NEOADJUVANT THERAPY

This study tests whether giving two drugs (pucotenlimab and vorolanib) before surgery can shrink kidney tumors enough to allow partial kidney removal instead of full removal. About 21 adults with high-risk clear cell renal cell carcinoma will receive the drug combination for seve…

This study tests two different treatment plans for people with locally advanced rectal cancer that has not spread. Both plans combine radiation, chemotherapy, an immunotherapy drug, and a pain reliever that may boost the immune response. The goal is to see which plan leads to a h…

This study tests whether a combination of chemotherapy and radiation before surgery (total neoadjuvant therapy) can help about half of rectal cancer patients achieve a complete response, allowing them to avoid surgery and preserve their rectum through a watch-and-wait strategy. T…

This study tests whether adding radiation therapy to a combination of chemotherapy and immunotherapy before surgery can improve outcomes for people with resectable stomach or gastroesophageal junction cancer. About 40 participants will be randomly assigned to receive either the s…

This study is for people with a specific type of colorectal cancer (dMMR/MSI-H) that hasn't spread far. It tests giving an immunotherapy drug (toripalimab) with or without an anti-inflammatory drug (celecoxib) before surgery. The goal is to see if this approach can shrink or elim…

This study tests a combination of the immunotherapy drug envafolimab and two chemotherapy drugs given before surgery for people with a type of esophageal cancer that can be removed. The goal is to see if this treatment can shrink or eliminate the tumor before the operation. About…

This study tests whether adding a probiotic called Probio-M9 to standard chemoradiation and immunotherapy (tislelizumab) can help shrink rectal tumors before surgery. About 50 adults with locally advanced rectal cancer will be randomly assigned to receive the probiotic or a place…

This study tests whether giving two drugs (sintilimab and bevacizumab) before surgery can lower the chance of liver cancer coming back. It involves 37 adults with resectable liver cancer that is beyond standard transplant criteria. The goal is to see if this approach improves 1-y…

This early-phase trial tests a new combination of the immunotherapy drug tislelizumab plus chemotherapy (FLOT) given before surgery for people with stomach, esophageal, or junction cancer that can be removed. The goal is to see if the combination is safe and works well enough to …

This study tests a new approach for people with a certain genetic lung cancer (KRAS G12C mutation) that can be removed with surgery. Before surgery, patients receive a targeted pill (fulzerasib) for 6 weeks, then a 2-week break, followed by 3 cycles of immunotherapy (sintilimab) …

This study tests whether women with breast cancer who have no signs of cancer in their armpit lymph nodes after chemotherapy can safely skip armpit surgery. Half the participants will have standard sentinel node surgery; the other half will have no armpit surgery at all. Research…

This study tests whether adding radiation to a chemotherapy-immunotherapy combination improves outcomes for people with a specific type of advanced rectal cancer (MSS/pMMR). About 192 participants will receive either the drug combo alone or with short-course radiation before poss…

This study tests whether giving a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus a targeted therapy (lenvatinib) before surgery can shrink kidney tumors enough to allow partial kidney removal in patients who otherwise would need full kidney removal. Ab…

This study tests if a special PET scan (FAPI-PET) and a fluorescent dye can help doctors find leftover lung cancer during surgery after standard treatment. About 200 people with stage II-IIIB non-small cell lung cancer will get the scan and dye before and during surgery. The goal…

This study tests whether a digital support program can help people with breast, prostate, or colorectal cancer reduce the time they spend sitting during their treatment. The goal is to improve their well-being and lower future health risks. The study will involve 172 participants…

This study tests a digital mind-body therapy that uses music and biofeedback to help women with locally advanced breast cancer sleep better and feel less distressed during neoadjuvant treatment. About 66 participants will be randomly assigned to receive the digital therapy or sta…

This study looks at 400 people with non-small cell lung cancer who had pre-treatment (like chemo or immunotherapy) and then needed a specific type of lung surgery called sleeve lobectomy. Researchers want to see if a less invasive surgery (using small cuts and a camera) works as …

This study looks at how chemotherapy or radiation given before surgery for colorectal cancer affects small blood vessels and scar tissue. Researchers will compare 34 patients who had pre-surgery treatment with 34 who went straight to surgery. The goal is to understand if these ch…

This study is looking at tiny molecules in the blood called microRNAs to see if they can predict how well breast cancer responds to chemotherapy given before surgery. Researchers will collect blood samples from 80 women with breast cancer before and after chemotherapy. The goal i…

This study is looking at whether proteins in urine can help doctors predict how well pre-surgery treatment works for people with locally advanced colorectal cancer. Researchers will collect urine samples from 400 patients before and after treatment and use advanced technology to …

This study is building a computer model to predict how well pre-surgery treatment works for people with non-small cell lung cancer. Researchers will collect data from 500 participants to see if the model can accurately forecast treatment results. The goal is to help doctors make …

This study looks at whether advanced blood tests and artificial intelligence can detect lung cancer coming back after surgery, earlier than standard scans. Researchers will follow 100 people who had lung cancer surgery and chemotherapy. The goal is to create a better monitoring s…