Fibroid removal before IVF: a Game-Changer for fertility?

NCT ID NCT07578623

Not yet recruiting Disease control Sponsor: Peking Union Medical College Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether surgically removing uterine fibroids (myomectomy) before in vitro fertilization (IVF) helps women with infertility have a baby. About 792 women aged 20-39 with fibroids 4-6 cm that do not distort the uterine cavity will be randomly assigned to either have surgery first or go straight to IVF. The main goal is to see if surgery improves the live birth rate within one year after IVF.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Myomectomy (surgical removal of uterine fibroids)
What this could lead to: If successful, this could show that removing certain fibroids before IVF improves the chance of a live birth, helping guide treatment decisions for infertile women.
What could go wrong: This trial has not started yet, and results may not show a clear benefit. Surgery itself carries risks like infection or scarring, and the fibroids may grow back.

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Conditions

The condition(s) this trial relates to.

fibroma infertility disorder leiomyoma uterine corpus leiomyoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IN VITRO FERTILIZATION (IVF) INFERTILITY UTERINE MYOMAS, LEIOMYOMAS, OR FIBROMAS

Contacts and locations

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