University Health Network, Toronto

This study is testing a procedure called radiofrequency ablation (RFA) as a potential cure for small, low-risk thyroid cancer. It aims to see if using targeted heat to destroy the tumor can be a safe and effective alternative to surgery for 30 eligible adults. The goal is to elim…

This study is testing a new type of targeted cancer drug, GSK5764227, for people with advanced head and neck cancer that has returned or spread. The drug works like a 'smart bomb' that seeks out cancer cells and delivers a chemotherapy agent directly to them. Researchers will giv…

This study is testing whether a new temperature-controlled system can better preserve donor hearts during transplant surgery compared to the standard method of using an ice box. The goal is to see if this new system reduces serious complications in the first 90 days after a heart…

This early safety trial tests whether treating donor kidneys with an experimental compound called SYN002 during organ preservation can reduce transmission of cytomegalovirus (CMV) to transplant recipients. The study involves 12 patients receiving kidneys from donors known to carr…

This study is testing whether adding a new drug called evofosfamide to standard hormone therapy can help control advanced prostate cancer that has stopped responding to initial treatments. It will involve about 35 men whose cancer has spread and progressed despite prior therapy. …

This study is testing whether using precise, high-dose radiation on a few spots where cancer is growing can help patients with advanced lung cancer stay on their current targeted drug therapy longer. It will involve 60 adults whose cancer has specific genetic changes and has star…

This is a very early study to find the safest dose of a new IV drug made from curcumin, the active part of turmeric. It will involve 20 adults with advanced multiple myeloma that has returned or stopped responding to all standard treatments. The main goal is to see what side effe…

This early-stage trial aims to find a safe dose of a new drug called BOLD-100 when given with standard chemotherapy (doxorubicin) for advanced soft tissue sarcoma. It will enroll about 32 adults who haven't had prior treatment for their advanced disease. The main goal is to check…

This study is testing whether a specialized talk therapy can help reduce traumatic stress symptoms in women with advanced ovarian cancer. Researchers will compare the therapy, called CALM-TF, to the usual standard of care. About 300 women will be randomly assigned to receive eith…

This study aims to see if adding two existing drugs, pentoxifylline and vitamin E, to standard lung cancer treatment can reduce lung damage caused by radiation therapy. Researchers will enroll 150 adults with stage III lung cancer who are receiving chemotherapy, radiation, and im…

This study aims to find out if using video calls is better than phone calls for educating breast cancer patients before they start radiation therapy. Researchers want to see if seeing their care team on video helps reduce patients' fears and concerns about the treatment more effe…

This study is testing if a nerve block in the neck can help people with long COVID. It aims to calm an overactive nervous system thought to cause symptoms like fatigue, brain fog, and dizziness. Researchers will compare the real procedure to a placebo injection in 78 participants…

This study aims to find out if a newer type of spinal cord stimulator, which works without causing a tingling sensation, is truly effective for chronic nerve pain or if its benefits are just a strong placebo effect. It will involve 90 people with severe, hard-to-treat pain who ar…

This study is testing a new system called STEP2 to see if it works as well as the current standard for connecting people with advanced cancer to palliative care. Palliative care focuses on improving quality of life by managing symptoms and providing support. In the study, some pa…

This study aims to find out if data from an Apple Watch, combined with basic health information, can predict when a person's heart failure is getting worse. Researchers will follow 360 adults with heart failure to see if the watch data can provide early warnings about declining f…