Sound waves aim to quiet shaky legs in rare tremor disorder
NCT ID NCT05547620
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether low-intensity focused ultrasound (LIFUS) can calm abnormal brain activity in the cerebellum that causes severe leg tremors when standing. Fifteen adults with primary orthostatic tremor will receive real or sham ultrasound while their tremor and brain circuits are measured. The goal is to see if this non-invasive technique can reduce tremor and improve balance.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- low-intensity focused ultrasound (LIFUS) device
- What this could lead to
- If it works, this could offer a non-invasive way to reduce tremor and improve standing stability for people with orthostatic tremor.
- What could go wrong
- This is a very early, small study with only 15 participants, so results may not apply widely. The treatment is still experimental and may not provide lasting benefit.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Toronto Western Hospital
Toronto, Ontario, M5T 2S8, Canada
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Other studies related to the condition(s) this trial covers.