Immune-boosting combo aims to wipe out rectal cancer before surgery
NCT ID NCT05507112
First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time
Summary
This study tests whether adding an immunotherapy drug (tislelizumab) to standard chemoradiation before surgery can improve outcomes for people with locally advanced rectal cancer. About 100 participants will receive the combination treatment, and researchers will measure how many achieve a complete response—meaning no cancer cells remain after treatment. The goal is to see if this approach can shrink or eliminate tumors more effectively than standard therapy alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tislelizumab (PD-1 inhibitor) plus capecitabine and radiation therapy
- What this could lead to
- If successful, this combination could become a new standard treatment before surgery for locally advanced rectal cancer, potentially increasing the chance of eliminating all cancer cells.
- What could go wrong
- This is a phase 2 trial with only 100 participants, so results may not apply to everyone. Combining immunotherapy with chemoradiation may increase side effects, and the treatment may not work for all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Peking Union Medical College Hospital
Beijing, Beijing Municipality, 100730, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a short burst of radiation plus triple chemotherapy wipe out rectal cancer before surgery?
- MRI-Guided radiation boosts hopes for rectal cancer patients
- Timing of chemo may boost rectal cancer remission
- New combo without chemotherapy aims to shrink rectal tumors before surgery
- Could chemo replace surgery for rectal cancer? new study explores
- Oxygen-Boosting injection may help rectal cancer patients avoid surgery