NEOADJUVANT THERAPY

This study is testing whether giving immunotherapy drugs before surgery can help shrink tumors in people with advanced colorectal cancer that has specific genetic features. About 270 participants will receive either toripalimab alone or combined with celecoxib to see which approa…

This study is testing two different treatment combinations for people with locally advanced rectal cancer that hasn't spread to distant organs. All participants receive chemotherapy and immunotherapy, but one group also gets a short course of radiation beforehand. The main goal i…

This study is testing a combination of radiation, chemotherapy, and two immunotherapy drugs given before surgery for stomach cancer. The goal is to see if this approach can shrink or eliminate the tumor to make surgery more successful. Researchers will compare two different order…

This study is testing if adding a specific probiotic supplement (Probio-M9) to a standard treatment plan improves results for people with locally advanced rectal cancer. All participants will receive chemotherapy, radiation, and an immunotherapy drug (tislelizumab). Researchers w…

This study is testing if a combination of two drugs, pucotenlimab and vorolanib, can shrink kidney tumors before surgery. The goal is to make it possible for surgeons to remove the cancer while saving the healthy part of the kidney in patients where this is normally very difficul…

This study is testing whether a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus a targeted drug (lenvatinib) can shrink kidney tumors before surgery. The goal is to make a kidney-sparing operation possible and safer for 25 patients whose tumors are curr…

This trial is testing two different intensive treatment combinations given before surgery for locally advanced rectal cancer. One group gets a longer course of radiation with chemotherapy. The other gets a shorter radiation course plus chemotherapy, an immunotherapy drug, and an …

This early-stage trial is testing whether combining a newer immunotherapy drug (tislelizumab) with standard chemotherapy (FLOT) is safe and tolerable when given before surgery for certain stomach and esophagus cancers. The goal is to see if giving more chemotherapy before surgery…

This large study is testing whether women with breast cancer who have no signs of cancer in their armpit lymph nodes on an ultrasound after chemotherapy can safely skip having those lymph nodes surgically removed. The goal is to see if avoiding this surgery leads to similar long-…

This study is testing whether giving two drugs, sintilimab and bevacizumab, before surgery can help people with liver cancer that is more advanced but still removable. The goal is to shrink the tumor and, most importantly, lower the high chance of the cancer returning after the o…

This study looks back at 400 lung cancer patients who had surgery after receiving drug treatments first. Researchers are comparing traditional open-chest surgery with newer, less invasive techniques. They want to see which approach leads to better recovery and longer survival wit…

This study is testing a new three-drug combination given before surgery for locally advanced esophageal cancer. The goal is to see if this treatment can shrink or eliminate the tumor to make surgery more successful and reduce the chance of the cancer coming back. It is for adults…

This study is testing two new imaging methods to help doctors better see lung cancer tumors. Before surgery, patients get a special PET scan. During surgery, doctors use a fluorescent dye that makes tumor tissue glow under special light. The goal is to see if these methods can mo…

This study aims to see if proteins in urine can predict how well patients with locally advanced colorectal cancer will respond to pre-surgery (neoadjuvant) therapy. Researchers will collect urine samples from 400 patients before and after treatment, using advanced protein analysi…

This study is testing whether a digital support tool can help people with breast, prostate, or colorectal cancer sit less during their treatment. The goal is to see if reducing long periods of sitting improves their well-being, reduces side effects, and lowers future health risks…

This study aims to understand how chemotherapy or radiation given before colorectal cancer surgery affects patients' blood vessels and healing. Researchers will compare 68 patients—half who received pre-surgery treatment and half who went straight to surgery—by examining tissue s…

This study aims to develop a new, non-invasive way to monitor lung cancer patients after surgery to see if the cancer might come back. Researchers will collect blood samples from 100 patients who have had lung cancer surgery and analyze them using advanced computer programs. The …

This study aims to develop a tool that can predict how well patients with non-small cell lung cancer will respond to treatment before surgery. Researchers will collect various types of data from 500 patients receiving chemo-immunotherapy followed by surgery. The goal is to create…