University Health Network, Toronto

This study aimed to test if giving a capsule containing healthy gut bacteria (called MET-2) to hospitalized patients after they finish antibiotics for a serious bloodstream infection could help prevent future drug-resistant infections. The trial was designed as a small pilot to s…

This study is testing whether the immunotherapy drug avelumab can help men with advanced penile cancer that has spread or cannot be removed by surgery. It is for patients who are not suitable for standard platinum-based chemotherapy or whose cancer has continued to grow despite t…

This study is testing a targeted radiation treatment called Lu-DOTATATE for people with advanced neuroendocrine tumors that have continued to grow despite other treatments. The treatment uses a radioactive drug that seeks out and delivers radiation directly to tumor cells. Resear…

This early-stage study tests whether modifying a patient's own leukemia cells to produce an immune-stimulating protein (IL-12) and returning them to the body is safe. It involves 9 adults with high-risk acute myeloid leukemia who cannot receive bone marrow transplants. Researcher…

This study is checking how safe it is to combine two standard treatments—radiation therapy and immunotherapy drugs—for people with advanced lung cancer that has spread. Researchers are watching 12 patients to see what side effects occur and how the treatment affects their quality…

This study aims to understand the best way to treat cancer patients whose cancer has spread to their thigh bone, putting them at high risk of a fracture. It follows 180 patients who receive either surgery (with or without radiation) or radiation therapy alone. Researchers will tr…

This early-stage study is testing whether adding an experimental drug called RP-6306 to standard chemotherapy (carboplatin and paclitaxel) is safe for patients with recurrent ovarian or uterine cancer that has a specific genetic change (TP53 mutation). The main goal is to find th…

This study is testing if adding a new pill called selumetinib to standard chemotherapy helps people with advanced bile duct or gallbladder cancer more than chemotherapy alone. It will compare two different schedules of the drug combination. The main goal is to see if the new comb…

This study aims to find out which treatment works better for people with high-risk myelofibrosis, a serious bone marrow cancer. Participants choose between a stem cell transplant (which could cure the disease but has serious risks) or the best available non-transplant drug therap…

This study follows 450 adults with very small, low-risk thyroid cancers to see which approach works better long-term: active surveillance (close monitoring without immediate surgery) or immediate thyroid removal surgery. Researchers track patients for up to 10 years to see how of…

This study is testing a new type of radiation machine that combines an MRI scanner with a radiation beam. The goal is to see if using real-time MRI images to guide and adjust radiation treatment can help doctors target cancer more precisely, improve survival, and reduce side effe…

This study is testing a new two-part radiation treatment for mesothelioma, a serious cancer of the lung lining, before surgery. Doctors want to find the highest safe dose of the first part (background radiation) when combined with a strong, targeted second dose (boost radiation) …

This study is testing if storing donor lungs at 10°C (50°F) is as safe as the current standard of packing them on ice. It aims to reduce the risk of severe lung failure after transplant, which is a major complication. The trial will compare outcomes for about 300 lung transplant …

This study is testing two different drug combinations to see how they affect advanced cancers that have stopped responding to standard treatments. It will enroll about 90 people with specific types of advanced colorectal cancer, pancreatic cancer, or a soft tissue sarcoma. The ma…

This study is testing whether adding a specific, lab-made mix of gut bacteria (called MET-4) to standard immunotherapy helps control advanced solid tumors. It will involve about 65 adults with incurable cancer who are receiving or starting immunotherapy. The main goals are to see…

This study is testing whether a three-drug combination can help the body's immune system fight advanced ovarian, fallopian tube, or primary peritoneal cancer that has returned after initial treatment. The treatment includes an immunotherapy drug (pembrolizumab), an investigationa…

This study is testing if a safe, injectable dye that glows under special light can help surgeons better see blood flow while connecting the stomach and intestine during gastric bypass surgery. The goal is to see if using this dye leads to fewer complications like ulcers, leaks, o…

This study is testing an intensive treatment plan for people with pancreatic cancer that has grown into a major artery. The plan involves chemotherapy and radiation before surgery to remove the tumor and reconstruct the artery, followed by more chemotherapy after surgery. The mai…

This study tests whether adding hydroxychloroquine (an anti-malaria drug) to standard chemotherapy helps control metastatic colorectal cancer in patients whose tumors show signs of drug resistance. About 155 patients will be screened, with up to 31 receiving the full four-drug co…

This study is testing whether using MRI scans to guide radiation treatment can more precisely target prostate tumors while sparing healthy tissue. It involves 40 men with localized prostate cancer who will receive standard radiation plus an extra focused dose to visible tumors. R…

This early-stage study tests a personalized cell therapy for people with advanced solid tumors. Doctors collect a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer, then infuse them back into the patient. The main goals are to chec…

This study is testing how well two drugs, atezolizumab and bevacizumab, work for people with inoperable liver cancer or non-small cell lung cancer that has spread to the liver. Researchers will measure how long it takes for the cancer to worsen and will collect blood and tumor sa…

This study is testing a new way to help surgeons during lung cancer surgery. Right after removing a piece of lung, they will scan it with a CT machine in the operating room to see if they got enough healthy tissue around the cancer. The goal is to give the surgeon immediate feedb…

This study is testing if a special combined scan (FLT-PET/MRI) can tell the difference between two problems that look the same after brain radiation treatment: radiation damage and the cancer growing back. The goal is to give doctors a clear answer without needing brain surgery. …

This study is developing a blood test to detect cancer early in people with an inherited high risk of cancer. Researchers are collecting blood samples from over 1,400 participants across Canada to see if the test can find cancer sooner than current methods. The study also explore…

This study is testing whether a blood test, called a liquid biopsy, can help people with advanced lung cancer start treatment faster. It compares the time it takes to get results from this blood test versus the standard method of testing a piece of the tumor. The goal is to see i…

This study is testing whether adding a supervised, 8-week exercise program to standard radiation treatment is safe, practical, and helpful for people with painful bone metastases from cancer. It aims to see if this combination can improve pain, physical function, and quality of l…

This study is testing a new, non-invasive brain stimulation technique called low-intensity focused ultrasound (LIFUS) to help people with primary orthostatic tremor (POT). POT causes a high-frequency shaking in the legs when standing, leading to a severe feeling of unsteadiness. …

This study is testing whether adding a personalized 30-minute education session with a radiation therapist can help breast cancer patients feel less anxious and more prepared during their radiation treatment. It compares this extra support to the current standard care. The goal i…

This study is testing whether a 10-week, home-based exercise program is practical, safe, and helpful for cancer survivors who have lasting nerve pain, numbness, or tingling from chemotherapy. Researchers will work with 40 participants to see if the program improves symptoms, stre…

This study is testing a new type of therapy that combines talk therapy with a single dose of psilocybin, the active compound in 'magic mushrooms.' It aims to help people with advanced cancer who are struggling with severe anxiety, depression, and fear related to their illness. Th…

This study is testing a specific spinal anesthesia technique for patients getting hip or knee replacements. Doctors are using a special, lighter anesthetic fluid and ultrasound to target a specific spot in the lower spine. The goal is to provide enough pain relief for surgery whi…

This study tested whether a mindfulness program delivered remotely could help reduce stress and burnout in healthcare workers during the COVID-19 pandemic. It involved 43 professionals from a radiation medicine program. Researchers measured participants' stress and coping levels …

This study aims to develop a better 'liquid biopsy'—a blood test—to monitor high-grade brain tumors without repeated surgeries. Researchers will collect blood samples from 70 patients before and after their radiation treatment to see if tumor DNA in the blood can be reliably dete…

This study aims to understand how doctors currently use fluids and a blood product called albumin in patients undergoing heart surgery. Researchers will observe 104 patients across multiple hospitals to see when, why, and how much of these products are given. The information will…

This study aims to better understand how tumors and nearby healthy organs move during radiotherapy for cervix cancer. Researchers will use frequent MRI scans on 12 patients to create a detailed motion map. The goal is to use this information to design more precise future treatmen…

This study aims to learn if measuring a specific protein (GATA6) in a patient's tumor can help doctors predict who will benefit most from a specific chemotherapy regimen given before and after surgery for pancreatic cancer. It involves 84 patients across Canada with early-stage, …

This study aims to create a clear set of normal measurements for how people swallow. Researchers will compare swallowing in 280 healthy adults to 300 adults with conditions like Parkinson's disease or who have had a stroke. The goal is to improve the diagnosis of swallowing probl…

This study aims to see how well a new MRI-guided radiation therapy facility works and how it affects the clinical team's daily routine. It will involve up to 150 adult patients with solid tumors who are already scheduled to receive imaging or treatment at this specific facility. …

This study is testing whether Fitbit devices can accurately measure sleep, activity, heart rate, breathing, and oxygen levels in hospitalized patients. Researchers are comparing Fitbit readings against medical-grade monitoring equipment used in hospitals. The goal is to see if co…

This study aims to understand how doctors currently use different fluids during heart surgery. Researchers will look back at the medical records of 505 adult heart surgery patients to see when and why they received albumin (an expensive blood product) versus standard IV fluids. T…

This withdrawn study aimed to learn how a 14-day course of an immune-modulating drug (Anakinra) changes the area immediately surrounding early-stage breast cancer tumors. It planned to enroll patients with small, early tumors who were not scheduled for chemotherapy before surgery…

This study is testing whether a new type of combined PET and MRI scan can create detailed maps showing which parts of a pancreatic tumor have low oxygen levels. Up to 20 patients with a specific type of advanced pancreatic cancer will have these scans before and after their stand…

This study aims to understand how low oxygen levels inside sarcoma tumors affect treatment success. Researchers will use a special PET/MRI scan with an experimental tracer called FAZA to measure tumor oxygen in about 70 patients before they start treatment. The goal is to gather …

This study aims to see if creating 3D models from a patient's tumor and analyzing its genetic information can help doctors find more personalized treatments for pancreatic cancer. It will enroll 200 patients in Ontario, either with cancer that can be removed by surgery or with mo…

This study aims to understand heart injury risks after COVID-19 vaccination. Researchers will use blood tests and heart scans to identify patients who might develop heart problems. The goal is to help doctors recognize at-risk patients earlier and determine who needs long-term mo…

This study is exploring whether a new, non-invasive technique using focused ultrasound can safely stimulate deep brain areas in people with Parkinson's disease and dystonia. Researchers are testing this on a small group of patients who already have surgically implanted brain stim…

This study follows adults with small, low-risk thyroid cancers to understand their choices between two approaches: immediate surgery or active surveillance (close monitoring with the option for surgery later). Researchers track which option patients choose, their reasons, and mea…

This study aims to learn if the amount of oxygen inside a cervical tumor and the fluid pressure around it can predict how well the tumor will respond to radiation therapy. Researchers will measure these factors in over 300 patients with newly diagnosed cervical cancer. The goal i…

This study aims to see if measuring vitamin D levels in the blood can help identify kidney injury in patients undergoing heart surgery. Researchers will check blood samples from 46 adults having surgery, comparing those with normal and impaired kidney function. The goal is to lea…

This study aims to understand how certain advanced cancers change during treatment. Researchers will collect blood and tumor samples from 39 patients with specific types of recurrent or metastatic squamous cell cancers (head/neck, esophagus, anal canal) who are starting chemother…

This study aims to better understand why some families have many cancers by analyzing their complete genetic information. Researchers will look at the inherited genes of patients and their family members, as well as the genes from any tumors. The goal is to find new genetic facto…

This study is testing a new online health survey called CHAMP, designed for older adults with cancer. The goal is to see if patients can easily complete the survey and if the results help their doctors make more personalized treatment decisions. Researchers are checking if using …

This study aims to understand how advanced cancers like melanoma and head/neck cancer change and evolve when treated with immunotherapy drugs. Researchers will collect tumor biopsies and blood samples from a small group of patients at different points during their treatment. The …

This study aims to understand if patients taking semaglutide (a diabetes and weight-loss medication) have full stomachs even after fasting before surgery, which can be dangerous during anesthesia. Researchers will use a simple bedside ultrasound on 100 elective surgery patients t…

This study aims to help doctors choose the best future treatments for patients with advanced cancers. Researchers are analyzing stored tumor samples from over 3,000 patients to look for specific genetic markers. The goal is to create a personalized profile for each patient's canc…

This study is testing a special type of PET scan to find areas of low oxygen inside lung cancer tumors. Low oxygen can make tumors harder to treat with radiation or chemotherapy. Researchers want to see if this scan can reliably provide this information to help guide future treat…