Peking Union Medical College Hospital

This early-phase study tests a new radioactive drug, 161Tb-LNC1011, in 15 men with advanced prostate cancer that no longer responds to hormone therapy. The drug is designed to seek out and deliver radiation directly to cancer cells. The main goals are to check safety, find the be…

This study tests whether a personalized approach using a special lung monitor (EIT) can improve survival in adults with severe lung failure (ARDS). About 574 patients will be randomly assigned to either the EIT-guided strategy or standard care. The main goal is to see if the pers…

This early-phase study tests an inhaled mRNA drug (BMD003) in 24 Chinese patients aged 12 and older with cystic fibrosis. The goal is to see if it is safe and can improve lung function. Participants will receive multiple doses and be monitored for one year.

This study tests whether adding enarodustat to standard cyclosporine treatment works better than cyclosporine alone for people newly diagnosed with a type of aplastic anemia that requires regular blood transfusions. About 90 adults who cannot have a stem cell transplant will take…

This study tests a combination of three drugs (cyclosporine, eltrombopag or hetrombopag, and romiplostim) in adults newly diagnosed with severe aplastic anemia or transfusion-dependent non-severe aplastic anemia. The goal is to see if this treatment can improve blood cell counts …

This study tests whether a drug called butylphthalide can help people who have had a minor stroke recover better over the long term. About 1,200 adults aged 40-80 will take either the drug or a placebo daily for 12 months. Researchers will track survival, stroke recurrence, disab…

This study compares a four-drug combination (Isa-VRD) against the standard three-drug regimen (VRD) in people newly diagnosed with a high-risk form of multiple myeloma who cannot have a stem cell transplant. The goal is to see if adding isatuximab helps eliminate more cancer cell…

This study tests a combination of three drugs (cyclosporine, eltrombopag or hetrombopag, and romiplostim) in 43 adults newly diagnosed with severe aplastic anemia, a condition where the bone marrow fails to produce enough blood cells. The goal is to see if this treatment can help…

This study tests whether adding enarodustat to standard cyclosporine treatment helps people with a type of aplastic anemia that needs regular blood transfusions. About 90 adults will receive either the drug combo or cyclosporine alone. The goal is to see if the combination improv…

This study tests whether combining two drugs—orelabrutinib and romiplostim—can help adults with chronic immune thrombocytopenia (ITP) maintain safe platelet levels and eventually stop other treatments. About 28 participants who have already tried at least one standard therapy wil…

This early-stage trial tests a new treatment called CAR-M cells, which are immune cells engineered to find and attack a protein called C-MET on pancreatic cancer cells. It is for people with advanced pancreatic cancer whose disease has worsened after chemotherapy. The main goals …

This study tests a daily oral drug called orelabrutinib in 50 adults with autoimmune hemolytic anemia (AIHA) that has not responded to standard treatments. The goal is to see if the drug can control the disease by stopping the immune system from destroying red blood cells. Partic…

This early study tests the safety of a drug called rituximab in 5 boys aged 6 to 10 with Duchenne muscular dystrophy who can still walk. The drug aims to lower certain immune proteins to possibly help muscles work longer. Researchers will watch for side effects and check walking …

This study will create a personalized management model for people diagnosed with type 2 diabetes before age 40. Researchers will combine traditional Chinese medicine with Western medical data to improve treatment and quality of life. The study plans to enroll 2000 participants an…

This study tests a new combination of two drugs—envafolimab (an immunotherapy shot) and axitinib (a targeted therapy pill)—for people with advanced kidney cancer that has not been treated before. The goal is to see if the combination can shrink tumors and control the cancer for a…

This study tests a drug called romiplostim N01 in 43 adults with aplastic anemia caused by chemotherapy or radiation that did not improve with standard treatments. The goal is to see if the drug can help the bone marrow produce more blood cells and improve blood counts. Participa…

This study tests whether the drug denosumab can help prevent bone fractures in people with type 2 diabetes who are at high risk for osteoporosis. About 358 adults aged 50 and older (or postmenopausal women aged 45+) will receive denosumab or a placebo. The goal is to see if the d…

This study tests a digital therapy app designed to help pregnant women with gestational diabetes manage their blood sugar. The app provides personalized diet and activity plans, risk alerts, and educational tips. Researchers will enroll 160 women between 24 and 28 weeks of pregna…

This study tests whether adding a traditional Chinese herbal formula to standard ovulation induction therapy improves pregnancy rates in women aged 22-39 with diminished ovarian reserve (low egg supply) and infertility. About 320 participants will receive either the combined trea…

This study tests a computer program that gives real-time feedback to doctors to help them set breathing machines more safely for critically ill patients with lung injury or respiratory failure. About 208 adults on breathing machines will be randomly assigned to either standard ca…

This phase 2 trial tests whether a higher radiation dose (58.75 Gy) given before surgery can improve complete response rates in 156 adults with locally advanced rectal cancer, compared to the standard dose (50 Gy). Participants receive radiation plus chemotherapy, then surgery or…

This study tests a combination of three drugs (disitamab vedotin, lenvatinib, and a PD-1 inhibitor) in 65 adults with advanced HER2-positive bile duct cancer that cannot be removed by surgery. The goal is to see how well the treatment shrinks tumors and how safe it is. Participan…

This study tests whether giving a PCSK9 inhibitor (a drug that lowers cholesterol) soon after a stroke can help people recover better. About 1,200 adults who had a stroke from narrowed brain arteries will receive either the drug or a placebo. The main goal is to see if more peopl…

This study tests whether adding a head-down tilt position or a traditional Chinese herbal formula to standard hospital care can lower the risk of death in people with severe pneumonia who need a breathing machine. About 1,500 adults in ICUs across China will take part. The main g…

This study tests a new oral drug, linprixel, in 22 adults with autoimmune hemolytic anemia that has not responded to or returned after other treatments. The drug aims to control the disease by reducing the immune system's attack on red blood cells. Participants take the drug dail…

This study tests whether transplanting healthy gut bacteria (fecal microbiota transplant) along with special prebiotics can help people with long-term constipation that hasn't improved with standard treatments. Nineteen adults with refractory functional constipation will receive …

This study tests a new drug combination (SHR-1811 plus bevacizumab) as a second-line treatment for people with metastatic colorectal cancer that has worsened after initial chemotherapy. About 80 adults aged 18-75 will participate to see if the combo shrinks tumors or slows cancer…

This study compares two treatments for blocked arteries in the leg: using a drug-coated balloon alone versus using it after removing some plaque first. The goal is to see which approach keeps the artery open longer. About 408 adults with leg artery blockages will take part and be…

This study is testing a small, hormone-releasing device placed in the uterus after an abortion to see if it helps the uterine lining heal better and faster. Researchers will compare this new device against a similar device without hormones in 200 women. The main goal is to see if…

This study tests a new type of PET scan that uses a special tracer (68Ga-BCMA nanobody) to find multiple myeloma lesions in the body. Researchers will compare it to the standard FDG-PET scan to see if it detects more disease spots. The goal is to improve diagnosis, staging, and e…

This study tests a new imaging agent called 18F-FCOB04 to see if it can help diagnose neurodegenerative diseases like Alzheimer's and Parkinson's. About 40 adults will receive a PET scan after getting the tracer, and researchers will look at how it binds to MAO-B in the brain. Th…

This study will test whether a new continuous glucose monitor (CGM) combined with artificial intelligence can diagnose gestational diabetes earlier and more accurately than current methods. Researchers will follow 300 pregnant women from early pregnancy through delivery, using CG…

This study will test an artificial intelligence (AI) system that reads eye scans (OCT) to diagnose common blinding eye diseases like diabetic retinopathy, macular degeneration, and glaucoma. Researchers will collect 2,000 real-world scans and see how well the AI can identify each…

This study aims to see if a new DNA test (CISENDO) on cells from a routine cervical smear can accurately detect endometrial cancer or precancerous lesions in women at medium-to-high risk. About 3,500 participants will provide a cervical sample and undergo standard hysteroscopy fo…

This study tests whether a traditional Chinese herbal formula (Bushen Tongzhi) can improve pregnancy rates in women with diminished ovarian reserve (low egg supply) who are doing IVF. About 348 women aged 22-39 will take either the herbal formula or a placebo for 3 months before …

This study tests whether playing a cloned recording of a family member's voice during nursing care can help reduce anxiety and depression in critically ill patients on breathing machines. About 234 adults in Chinese ICUs will receive this voice-cloning care until their breathing …

This study tests if a new drug called Tegileridine is as good as morphine for pain relief in teenagers after scoliosis surgery. About 171 teens will receive either Tegileridine or morphine through a pump they control. Researchers will compare pain scores and side effects over 48 …

This study tests whether giving ondansetron (an anti-nausea drug) before an unsedated emergency endoscopy for upper gastrointestinal bleeding can reduce patient discomfort and gagging. About 80 adults will receive either ondansetron or a placebo, and doctors will rate patient coo…

This study observes how patients with advanced small cell lung cancer are treated in everyday hospital settings and how they respond. About 96 adults will join, and researchers will collect data from medical records and regular check-ins every 3 months. No experimental treatments…

This study looks at why some people's coronary artery disease gets worse quickly while others' does not. Researchers will compare medical history, test results, and imaging from 52 adults who have had heart procedures. The goal is to find patterns that could help predict and mana…

This study will follow 6,743 adults with obesity-related cancers (like breast, colon, or lung cancer) to see how changes in body fat and muscle affect survival, recurrence, and quality of life. Researchers will use advanced imaging to measure body composition, aiming to better un…

This study looks at DNA from 100 families where a baby had a birth defect but standard genetic tests found no clear cause. Researchers will use advanced DNA sequencing to find hidden changes in the structure of genes. The goal is to create a reference map for the Chinese populati…

This study looks at where colon cancer spreads to lymph nodes in the small intestine's lining. About 406 adults with right-sided colon cancer will have their surgical tissue examined. The goal is to learn the exact pattern of spread so surgeons can remove the right amount of tiss…

This study looks at what treatments work best for people with diffuse large B-cell lymphoma (DLBCL) after a drug called polatuzumab vedotin stops working. Researchers will track 200 patients to see which salvage therapies lead to the best outcomes. The goal is to gather real-worl…

This study aims to find better ways to identify people at high risk for prediabetes using continuous glucose monitors (CGMs) and artificial intelligence (AI). Researchers will enroll 1000 adults aged 35 and older with a high diabetes risk score but normal blood sugar levels. By a…

This study looks at how the bacteria in your gut might influence how well a drug called glofitamab works against a type of lymphoma (DLBCL). Researchers will collect stool samples from 30 patients before, during, and up to one year after treatment to see if certain gut bacteria a…

This study enrolls 200 adults scheduled for surgery to remove pheochromocytoma or paraganglioma tumors. Researchers will test a model that uses 6 factors to predict severe blood pressure swings during the operation, and a real-time tool that warns of changes 60 seconds ahead. Par…