Could storing lungs at 10°C improve transplant outcomes?

NCT ID NCT05898776

Ongoing Disease control Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether storing donor lungs at 10°C instead of the usual ice cooler reduces severe lung injury after transplant. About 300 people receiving a lung transplant will be randomly assigned to one of two storage methods. The main goal is to see if the 10°C method is at least as safe as the standard ice method.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 10°C lung preservation using X°Port Lung Transport Device
What this could lead to: If this works, it could reduce the risk of severe lung injury after transplant and allow safer, longer storage times for donor lungs.
What could go wrong: This is a non-inferiority trial, so it may only show that 10°C storage is as safe as ice, not better. The results may not apply to all donor lungs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG TRANSPLANT ORGAN PRESERVATION

Contacts and locations

Locations

Centre Hospitalier Universitaire Vaudois (CHUV)

Lausanne, Switzerland
Centre hospitalier de l'Université de Montréal

Montreal, Quebec, H2X0A9, Canada
Corewell Health Research Institute

Grand Rapids, Michigan, 49503, United States
Dignity Health (St. Joseph's Hospital and Medical Center)

Phoenix, Arizona, 85050, United States
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Puerta de Hierro-Majadahonda

Madrid, Spain
Mayo Clinic

Rochester, Minnesota, 55905, United States
Medical University of Vienna

Vienna, Austria
St Vincent's Hospital Sydney Limited

Sydney, New South Wales, 2010, Australia
The Saint Joseph Hospital Foundation (Hôpital Marie Lannelongue)

Paris, 75014, France
University Health Network (Toronto General Hospital)

Toronto, Ontario, M5G 2C4, Canada
University Hospital Zurich

Zurich, Switzerland
University Hospitals Leuven

Leuven, Belgium
University of California San Francisco

San Francisco, California, 94143, United States
University of Miami

Coral Gables, Florida, 33146, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.