Peking Union Medical College Hospital

This study tests if a monthly injection of Compound Betamethasone (Diprospan) works better than daily prednisone pills for people with early-stage pulmonary sarcoidosis. About 126 participants will receive either the injection or pills for 24 weeks, with lung function tests and s…

This phase 3 trial tests whether adding a platelet-boosting drug (rhTPO) to standard cyclosporine therapy can safely raise platelet counts in 78 adults with lower-risk myelodysplastic syndromes (MDS) who have very low platelets. The goal is to reduce bleeding and the need for pla…

This study tests a light-activated drug (HAL-PDT) to treat cervical precancer (CIN2) in 500 women aged 18-50. The treatment is guided by how the cervix responds, with up to 4 sessions. The main goal is to see if the abnormal cells shrink or disappear within 6 months, avoiding the…

This study tests whether freeze-dried fecal bacteria, given as oral capsules, can improve symptoms in 40 adults with active rheumatoid arthritis that hasn't responded to standard drugs. Participants will receive either the fecal transplant or a placebo for 24 weeks. The main goal…

This study tests whether a tablet-based brain training program and/or a powerful cholesterol-lowering drug (PCSK9 inhibitor) can improve thinking and memory in 420 adults aged 55-80 with narrowed brain arteries. Participants will be split into four groups, combining or not combin…

This study looks at whether surgically removing uterine fibroids (myomectomy) before in vitro fertilization (IVF) helps women with infertility have a baby. About 792 women aged 20-39 with fibroids 4-6 cm that do not distort the uterine cavity will be randomly assigned to either h…

This study tests a drug called romiplostim N01 in 43 adults whose bone marrow has stopped making enough blood cells after chemotherapy or radiation. The goal is to see if the drug can improve blood counts and reduce the need for transfusions. Participants must have tried other tr…

This phase 2 trial tests a combination of three drugs—cyclosporine, a thrombopoietin receptor agonist (eltrombopag or hetrombopag), and romiplostim—in 43 adults newly diagnosed with severe aplastic anemia or transfusion-dependent non-severe aplastic anemia. The goal is to see if …

This early-stage trial tests a new type of cell therapy for people with advanced pancreatic cancer that has stopped responding to chemotherapy. The treatment uses a patient's own immune cells, called macrophages, that are engineered in a lab to recognize and attack cancer cells c…

This Phase 3 trial tests whether adding enarodustat to standard cyclosporine treatment helps people with transfusion-dependent non-severe aplastic anemia. The study will enroll 90 newly diagnosed adults who cannot have a stem cell transplant. The goal is to see if the combination…

This early-phase study tests an inhaled mRNA drug (BMD003) in 24 people aged 12 and older with cystic fibrosis. The goal is to see if it is safe and can improve lung function by delivering instructions to make a working CFTR protein. Participants will receive multiple doses and b…

This study tests the safety of a drug called rituximab in 5 boys aged 6-10 with Duchenne muscular dystrophy (DMD) who can still walk. The drug aims to lower certain immune proteins to possibly slow muscle damage. Researchers will monitor side effects and measure changes in walkin…

This study tests whether a single injection of Recaticimab, a cholesterol-lowering drug, can help people recover better after a stroke caused by narrowed brain arteries. About 1,200 participants will receive either the drug or a placebo, plus standard care. The main goal is to se…

This study compares two ways to treat chronic blockages in the leg arteries: using a drug-coated balloon alone versus using the balloon along with a plaque-removal procedure (like laser or atherectomy). About 408 people with blocked leg arteries will be enrolled. The main goal is…

This large trial in China will test two additional treatments for people with severe pneumonia who need a breathing machine. One group will have their bed tilted head-down for at least 12 hours a day. Another group will receive a traditional Chinese herbal formula. The goal is to…

This phase 2 study tests whether combining orelabrutinib (a targeted drug) with romiplostim (a platelet booster) can improve platelet counts in adults with chronic immune thrombocytopenia (ITP) who haven't responded well to standard treatments. About 28 participants will receive …

This study tests whether transplanting healthy gut bacteria (fecal microbiota transplant, or FMT) combined with prebiotics can relieve chronic constipation. Nineteen adults with hard-to-treat constipation will receive the treatment via colonoscopy. The goal is to improve bowel mo…

This study tests a special stent placed in the uterus right after an abortion. The stent releases estrogen to help the uterine lining grow back thicker and heal faster. About 200 women will get either the estrogen stent or a plain stent, and doctors will check healing with ultras…

This early-phase study tests a new radioactive drug, 161Tb-LNC1011, in 15 men with advanced prostate cancer that no longer responds to hormone therapy. The drug is designed to seek out and deliver radiation directly to cancer cells. The main goals are to check safety and find the…

This study tests whether adding denosumab to standard care can strengthen bones and prevent fractures in 358 adults with type 2 diabetes who are at high risk for breaks. Participants will receive the drug or a placebo, and researchers will measure changes in bone density and frac…

This study tests a new drug combination (SHR-1811 plus bevacizumab) as a second-line treatment for people with metastatic colorectal cancer that has worsened after initial therapy. About 80 adults aged 18-75 will participate. The goal is to see if the combo shrinks tumors and del…

This clinical trial tests whether a traditional Chinese herbal formula, Bushen Tongzhi, can improve pregnancy rates in women with diminished ovarian reserve who are undergoing IVF. About 348 women aged 22-39 will take either the herbal granules or a placebo three times daily for …

This study compares a four-drug regimen (isatuximab plus standard VRD) against the standard three-drug VRD in 117 newly diagnosed multiple myeloma patients who are not eligible for transplant and have high-risk features. The goal is to see if adding isatuximab leads to more patie…

This study tests whether a personalized ventilation strategy guided by electrical impedance tomography (EIT) can improve survival in adults with acute respiratory distress syndrome (ARDS). About 574 participants will be randomly assigned to receive either EIT-guided ventilation (…

This study will enroll 2000 adults diagnosed with type 2 diabetes before age 40. Researchers will combine traditional Chinese medicine with Western medical data to create a personalized treatment model. The goal is to improve blood sugar control and quality of life through a tail…

This Phase 3 trial will test whether adding a traditional Chinese herbal formula to the standard fertility drug letrozole can improve natural pregnancy rates in women aged 22–39 with diminished ovarian reserve (low egg supply). The study plans to enroll 320 women who will receive…

This Phase 3 trial tests whether butylphthalide, a compound from celery seed, can improve long-term recovery in people who have had a minor ischemic stroke. 1,200 participants aged 40–80 will take either the drug or a placebo for 12 months. Researchers will measure survival, stro…

This study tests whether a higher dose of radiation (58.75 Gy) given before surgery can help more people with locally advanced rectal cancer achieve a complete response (no cancer left) compared to the standard dose (50 Gy). About 156 adults aged 18-79 will receive radiation plus…

This study tests a digital therapy app designed to help pregnant women with gestational diabetes manage their blood sugar. The app provides personalized diet and exercise plans, tracks blood sugar and weight, and generates reports. Researchers will enroll 160 women to see if usin…

This phase 2 trial tests a combination of three drugs—disitamab vedotin, lenvatinib, and a PD-1 inhibitor—for people with HER2-positive advanced biliary tract cancer that cannot be removed by surgery. The study will enroll 65 participants to see how well the treatment shrinks tum…

This study tests a combination of two drugs—envafolimab (an immunotherapy injection) and axitinib (a targeted therapy pill)—as a first treatment for people with advanced kidney cancer that has spread or cannot be removed. About 30 participants will receive the treatment for up to…

This phase 2 trial tests linprixel, a daily pill, in 22 adults with relapsed or refractory autoimmune hemolytic anemia (AIHA). The study aims to see if the drug can improve red blood cell counts after 12 weeks. Participants start at 40mg daily, with possible dose increases if nee…

This trial tests whether a special AI system can help doctors diagnose rare diseases more accurately and efficiently. About 1,000 people with suspected rare or hard-to-diagnose conditions will take part. Before seeing the doctor, the AI will gather the patient's medical history a…

This study tests whether an artificial intelligence (AI) tool can help doctors better diagnose rare diseases. About 150 doctors will either use the AI or rely on standard methods to diagnose real patient cases. The goal is to see if AI improves accuracy and speed, which could lea…

This study tests a new imaging method called 68Ga-NYM207 PET/CT to see if it can safely and accurately detect liver cancer (hepatocellular carcinoma). About 100 adults with suspected or known liver cancer will receive the scan. The goal is to improve how doctors find and monitor …

This early-phase trial will test a new radioactive tracer called 18F-FCOB04 in 40 people with neurodegenerative diseases like Alzheimer's or Parkinson's. The tracer targets a brain protein called MAO-B and is used with PET scans to see if it can help diagnose these conditions. Th…

This study tests a new type of PET/CT scan that uses a special tracer (68Ga-BCMA nanobody) to find multiple myeloma lesions in the body. Researchers will compare it to the standard FDG-PET/CT scan in 30 patients with newly diagnosed or relapsed multiple myeloma. The goal is to se…

This observational study will test a new molecular test called CISENDO, which looks at DNA methylation in cells from a routine cervical smear. The goal is to see if it can accurately detect endometrial cancer or precancerous lesions in women at medium-to-high risk. Researchers wi…

This study will test a new artificial intelligence (AI) system that reads eye scans (OCT) to diagnose common blinding eye diseases like diabetic retinopathy, glaucoma, and age-related macular degeneration. Researchers will collect 2000 eye scans from patients at Peking Union Medi…

This study tests whether semaglutide (Ozempic/Wegovy) can prevent repeat episodes of acute pancreatitis caused by very high triglycerides. About 396 adults who recently had such an attack will receive either semaglutide injections or a placebo for 18 months, alongside standard ca…

This study tests if a new pain medicine called tegileridine works as well as morphine for teenagers recovering from scoliosis surgery. About 171 teens will receive either tegileridine or morphine through a pump they control. Researchers will compare pain levels and side effects o…

This study tests whether playing a cloned recording of a loved one's voice can help reduce anxiety in critically ill patients on breathing machines in the ICU. The voice is used three times a day for reassurance and preparation. Researchers will track anxiety, depression, and rec…

This study tests whether giving ondansetron (a common nausea medicine) before an unsedated emergency endoscopy can reduce discomfort and gagging in people with upper gastrointestinal bleeding. About 80 participants will receive either ondansetron or a placebo, and doctors will ra…

This study will use millimeter-wave radar to measure how the pelvic floor muscles move in 2,000 women, both healthy and those with stress urinary incontinence. The goal is to create a large database of normal movement patterns and build a standard assessment system. This is an ob…

This study will enroll 1,000 adults at high risk for prediabetes to see if continuous glucose monitors (CGMs) combined with artificial intelligence can detect the condition earlier and more accurately than current tests. Participants will wear a CGM and provide other health data.…

This study will enroll 200 patients scheduled for surgery to remove rare adrenal tumors called pheochromocytomas or paragangliomas (PPGL). Before surgery, researchers will use a model to predict the risk of severe blood pressure swings during the operation. During surgery, a real…

This study aims to find hidden DNA changes in 100 families where a baby has a major birth defect but standard genetic tests came back normal. Using advanced DNA sequencing, researchers will create a detailed map of structural variations (like missing or rearranged DNA pieces) spe…

This study looks at whether the bacteria living in your gut can influence how well a drug called glofitamab works against diffuse large B-cell lymphoma (DLBCL). Researchers will collect stool samples from 30 patients before and after treatment to track changes in gut microbiome a…

This study looks at what happens to people with diffuse large B-cell lymphoma (a common blood cancer) after treatment with polatuzumab vedotin stops working. Researchers will track 200 patients in China to see which salvage treatments are used and how well they work. The goal is …

This study will enroll 300 pregnant women to see if continuous glucose monitors (CGMs) and AI tools can diagnose gestational diabetes earlier and more accurately than current methods. Researchers will also look at how CGM data relates to health outcomes for mothers and babies. Th…

This study aims to understand why some people's coronary artery disease gets worse quickly while others' stays stable. Researchers will compare medical history, lab results, and imaging from 52 patients—34 with rapidly progressive disease and 18 with non-rapidly progressive disea…

This study will follow 96 adults with extensive-stage small cell lung cancer to see how they are treated in everyday hospital settings and how they respond. Doctors will choose treatments as usual, and researchers will collect data from medical records and regular check-ins every…

This large study will follow over 6,700 adults with obesity-related cancers (like breast, colorectal, or lung cancer) to track changes in their body fat and muscle using advanced imaging. The goal is to see how these changes relate to survival, cancer recurrence, and quality of l…

This observational study will examine lymph nodes from the ileum mesentery in 406 people undergoing surgery for right-sided colon cancer. Researchers want to learn where cancer spreads in these nodes to help surgeons decide how much tissue to remove. Participants will be followed…