University Health Network, Toronto

This study tests whether precisely targeted radiation (SBRT) can stop or slow the growth of a few resistant spots in metastatic lung cancer patients who are already on targeted therapy (TKI). About 60 adults with EGFR or ALK mutations will receive radiation to those spots, and do…

This study investigates whether adding isunakinra, a modified protein that blocks inflammation, can make triple-negative breast cancer more sensitive to standard immunotherapy and chemotherapy. The trial enrolls adults with newly diagnosed, locally advanced triple-negative breast…

About one in four older adults experiences confusion (delirium) after cardiac surgery, which can lead to longer hospital stays and higher risks. This pilot study tests whether using a brain-monitoring device to personalize blood pressure during surgery can help prevent delirium. …

This study tests a new drug called samuraciclib added to standard chemotherapy for people with a specific type of advanced pancreatic cancer (basal-like). The goal is to find the safest dose and see if the combination helps shrink tumors or slow the cancer. About 67 adults with n…

This study tests whether tamoxifen, a drug commonly used for breast cancer, can speed up testosterone recovery in men with prostate cancer who have completed hormone therapy (ADT). Many men experience low testosterone for months or years after stopping ADT, causing fatigue, depre…

This phase 2 trial tests asciminib, a newer targeted drug, alone or with dasatinib, in 45 adults with chronic myeloid leukemia (CML) whose first treatment stopped working. The goal is to see if this approach can reduce cancer cells to very low levels within 24 weeks. Patients wit…

This study tests a personalized radiation approach for men whose prostate cancer has returned after surgery. Using PSMA PET scans, doctors will give higher radiation doses to active cancer spots and lower doses to healthy areas, all in just 5 treatments over two weeks. The goal i…

This early-stage trial tests whether treating a donor kidney with a drug called SYN002 before transplant can safely reduce the risk of passing cytomegalovirus (CMV) to the recipient. About 12 adults waiting for a kidney transplant will receive a treated organ. The main goal is to…

This phase 2 trial tests whether adding evofosfamide to standard hormone therapy can help men with castration-resistant prostate cancer that has spread. The drug targets low-oxygen areas in tumors. 35 participants will receive the drug combination and be monitored for PSA respons…

This early-phase trial tests a new drug called BOLD-100 combined with standard chemotherapy (doxorubicin) in 32 people with advanced soft tissue sarcomas that cannot be removed by surgery or have spread. The goal is to find the safest dose and see if the combination can shrink tu…

This pilot study is testing whether a special PET/MRI scan using a radioactive tracer called 68Ga-PSMA-11 can better identify all areas of significant prostate cancer in men with localized disease. The goal is to improve selection for focal therapy, a treatment that targets only …

This study asks whether sitting upright during radiation therapy feels better than the standard lying-down position. People receiving radiation therapy, along with their caregivers, will try both positions and share their comfort levels and preferences. The goal is to see if upri…

This study tests whether an 8-week virtual wellness program is practical and helpful for unpaid caregivers of people with advanced heart or lung disease. The program includes personalized exercise, nutrition advice, and stress management, all delivered at home with professional s…

This study tests whether a newer form of spinal cord stimulation (paresthesia-free SCS) actually reduces chronic pain or if its benefits are just a placebo effect. Ninety adults with severe neuropathic pain will receive both active and placebo stimulation for six weeks each, with…

This study is testing a program called Care and Connect, where trained volunteers provide support and information to people with lung cancer. The goal is to see if this program helps reduce distress and makes it easier for patients to get the care they need. About 50 adults with …

This phase III trial tests a therapy called CALM-TF for women with advanced ovarian cancer who experience traumatic stress. 300 participants will either receive 3-6 sessions of this trauma-focused therapy or standard care. Researchers will measure stress, depression, and quality …

This study looks at whether diaphragm ultrasound gives consistent results when performed by different anesthesiologists. Two doctors will each scan the diaphragm using three different methods, and their measurements will be compared to see which method is most reliable. The goal …

This pilot study will test whether a women-focused education program, called Cardiac College for Women, helps women with heart disease learn more about their condition and feel better. About 50 women in cardiac rehab across Canada will either get the program plus usual care or us…