Peking Union Medical College Hospital

This study tests whether combining two drugs, camrelizumab and apatinib, with standard chemotherapy can help women with a rare but aggressive pregnancy-related cancer called gestational trophoblastic neoplasia (GTN). The trial includes two groups: those with ultra high-risk GTN w…

This study tests whether starting with one bone-building drug (teriparatide) for 6 months and then switching to another (denosumab) works better than taking denosumab alone to prevent new fractures in people with osteoporosis who have already had a fracture. About 2,478 men and w…

This study tests whether adding a targeted procedure (like chemoembolization) to standard immunotherapy and anti-VEGF drugs can better shrink tumors in people with advanced liver cancer. About 300 adults with BCLC stage B or C liver cancer will be split into two groups: one gets …

This study tests a new type of radiation therapy that adjusts the beam in real time to match the patient's body shape each day. It includes 40 women who have had breast cancer surgery and need radiation. The goal is to see if this approach delivers the dose more accurately and ca…

This study tests whether adding two immunotherapy drugs (tuvonralimab and iparomlimab) to standard chemotherapy before surgery can help people with bile duct or gallbladder cancer. About 45 adults with tumors that can be surgically removed will receive 2-4 cycles of the combinati…

This study tests a drug called ivosidenib, combined with lenvatinib or an immunotherapy, for people with advanced bile duct cancer that has a specific IDH1 gene change and has stopped responding to standard chemotherapy. The goal is to see if this targeted approach can shrink tum…

This early-phase study tests a new radioactive drug (177Lu-P17-087/088) in 30 men with advanced prostate cancer that no longer responds to hormone therapy or chemotherapy. The goal is to check safety and find the best dose by giving a single injection and tracking how the drug sp…

This early-stage trial tests an mRNA drug called XH-02 in 15 adults with hypoparathyroidism, a condition where the body doesn't make enough parathyroid hormone. The drug is injected under the skin to help the body produce the missing hormone. The main goal is to check safety, but…

This study tests a new way to repair complex aortic aneurysms (bulging blood vessels) using stents placed through small incisions, avoiding major open surgery. The procedure uses off-the-shelf devices to rebuild branches that supply vital organs. Researchers will check safety and…

This study tests whether a comprehensive treatment can reduce heart attacks and other serious events in people with rapidly-progressive coronary artery disease caused by inflammation. About 39 adults who have already had heart procedures like stents or bypass surgery will receive…

This study tests an mRNA drug called XH-02 that helps the body produce a missing hormone (PTH) in adults with hypoparathyroidism. The drug is given as a shot under the skin. The goal is to see if it is safe and can better control calcium and phosphorus levels than standard treatm…

This study tests whether a newer, more precise type of radiation (online adaptive radiotherapy) can reduce side effects and better control cervical cancer compared to standard image-guided radiotherapy. About 124 women with advanced cervical cancer will receive either the new or …

This study tests whether a newer, less invasive laparoscopic surgery (with special steps to avoid spreading cancer cells) works as well as standard open surgery for people with stage IB2 cervical cancer. About 524 participants will be randomly assigned to one of the two surgeries…

This study tests whether a combination of light therapy on acupoints and a traditional Chinese medicine pill (Dingkun Dan) can improve ovarian function in women with diminished ovarian reserve (DOR). About 90 women aged 25-40 will be split into three groups: light therapy plus pl…

This study tests a new drug called QL1706 (a type of immunotherapy) combined with standard chemotherapy for people with a certain stage of non-small cell lung cancer that can be removed with surgery. About 30 participants will receive the drug combination before surgery to shrink…

This study tests whether giving immunotherapy before surgery can help completely remove T4 colon cancers that have a genetic feature called dMMR. These cancers often don't respond to standard chemotherapy. The trial aims to see if this approach increases the chance of clean surgi…

This study tests whether Edaravone Dexborneol sublingual tablets can help people recover better and avoid another stroke after a mild stroke caused by small vessel disease. About 600 adults aged 30–80 will take the tablet or a placebo daily for 24 weeks, with follow-up for one ye…

This study tests whether the drug lenalidomide can safely heal mouth ulcers in adults with a rare condition called mucosal Behçet's syndrome. About 42 participants will take the drug for 12 weeks to see if their ulcers disappear or become fewer. The goal is to control the disease…

This study compares two treatment strategies for people with IgG4-related disease affecting superficial organs like glands or lymph nodes. About 60 adults will receive either prednisone plus iguratimod or prednisone plus leflunomide for 12 months. The goal is to see which combina…

This study looks at whether berberine, a natural compound, can help blood thinners work better in people who have had a heart stent placed. About 64 adults who are already taking aspirin and clopidogrel will receive different doses of berberine or no extra treatment. The goal is …

This study tests whether giving a special type of radiation (ultra-fraction radiotherapy) before CAR-T cell therapy can safely improve outcomes for people with relapsed or refractory diffuse large B-cell lymphoma. About 20 adults whose cancer has not responded to at least two pri…

This early-stage trial tests an experimental mRNA drug called XH02 in 6 adults with hypoparathyroidism, a condition where the body lacks parathyroid hormone (PTH). The drug aims to temporarily replace PTH after a single intravenous dose. Researchers will monitor safety and measur…

This study tests whether giving a combination of two immunotherapy drugs (iIparomlimab and tuvonralimab) plus a targeted therapy (lenvatinib) before surgery can help shrink liver cancer and lower the chance of it coming back. About 33 adults with resectable liver cancer at high r…

This study tests whether adding lenalidomide to standard prednisone treatment can better control active IgG4-related disease (IgG4-RD), a rare condition causing swelling and damage in organs. About 198 adults with active disease will receive either 5mg or 10mg lenalidomide plus p…

This study tests a new treatment for people with advanced bile duct cancer whose standard first-line therapy has stopped working. The treatment combines a special form of the chemotherapy drug paclitaxel with immunotherapy. The goal is to see if this combination can shrink tumors…

This study compares different immunosuppressive drugs to treat idiopathic membranous nephropathy, a kidney condition where the immune system attacks the kidneys. About 200 adults with severe protein in their urine will be followed for 24 months to see which treatment leads to rem…

This study tests whether adding pembrolizumab (an immunotherapy) to standard chemotherapy or lenvatinib can help people with advanced bile duct or gallbladder cancer live longer and slow tumor growth. About 60 adults with cancer that cannot be removed by surgery will receive diff…

This study tests a drug called pyrotinib as a first treatment for people with advanced non-small cell lung cancer that has a specific change in the HER2 gene. About 18 adults with stage IIIB or IV cancer who haven't had prior treatment will take pyrotinib pills. The goal is to se…

This study tests whether tocilizumab, an anti-inflammatory drug, can improve symptoms and breathing in adults with anti-MDA5-positive dermatomyositis, a rare autoimmune disease affecting muscles, skin, and lungs. About 110 participants will receive either the drug or a placebo ev…

This study tests a drug called glofitamab in 20 Chinese patients with a type of blood cancer (diffuse large B-cell lymphoma) that has come back or not responded to at least two prior treatments. The goal is to see if the drug can control the cancer and how safe it is. Participant…

This study looks at how losing weight and then regaining it (weight cycling) affects hormone levels and insulin resistance in women with Polycystic Ovary Syndrome (PCOS). Researchers will follow 425 women with PCOS, some at normal weight and some overweight, as they try to lose w…

This study is testing a new type of PET scan (68Ga-Pentixafor) to see if it can better tell apart two main types of Cushing's syndrome and find hidden tumors. Researchers will scan 160 adults with suspected or confirmed Cushing's. The goal is to improve diagnosis accuracy compare…

This study tests a newer PET/CT tracer (Al18F-NOTA-LM3) against the standard one (68Ga-DOTATATE) to see which finds more tumors in people with pheochromocytoma or paraganglioma (PPGL). About 40 adults with suspected or confirmed PPGL will receive both scans. The goal is to improv…

This study tests a new type of PET/CT scan using a tracer called Al18F-NOTA-LM3 to find tumors that cause tumor-induced osteomalacia, a condition where bones become soft and weak. About 40 adults with suspected or confirmed disease will receive both the new scan and a standard sc…

This study is testing a new type of PET imaging (Al18F-NOTA-FAPI-04) to see if it can better detect and guide treatment for cancers, heart problems, and immune diseases like hyperthyroidism. About 600 adults will receive the imaging agent and be monitored for safety and accuracy.…

This study tests a new imaging agent, 68Ga-P16-093, against the standard 68Ga-PSMA-11 for detecting prostate cancer. About 50 men with untreated prostate cancer will receive both PET scans within a week. The goal is to see which agent finds more tumors and gives clearer images.

This study is testing a new imaging agent called [68Ga]Ga-NI-FAPI-04 for PET/CT scans to see if it can better detect diseases linked to fibroblast activation, such as tumors, heart conditions, and pulmonary fibrosis. About 30 participants, including patients and healthy volunteer…

This study tests a new bedside method using saline contrast and electrical impedance tomography (EIT) to diagnose acute pulmonary embolism (blood clots in the lungs). It compares this method to the standard CT scan (CTPA) in 343 adults with suspected clots. The goal is to see if …

This study is testing two new types of PET scans to get a clearer picture of what's happening inside the glands of people with Sjögren's syndrome. Researchers want to see if one scan can show how much healthy gland tissue is left, while the other scan shows areas of active inflam…

This study looks at whether a gentle mind-body exercise called Baduanjin can help pregnant women with low back and pelvic pain. About 84 women in their second trimester will do the exercise for 12 weeks. Researchers will measure pain levels and quality of life to see if it helps.

This study looks at whether spraying a low-dose numbing medicine (lidocaine) under the diaphragm during single-incision laparoscopic surgery can reduce shoulder pain after the operation. About 100 women having surgery for benign conditions like ovarian cysts or uterine fibroids w…

This study tests whether a virtual reality system that lets ICU patients on ventilators see and interact with their families can lower their risk of delirium (sudden confusion). About 102 adults who are expected to be on a breathing machine for at least 24 hours will take part. T…

This small pilot study tests whether a fecal microbiota transplant (FMT) combined with a prebiotic nutritional drink can safely improve chronic constipation. Five adults with functional constipation will receive the treatment and be monitored for changes in bowel frequency, stool…

This study compares two versions of a procedure called POEM for people with achalasia, a condition that makes it hard to swallow. About 52 participants will receive either the standard circular muscle cut or a full-thickness cut. The goal is to see which method better relieves sy…

This study looks at whether ear acupuncture can help with slow stomach emptying after certain abdominal surgeries. About 159 adults aged 40-70 having Whipple, pancreas, or stomach cancer surgery will be observed. Researchers will track symptoms like nausea and fullness, and check…

This study tests whether a dietary supplement called β-alanine can reduce fatigue in people with advanced liver cancer who are receiving standard immunotherapy. About 158 participants will take either β-alanine or a placebo alongside their regular treatment. The main goal is to s…

This study looks at why some people with heart disease get worse much faster due to inflammation. Researchers will compare 20 patients with inflammation-related rapid coronary artery disease to 10 patients with typical disease. The goal is to find patterns in their health history…

This study looks at 200 people with HIV to see if two types of HIV drugs (NNRTI and INSTI) cause different amounts of fat buildup or scarring in the liver. Participants will have ultrasound and other scans to measure liver health. The goal is to understand which drug might be saf…

This study looks at 50 adults on breathing machines for acute respiratory failure. Researchers compare two methods—electrical impedance tomography (EIT) and the recruitment-to-inflation ratio—to see how well they predict lung reopening. Participants undergo a standard procedure t…

This study is testing a new imaging agent called 68Ga-NYM096, which is used with PET/CT scans to see how it collects in various cancers, including both primary tumors and those that have spread. Researchers will measure how bright the tracer appears in tumors compared to normal t…

This study is testing a new, radiation-free imaging technique called photoacoustic imaging to look at brown adipose tissue (brown fat), which helps burn energy. Researchers will compare brown fat activity in 100 healthy adults and people with metabolic syndrome, both at rest and …

This study tests whether listening to bowel sounds can help doctors predict which patients with acute pancreatitis will develop a severe form. Researchers will monitor 352 adults for 48 hours using a special device. The goal is to catch warning signs early so treatment can start …

This study follows 120 adults with coronary artery disease and signs of chronic inflammation to understand their symptoms, current treatments, and health outcomes over time. Researchers will track major heart events like heart attacks, need for procedures, or death. The goal is t…

This study looks at 400 women living with HIV to understand how the bacteria in their gut and vagina may influence HPV infection and cervical cell changes. Researchers will collect samples to see if an imbalance in vaginal bacteria makes these women more likely to get HPV and dev…

This study is observing 3,000 Chinese patients with pancreatic cancer who are receiving a drug called irinotecan liposome. Researchers are collecting real-world data on side effects, survival, and how well the drug controls the cancer. The goal is to understand the drug's safety …

This study looks at how lying on the stomach (prone position) changes lung function in patients with severe breathing problems (ARDS). Researchers will use a special 3D imaging technique called EIT to see air and blood flow in the lungs. The goal is to better understand why prone…

This study looks at how blood flow in the gut changes after feeding in critically ill ICU patients. Doctors will use a bedside ultrasound to measure these changes and see if they can predict gut injury. The goal is to make feeding safer and reduce complications. About 80 adults w…

This study collects thousands of breast ultrasound images and has expert doctors label them. Then, different AI models are tested to see how accurately they can identify cancer compared to the experts. The goal is to build a standard way to evaluate AI for breast imaging, not to …

This study is testing a new, faster MRI scan for the abdomen and pelvis that uses artificial intelligence to create clear images. About 300 adults who need an MRI as part of their regular care will get both the standard scan and the faster one. The goal is to see if the fast scan…

This study aims to find out if general anesthesia given before school age has any long-term effects on thinking and behavior in children with congenital scoliosis (a spine curve present at birth). Researchers will test 150 children aged 6-16 using intelligence and behavior checkl…

This study watches 500 cancer patients to learn about immune-related side effects from immunotherapy drugs. Researchers will track what side effects happen, how bad they are, and whether it's safe to restart the same treatment after side effects go away. The goal is to help docto…

This study follows 66 people with chronic viral infections in the brain, like PML, to see if using immune checkpoint inhibitors can improve their long-term health. Researchers will track disability, brain scans, and virus levels over one year. The goal is to learn whether this ap…

This study looks at how different types of anemia (low red blood cells) before surgery affect the chance of complications like heart injury, kidney injury, or stroke. Researchers will follow 1000 adults having moderate- to high-risk surgery. The goal is to see if the type of anem…

This study is testing whether a special PET scan called FAPI PET/CT can see inflammation in people with Sjögren's syndrome, an autoimmune disease that causes dryness. Researchers will compare the scan results with blood tests and also look at scans from people with tumors. The go…