New study: could Chemo-Radiation replace surgery for rectal cancer?

NCT ID NCT06758830

Recruiting now Disease control Sponsor: National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos Source: ClinicalTrials.gov ↗

First seen May 13, 2026 · Last updated May 13, 2026

Summary

This study tests whether a combination of chemotherapy and radiation (total neoadjuvant therapy) can help about half of rectal cancer patients avoid surgery and keep their rectum. Participants who respond well will be monitored closely instead of having surgery. The study will compare their quality of life, side effects, and survival to those who have surgery first. It involves 400 adults with early-stage rectal cancer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Nacional Cancer Institute
RECRUITING

Vilnius, 08660, Lithuania

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact

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Conditions

Explore the condition pages connected to this study.

CHEMORADIOTHERAPY CHEMOTHERAPY CHEMOTHERAPY SIDE EFFECTS LOW ANTERIOR RESECTION SYNDROME NEOADJUVANT THERAPY ORGAN PRESERVATION QUALITY OF LIFE RADIOTHERAPY RADIOTHERAPY SIDE EFFECT RECTAL CANCER TOTAL NEOADJUVANT TREATMENT