Peking Union Medical College Hospital

This phase II trial tests whether a combination of durvalumab (an immunotherapy), chemotherapy (GEMOX or GC), followed by lenvatinib (a targeted therapy) can prevent biliary tract cancer from coming back after surgery. About 222 adults with bile duct or gallbladder cancer will be…

This trial tests a real-time algorithm-driven system that gives doctors feedback on ventilator settings to protect the lungs of critically ill patients. The study will include 208 adults on breathing machines with acute respiratory distress syndrome (ARDS). The goal is to see if …

This phase II trial is testing a combination of three drugs—trastuzumab rezetecan, adebrelimab, and lenvatinib—as a first treatment for people with advanced or metastatic biliary tract cancer that has HER2 markers. The study aims to see how well the drugs shrink tumors and contro…

This study tests the drug lenalidomide in 42 adults with Behçet's syndrome who have stubborn mouth ulcers. Participants take 10 mg of lenalidomide daily for 12 weeks, then stop for 4 weeks of observation. The main goal is to see if the ulcers completely disappear by week 12.

This early-phase trial tests a gene therapy called PUMCH-E111 for a rare inherited retinal disease caused by RLBP1 mutations. Six adults aged 18-55 will receive a single injection into the eye at a low or high dose. The main goal is to check safety, but researchers will also meas…

This study tests a daily pill called orelabrutinib for people with autoimmune hemolytic anemia (AIHA) that hasn't responded to standard treatments. AIHA is a condition where the immune system mistakenly attacks red blood cells, causing fatigue and anemia. The trial will enroll 50…

This study tests whether adding a PCSK9 inhibitor (Recaticimab) to standard statin therapy can reverse plaque buildup in brain arteries of people with asymptomatic intracranial atherosclerosis. About 300 participants will receive either the drug combo or statins alone for 24 week…

This study tests whether adding immunotherapy (adebrelimab) to different chemotherapy or targeted therapy regimens can help prevent cancer recurrence in people with intrahepatic cholangiocarcinoma who have a high risk of the cancer coming back after surgery. About 90 participants…

This early-phase trial tests an mRNA drug called XH02 in 6 adults with hypoparathyroidism, a condition where the body lacks parathyroid hormone (PTH). The drug is designed to instruct cells to produce PTH after being given through a vein. The main goal is to check safety, while a…

This study tests an mRNA drug called XH-02 that helps the body produce parathyroid hormone (PTH) in adults with hypoparathyroidism, a condition where PTH levels are too low. The drug is given as a shot under the skin. The goal is to see if it safely improves calcium and phosphoru…

This study tests a two-step treatment for functional hypothalamic amenorrhea, a condition where women stop having periods due to stress, low weight, or excessive exercise. It combines Western medicine to quickly restart menstruation with Chinese herbs to support long-term balance…

This phase 2 trial tests whether giving a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus a targeted therapy (lenvatinib) before surgery can improve outcomes for people with liver cancer at high risk of recurrence. About 33 participants will receive the…

This early-stage trial tests an mRNA drug called XH-02 in 15 adults with hypoparathyroidism, a condition where the body doesn't make enough parathyroid hormone. The drug is injected under the skin to help replace the missing hormone and control calcium levels. The main goal is to…

This study tests two treatment plans for people with IgG4-related disease affecting superficial organs like glands or skin. One group gets prednisone plus iguratimod, the other gets prednisone plus leflunomide. Over 12 months, researchers will track how many patients have a relap…

This study is testing whether immune checkpoint inhibitors, drugs that help the immune system fight infections, can improve outcomes for people with progressive multifocal leukoencephalopathy (PML), a rare brain virus. Researchers will follow 66 patients over a year, measuring di…

This study compares a newer, less invasive laparoscopic hysterectomy (with special tumor-free techniques) to the standard open abdominal surgery for stage IB2 cervical cancer. About 524 women will be randomly assigned to one of the two surgeries. The main goal is to see if the la…

This study tests a drug called glofitamab in 20 Chinese patients whose diffuse large B-cell lymphoma has returned or not responded to at least two prior treatments. The goal is to see if the drug can control the cancer and how safe it is. Participants receive glofitamab alone, an…

This study tests whether giving a special type of radiotherapy (ultra-fraction) before CAR-T cell therapy can safely improve outcomes for people with relapsed or refractory diffuse large B-cell lymphoma. About 20 adults who have failed at least two prior treatments will receive t…

This study tests a new type of radiation therapy that adjusts the beam in real time to match the patient's body shape each day. It includes 40 women who have had breast cancer surgery and need radiation. The goal is to see if this approach delivers the dose more accurately and ca…

This study is testing a new drug called QL1706, which helps the immune system fight cancer, combined with standard chemotherapy before surgery for people with stage IIB-IIIB non-small cell lung cancer. About 30 participants will receive three cycles of the drug combo, then have s…

This study tests whether combining two drugs, camrelizumab and apatinib, with standard chemotherapy can help women with a rare but aggressive pregnancy-related cancer called gestational trophoblastic neoplasia (GTN). The trial includes two groups: those with ultra high-risk disea…

This pilot study tests whether a fecal microbiota transplant (FMT) combined with a high-fiber diet can safely and effectively treat chronic constipation. Five adults with functional constipation will receive FMT via colonoscopy and take a dietary fiber supplement. Researchers wil…

This study tests whether tocilizumab, a drug that blocks inflammation, can improve symptoms and breathing in adults with anti-MDA5+ dermatomyositis, a rare autoimmune disease affecting muscles, skin, and lungs. About 110 participants will receive either tocilizumab or a placebo e…

This study tests whether a combination of light therapy on acupoints and a traditional Chinese medicine pill can improve ovarian function in women with diminished ovarian reserve (DOR). Ninety women aged 25-40 will be split into three groups: light plus placebo, light plus Chines…

This study compares two treatment plans for people with osteoporosis who have already had a fracture. One group receives a bone-building drug (teriparatide) for 6 months followed by a bone-strengthening drug (denosumab), while the other group takes denosumab alone. The goal is to…

This study compares online adaptive radiotherapy (oART) to standard image-guided radiotherapy for cervical cancer. oART adjusts the radiation beam daily based on the tumor's changing shape and position. The goal is to reduce side effects like bowel and bladder problems while keep…

This study tests whether adding lenalidomide to standard steroid treatment can better control active IgG4-related disease (IgG4-RD), a rare condition that causes swelling and damage in organs. About 198 adults will receive either lenalidomide plus prednisone or prednisone alone f…

This study tests a precision medicine approach for people with advanced biliary tract cancer that has a specific IDH1 gene mutation and has stopped responding to standard chemotherapy. About 300 participants will receive a combination of ivosidenib (a targeted pill) plus either l…

This phase 2 trial is testing whether adding the immunotherapy drug pembrolizumab to standard chemotherapy or the targeted drug lenvatinib can help people with advanced biliary tract cancer live longer and control their tumors better. The study will enroll 60 adults whose cancer …

This study compares different immune-suppressing drugs to treat a kidney disease called idiopathic membranous nephropathy. About 200 adults with high protein in their urine will receive one of several treatments. The goal is to see which drug works best to reduce protein leakage …

This phase 2 trial is testing whether adding two immunotherapy drugs (tuvonralimab and iparomlimab) to standard chemotherapy before surgery can improve outcomes for people with bile duct or gallbladder cancer. About 45 adults with resectable or borderline-resectable cancer will r…

This study looks at how losing weight and then regaining it (weight cycling) affects hormone levels and insulin resistance in women with Polycystic Ovary Syndrome (PCOS). Researchers will follow 425 women with PCOS, some at normal weight and some with overweight or obesity, as th…

This phase 2 study is testing a daily pill called pyrotinib as a first treatment for people with advanced non-small cell lung cancer that has a specific change in the HER2 gene. The trial will enroll 18 adults who have not had prior treatment for their advanced cancer. Researcher…

This Phase 2 trial is testing whether adding interventional procedures (like TACE or HAIC) to a combination of immune checkpoint inhibitors and anti-VEGF drugs works better than the drugs alone for advanced hepatocellular carcinoma. About 300 participants with BCLC stage B or C l…

This study tests whether adding berberine, a natural compound, can improve blood thinning in heart patients who already take aspirin and clopidogrel after a stent procedure. About 64 adults will receive either standard treatment or berberine at increasing doses for 12 weeks. The …

This study tests whether a comprehensive treatment plan can reduce heart attacks and other serious events in people with rapidly-progressive coronary artery disease tied to inflammation. Researchers will compare each participant's outcomes before and after treatment. The study en…

This early-phase trial is testing two new radioactive drugs, 177Lu-P17-087 and 177Lu-P17-088, in 30 people with metastatic castration-resistant prostate cancer that has stopped responding to other treatments. The study first checks how the drug spreads in the body and its safety,…

This study tests whether a sublingual tablet (edaravone dexborneol) can improve outcomes for people who recently had a stroke due to small vessel disease. About 600 adults aged 30–80 will receive either the tablet or a placebo for 24 weeks, with follow-up for one year. The goal i…

This Phase 2 trial is testing a combination of paclitaxel polymer micelle and immunotherapy for people with advanced biliary tract cancer whose disease has progressed after standard first-line treatment. The study aims to see if this new drug combo can shrink tumors and control t…

This trial tests whether giving the immunotherapy drug camrelizumab before surgery can help completely remove T4 colon cancers that have a specific genetic feature (dMMR). These cancers often don't respond well to standard chemotherapy. The study will enroll 18 adults who will re…

This early-stage trial is testing a new procedure called BAO-G for people with complex aortic aneurysms (bulging of the main artery in the chest and abdomen). The technique uses off-the-shelf stent grafts to rebuild the artery's branches from inside the blood vessel, avoiding maj…

This study is testing whether a special PET-CT scan using a radioactive tracer called 68Ga-RGD can help doctors diagnose keloids and see how well treatment is working. Keloids are raised scars that grow beyond the original wound, and current diagnosis relies on physical exams. Th…

This study is testing a more accurate way to diagnose primary aldosteronism, a common but often missed cause of high blood pressure that can be cured with surgery. Researchers will measure urine aldosterone using a precise lab method (LC-MS/MS) in 800 healthy volunteers and patie…

This study tests a special PET/CT scan using a radioactive tracer called 68Ga-NYM096 to see if it can accurately detect clear cell kidney cancer in people with complex kidney cysts who are scheduled for surgery. About 70 participants will receive the tracer and undergo imaging be…

This study tests a new, faster MRI scan for the abdomen and pelvis that uses artificial intelligence to create clear images. About 300 adults who need an MRI as part of their care will get both the standard scan and the fast version. The goal is to see if the fast scan is just as…

This study tests a new radioactive dye called 68Ga-NI-FAPI for PET/CT scans. It aims to better detect diseases like tumors, heart problems, and lung scarring by targeting a protein linked to tissue damage. About 30 people, including healthy volunteers and patients, will take part…

This study tests a new imaging method called Al18F-NOTA-FAPI-04 PET/CT or PET/MRI to see if it can better detect and guide treatment for malignant tumors, heart problems, and autoimmune diseases like hyperthyroidism. About 600 adults will receive the imaging agent and be monitore…

This study tests a new type of PET/CT scan using a tracer called Al18F-NOTA-LM3 to find tumors that cause tumor-induced osteomalacia (TIO), a rare condition where bones soften and weaken. Researchers will compare this new scan to the standard 68Ga-DOTATATE PET/CT in 40 adults wit…

This study tests a new type of PET scan using a tracer called 68Ga-Pentixafor to help doctors tell apart the two main types of Cushing's syndrome (ACTH-dependent vs. ACTH-independent) and find the source of the problem. Researchers will enroll 160 adults with suspected or confirm…

This study explores whether a special type of PET scan, called PSMA PET, can help doctors see how well the salivary glands are working in people with Sjögren's syndrome. Researchers will compare these scans with another type of PET scan (FAPI PET) that shows inflammation. The goa…

This study tests a newer type of PET/CT scan (Al18F-NOTA-LM3) against the current standard (68Ga-DOTATATE) to see which finds more tumors in people with pheochromocytoma or paraganglioma (PPGL). About 40 adults with suspected or confirmed PPGL will receive both scans, and doctors…

This study tests a special PET scan that uses a radioactive tracer called 68Ga-FAPI to see inflammation in people with Sjögren's syndrome, an autoimmune disease that causes dryness. Researchers will compare the scan results with standard blood tests and also look at scans from ca…

This study compares a new, radiation-free bedside test using saline contrast and electrical impedance tomography (EIT) against standard CT scans (CTPA) for diagnosing acute pulmonary embolism (blood clots in the lungs). Researchers will enroll 343 patients with suspected or confi…

This study compares a new radioactive tracer, 68Ga-P16-093, with the standard tracer 68Ga-PSMA-11 for PET/CT imaging in 50 men with untreated prostate cancer. The goal is to see which tracer better detects tumors and their spread. Participants will receive both tracers within a w…

This study is testing a new radioactive tracer called 68Ga-NYM096 in 120 adults with various cancers. Participants receive one injection of the tracer followed by a PET/CT scan to see how well it highlights both primary tumors and cancer that has spread. The goal is to identify w…

This study tests whether spraying a low-dose lidocaine solution under the diaphragm during single-incision laparoscopic surgery can reduce shoulder pain afterward. About 100 women having surgery for benign gynecological conditions like ovarian cysts or uterine fibroids will take …

This trial tests whether a virtual reality system that lets family members appear and comfort patients can reduce delirium in ICU patients on breathing machines. About 102 adults in China will use the VR headset until their breathing tube is removed. Researchers will track deliri…

This study tests whether a dietary supplement called β-alanine can reduce fatigue in people with advanced liver cancer who are receiving standard immunotherapy. About 158 participants will take either the supplement or a placebo alongside their regular treatment. The main goal is…

This study compares two versions of a procedure called POEM for people with achalasia, a condition where the esophagus doesn't relax properly, making swallowing difficult. About 52 adults with type I or II achalasia will be randomly assigned to receive either the standard circula…

This study looks at whether ear acupuncture can help with slow stomach emptying after abdominal surgeries like Whipple or gastrectomy. Researchers will track symptoms like nausea and fullness in 159 adults aged 40-70. The goal is to see if this simple, needle-based therapy improv…

This study tests whether a 12-week program of Baduanjin, a gentle Chinese mind-body exercise, can reduce low back and pelvic pain in pregnant women. Researchers will enroll 84 women with single pregnancies between 14-20 weeks. The goal is to see if this safe, drug-free approach i…

This study looks at why people with pancreatic cancer often lose muscle and weight (cachexia). Researchers will collect blood, tissue, and imaging data from 500 patients to understand the biology and build an AI model that could warn doctors early. It is an observational study, s…

This observational study will follow 5000 people with pulmonary hypertension to understand a severe complication called pulmonary hypertension crisis. Researchers will collect medical data and samples to build a risk prediction tool. The goal is to identify who is at risk and imp…

This study observes 30 adults with distributive shock who are on a ventilator and receiving norepinephrine to maintain blood pressure. Researchers measure critical closing pressure—the pressure at which small blood vessels collapse—before and 30 minutes after doctors reduce the n…

This study will screen 2,000 people with HIV for fatty liver disease using a painless ultrasound technique. The goal is to catch liver problems early and improve long-term care. Researchers will also track how different HIV medications affect liver health.

This study looks at whether wearing a fitness tracker before surgery can help predict dangerous drops in blood pressure during anesthesia in patients 65 and older. Researchers will monitor physical activity and sleep patterns with an ActiGraph device, then check for links to hear…

This study is developing a machine learning model to predict the risk of low blood pressure after anesthesia in elderly patients having non-cardiac surgery. Researchers will collect data from 500 participants aged 65 and older, including heart rate variability and other health de…

This study explores whether monitoring bowel sounds can help predict which patients with acute pancreatitis will develop a severe form of the disease. Researchers will enroll 352 adults across three hospitals and track their bowel sounds for at least 48 hours. The goal is to see …

This study will test how well artificial intelligence (AI) can interpret breast ultrasound images using the latest BI-RADS criteria. Researchers will collect over 1,300 past ultrasound images with confirmed diagnoses and have expert radiologists annotate them. Then, various AI mo…

This observational study tracks 500 cancer patients who have experienced immune-related side effects from immunotherapy drugs like checkpoint inhibitors. Researchers aim to understand how common these side effects are, how they are managed, and whether it is safe to restart immun…

This observational study will enroll 50 mechanically ventilated patients with acute respiratory failure to compare two methods of assessing lung recruitment: the recruitment-to-inflation ratio (R/I ratio) and 2D/3D electrical impedance tomography (EIT). Participants will undergo …

This study will use a 3D electrical impedance tomography (EIT) device to monitor how lung ventilation and blood flow change when ARDS patients are placed on their stomach (prone position). Researchers will track 30 patients on mechanical ventilation at three time points: lying on…

This study is testing a new, safe imaging technique called photoacoustic imaging to look at brown adipose tissue (BAT), a type of body fat that burns energy. Researchers will compare BAT in healthy adults and people with metabolic syndrome to see if the imaging can spot differenc…

This study will follow 3,000 pancreatic cancer patients in China who are receiving irinotecan liposome II as part of their treatment. Researchers will collect data on side effects, survival, and how well the drug controls the cancer. The goal is to understand how this treatment w…

This study looks at 400 women living with HIV to understand how the bacteria in their gut and vagina might influence HPV infection and cervical changes. Researchers will collect samples to see if an imbalance in vaginal bacteria makes these women more likely to get HPV and develo…

This study is observing 1000 adults having moderate- to high-risk surgery to see if the type and severity of anemia they have before surgery affects their risk of complications like heart injury, kidney injury, or stroke. Researchers will compare patients with iron-deficiency ane…

This study looks at a fast-progressing type of coronary artery disease that may be driven by inflammation. Researchers will compare 20 patients with this condition to 10 patients with typical heart disease, using lab tests, imaging, and physical assessments. The goal is to better…

This study aims to learn more about heart disease that is linked to inflammation but does not progress quickly. Researchers will follow 120 adults with this condition to track their treatments and health outcomes, such as heart attacks or the need for procedures. The goal is to b…

This study checks if general anesthesia given before school age has long-term effects on the thinking and behavior of children with congenital scoliosis (a curved spine present at birth). Researchers will test 150 children aged 6-16 using IQ and behavior questionnaires. The goal …

This study looks at 80 critically ill ICU patients who need tube feeding. Doctors will use a bedside ultrasound to measure blood flow in the gut artery after feeding starts. The goal is to see if changes in blood flow can predict gut injury, so feeding can be adjusted to be safer…