University Health Network, Toronto

This early-phase study tests a treatment called TBI-1301 for people with advanced solid tumors (like sarcoma, melanoma, or ovarian cancer) that have not responded to other therapies. The treatment uses a patient's own immune cells, which are genetically modified in a lab to bette…

This study tests how well the drugs atezolizumab and bevacizumab work together in people with liver cancer or non-small cell lung cancer that has spread to the liver. About 36 adults will receive the drugs and be monitored for how long their cancer stays under control. Researcher…

This early-stage study tests a new approach for people with acute myeloid leukemia (AML) that has returned or is likely to return, and who cannot have a bone marrow transplant. Researchers take the patient's own leukemia cells, modify them in the lab to produce a protein called I…

This study tests whether adding the targeted drug selumetinib to standard chemotherapy (cisplatin and gemcitabine) helps shrink tumors better than chemo alone in people with advanced bile duct or gallbladder cancer. About 57 adults who have not had prior treatment for their cance…

This study tests whether combining a cancer vaccine (DPX-Survivac) with an immunotherapy drug (pembrolizumab) and low-dose chemotherapy can shrink tumors in people with advanced ovarian, fallopian tube, or primary peritoneal cancer. The vaccine trains the immune system to attack …

This study tests whether semaglutide (a once-daily pill) works better than sitagliptin (another diabetes drug) at controlling blood sugar and body weight in people who have had a liver transplant and have poorly controlled diabetes. About 58 adults who are at least 3 months post-…

This study looks at how teriparatide, a bone-building drug, affects the inner structure of bones in 100 men and women with osteoporosis over 24 months. Researchers use a special 3D scanner to see changes in bone thickness and shape at the wrist and shin, beyond just bone density.…

This study is for people with pancreatic cancer that has spread to a major artery. It tests whether giving chemotherapy and radiation before surgery can make the tumor removable and improve survival. The trial involves 30 participants and tracks side effects, how many can have su…

This study tests a radioactive drug called Lu-DOTATATE in people with neuroendocrine tumors that have a specific marker (somatostatin receptors). The treatment delivers radiation directly to tumor cells, and the dose is adjusted for each patient. The goal is to see if it can stop…

This study looks at how teriparatide, a drug that builds new bone, changes bone structure in 60 postmenopausal women with severe osteoporosis over two years. Researchers want to see if the drug affects bone thickness differently at the wrist versus the ankle, which could help pre…

This study tested a treatment called MET-2, a mix of gut bacteria given as pills, to help clear antibiotic-resistant germs from the body. It was designed for adults hospitalized with a bloodstream infection caused by resistant bacteria. The trial was withdrawn before enrolling an…

This study explores whether lungs from donors with hepatitis C can be safely given to recipients without the virus. The lungs are treated with a special machine (EVLP) to try to reduce the virus, and if infection occurs, standard antiviral drugs are used. The goal is to see if th…

This study compares storing donor lungs at 10°C instead of the usual ice-cold method to see if it reduces severe lung injury after transplant. About 300 people receiving a lung transplant will take part. The goal is to improve recovery and make transplant logistics easier.

This study explores whether a fecal microbiome treatment called MET-4 can make immunotherapy more effective for people with advanced solid tumors. About 65 participants will receive MET-4 alongside standard immunotherapy or immunotherapy alone. The goal is to see if MET-4 is safe…

This study tests whether adding hydroxychloroquine (a malaria drug) to standard chemotherapy can improve treatment for people with advanced colorectal cancer that has spread. The drug targets cancer cells that survive initial treatment. About 155 participants will be screened, an…

This early-phase study tests a new drug (RP-6306) combined with two standard chemotherapies for people with recurrent ovarian or uterine cancer that has a specific gene change (TP53 mutation). The main goals are to find the safest dose and see if the combination can shrink tumors…

This study tests a non-live RSV vaccine in 100 adults who have received a lung or stem cell transplant. The goal is to see if the vaccine is safe and helps their immune system fight RSV, a common virus that can be dangerous for them. Participants will give blood samples and be mo…

This study is for people with a rare cancer called malignant pleural mesothelioma that affects the lining of the lungs. It tests a new way of giving radiation (called boost radiation) followed by surgery to remove the cancer. The goal is to find the highest safe dose of radiation…

This phase 2 trial tests the drug avelumab in 25 people with advanced penile cancer who cannot have standard platinum chemo or whose cancer worsened after it. Avelumab works by blocking a protein called PD-L1, which may help shrink or stop tumor growth. The main goal is to see ho…

This study tests whether using MRI to guide a radiation boost to visible prostate tumors is feasible and safe. Forty men with localized prostate cancer will receive the targeted boost before or after standard whole-gland radiation. They will be followed for up to 5 years to check…

This study compares a stem cell transplant to the best available non-transplant treatments for people with high-risk myelofibrosis, a serious bone marrow cancer. About 90 participants will choose which treatment they prefer, and researchers will track survival and quality of life…

This study tests a new type of PET/MRI scan to tell the difference between a brain tumor growing back and a side effect of radiation called radionecrosis. Both conditions look very similar on regular scans and cause similar symptoms, so doctors often need surgery to find out whic…

This study is developing a blood test to find early-stage tumors in people with hereditary cancer syndromes. Researchers will collect blood samples and medical data from 1,416 participants across Canada. They will also interview patients and doctors to see if the test is useful a…

This study is testing whether a simple blood test, called a liquid biopsy, can help doctors decide on treatment for advanced lung cancer faster than the current standard method, which requires testing a piece of the tumor. Researchers will compare how long it takes to get results…

This study tests a new, non-invasive treatment for primary orthostatic tremor, a rare condition that causes leg shaking and a feeling of falling when standing. The treatment uses low-intensity focused ultrasound to calm overactive brain circuits in the cerebellum. Researchers wil…

This study looks at whether a small dose of a lighter-than-spinal-fluid anesthetic, injected at the lowest spine gap, can still numb the area enough for hip or knee replacement surgery. The goal is to help patients regain feeling and movement in their legs faster after the operat…

This study looks at whether a 30-minute education session with a radiation therapist can help breast cancer patients feel less anxious and more in control during their radiation treatment. About 109 patients will be randomly assigned to either receive this extra session or standa…

This early study tests whether a 10-week home exercise program is safe and helpful for cancer survivors who have lasting nerve pain, numbness, or tingling from chemotherapy. About 40 people will take part, doing remote exercise sessions and health coaching calls. The main goal is…

This study looks at whether a structured, supervised exercise program is safe and doable for people who have had radiation for painful bone metastases (cancer that spread to bones, but not the spine). About 20 adults with good mobility and a life expectancy of at least 6 months w…

This study tests whether a single high dose of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with advanced cancer feel less anxious and more connected. Fifteen adults with stage IV cancer will receive the treatment and be followe…

This study tested whether a mindfulness program delivered remotely could help healthcare workers feel less stressed and burned out during the COVID-19 pandemic. 43 staff from a hospital radiation medicine program took part. Researchers measured stress and coping before and after …

This study looks at the long-term symptoms and side effects that nasopharyngeal cancer survivors may experience years after finishing radiation and chemotherapy. Researchers will assess quality of life, hearing, hormone levels, and thinking abilities in 108 adults who are cancer-…

This study reviewed the records of 505 adults who had heart surgery to understand how doctors give fluids (crystalloids and albumin) during the procedure. Albumin is a costly blood product with limited supply, and its use varies widely. The goal was to describe current practices …

This study involves 70 adults with high-grade gliomas, a serious type of brain cancer. Researchers are collecting blood samples to detect and analyze tumor DNA that circulates in the bloodstream. The goal is to develop a simple blood test that can monitor how the tumor changes ov…

This study looks at whether vitamin D levels in the blood can help doctors identify kidney injury in people who have had heart surgery. Researchers will measure vitamin D and kidney function in 46 adults with different levels of kidney health. The goal is to see if vitamin D coul…

This study tests two drug combinations in people with advanced colorectal, pancreatic, or leiomyosarcoma cancers that have not responded to standard treatments. Participants receive either olaparib plus durvalumab or cediranib plus durvalumab. The main goal is to measure changes …

This study tests an online questionnaire called CHAMP that older adults with cancer can fill out before their doctor visit. The tool helps doctors understand each patient's overall health to choose the best treatment and support. About 180 people aged 65 and older from four hospi…

This study looks at how tumors evolve when patients with advanced head and neck cancer or melanoma receive immune checkpoint inhibitors. Researchers collect blood samples and tumor biopsies to track genetic changes in the cancer over time. The goal is to understand how tumors ada…

This study measures oxygen levels and internal pressure in cervical tumors to see if these factors affect how well radiation therapy works. Researchers will follow 346 participants with newly diagnosed cervical cancer. The goal is to learn whether these tumor measurements can hel…

This study was designed to see how a 14-day course of an IL-1 blocking drug (Anakinra) changes the immune environment inside early-stage breast cancer tumors. It planned to include people with triple-negative or ER-low breast cancer who were not getting chemotherapy before surger…

This study looks at the DNA of people and families with a high risk of hereditary cancer. Researchers use advanced genetic tests to find new causes of cancer. The goal is to better understand why some cancers run in families. About 10 adults will take part.

This study collects tumor samples from over 3,000 adults with advanced cancers to look for specific genetic markers, called biomarkers. The goal is to help doctors choose the most promising targeted therapy or clinical trial for each patient. Participants do not receive a new tre…

This study looks at whether a biomarker called GATA6 can help predict how well chemotherapy works for people with pancreatic cancer that can be surgically removed. About 84 participants will receive chemotherapy before and after surgery, and researchers will measure their GATA6 l…

This study looks at 12 people with stage IV non-small cell lung cancer who are already receiving immunotherapy (nivolumab or pembrolizumab) and also get palliative radiation to the chest. The goal is to track side effects from the combination and how it affects patients' quality …

This study checks how well a new machine that combines MRI and radiation therapy works for treating solid tumors. About 150 adults will take part. The goal is to see if the machine can be used smoothly in the clinic, not to test a new treatment.

This study tests a new way to deliver radiation therapy for cancer using an MRI machine built into the radiation device. The goal is to see if this approach can more precisely target tumors while reducing side effects. About 377 adult cancer patients will receive this treatment a…

This study planned to test a computer navigation system that helps surgeons remove chest wall tumors with greater accuracy. The goal was to avoid taking too much or too little tissue during surgery. However, the study was withdrawn before any participants were enrolled, so no res…

This study looks at 200 people with pancreatic cancer to see if analyzing their tumor's genes and creating mini-tumors in a lab can help doctors choose more effective treatments. Participants provide tissue, blood, and stool samples, and their health information is tracked over t…

This study examines 57 people who had heart symptoms after a COVID-19 vaccine to understand why some develop heart inflammation. Researchers use advanced heart scans and blood tests to compare those with and without symptoms. The goal is to identify who is at risk and whether lon…

This study looks at whether using a CT scan during lung cancer surgery helps surgeons decide if they need to remove more tissue. Currently, doctors only know if the cancer is fully removed after surgery. The trial involves 80 patients and 9 surgeons. The goal is to see if this re…

This study tests a very small camera, called a composite optical fiberscope, to see if it can reach and view lung tumors in the outer parts of the lung. Researchers will use lung tissue removed from 50 patients during surgery. The goal is to see if the camera can help doctors spo…

This study tests whether a green dye, injected during gastric bypass surgery, helps surgeons see blood flow at the new stomach connection. About 300 adults having this weight-loss surgery will take part. The goal is to see if better blood flow checks can reduce problems like ulce…

This study looks at 100 adults taking semaglutide who are fasting before planned surgery. The main goal is to see how often they have a 'full stomach' despite fasting, which could raise the risk of complications during anesthesia. Researchers will also check how the time since th…

This study involves 40 adults with a specific type of neuroendocrine tumor (G2-G3 GEP-NET). Researchers are using two different PET scans to see how active the tumors are and whether the extra scan helps doctors choose the best treatment. The goal is to learn more about tumor beh…

This study follows 180 cancer patients whose cancer has spread to the thigh bone, putting them at high risk of a fracture. Researchers compare outcomes between those who have surgery (with or without radiation) and those who receive radiation alone. The goal is to see which appro…

This study watches how doctors give fluids and albumin to adults during heart surgery. It does not test a new drug or treatment. Instead, it collects data from about 104 patients to find patterns that could improve future care. The goal is to learn the best way to manage fluids a…

This study follows 110 people with brain metastases who receive either focused or whole-brain radiation. Researchers use advanced MRI scans and thinking tests before treatment and for two years after to see how the brain changes. The goal is to find early signs of cognitive decli…

This study looks at how healthy adults of all ages swallow, using video X-rays to create standard reference values. Researchers will compare these to swallowing patterns in people with swallowing disorders (dysphagia) to improve diagnosis. About 580 participants, including health…

This study looks at how patients with early-stage, low-risk thyroid cancer decide between active surveillance (close monitoring) and surgery. Researchers track why patients choose each option and how they feel about their decision one year later. The goal is to understand if moni…

This study aims to identify clinical and genetic risk factors for atypical femur fractures (AFFs) in people taking anti-resorptive therapy (ART) for osteoporosis. Researchers will compare 330 people who had an AFF with 660 people who did not, matching them by age, sex, race, and …

This study looks at how certain cancers (head and neck, esophagus, and anal) change at the genetic and immune level when treated with chemotherapy or immunotherapy. About 39 adults with advanced cancer will provide blood and tumor samples before and during treatment. The goal is …

This study looks at whether a special PET scan combined with MRI can measure low oxygen levels (hypoxia) in soft tissue sarcoma tumors. About 70 adults with high-risk sarcoma will receive an injection of a radioactive tracer called FAZA before their standard treatment. The goal i…

This study involves 12 people with cervix cancer who are receiving radiation therapy. The goal is to use frequent MRI scans to see how the tumor and nearby organs move during treatment. By understanding this movement, doctors hope to better target the tumor and reduce damage to h…

This study looks at how low oxygen levels (hypoxia) and fluid pressure inside cervical cancer tumors affect how well radiation therapy works. Researchers will measure these factors in 500 patients before and during treatment. The goal is to find the best way to identify which pat…

This study looks at whether a PET scan using a special tracer called FAZA can detect low oxygen levels (hypoxia) in lung cancer tumors. Hypoxia can affect how tumors grow and respond to treatments like radiation. About 36 adults with stage II or III lung cancer will receive one F…

This study explores whether a special PET scan can detect low oxygen levels (hypoxia) in cervix cancer tumors. Hypoxia may affect how tumors grow and respond to standard treatments like radiation and chemotherapy. About 30 adults with cervix cancer will receive the PET tracer FAZ…

This study explores whether a special PET scan combined with MRI can measure oxygen levels in pancreatic tumors. About 20 adults with advanced, non-removable pancreatic cancer will get scans before and after standard radiation. The goal is to see if this imaging method can track …

This study checks if Fitbit Sense 2 devices can accurately measure heart rate, breathing, oxygen levels, sleep, and activity in 100 adults admitted to a general medicine ward. Researchers compare Fitbit data to medical-grade monitors and sleep diaries. The goal is to see if weara…

This study looks at two ways to manage very small, low-risk papillary thyroid cancers: active surveillance (regular check-ups to watch for changes) or immediate surgery. Researchers want to see how often each approach fails to control the disease over the long term. About 450 adu…

This study explores whether low-intensity ultrasound can safely and effectively stimulate deep brain areas in people with Parkinson's disease or dystonia. Ten adults who already have implanted deep brain stimulation (DBS) leads will receive ultrasound pulses while researchers rec…