NEOADJUVANT THERAPY

This study tests a new drug called Ivonescimab for people with non-small cell lung cancer who need surgery. The drug is given before surgery to shrink tumors and make them easier to remove. The study compares Ivonescimab to standard treatments and looks at how well it works and w…

This phase II trial tests whether adding the targeted drug nimotuzumab to immunotherapy and chemotherapy before surgery can improve outcomes for people with locally advanced head and neck cancer. About 182 participants will receive the combination or standard treatment. The main …

This study tests whether a combination of chemotherapy and radiation (total neoadjuvant therapy, or TNT) can shrink rectal tumors enough so that some patients can avoid surgery and instead be monitored closely. About 400 adults with early-stage rectal cancer will be randomly assi…

This study tests whether adding radiotherapy to a combination of chemotherapy (CAPOX) and an immunotherapy drug (Toripalimab) can improve outcomes for people with a specific type of locally advanced rectal cancer (MSS/pMMR). About 192 participants will receive either the drug com…

This study tests a new treatment approach for people with a specific type of lung cancer (KRAS G12C mutation) that can be removed by surgery. About 30 participants will receive a targeted pill (fulzerasib) for 6 weeks, followed by a short break, then 3 cycles of immunotherapy (si…

This phase 2 trial is testing whether adding a probiotic called Probio-M9 to standard chemoradiation and an immunotherapy drug (tislelizumab) can improve outcomes for people with locally advanced rectal cancer. About 50 participants will be randomly assigned to receive either the…

This phase 2 trial is testing whether a combination of two immunotherapy drugs (QL1706) and a targeted therapy (lenvatinib) can shrink kidney tumors before surgery. The goal is to make partial nephrectomy (removing only the tumor) possible for patients whose tumors are currently …

This study tests whether giving two drugs (pucotenlimab and vorolanib) before surgery can shrink kidney tumors enough to allow partial kidney removal instead of full removal. It includes 21 adults with high-risk clear cell renal cancer who need surgery but have tumors that make k…

This study tests whether women with breast cancer who have no signs of cancer in their armpit lymph nodes after chemotherapy can safely skip armpit surgery. About 464 participants will be randomly assigned to either have or skip the surgery. The goal is to see if skipping surgery…

This phase 2 trial is testing whether giving two drugs—sintilimab (an immunotherapy) and bevacizumab (a targeted therapy)—before surgery can help prevent liver cancer from coming back. The study includes 37 adults with resectable liver cancer that is beyond the Milan criteria, me…

This early-phase trial tests a new combination of the immunotherapy drug tislelizumab plus standard chemotherapy (FLOT) given before surgery for people with stomach, esophageal, or gastroesophageal junction cancer that can be removed. The goal is to see if this longer pre-surgery…

This study tests a new drug called envafolimab combined with standard chemotherapy given before surgery for people with a type of esophageal cancer that can be removed. The goal is to see if this combination can shrink the tumor more effectively, potentially leading to better lon…

This phase 2 trial is testing whether giving the immunotherapy drug toripalimab, with or without the anti-inflammatory drug celecoxib, before surgery can improve outcomes for people with a specific type of colorectal cancer (dMMR/MSI-H). About 270 participants will receive the dr…

This phase 2 trial tests whether adding radiotherapy and two immunotherapy drugs (iparomlimab and tuvonralimab) to standard chemotherapy can improve outcomes for people with resectable stomach or gastroesophageal junction cancer. About 40 participants will be randomly assigned to…

This phase II trial tests whether adding an immunotherapy drug (serplulimab) and a COX-2 inhibitor (celecoxib) to standard chemoradiotherapy can improve outcomes for people with locally advanced rectal cancer. 138 participants will receive either long-course or short-course radia…

This study tests whether a special PET/CT scan (FAPI-PET/CT) and a fluorescent dye can better predict how well lung cancer responds to pre-surgery therapy and help surgeons see tumors during operation. 200 adults with stage II-IIIB non-small cell lung cancer will receive the scan…

This study tests a digital mind-body therapy that uses music and biofeedback to help women with advanced breast cancer who are undergoing chemotherapy before surgery. The goal is to see if it can reduce sleep problems, anxiety, and depression. Sixty-six participants will be rando…

This study tests whether a digital support program can help people with breast, prostate, or colorectal cancer reduce the time they spend sitting during their treatment. The goal is to improve their well-being and lower future health risks. About 172 participants will use an acti…

This study is looking at small molecules called microRNAs in the blood of 80 women with breast cancer. Researchers want to see if changes in these molecules can predict how well chemotherapy works before surgery. The goal is to find a simple blood test that helps doctors choose t…

This study looks at whether a computer model can predict how well non-small cell lung cancer responds to chemotherapy and immunotherapy given before surgery. Researchers will collect data from 500 participants to build and test this prediction tool. The goal is to improve treatme…

This study looks at whether advanced blood tests and artificial intelligence can help detect lung cancer recurrence earlier and without invasive procedures. About 100 adults who had surgery for stage IB-IIIA lung cancer and received standard chemo-immunotherapy before surgery wil…

This study looks at how chemotherapy or radiation before colorectal cancer surgery affects tiny blood vessels and scarring in skin tissue, and whether this leads to more complications. Researchers will compare 34 patients who had pre-surgery therapy with 34 who went straight to s…

This study looks at 400 lung cancer patients who had chemotherapy or immunotherapy before surgery. Researchers compare two surgical techniques: minimally invasive (using small cuts and a camera) versus traditional open chest surgery. The goal is to see which approach leads to bet…

This study looks at whether proteins in urine can help doctors predict how patients with advanced colorectal cancer will respond to treatment given before surgery. Researchers will collect urine samples from 400 participants before and after therapy and use advanced technology to…