NEOADJUVANT THERAPY

This study tests a new drug called Ivonescimab, combined with chemotherapy, given before surgery to people with a type of esophageal cancer that can be removed. The goal is to see if this combination can shrink or eliminate the tumor before surgery, improving long-term outcomes. …

This study tests a new drug (QL1706) combined with chemotherapy before surgery in 40 people with early triple-negative breast cancer. The goal is to see if some patients can avoid a type of chemo called anthracyclines, which can harm the heart. After four cycles of treatment, tho…

This study tests a drug called Vebreltinib given for 8 weeks before surgery in people with a specific type of lung cancer (stage IIA-IIIB NSCLC with METex14 skipping mutation). The goal is to see if the drug can shrink or control the tumor, making surgery more effective. About 30…

This pilot study looks at whether it is safe and feasible to skip surgery in patients with stage II-III non-small cell lung cancer whose tumors completely disappear after chemotherapy and immunotherapy. Fourteen participants will be randomly assigned to either standard surgery or…

This study tests a new approach for women with a common type of early breast cancer (HR+/HER2-). Instead of standard chemotherapy before surgery, some participants may receive a combination of hormone therapy and a targeted drug (abemaciclib) based on a gene test result from thei…

This study tests a combination of two drugs, sacituzumab tirumotecan and pembrolizumab, given before surgery to people with stage II or III triple-negative breast cancer (TNBC). The goal is to see if this treatment can eliminate all signs of cancer by the time of surgery. About 5…

This study tests whether adding the drug adebrelimab to standard chemotherapy before surgery can help shrink pancreatic tumors and improve complete removal. About 30 adults with resectable pancreatic cancer will receive this combination. The goal is to see if it increases the cha…

This study tests whether giving a combination of three drugs (camrelizumab, chemotherapy, and ivarmacitinib) before surgery can help people with a type of esophageal cancer. The goal is to shrink or eliminate tumors before removal, potentially improving outcomes. About 45 adults …

This study tests two drugs, zanidatamab and tislelizumab, together with chemotherapy or radiation for people with HER2-positive gastrointestinal cancers like rectal, stomach, and colon cancer. About 70 adults will receive the treatment to see if it can shrink tumors before surger…

This study tests a simple idea: wearing tight surgical gloves during chemotherapy sessions might prevent nerve damage in the hands. About 44 breast cancer patients will try it on one hand only, so doctors can compare. The goal is to see if this cheap, easy method can reduce numbn…

This study tests whether a family-supervised program of exercise, nutrition, and psychological support before stomach cancer surgery can lower the risk of serious complications. About 90 adults who will receive chemotherapy before surgery will be randomly assigned to the program …

This study aims to develop an artificial intelligence (AI) system that helps doctors choose the best treatment for each person with esophageal cancer. Researchers will collect medical images and tissue samples from 7,000 patients to train the AI to predict how well a treatment wi…