution ultrasound to guide a laser that precisely heats and destroys the tumor. The goal is to see if this targeted approach is safe and effe…

This study is testing whether a special breathing exercise program can help people waiting for a lung transplant. The goal is to see if strengthening the breathing muscles before surgery helps patients recover faster afterward, potentially needing less time on a breathing machine…

This early-stage study is testing whether combining an experimental drug called binimetinib with an existing immunotherapy (pembrolizumab) is safe and helpful for people with advanced non-small cell lung cancer. Researchers will first find the safest dose of the combination, then…

This study is testing whether adding focused, high-dose radiation to a small number of spots where melanoma is spreading can help patients stay on their current drug treatments longer. It involves adults with advanced melanoma whose cancer is mostly controlled by immunotherapy or…

This study is testing which of two different drug combinations works better for people with advanced pancreatic cancer that has specific genetic changes (BRCA1, BRCA2, or PALB2 mutations) and has stopped responding to their first treatment. It will compare a newer combination cal…

This study is testing if the drug cabozantinib can help control liver cancer that has come back in people who previously had a liver transplant. The drug works by blocking proteins that help cancer tumors grow. About 20 participants will take the drug until it stops working or si…

This study is testing a shorter, more focused form of radiation therapy for people with lung tumors. It aims to see how well this treatment controls cancer growth and what side effects occur. Participants will receive high-dose radiation over 1-2 weeks instead of the usual severa…

This study is testing if a combination of intravenous ketamine and online cognitive behavioral therapy (i-CBT) can quickly and effectively reduce suicidal thoughts and behaviors in people with treatment-resistant depression. Over 13 weeks, 110 participants will all receive weekly…

This study is testing whether adding a newer antiviral drug (letermovir) to the standard treatment helps clear a common and serious viral infection (CMV) faster in people who have received a lung transplant. The trial will involve 40 participants who have active CMV infection. Re…

This study is testing if a shorter, more intense radiation schedule (every other day for 2 weeks) is as safe as a longer, weekly schedule (6 weeks) for treating the prostate in men whose cancer has spread. It aims to control the disease while comparing side effects and quality of…

This study is testing a new, shorter radiation schedule for women whose breast cancer has returned in a previously treated breast. Instead of the standard 3-5 weeks of treatment, participants receive radiation focused only on the tumor area over just 5 days (one week). The main g…

This study is testing a new way to use muscle-relaxing drugs for patients in the ICU with severe breathing failure who are on a ventilator. Instead of completely paralyzing the patient, doctors aim to use a lower dose to allow some safe, gentle breathing effort. The goal is to se…

This study is testing a non-invasive radiation treatment for people with dangerous heart rhythm problems that don't respond to standard medications or procedures. It aims to see if targeted radiation can reduce the number of painful shocks from a heart device and lower medication…

This study is testing a new, more precise way to deliver radiation when prostate cancer returns after surgery. Using a special scan to pinpoint exactly where the cancer has come back, doctors will give a stronger radiation dose to those spots and a lower dose to healthy areas. Th…

This study is testing an investigational drug called AZD2936 to see if it can clear tiny traces of leftover cancer and prevent the disease from returning. It is for patients with high-risk, locally advanced head and neck cancer who have already finished their main treatment (like…

This early-stage study aims to find a safe dose for combining a drug called talazoparib with low-dose chest radiation. It is for people with extensive-stage small cell lung cancer whose disease has not worsened after initial chemotherapy. The main goal is to see how well patients…

This study is testing whether giving intravenous iron to patients with iron deficiency after heart surgery helps them recover better. It will involve 60 patients across three Canadian hospitals who will receive either the iron treatment or a placebo. The main goal is to see if th…

This small pilot study is testing whether a mild electrical stimulation to the spine, combined with balance training, can help people who have had a stroke improve their stability and reduce their risk of falling. The study will compare the effects of real stimulation versus a sh…

This study is testing whether a more precise, adaptive form of radiation therapy causes fewer urinary side effects than standard radiation, while still effectively treating localized prostate cancer. It will involve 320 men who are eligible for a short, high-dose radiation treatm…

This study is testing a personalized approach to radiation therapy for anal cancer. Doctors will use MRI scans during treatment to guide radiation and adjust the dose based on each patient's specific risk level. The goal is to better control the cancer while trying to reduce side…

This international study is testing if a single, very high dose of precisely targeted radiation is better than a standard high dose for treating tumors that have spread to the liver from other cancers. It will involve 114 patients and uses advanced MRI-guided technology to delive…

This trial is testing whether injections made from a patient's own bone marrow or processed fat tissue can help control knee osteoarthritis better than a placebo injection. About 148 adults with moderate knee pain and arthritis will receive one of the two experimental treatments …

This study is testing a targeted treatment called NanoKnife for men with intermediate-risk prostate cancer. It uses electrical pulses to kill cancer cells in the prostate while trying to avoid damaging nearby healthy tissue, which could help preserve urinary and sexual function. …

This early-stage study aims to find the best way to prepare a patient's body before they receive a powerful cell therapy called CAR-T. Researchers are testing different combinations of chemotherapy and low-dose radiation in about 40 adults with a type of aggressive lymphoma that …

This study is testing if using precise, high-dose radiation on a few spreading cancer spots can control advanced prostate cancer better than the current standard, which is to switch medications. It will compare keeping patients on their current drugs while adding radiation agains…

This study is testing a new method to safely use lungs from donors who have Hepatitis B for patients who need a lung transplant but don't have the virus. Doctors will clean the donor lungs outside the body using a special UV light treatment, then give the transplant recipient ant…

This early-stage study is testing a new technique called In Vivo Lung Perfusion (IVLP) for people with bone or soft tissue sarcoma that has spread to both lungs. During surgery to remove visible tumors, doctors will deliver chemotherapy directly to one lung for 3 hours to try to …

This study is testing a less invasive robotic surgery as the first treatment for testicular cancer that has spread to nearby lymph nodes. It aims to see if this approach can effectively control the cancer while allowing patients to potentially avoid chemotherapy and radiation, wh…

This study is testing a special 6-month heart health program for young cancer survivors who are at risk for heart problems due to their past cancer treatments. The program combines supervised and home-based exercise with lifestyle coaching and is compared against standard advice.…

This study is testing a new approach for people with early-stage lung cancer who have had surgery. Researchers are using a special blood test to look for tiny traces of leftover cancer. If the test finds these traces, patients receive a combination of chemotherapy and immunothera…

This study aims to find out if cancer survivors can safely stop taking heart failure medications after their heart function has returned to normal following cancer treatment side effects. Researchers will compare two groups: one that continues medications and one that stops them,…

This study aims to see if custom, precision treatments can help control advanced cancer in patients who have exhausted all standard options. It will enroll 400 participants. Doctors will use each patient's unique tumor genetics to design a personalized treatment plan, then track …

This study is testing whether adding a drug called belimumab to standard treatment helps people with autoimmune hepatitis, a chronic liver disease. It aims to see if the combination can better control the disease and allow patients to reduce their use of steroid medications, whic…

This study is testing whether a combination of two drugs, venetoclax and azacitidine, is safe and effective for people with advanced forms of a rare blood cancer called myeloproliferative neoplasm. The trial will enroll about 40 participants to see if the treatment can put the di…

This large, ongoing trial is testing many different new treatments for patients with severe, life-threatening lung failure. It aims to find better ways to help patients breathe, improve survival, and reduce long-term harm from breathing machines. The study will test new drugs, di…

This study is testing an experimental oral drug, ABSK043, in about 20 adults with advanced forms of a rare cancer called angiogenic sarcoma. The drug works by blocking a protein that can hide cancer cells from the immune system, potentially helping the body fight the cancer. The …

This study is testing a new blood test designed to find cancer early in people who have a high inherited risk for certain cancers. Researchers will compare how well the new blood test works against standard screening methods to see if it can detect cancer earlier. The study also …

This study is testing a new, smaller, and more portable type of brain scanner called the Radialis PET Imager. Researchers want to see if it can detect the amyloid plaques linked to Alzheimer's disease as accurately as the standard, larger PET scanners currently in use. The goal i…

This study is testing whether a special green dye that glows under a camera can find lymph nodes as accurately as the current standard method in breast cancer patients who have had chemotherapy first. During surgery, doctors will use both the new glowing dye and the standard meth…

This study is testing a vaccine to prevent serious Respiratory Syncytial Virus (RSV) infections in adults who have received a lung or stem cell transplant. These patients have weakened immune systems and are at high risk from viruses like RSV. Researchers will give 100 participan…

This large international study is testing if giving an intravenous drug called lidocaine during breast cancer surgery can prevent patients from developing long-lasting pain months later. Over 1,600 patients will be randomly assigned to receive either the lidocaine infusion or a p…

This study aims to find out which of two radiofrequency needle techniques works better for reducing chronic neck pain caused by arthritis in the neck joints. Researchers will compare a standard straight needle approach with a newer three-pronged needle approach in 72 adults with …

This study aims to see if using a standard, evidence-based prescription for pain pills after hand or forearm surgery can reduce the number of leftover opioid pills in the community while still providing good pain relief. Researchers will compare this standard prescription to the …

This study is testing whether a special therapy program called EASE can help parents of children recently diagnosed with cancer cope with traumatic stress. Researchers will compare parents who receive the EASE program plus usual care against those who receive only usual care. The…

This study is evaluating a national online program called SHAReClinic, designed to support sexual health and intimacy for prostate cancer patients and their partners after treatment. It aims to see if this virtual clinic improves sexual function, reduces distress, and strengthens…

This study is testing if adding early palliative (comfort) care to standard cancer treatment improves well-being for patients with multiple myeloma or aggressive lymphoma. It will involve 144 patients, and some of their caregivers, who will be randomly assigned to receive either …

This study is testing whether daily capsules containing cannabis compounds (CBD or THC) can help manage pain from hip or knee osteoarthritis. One hundred participants will take either CBD, THC, or a placebo pill for eight weeks and track their pain. The main goal is to see if a l…

This study is testing whether a special type of supportive talk therapy, called CALM, is practical and helpful for people dealing with the emotional stress of a new or returning advanced ovarian cancer diagnosis. It will involve about 50 participants who will answer questionnaire…

This study is testing whether a more precise, daily-adjusted radiation therapy can better protect the saliva glands during head and neck cancer treatment. It aims to reduce the severe dry mouth that is a common and debilitating side effect. About 50 patients will be randomly assi…

This study is testing a new support program designed to help adults with brain metastases manage the thinking and memory problems that often come with their condition. The program screens patients for these issues and offers different levels of support, from educational materials…

This study is testing whether breathing pure oxygen in a special pressurized chamber (hyperbaric oxygen therapy) can help improve thinking problems like 'brain fog' in people with Long COVID. Researchers will enroll 120 adults who have had COVID-19 symptoms for at least 3 months …

This study is testing whether adding gentle electrical stimulation to balance training can help people with Multiple Sclerosis (MS) walk better and feel more steady. Up to 24 participants will be randomly assigned to do balance games with or without electrical pulses to their leg…

This study is testing whether a special breathing device called Hi-OxSR can help reduce symptoms of Long COVID, especially brain fog and fatigue. The device works by having participants re-breathe a small amount of carbon dioxide, which may calm an overactive immune system. Resea…

This study is testing whether a new radiation technique called lattice therapy reduces pain better than standard radiation for people with large tumors. It will enroll 148 adults with solid tumors measuring 5cm or larger who need pain relief. Researchers will compare if more pati…

This study is testing whether a special eye training program can help people with glaucoma use their remaining vision more effectively. 70 participants will be randomly assigned to either receive the training or be in a control group. The training uses visual and audio feedback t…

This study is testing if a simple nerve block injection can temporarily relieve the severe, position-related headaches caused by spontaneous intracranial hypotension (a spinal fluid leak). Researchers will give the injection to 34 patients and measure how much their headache pain…

This early-stage study is testing whether a new rehabilitation system is safe and practical for people with neck spinal cord injuries. The system combines augmented reality glasses with gentle electrical stimulation to help participants practice hand and arm movements. The main g…

This study is testing an 8-week online rehabilitation program designed to help cancer survivors manage long-term side effects and improve their daily function. Researchers will compare the virtual program to usual care for 388 adults who have finished primary cancer treatment but…

This study is testing if a single, high-dose intravenous (IV) ketamine infusion can reduce the frequency and severity of chronic daily headaches. About 56 participants will be randomly assigned to receive either the ketamine infusion or a saline (placebo) infusion. Researchers wi…

This study aims to create a large collection of blood samples from cancer patients and people at high risk for cancer. Researchers will use these samples to build a research library for future studies on 'liquid biopsies'—blood tests that can detect cancer DNA. The goal is to hel…

This study aims to find biological markers in blood and tissue samples from patients with advanced ovarian cancer. Researchers will collect samples from 510 participants to identify patterns that might predict how patients respond to treatments and how long they survive. The find…

This study is testing whether special brain scans (MRI and CT) taken before and after radiation treatment can predict how well patients with brain metastases will respond. Researchers want to see if changes visible on these scans can help doctors choose the best treatment approac…

This study aims to learn more about the genetic and immune system changes in gynecologic cancers like ovarian, uterine, and cervical cancer. Researchers will collect tumor tissue and blood samples from up to 1000 patients to analyze these changes. The goal is to understand how th…

This study is testing whether using MRI scans right before each radiation treatment session is practical and can provide useful information. It involves 30 adults with liver or pancreatic cancer who will get up to 5 MRI scans during their radiation therapy. The main goal is to se…

This study aims to find out if a blood test for HPV and a special PET scan can better detect leftover cervical cancer cells after a patient finishes standard treatment. It involves 64 women with cervical cancer who are receiving standard chemotherapy and radiation. The goal is to…

This study aims to find markers in lung fluid that can predict how soft-tissue sarcoma spreads to the lungs. Researchers will collect fluid and tissue samples from about 70 adults with sarcoma who are already scheduled for lung surgery as part of their standard care. The goal is …

This study aims to find better ways to predict if a type of cancer called soft-tissue sarcoma will spread to other parts of the body. Researchers will use a special type of MRI scan and blood tests to look for signs linked to cancer spread in 145 adult patients. The goal is to ga…

This study aims to understand how different types of spinal cord stimulation (some with a tingling sensation, some without) relieve chronic nerve pain. Researchers will use brain scans and pain tracking in 90 patients to learn how these treatments work in the body and to identify…

This study aims to understand if a targeted radiation therapy for neuroendocrine tumors (PRRT) increases the risk of patients later developing serious blood cancers like myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Researchers will collect and analyze blood sam…

This study aims to understand how much waste is created by anesthesia teams during surgery and what can be done about it. Researchers will first measure the trash from 60 surgical cases, then run an education program for staff on reducing, reusing, and recycling. Finally, they wi…

This study is testing whether cancer patients receiving palliative radiation therapy can wear a special smart shirt to monitor their health. Researchers want to see if the shirt can help detect treatment side effects earlier by tracking things like heart rate, breathing, and acti…

This study aims to understand how cancer doctors decide between two different radiation treatments for patients whose cancer has spread to the spine. Researchers will observe 100 adult patients receiving either standard radiation or a more focused type called SBRT. By tracking pa…

This is the first-ever study in people testing a new imaging agent made of tiny particles called porphysomes. The goal is to see if these particles can safely travel through the body and light up where advanced gynecological cancers have spread, using a PET/CT scan. The study wil…

This study aims to use repeated MRI scans to better understand how head and neck cancer tumors respond to radiation therapy. Researchers will scan patients during their treatment to see if changes in the tumor can predict outcomes. The goal is to gather information that could hel…

This study aims to understand how often and why serious problems occur when doctors remove a patient's breathing tube after surgery or a stay in intensive care. It will observe 3,000 adult patients worldwide to track complications like severe drops in oxygen or cardiac arrest. Th…

This study aims to better understand head and neck cancer by comparing MRI scan images with actual tumor tissue samples taken during treatment. Researchers will follow 60 patients receiving either radiation or surgery, collecting multiple scans and biopsies to see how the cancer …

This study aims to gather real-world information from 5,500 Canadian adults with cancer who have uncommon genetic changes in their tumors. It will track their health journeys, treatments, and quality of life to understand how different therapies work for these specific genetic pr…

This study aims to create a better prediction model for how memory and thinking problems worsen over time in people with early dementia or mild cognitive impairment. Researchers will collect blood samples, perform brain scans, conduct memory tests, and gather information from clo…

This study aims to understand how the timing of radiation therapy affects head and neck cancer tumors. Researchers will enroll 40 patients and randomly assign them to receive standard radiation or a schedule where some areas are treated later. The main goal is to see if delaying …

This study aims to learn more about advanced prostate cancer by using two different types of PET scans on the same patients. Researchers want to see how the cancer looks at different stages and during treatment. This information could help doctors choose better treatments and mon…

This study aims to find better ways to predict which cancer patients might develop heart or lung problems after receiving radiation therapy to the chest. Researchers will use a special combined PET/MRI scan and blood tests to look for early signs of damage in 40 adult patients. T…