Can a targeted radiation combo boost rectal cancer remission?
NCT ID NCT07057089
First seen Jul 31, 2026 · Last updated Jul 31, 2026
Summary
This trial is testing whether a more focused radiation field, combined with chemotherapy and an immunotherapy drug called camrelizumab, can improve outcomes for people with a certain type of locally advanced rectal cancer. The study will compare this new approach to a standard treatment that uses a larger radiation field. The main goal is to see if the new combination leads to a higher rate of complete response, meaning the cancer disappears or shrinks significantly before surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A combination of capecitabine (chemotherapy), camrelizumab (PD-1 inhibitor immunotherapy), and involved-field radiation therapy, followed by surgery.
- What this could lead to
- If successful, this approach could increase the chance of eliminating the tumor before surgery, potentially allowing some patients to avoid surgery or preserve more organs.
- What could go wrong
- This is a phase 2 trial with a relatively small number of participants. The combination may not improve outcomes and could increase side effects compared to standard treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
the Fourth Hospital of Hebei Medical University
Shijiazhuang, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New combo without chemotherapy aims to shrink rectal tumors before surgery