Infertility disorder

This trial tests whether injecting a man's own purified stem cells into his testicles can restart sperm production. It is for men with non-obstructive azoospermia, a condition where the testicles produce little or no sperm. The stem cells are taken from the patient's bone marrow,…

This study tests a gel called PKB171, which contains a drug used to improve blood flow and sperm movement. Couples with mild male infertility who have been trying to conceive for 6 to 24 months apply the gel after sex. The goal is to see if it increases pregnancy rates compared t…

This phase 3 trial compares a once-weekly growth hormone injection (lonapegsomatropin) to a daily one (somatropin) in 186 prepubertal children with growth failure due to Turner syndrome, SHOX deficiency, being small for gestational age, or idiopathic short stature. The goal is to…

This study tests whether adding a substance called hyaluronan to the liquid used during embryo transfer can improve pregnancy rates in IVF. Researchers will compare live birth rates between women whose embryos are placed in a hyaluronan-rich medium versus a standard one. The tria…

This study tests whether a single midline incision in the pubic area works as well as the standard two incisions (one on each side) for repairing varicoceles in both testicles. The trial enrolls men aged 18 to 45 with a palpable bilateral varicocele and infertility lasting at lea…

This Phase 3 trial tests a new combination of two hormones (follitropin alfa and lutropin alfa) against a standard treatment (hMG) for Japanese women with LH and FSH deficiency who are undergoing IVF. The goal is to see which treatment helps produce more eggs for retrieval. About…

This phase 3 trial tests whether tamoxifen or letrozole works better for preserving fertility in women with estrogen-sensitive breast cancer before starting chemotherapy. About 309 participants will take one of the two drugs during ovarian stimulation to freeze their eggs. The ma…

This study is for overweight or obese women aged 18–45 with atypical endometrial hyperplasia, a precancerous condition of the uterine lining. Participants will receive either a levonorgestrel-releasing IUD (Mirena) or megestrol acetate pills, combined with a weight management pro…

This study tests whether Fertilo, a new solution for maturing eggs outside the body, works better than the current standard (MediCult IVM) for women aged 18-35 undergoing IVF. About 500 participants will have their eggs treated with either Fertilo or MediCult, and researchers wil…

This study compares a longer course of the fertility drug Clomid against the standard short course for women with diminished ovarian reserve undergoing IVF. The goal is to see if the extended protocol leads to more mature eggs retrieved while reducing the number of injections and…

This study tests a method to sort sperm by gender (X or Y chromosome) using a density gradient. The goal is to help couples undergoing IVF or insemination have a baby of a desired sex, for medical or personal reasons. About 2000 couples will take part, and researchers will check …

This study looks at whether a surgery called transcervical resection of the septum (TCRS) can improve pregnancy outcomes for infertile women with a uterine septum who are planning IVF. The trial will compare live birth rates between women who get the surgery and those who don't. …

This early-stage trial tests a drug called atipeksen for people with Ataxia-Telangiectasia (A-T), a rare genetic disease that affects movement and coordination. The drug is designed to fix a specific genetic error in the ATM gene and is given via spinal injection. The study will …

This study looks at 100 women with infertility to see how common chronic endometritis (a long-term inflammation of the womb lining) is and whether antibiotic treatment can improve their chances of getting pregnant and having a healthy baby. Participants will have a camera test an…

This study tests whether adding a hormone drug called Decapeptyl to standard IVF treatments can increase the number of live births. About 784 women under 43 with subfertility will receive either the drug or a placebo during egg retrieval and embryo transfer. The goal is to see if…

This study tests vosoritide, a protein that stimulates bone growth, in 30 children with Noonan syndrome who are not growing well despite growth hormone treatment. The goal is to see if vosoritide can safely increase their growth rate over six months. Participants will receive one…

This study tests whether adjusting sex hormone levels with aromatase inhibitors can improve metabolic health and sperm production in men with Klinefelter syndrome. It also examines if adding semaglutide (a weight-loss drug) or hCG provides extra benefits. The trial involves 150 m…

This study tests whether a cheaper hormone (dydrogesterone) works as well as a standard drug (GnRH antagonist) to prevent early ovulation in women with low ovarian response undergoing double ovarian stimulation. About 120 women will be randomly assigned to one of the two treatmen…

This study tests whether performing intrauterine insemination (IUI) at 42 hours after a hormone trigger shot leads to more live births than the standard 36-hour timing. About 692 women with infertility will be randomly assigned to one of the two timing groups. The goal is to see …

This study aims to help 10 women with absolute uterine infertility (no uterus or one that doesn't work) have a baby through a uterus transplant from a donor. Participants will first undergo IVF to create embryos, then receive the transplant, followed by embryo transfer and pregna…

This study tests whether a donated uterus can help 10 women who were born without a uterus or had it removed to carry a pregnancy. Participants will receive a uterus from a living or deceased donor, then try in vitro fertilization (IVF) to become pregnant. The goal is a live birt…

This phase 3 trial tests whether a daily injection of human menopausal gonadotropin (hMG) can help women with infertility develop more eggs and achieve a live birth during IVF. About 659 women aged 18-42 will receive either the hormone or a placebo. The main goal is to see if the…

This phase 3 trial compares two ways to prepare the womb lining for a frozen embryo transfer: a modified natural cycle using progesterone only, versus standard hormone replacement therapy. The study will enroll 336 women aged 21-44 with regular cycles to see which method leads to…

This study tests whether a uterus from a deceased donor can be transplanted into women who cannot get pregnant due to a missing or non-working uterus. Participants must first create and freeze at least six embryos through IVF. After transplant and recovery, embryos are implanted.…

This study looks at whether surgically removing deep endometriosis from the bowel before IVF improves pregnancy rates compared to IVF alone. It includes 120 women with infertility and pain from deep endometriosis. Participants are randomly assigned to either have surgery then IVF…

This study tests a new way to help men who lost fertility due to cancer or autoimmune treatments. Doctors will transplant the patient's own frozen testicular tissue back into them. The goal is to see if it is safe and can restart sperm production.

This pilot study tests whether transplanting a man's own frozen testicular tissue, stored before childhood cancer treatment, can restore fertility. Twenty men with azoospermia (no sperm) who want children will undergo the procedure. Doctors will check if the graft produces sperm …

This study tests whether giving platelet-rich plasma (PRP) inside the uterus can improve the immune environment and thickness of the lining in women undergoing IVF. Researchers will take biopsies before and after PRP to measure changes in immune cells. The goal is to see if PRP c…

This study tests whether a probiotic called Fertibiome can help restore a healthy balance of bacteria in the vagina for women or couples having trouble getting pregnant. About 120 participants will take either the probiotic or a placebo for up to 6 months. The goal is to see if t…

This study tests whether using special devices during embryo transfer can help more IVF patients get pregnant. The devices keep the embryo at the right temperature and control the transfer process to reduce human error. About 160 women having frozen embryo transfers will be rando…

This study tests whether a strict low-carbohydrate diet combined with lifestyle guidance can help obese men (BMI 30+) lose weight and improve their fertility. Researchers will track weight, semen quality, and reproductive outcomes in 98 men aged 22-40. The goal is to find a non-d…

This Phase 2 trial is testing whether a fixed dose of the hormone follitropin delta (Rekovelle) can improve ovarian stimulation for intrauterine insemination (IUI) in women with regular cycles. The goal is to promote the growth of two mature eggs per cycle to increase pregnancy c…

This study tests whether adding a hormone called LH to standard IVF treatment helps women over 35 who had a low number of eggs in previous cycles. Participants will receive either the usual FSH hormone alone or FSH plus LH, and researchers will measure hormone levels on the day o…

This study tests whether removing tiny cell fragments from day-4 embryos (a procedure called defragmentation) can help them develop into healthy blastocysts and lead to more pregnancies. About 320 women undergoing IVF will be randomly assigned to have their embryos defragmented o…

This phase 3 trial tests whether a lower daily dose (600 mg) of vaginal progesterone works as well as the standard dose (800 mg) for supporting pregnancy after a frozen embryo transfer. About 1,020 women undergoing IVF will be randomly assigned to one of the two doses. The main g…

This study tests whether shining a special red light on eggs and embryos during IVF can help them develop better. As women age, their egg cells have less energy, which can make fertilization and embryo growth harder. The light treatment, called photobiomodulation, aims to boost t…

This study tests a new automated system called AURA that handles sperm, eggs, and embryos during IVF. About 150 patients will have their samples processed by the machine, while some eggs are handled the usual way for comparison. The goal is to see if the robot can perform lab tas…

This study compares three surgical treatments for endometriomas (ovarian cysts from endometriosis) in 332 women aged 18-43 who want to become pregnant. Participants are randomly assigned to cystectomy, plasma vaporization, or sclerotherapy. The main goal is to see which approach …

This study aims to improve fertility-sparing treatment for young women (ages 18-45) with endometrial cancer by tailoring therapy to the tumor's genetic profile. Participants will receive either hormone therapy (progestins) or a combination with an immunotherapy drug (sintilimab),…

This study looks at whether drinking a daily serving of gazpacho, a cold tomato-based soup, can improve semen quality in men with low sperm counts or poor sperm movement. Eighty men will follow a Mediterranean diet for 12 weeks, with half also drinking gazpacho each day. Research…

This program provides an experimental drug, levacetylleucine, to people with Ataxia-Telangiectasia (A-T), a rare genetic disease that affects movement and immunity. It is for patients who cannot join clinical trials and have no other good treatment options. The goal is to offer p…

This study compares two common ovarian stimulation protocols used during IVF in women with polycystic ovary syndrome (PCOS). The PPOS protocol uses a progestin hormone to suppress ovulation, while the antagonist protocol uses a different drug. Researchers will track which method …

This study compares two IVF methods for couples where the male partner has severe sperm shape issues (teratospermia). One group gets standard ICSI (sperm injected into egg), the other gets ICSI plus a chemical boost to activate the egg. The goal is to see which leads to more live…

This study tests a new drug called TCC1727 combined with other medicines (benmelstobart, olaparib, or topotecan) in people with advanced solid tumors, including lung, stomach, endometrial cancer, and melanoma. The goal is to find the safest dose and see if the combination helps s…

This study offers girls facing fertility-threatening medical treatments the option to freeze their ovarian tissue for future use. Up to 40 participants will have a small piece of ovary removed laparoscopically and stored. The goal is to see how many choose this option and at what…

This study is testing a new device called Plan A that blocks sperm from passing through the vas deferens, similar to a vasectomy, but designed to be reversed later. Forty healthy men aged 25 to 65 will receive the device and be monitored for safety and effectiveness. The goal is …

This study looks at whether giving levothyroxine (a thyroid hormone medication) to women with subclinical hypothyroidism (a mild underactive thyroid) can improve their chances of having a baby through IVF. About 900 women aged 18-45 will be included, and researchers will compare …

This study looks at whether giving a GnRH agonist before a frozen embryo transfer can help women with endometriosis or adenomyosis get pregnant. About 180 women aged 18 to 36 will be randomly assigned to receive either standard hormone support or standard support plus one or two …

This study tests whether taking probiotics daily for about 100 days can improve sperm count, movement, and shape in men with infertility. Sixty men aged 20 to 45 will be randomly assigned to receive either probiotics or a placebo. Researchers will measure sperm quality at the sta…

This Stanford study tests whether injecting a man's own platelet-rich plasma (PRP) into his testicles can help produce sperm. Ten men with nonobstructive azoospermia who previously failed sperm retrieval will receive the injection. Three months later, doctors will check for sperm…

This study tests whether giving growth hormone or DHEA (a natural hormone) can improve egg production and pregnancy rates in women with poor ovarian reserve who are undergoing IVF. 165 women will receive one of these treatments or a placebo (folic acid only) for 1-3 months before…

This study tests whether treating eggs and sperm before fertilization can help people who have had complete failure with standard IVF or one prior ICSI cycle. Researchers will measure fertilization rates and embryo development. The goal is to improve chances of pregnancy for thos…

This study tests a milder form of IVF called CAPA in-vitro oocyte maturation (IVM). Instead of giving women strong hormones to stimulate egg growth, eggs are collected early and matured in a lab. The goal is to reduce side effects and costs for women with infertility or those pre…

This study offers boys aged 0-17 the chance to freeze testicular tissue before undergoing treatments like chemotherapy or radiation that could cause permanent infertility. The tissue is stored for potential future use to achieve pregnancy. Researchers will track whether transplan…

This study compares taking the fertility drug letrozole for 10 days versus the usual 5 days in women with PCOS who want to get pregnant. About 20 women aged 18-40 will be randomly assigned to one of the two groups. The goal is to see if the longer treatment leads to more ovulatio…

This study compares two approaches for women under 39 with advanced endometriosis who want to get pregnant: having surgery to remove endometriosis lesions before IVF, or going straight to IVF. The goal is to see which leads to more live births within three years. The trial will e…

This early-phase study tests whether a woman's own natural killer cells, processed in a lab and infused into her uterus, can improve uterine immune function and lead to successful pregnancy. It includes 14 women with a history of recurrent miscarriage, failed IVF, unexplained inf…

This study tests whether adding hydroxychloroquine (an anti-inflammatory drug) to levothyroxine (a thyroid hormone) can increase live birth rates in women with thyroid antibodies and unexplained recurrent pregnancy loss. About 800 women will take either the combination or levothy…

This study compares a generic version of the drug cetrorelix acetate to the original brand in women undergoing IVF. The goal is to see if the generic works just as well at preventing early ovulation and improving live birth rates. Over 1,300 women will participate, and the result…

This study tests whether round spermatids (immature sperm cells) can be used in IVF to help men with a condition called non-obstructive azoospermia, where no mature sperm are present. Researchers will collect these cells from the testicles and inject them into eggs to see if they…

This study tests whether taking a low dose of the hormone hCG for 8 weeks before IVF can increase the number of eggs retrieved in women with diminished ovarian reserve. About 80 women will be randomly assigned to receive either hCG or a placebo. The main goal is to see if hCG lea…

This study looks at whether it's possible and safe to freeze testicular tissue for males of any age who face infertility due to medical treatments like chemotherapy or radiation. Researchers will collect a small sample of testicular tissue through a biopsy and freeze it for poten…

This study compares a single injection of corifollitropin alfa (Elonva) to daily shots of follitropin beta (Puregon) for ovarian stimulation in egg donors. Both groups also take medroxyprogesterone acetate to prevent early ovulation. The goal is to see if the simpler one-shot app…

This study tests whether transplanting a woman's own frozen ovarian tissue can restore fertility after cancer treatment. Ten women who became infertile due to chemotherapy or radiation will receive the transplant. The goal is to see if they can get pregnant and have normal menstr…

This study is tracking 2,600 Chinese children with growth disorders who are receiving a long-acting growth hormone injection. The goal is to see how well it works and how safe it is over the long term in real-world settings. Researchers will measure changes in height and look for…

This study looks at two ways of taking progesterone for teens with Turner syndrome who are on hormone replacement therapy. One group takes progesterone for 12 days each month, the other takes it every day. Researchers will track bleeding patterns and how the teens feel, to see wh…

This study tests whether adding levothyroxine (a thyroid hormone) to the standard fertility drug letrozole helps women with PCOS and mild underactive thyroid ovulate and get pregnant. Two hundred women will be randomly assigned to receive either letrozole alone or letrozole plus …

This study is testing whether a simple ultrasound procedure, called saline infusion sonohysterography (SIS), can accurately detect pelvic adhesions (scar tissue) in infertile women. Researchers will compare SIS results to those from laparoscopy, the current standard. If SIS prove…

This study compares two pain management plans after laparoscopic tubal sterilization: one with opioids and one without. About 38 women will report their pain levels and satisfaction. The goal is to see if non-opioid drugs like Tylenol and ibuprofen work just as well.

This study tests whether infusing platelet-rich plasma (PRP) into the uterus can thicken the uterine lining and improve pregnancy success in women with infertility who have had failed IVF cycles due to a thin lining. About 62 women will receive either PRP or a placebo during a fr…

This early-stage study is testing a new drug called STSP-0902 to see if it is safe for men. It includes healthy volunteers and men with low sperm count or low sperm movement. The main goal is to check for side effects and how the drug moves through the body. This is a first step …

This study tests whether warming the contrast dye used in a hysterosalpingogram (HSG) — a standard X-ray test for blocked fallopian tubes — can reduce pain and cramping during the procedure. About 240 women aged 18–45 will be randomly assigned to receive either warm or room-tempe…

This study tests whether inhaling lavender essential oil for four weeks can reduce anxiety, stress, and depression in women waiting for IVF treatment. 120 women will be split into three groups: one using real lavender oil, one using a placebo scent, and one receiving no scent. Th…

This study tests whether a brain-training technique called neurofeedback can help reduce anxiety in women who have had repeated pregnancy losses. Participants use a headband that monitors brain activity and plays a calming sound when the brain is in a relaxed state. The trial com…

This study tests if receiving weekly supportive messages during pregnancy can improve live birth rates and quality of life for people who have had multiple pregnancy losses. About 60 pregnant participants will interact with the messages and complete surveys. The goal is to see if…

This study explores whether hyperbaric oxygen therapy (HBOT) can help men with low sperm count (oligospermia) improve their fertility. Researchers will measure changes in sperm count, shape, and movement in 15 participants. The goal is to see if HBOT offers a new, non-drug option…

This study tests whether pentoxyfilline, a drug that improves blood flow, can thicken the uterine lining and increase pregnancy rates in women with unexplained infertility undergoing frozen embryo transfer. About 100 women with good-quality embryos will receive the drug or a plac…

This study tests whether tadalafil, a drug that improves blood flow, can thicken the uterine lining and increase pregnancy rates in women with unexplained infertility. About 100 women who have good-quality frozen embryos will take tadalafil before embryo transfer. The main goal i…

This study looks at whether a smartphone app with daily mindfulness exercises can help reduce anxiety and improve quality of life for women undergoing IVF. About 150 women will either use the app for 15 minutes a day or receive standard care. Researchers will measure anxiety, dep…

This study tests whether taking Gushen Antai pills, a blend of 10 herbs, can increase the chance of an ongoing pregnancy (past 12 weeks) in women with normal ovarian reserve who are undergoing IVF. 800 women will be randomly assigned to receive either the herbal pill or a placebo…

This study tests a medicine called probenecid to see if it can improve sperm movement in men with spinal cord injury. Many of these men have normal sperm counts, but their sperm don't swim well, causing infertility. The trial will enroll 90 men and measure changes in sperm qualit…

This study tests whether taking semaglutide (a weight-loss medication) for 12 weeks before starting IVF can lead to better-quality embryos in overweight or obese women. About 62 women aged 38 or younger with a BMI between 27 and 40 will be randomly assigned to receive semaglutide…

This study tests whether a sedative called remimazolam, combined with alfentanil, can lower the chance of low oxygen levels (hypoxia) during egg retrieval for IVF. About 400 women aged 18-50 will be randomly assigned to receive either remimazolam or the standard drug propofol. Th…

This study tests whether using calming, reassuring words (verbal analgesia) can lower pain during a minimally invasive uterine exam in women with infertility. About 92 women will be randomly assigned to receive either verbal reassurance or standard care. The goal is to see if a s…

This study tests whether giving progesterone (a hormone) after intrauterine insemination (IUI) with mild ovarian stimulation increases the chance of a live birth. About 1,000 couples with unexplained infertility will take part. The goal is to see if this simple support can improv…

This study tests whether giving the painkiller ketorolac after egg retrieval can safely reduce pain without lowering the chance of pregnancy in fresh embryo transfers. About 200 IVF patients will be randomly assigned to receive either ketorolac or no ketorolac after their egg ret…

This study tests whether atosiban, a drug that relaxes the womb, can improve live birth rates in women who have had previous IVF failures and have abnormal womb contractions. About 792 women aged 20-40 will receive either atosiban or a placebo before a single embryo transfer. The…

This study compares two embryo transfer liquids—one with a high amount of hyaluronic acid (a natural 'sticky' substance) and one with a low amount—to see which leads to more live births. About 858 women having a single embryo transfer will take part. The goal is to find out if th…

This study tests a computer tool called Opt-IVF that creates personalized drug plans for women undergoing IVF. The goal is to improve the number and quality of eggs and embryos retrieved. About 200 infertile women will participate to see if this tailored approach leads to better …

This study tests whether a 9-step mindset management program called Organic Conceptions can reduce stress in women struggling with infertility. About 66 new patients at a fertility clinic will either take the program or serve as a control group. Researchers will measure stress le…

This study tests a new ultra-rapid freezing method for embryos (blastocysts) in women receiving donor eggs. The goal is to see if this faster approach is as safe and effective as the standard freezing method. Researchers will compare how many embryos survive thawing and how many …

This study aims to understand how reproductive disorders, such as delayed or early puberty, are inherited. Researchers will collect blood samples and medical histories from 850 people with these conditions and their family members. No treatment is provided; the goal is to identif…

This study collects and stores ovarian tissue from females aged 4 to 35 who choose to freeze a sample before cancer treatment that could harm their fertility. Researchers will also gather medical data and annual surveys for up to 30 years. The goal is to build a national database…

This study is looking at whether women with lower ovarian reserve (fewer eggs) have had more early miscarriages in the past. Researchers will measure ovarian reserve with a blood test (AMH) and an ultrasound (antral follicle count) in over 2,000 women seeking fertility care. This…

This study tracks immune-related substances in the blood of 40 women undergoing a frozen embryo transfer. Researchers want to see how these markers change before and after the transfer, and whether they relate to pregnancy success. The goal is to better understand the role of the…

This study looks at whether freezing ovarian tissue can help preserve fertility in people aged 2-21 with conditions like Turner syndrome, galactosemia, or premature ovarian insufficiency. Participants may have surgery to remove and freeze a gonad, with a small piece used for rese…

This study tests a new AI-assisted platform called IntelliWell to find rare sperm cells in testicular tissue from men with non-obstructive azoospermia, a condition where standard analysis finds no sperm. The platform processes tissue that would otherwise be discarded, and if sper…

This study follows women aged 18 to 44 who are trying to conceive at a fertility clinic. Researchers want to learn how lifestyle habits like sleep, nutrition, and physical activity before pregnancy affect the chances of having a baby. Participants will be followed for up to 25 ye…

This study looks at why some people's fertility treatments don't work. Researchers will follow 5,000 infertile patients (half men, half women) to see how things like pollution from plastics, daily habits, and social factors affect the chance of having a baby through treatments li…

This study is developing an artificial intelligence (AI) platform to analyze sperm samples and predict how likely they are to lead to a successful pregnancy during IVF. Researchers will collect and study 500 semen samples from men undergoing IVF, using AI to look for patterns tha…

This study is creating a biobank of male biological samples, such as sperm and testicular tissue, from men undergoing fertility treatments. The goal is to collect and store these samples for future research on male infertility and assisted reproductive technologies. Up to 1,000 p…

This study looks at how the age of the male partner and the way sperm is chosen might affect embryo growth in IVF. About 100 couples having their first IVF cycle will take part. Researchers will compare a special sperm selection device (Zymot) with the usual method to see which l…

This study uses embryos that were not used in fertility treatments to help researchers learn how to improve freezing methods and develop tests that predict which embryos are most likely to lead to a successful pregnancy. The goal is to make in vitro fertilization (IVF) more effec…

This study looks at whether changing the oxygen level during embryo growth in IVF can improve the chance of having a healthy, full-term baby. About 980 women undergoing IVF will have their embryos grown in either a constant 5% oxygen or a sequential 5% then 2% oxygen environment.…

This study looks at whether a single session of a brain stimulation technique called rTMS can change heart activity in women who have had multiple pregnancy losses and also have anxiety. Forty-six women will receive either real or fake stimulation while their heart rate is monito…

This study is observing 400 people aged 12 and older who have noncirrhotic portal hypertension (NCPH) or are at risk for it. NCPH is a liver condition that increases blood pressure in the liver's blood vessels without causing cirrhosis, and often has no early symptoms. Researcher…

This pilot study uses a special ultrasound technique called shear wave elastography to measure how stiff the uterus, cervix, and ovaries are in women with and without fertility problems. Researchers will track changes across the menstrual cycle in 40 women to establish normal ran…

This study looks at whether performing assisted hatching on day 3 or day 5-7 of embryo development leads to better outcomes in IVF. Researchers will compare blastulation rates and embryo quality in 75 participants. The goal is to find the optimal timing for this common lab proced…

This study looks at 300 women who had a C-section and are now having trouble getting pregnant or have other symptoms. Researchers use a special ultrasound called saline infusion sonohysterography (SIS) to check the scar on the uterus. The goal is to see how well SIS finds scar de…

This study explores whether a non-invasive brain stimulation technique called rTMS can change heart activity in women who have had multiple pregnancy losses and also suffer from anxiety. Fifty-five women will receive six different intensities of stimulation while their heart rate…

This study aims to help boys who need strong cancer treatments that could harm their ability to have children later. For those who haven't gone through puberty, doctors will freeze a small piece of testicular tissue to save stem cells. The goal is to protect future fertility and …

This study aims to discover the genetic reasons behind recurrent pregnancy loss (RPL) by analyzing DNA from parents and pregnancy tissue. Researchers at Yale University will enroll 500 women who have had multiple pregnancy losses. The goal is to identify genetic markers that pred…

This study gathers information from female Canadian Armed Forces members and Veterans about their reproductive health, including contraception, pregnancy, infertility, and pelvic floor issues. Researchers will use surveys and interviews to learn about their experiences, access to…

This study looks at how pesticides and the bacteria in your gut and genital tract might be linked to endometriosis and infertility. Researchers will compare 160 women with and without endometriosis to find patterns in their DNA and bacteria. The goal is to better understand the d…

This study aims to create a large genetic database of people with Turner syndrome, a rare condition where a person is missing all or part of an X chromosome. Researchers want to compare the genes of women with Turner syndrome who are fertile with those who are not. Up to 500 part…

This study looks at 1,000 women undergoing IVF to understand how tiny organisms in the womb (the microbiome) may cause chronic endometritis, a condition that can harm fertility. Researchers will collect samples from the vagina and womb to compare the microbes in women with and wi…

This study is for women undergoing frozen embryo transfer with hormone replacement therapy. It aims to see if higher progesterone levels on the day of transfer lead to higher pregnancy rates. Researchers will track 370 participants to better understand this link and improve ferti…

This study is testing a new technique called diamond magnetometry to measure free radicals in individual sperm cells and blood. Free radicals are natural but can damage sperm if out of balance. Researchers will also look at the bacteria in semen and how lifestyle and diet affect …

This study looks at whether a short diet change can improve sperm quality in men whose partners are undergoing IVF. One hundred couples in Sweden will take part. Men will follow Nordic dietary guidelines for a few weeks. Researchers will check sperm count, movement, and small RNA…

This study compares a new semi-automatic machine (GAVI®) to the standard manual method for freezing donor eggs. Researchers want to see if the machine can freeze eggs just as well, with similar survival rates after thawing. The trial involves 50 egg donors and will also look at f…

This study looks at whether measuring telomeres—parts of our cells linked to aging—can help explain why some women still can't get pregnant even after fertility treatments. Fifteen women aged 25 to 42 will get blood tests to check their biological age, then receive a personalized…

This study follows 900 couples in Paris who tried preimplantation genetic diagnosis (PGD) to avoid passing on a severe genetic disease but did not have a baby from it. Researchers want to know how many later have a healthy child naturally, through other treatments, or decide to s…

This study surveys 400 men undergoing ICSI due to low sperm quality. Researchers want to understand their emotional experiences, social burden, and testosterone levels, and compare results to a similar study from 2008. The goal is to see if men's needs in fertility care have chan…

This study tests whether an artificial intelligence program called STIMAI® can help choose the best day to give the final 'trigger' shot in IVF, compared to doctors making the decision alone. About 644 women undergoing ovarian stimulation for IVF will be randomly assigned to eith…

This study investigates whether blocking a protein called RANKL can help eggs mature and improve fertility treatments. Researchers will use denosumab, a drug already approved for osteoporosis, in lab studies with human and mouse eggs. The goal is to understand if RANKL manipulati…

This study collects and freezes testicular tissue from boys and young men who are at risk of becoming infertile due to cancer, autoimmune disorders, or their treatments. The tissue is stored in a research bank, with the hope that future medical advances will allow it to be used t…

This study compares two sperm collection timings—1 hour versus the usual 2-5 days of abstinence—to see which leads to more embryos with normal chromosomes during IVF. Researchers will track embryo health and pregnancy rates in 187 women. The goal is to find a simple way to improv…

This study looks at how the natural microbes and chemical profiles in couples' bodies relate to IVF outcomes. Researchers will collect samples from 1000 couples and track whether they have a baby, miscarriage, or other pregnancy results. The goal is to find patterns that might he…

This study tests whether a smartphone platform called Frame™ can help women who have had a first fertility consultation actually begin treatment and feel better emotionally. About 400 women from several fertility clinics will be randomly assigned to use the platform or not. Resea…

This observational study aims to identify and classify Traditional Medicine (TM) syndromes in men aged 18 to 60 with male infertility and oligoasthenoteratozoospermia (OAT) syndrome. Researchers will first review TM literature to list symptoms, then survey 300 participants and us…

This study compares two ways to screen embryos in women with polycystic ovary syndrome (PCOS) undergoing IVF. One method looks at DNA methylation patterns (PIMS), while the other checks for chromosome issues (PGT-A). The goal is to see if PIMS can lower the rate of early pregnanc…

This study looks at whether transferring embryos after 3 days or 5 days leads to more live births in IVF patients who have 5 or fewer embryos. About 1,126 people will take part, and researchers will also track patient satisfaction and complications. The goal is to help doctors an…

This study looks at whether blood-thinning medications (like aspirin or heparin) can improve the uterine lining and pregnancy rates in women struggling with infertility. Researchers will use special ultrasound scans to measure the womb's thickness, blood flow, and movement in abo…

This study aims to better understand cervical mucus and find biological markers that could help diagnose or predict reproductive problems like infertility. Researchers will use infrared spectroscopy to analyze mucus samples from 24 women—some healthy and some with unexplained inf…

This study is collecting cervical mucus from 476 women undergoing IVF or frozen embryo transfer. Researchers will analyze the proteins in the mucus to find markers that indicate when the uterus is most receptive to an embryo. By comparing samples from women who become pregnant wi…

This study looks at male factors that influence a couple's chance of getting pregnant. Researchers will compare fertile and subfertile couples to create a fertility index that combines male and female factors to predict pregnancy. The goal is to better understand male reproductiv…

This observational study aims to understand how the CFTR gene is regulated in epididymal cells, which may help explain male infertility linked to cystic fibrosis. Researchers will collect leftover tissue samples from 20 men already scheduled for surgery. No extra procedures are n…

This study tracks 356 women undergoing frozen embryo transfer to see how different hormone preparations affect uterine contractions (called endometrial peristalsis) and pregnancy rates. Researchers will measure contractions at three key times and link them to pregnancy outcomes. …

This study looks at immune cells in the womb lining and blood of women with unexplained infertility or repeated miscarriages, compared to fertile women. Researchers want to see if differences in these cells help explain why some women have trouble getting pregnant. The study invo…

This study follows 200 adult women who visit the gynecological emergency department for endometriosis or related symptoms. Researchers want to see if emergency care leads to proper follow-up, like specialist visits or imaging. The goal is to understand how well the emergency syst…

This study aims to find genes that may cause infertility in people with non-obstructive azoospermia (low or no sperm) or primary ovarian insufficiency (early menopause). Researchers will collect saliva samples from 500 adults to look for genetic differences. No new treatments are…

This study looks at how the uterus absorbs fluid during early pregnancy, which may affect fertility. Researchers will compare tissue samples from women with and without endometriosis or infertility. The goal is to understand the role of certain proteins in this process. No treatm…

This study compares two common forms of vaginal progesterone—soft capsules and pessaries—used during frozen embryo transfer. Researchers want to see which one women find more satisfying, convenient, and tolerable. About 400 women will use one of the two forms and report their exp…

This study follows 60 girls and women with classic galactosemia, a rare genetic condition that affects how the body processes sugar. Researchers want to understand why many develop early ovarian failure and how puberty progresses. By tracking hormone levels and growth, they hope …

This study aims to preserve fertility for up to 500 female patients under 40 who are at risk of infertility due to cancer, autoimmune diseases, or their treatments. Participants will have an ovary surgically removed and frozen for potential future use. Researchers will also study…

This study tests a new lab technique called HyperSperm to see if it can make sperm move better and stay healthy. Researchers will collect semen samples from 300 men with different fertility issues and compare the new method to the standard one. The goal is to find a safer and mor…

This study follows 650 women with endometriosis who want to have children after diagnosis. Researchers compare pregnancy rates and the need for fertility treatments between those who had surgery and those who took medication. The goal is to understand which approach leads to bett…

This study is testing whether an artificial intelligence (AI) tool can help people undergoing IVF treatment stay engaged and follow their doctor's recommendations. Researchers will enroll 774 infertility patients aged 18-45 in Portugal. The goal is to see if personalized AI guida…

This study looks at how infertility and fertility treatments like IVF affect women's sexual function and behavior. About 500 women under 45 with infertility will fill out an anonymous questionnaire about their sexual desire, satisfaction, and activities. The goal is to help docto…

This study compares two hormone protocols used during IVF to see which leads to better embryo development. About 148 women will be randomly assigned to receive either a fixed PPOS protocol or a GnRH antagonist protocol. Embryos will be monitored with a special time-lapse incubato…

This study looks at 1,000 women to see how ultrasound features of adenomyosis (a condition where the uterine lining grows into the muscle wall) match up with their symptoms like pain and heavy bleeding. Participants get one routine ultrasound and fill out a symptom questionnaire.…

This study is looking at how things in your everyday environment, like chemicals from plastics or air pollution, and personal habits, such as diet and stress, might affect the success of fertility treatments like IVF. Researchers will follow about 5,000 couples in China who are a…

This study aims to understand why people with Turner syndrome often lose their hearing. Researchers will look at genetic and epigenetic markers in 150 adults aged 18-60. Participants will have hearing, balance, blood, and imaging tests. The goal is to find new ways to treat or de…

This study is testing a new test called the Aurora test, which uses cells that normally surround the egg (cumulus cells) to help select the best embryo for transfer in IVF. The test is non-invasive and aims to improve pregnancy and live birth rates compared to the standard method…

This study will follow 2,500 Chinese women who are prescribed REKOVELLE for the first time during IVF or ICSI treatments. Researchers will track how the drug is used in routine practice, its effectiveness (including live birth rates), and any side effects. The goal is to understa…

This study looks at how physical activity, fitness, stress, and sleep affect pregnancy rates in women receiving fertility treatments like IVF or IUI. Researchers will track 115 women aged 18-43 to see if being more active improves their chances of getting pregnant. The goal is to…

This study follows 93 women with Turner syndrome who wanted to become parents. Researchers will track how many succeeded through natural pregnancy, egg donation, or adoption. The goal is to understand the real-world chances of parenthood for these women.

This study looks at different ways to track ovulation and the luteal phase using the Premom app. Thirty women will record cervical mucus, urine test results, and body temperature over three cycles. The goal is to see which combination of signs gives the most accurate picture of w…

This study follows 100 cancer patients aged 0-50 who used fertility preservation services to protect their ability to have children. Researchers will review medical records to see which methods led to successful pregnancies and what factors—like age or treatment type—influenced o…

This study compares the usual timing of the 'trigger' shot in IVF with a 1-2 day delay. Researchers want to see if waiting longer leads to more high-quality embryos and higher live birth rates. About 834 women undergoing their first or second IVF cycle will take part.

This study looks at how women getting infertility treatment feel about artificial intelligence and how that relates to their anxiety and quality of life. About 191 women aged 18-45 who are currently undergoing treatment will answer surveys. The goal is to understand if attitudes …

This study is testing whether an artificial intelligence tool can analyze 3D ultrasound images of the ovaries to better predict how well a woman will respond to fertility treatments like IVF. Researchers will enroll about 4,000 patients undergoing ovarian stimulation. The goal is…

This study watches blood sugar levels in 100 women getting fertility treatments like IVF. Participants wear a continuous glucose monitor to track sugar changes. The goal is to see if these changes affect pregnancy results. This is an observation-only study, not a treatment.

This study looks at how things in your environment—like pollution, chemicals, diet, and sleep—might affect your hormones and reproductive health. Researchers will follow 300 people aged 8 and older who have conditions like low or high hormone levels, early or late puberty, or inf…

This study looks at how different ovarian stimulation protocols affect blood clotting in 300 infertile women, including those with endometriosis. Researchers will measure clot formation and breakdown before and after treatment. The goal is to understand which protocols may be saf…

This study looks at whether low levels of a protein called mannose-binding lectin (MBL) in the blood are linked to repeated pregnancy loss or failed IVF attempts. Researchers will measure MBL levels in 500 women with these conditions and compare them to the general population. Th…

This study tests whether a new automated system can freeze human eggs and embryos as effectively as the current manual method. Researchers will compare survival rates after thawing between the two methods using surplus eggs and embryos from 125 IVF patients. If successful, automa…

This study follows 5,300 women aged 18-42 with endometriosis or adenomyosis to see if these conditions get worse over time. Researchers track pain, bleeding, fertility, and use imaging to monitor changes. They also explore immune system and gut bacteria links. No new treatment is…

This study collects and freezes testicular tissue from prepubertal boys before they start cancer treatment that has a high risk of causing infertility. The tissue is stored for potential future use to restore fertility and for research to better understand germ cell development. …

This study looks at whether chlordecone, a pesticide still present in the environment in Guadeloupe, is linked to fertility problems in women. Researchers will measure a key fertility hormone (AMH) and count egg follicles in 634 women seeking fertility treatment. The goal is to u…

This study looks at whether levels of Anti-Müllerian hormone (AMH) in the fluid around a woman's eggs can predict if an embryo has the right number of chromosomes. Researchers will collect fluid from one follicle in each ovary during egg retrieval in 300 women undergoing IVF. The…

This study looks at how searching for health information online affects stress and emotional well-being in women going through infertility treatment. Researchers will survey about 200 women to understand their online search habits, stress levels, and overall mental health. The go…

This study looks at two ways to fertilize eggs with frozen donor sperm: ICSI (injecting a single sperm into an egg) and conventional IVF (mixing eggs and sperm in a dish). About 95 women without male fertility issues will have their eggs split into two groups, one fertilized with…

This study uses artificial intelligence to analyze vaginal ultrasound images of the uterine lining taken during routine IVF treatment. The goal is to see if the AI can predict whether an embryo will successfully implant. Researchers will enroll 1,500 women aged 18-40 undergoing I…

This study is looking at how the uterus expands (distension) during a special ultrasound procedure in women who are having trouble getting pregnant and are undergoing IVF or ICSI. Researchers will compare these women to fertile women to see if there are differences. The goal is t…

This study follows 270 women under 40 who have had melanoma removed and are now taking adjuvant therapies like dabrafenib, trametinib, pembrolizumab, or nivolumab. Researchers will measure ovarian reserve using a blood test before and after treatment to see how these drugs affect…

This pilot study tests a program to help young female cancer survivors in rural Imperial County, California, get reproductive health care that matches their personal goals. The program includes a quick needs assessment during oncology visits, followed by a session with a social w…

This study looks at whether doing a laser-assisted hatching procedure on Day 3 or Day 5 of embryo growth changes the genetic test results in IVF. About 200 people having IVF with genetic testing will take part. The goal is to see if timing affects embryo health and the accuracy o…