New cocktail aims to shrink rectal tumors before surgery
NCT ID NCT07150949
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase II trial tests whether adding an immunotherapy drug (serplulimab) and a COX-2 inhibitor (celecoxib) to standard chemoradiotherapy can improve outcomes for people with locally advanced rectal cancer. 138 participants will receive either long-course or short-course radiation plus chemotherapy, with the new drugs added. The main goal is to see how many patients have a complete response, meaning no cancer remains after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Oxaliplatin, capecitabine, serplulimab (PD-1 antibody), and celecoxib (COX-2 inhibitor)
- What this could lead to
- If successful, this combination could increase the chance of eliminating the tumor before surgery, potentially allowing some patients to avoid surgery altogether.
- What could go wrong
- This is an early phase II trial with only 138 participants, so results may not apply to everyone. Adding immunotherapy and a COX-2 inhibitor may increase side effects like immune-related reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Fudan University Shanghai Cancer Center
RECRUITINGShanghai, Shanghai Municipality, 200030, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a triple threat of drug, immunotherapy, and radiation wipe out High-Risk urinary tract cancer before surgery?
- Could a Triple-Drug attack before surgery eliminate more breast cancer in older women?