Peking Union Medical College Hospital

This study is testing a new, faster type of radiation therapy for women who have had surgery for breast cancer. It uses artificial intelligence to quickly adjust the radiation plan right before each treatment, aiming to target the cancer more precisely while better protecting hea…

This study compares two versions of a minimally invasive procedure called POEM that helps people with achalasia swallow more easily. Doctors are testing whether cutting just the inner muscle layer or cutting through the full muscle thickness works better for relieving symptoms wh…

This study is testing a more precise type of radiation therapy for cervical cancer. It compares a new 'online adaptive' method, which adjusts treatment in real-time, against standard radiation to see if it causes fewer side effects and better controls the tumor. The trial will in…

This study aims to understand how weight loss and diet affect hormone levels and insulin resistance in women with Polycystic Ovary Syndrome (PCOS). It will follow 425 women, comparing different weight loss amounts and testing a personalized diet plan against a standard one to see…

This study aims to find out which of two standard drug combinations works better for treating idiopathic membranous nephropathy, a kidney disease that causes protein loss in urine. Researchers will compare a steroid-cyclophosphamide combination against rituximab treatment in 200 …

This study is testing if a drug called lenalidomide can help heal painful mouth and genital sores in adults with Behçet's syndrome who haven't responded well to standard treatments. It will involve 42 participants who will take the drug daily for 12 weeks. The main goal is to see…

This early study is testing two new radioactive drugs for men with advanced prostate cancer that has spread and stopped responding to standard hormone treatments. Researchers will give patients a single injection and closely monitor them to check safety, measure how the drug trav…

This study is testing whether giving immunotherapy drugs before surgery can help surgeons completely remove advanced colon tumors while preserving nearby organs. It focuses on patients whose cancer has a specific genetic feature that makes it respond poorly to standard chemothera…

This study is testing three different first-line treatment combinations for advanced bile duct cancer. It will compare an immunotherapy drug (pembrolizumab) given alone, with chemotherapy, or with another targeted drug (lenvatinib). The goal is to see which approach best controls…

This study aims to find the better treatment strategy to control IgG4-related disease (IgG4-RD), a rare autoimmune condition, and prevent it from flaring up. It will compare two different combinations of a steroid pill (prednisone) with another immune-modifying drug over 12 month…

This study is testing a two-part treatment for a type of blood cancer called diffuse large B-cell lymphoma that has come back or hasn't responded to standard chemotherapy. First, patients receive a short, intense course of radiation therapy. Then, they receive a personalized cell…

This study is testing an oral drug called pyrotinib as the first treatment for people with advanced non-small cell lung cancer that has specific HER2 genetic changes. The goal is to see if the drug is safe and effective at shrinking tumors and controlling the cancer. Researchers …

This study aims to find out if a less invasive 'keyhole' surgery is as good as the standard open surgery for treating a specific stage of cervical cancer. It will involve 524 women with stage IB2 cervical cancer who will be randomly assigned to receive one of the two surgeries. R…

This study is testing whether a new tablet placed under the tongue can help people recover better after a specific type of stroke. It will involve 600 adults in China who recently had a small stroke linked to underlying blood vessel disease in the brain. Participants will take ei…

This study is testing a combination treatment for people with advanced bile tract cancer that has worsened after standard first-line therapy. It combines a chemotherapy drug (paclitaxel) delivered in tiny particles with immunotherapy to help the body fight the cancer. The main go…

This study is testing whether adding a new immunotherapy drug called QL1706 to standard chemotherapy helps people with a certain type of lung cancer that can be removed by surgery. About 30 participants will receive the drug combination before their operation, aiming to shrink th…

This early-stage study is testing a new mRNA drug called XH02 for adults with hypoparathyroidism, a condition where the body doesn't make enough parathyroid hormone. The drug is designed to instruct the body to produce this missing hormone after being given through an IV. The mai…

This study is testing whether the drug tocilizumab can help control symptoms and lung problems in adults with a specific, serious form of dermatomyositis (anti-MDA5+). Researchers will compare the drug to a placebo (inactive substance) in 110 participants to see if it improves sk…

This study is testing if adding a medication called lenalidomide to the standard steroid treatment works better for people with active IgG4-Related Disease (IgG4-RD). It will involve about 200 adults to see if the combination lowers the chance of the disease flaring up again over…

This study is testing a comprehensive treatment plan for a specific, fast-worsening type of coronary artery disease believed to be driven by inflammation. It will enroll about 39 patients who have this condition. Researchers will compare each patient's health outcomes before and …

This small, early study is testing whether a fecal transplant (transferring gut bacteria from a healthy donor) combined with a special prebiotic diet can help adults with long-term functional constipation. The goal is to see if this approach is safe and can improve symptoms like …

This study is testing whether adding two newer drugs (camrelizumab and apatinib) to standard chemotherapy can better control a rare cancer that develops from pregnancy tissue, called gestational trophoblastic neoplasia (GTN). It is for patients with very high-risk or hard-to-trea…

This study is testing if adding a natural compound called berberine to standard blood-thinning medications (aspirin and clopidogrel) can better prevent dangerous blood clots in patients who have had a heart stent placed. It will involve about 64 patients who are 8 to 40 weeks pas…

This study is testing if adding a targeted procedure to a two-drug combination works better for advanced liver cancer. It will compare two groups: one gets the drugs alone, and the other gets the drugs plus a procedure that delivers treatment directly to the liver tumor. Research…

This study is testing whether a combination of light therapy on specific body points and a traditional Chinese herbal formula can improve ovarian function in women with diminished ovarian reserve. Researchers will compare the light therapy plus herbs, light therapy alone, and her…

This study aims to find the best way to prevent new bone fractures in people with osteoporosis who have just had a fracture. It will compare two treatment approaches: starting with one bone-building drug followed by another, versus using the second drug alone. The goal is to see …

This study is testing a new, less invasive surgical technique called BAO-G to repair dangerous, complex aortic aneurysms (bulges in the body's main artery). The technique uses readily available devices to rebuild the artery's vital side branches. The trial will enroll 60 patients…

This study is testing whether a targeted drug called ivosidenib, when combined with other cancer therapies, can help control advanced bile duct cancer in patients who have a specific genetic change called an IDH1 mutation and whose cancer has worsened after standard chemotherapy.…

This study is testing if adding a dietary supplement called beta-alanine to standard first-line immunotherapy helps people with advanced liver cancer. The main goal is to see if it reduces cancer-related fatigue and is safe to take. Researchers will also explore if this combinati…

This study is testing whether giving two immunotherapy drugs (Tuvonralimab and Iparomlimab) plus chemotherapy before surgery can improve outcomes for people with bile duct cancer. Researchers want to see if this approach helps surgeons remove more of the cancer completely and red…

This study is testing a new type of PET/CT scan to see if it can better find the small, hard-to-locate tumors that cause a rare bone-softening disease called tumor-induced osteomalacia (TIO). The main treatment for TIO is surgery to remove these tumors, so finding them precisely …

This study is testing a new imaging agent for PET scans to see if it can find tumors better than the current standard scan. It will involve 40 adults with a rare type of tumor called pheochromocytoma or paraganglioma. Each participant will get both the new and the standard scan s…

This study is testing a new type of PET/CT scan to see if it can better detect and measure areas of scarring (fibrosis) and tumors in the body. It will involve 30 participants, including patients with various diseases and healthy volunteers. The goal is to see if this imaging met…

This study is testing a new type of PET scan to help doctors better diagnose and locate the source of Cushing's syndrome, a condition caused by too much of the stress hormone cortisol. Researchers will see if this scan, which targets a specific protein, is better than current met…

This study is testing whether a new bedside imaging method can accurately diagnose acute pulmonary embolism (dangerous blood clots in the lungs). Researchers will compare this new method, which uses harmless saline and electrical measurements, against the current standard CT scan…

This study is testing a new imaging agent called 68Ga-P16-093 to see if it can detect prostate cancer tumors as well as or better than the current standard tracer, 68Ga-PSMA-11. Fifty men with newly diagnosed, untreated prostate cancer will receive both types of scans within a we…

This study is testing a new type of PET scan that uses a special tracer called Al18F-NOTA-FAPI-04. The goal is to see if this scan can create clearer pictures to help doctors better detect and guide treatment for cancers, heart problems, and autoimmune diseases like hyperthyroidi…

This study is testing a new type of PET scan to see if it can better show inflammation in people with Sjögren's syndrome, a condition that causes dry mouth and eyes. Researchers will compare the scan results in 60 people with Sjögren's to scans from people with cancer to see if t…

This study is testing whether a virtual reality system that lets family members visit can help reduce delirium in ICU patients who are on breathing machines. Researchers will give 102 patients VR headsets to block out the stressful ICU environment and connect them with family for…

This study is testing whether ear acupuncture can help patients recover normal stomach function after major abdominal surgeries like Whipple procedures or partial stomach removal. Researchers will observe 159 patients aged 40-70 to see if the therapy reduces symptoms like nausea,…

This study is testing whether a 12-week Baduanjin exercise program can help reduce low back and pelvic pain in pregnant women and improve their quality of life. Researchers will enroll 84 women who are 14-20 weeks pregnant and randomly assign them to either do the exercises or re…

This study aims to understand how different types of anemia affect complication risks after surgery. Researchers will observe 1,000 adults undergoing moderate-to-high-risk operations, comparing those with iron-deficiency anemia, anemia from chronic disease, or combined anemia to …

This study aims to better understand a specific type of coronary artery disease (CAD) that is linked to chronic inflammation, often affects younger women, and doesn't respond well to standard heart treatments. Researchers will observe 120 patients with this condition over two yea…

This study aims to better understand the side effects that can occur when cancer patients take immunotherapy drugs. Researchers will observe 500 patients who develop these side effects to learn how they happen, how they are managed, and whether it is safe to restart the immunothe…

This study aims to understand how the community of bacteria in the gut and vagina might influence a woman's risk of getting an HPV infection and developing cervical problems. It will follow 400 women living with HIV in China, collecting samples to analyze their bacteria and track…

This study aims to understand why some critically ill patients in the ICU have trouble tolerating liquid food given through a tube. Researchers will use a bedside ultrasound machine to measure blood flow in the gut before and after feeding. They hope to find patterns that can pre…

This study aims to better understand how turning patients with severe lung failure (ARDS) onto their stomach affects air and blood flow in different parts of the lungs. Researchers will use a special 3D imaging technique on 30 adult patients who are on breathing machines and need…

This study aims to understand how a specific chemotherapy drug works for pancreatic cancer patients in everyday medical practice, not a controlled trial. It will observe 3000 patients in China who are already receiving this treatment to collect information on side effects and how…

This study aims to better understand a specific, fast-progressing type of heart disease linked to inflammation. Researchers will compare 20 patients with this inflammation-linked disease to 10 patients with the more common type of heart disease. They will look at medical historie…

This study is testing two new types of PET scans to better understand and track Sjögren's syndrome, a chronic autoimmune disease that damages glands. Researchers will scan 60 people, including patients and healthy volunteers, to see if these scans can provide a clearer picture of…

This study aims to understand if receiving general anesthesia for scoliosis surgery at a young age has any long-term effects on a child's brain development. Researchers will measure intelligence, reasoning, and behavior in 150 children and teens (ages 6-16) who were born with a c…

This study aims to understand if different types of HIV medication affect the development of fatty liver disease. Researchers will follow 200 Chinese patients with HIV to see if starting or switching certain drugs leads to more severe liver fat buildup or scarring. The goal is to…

This study is testing a new imaging agent called 68Ga-NYM096 to see how well it shows up in different types of cancer on PET/CT scans. It will involve 120 adult patients with confirmed cancer who will receive one injection of the tracer followed by a full-body scan. The goal is t…

This study is testing a new, radiation-free imaging method to see if it can measure 'brown fat,' a type of fat that burns calories. Researchers want to see if this scan can spot differences in brown fat between healthy people and people with metabolic syndrome, a group of conditi…

This study aims to compare different imaging methods to see how well they predict whether a patient's lungs can be opened up during mechanical ventilation. It will observe 50 sedated patients with acute respiratory failure who are already on a ventilator. Researchers will use spe…