Ear stimulation may boost IVF success – a trial investigates

NCT ID NCT06742788

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This pilot trial tests whether a non-invasive device that gently stimulates a nerve in the ear, called transcutaneous auricular vagus nerve stimulation (taVNS), is feasible and well-tolerated in people undergoing in vitro fertilization (IVF). The study will enroll 90 infertility patients aged 20 to 40 and compare taVNS to a sham device and no additional treatment. The main focus is on recruitment, adherence, and preliminary pregnancy outcomes, such as clinical pregnancy rates. If successful, this could lead to a larger trial to see if taVNS truly enhances IVF success.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive device that delivers mild electrical pulses to the ear
What this could lead to
If this approach proves feasible and shows promise, it could offer a drug-free, low-risk add-on to IVF that may improve pregnancy outcomes for people with infertility.
What could go wrong
This is a small pilot study focused on feasibility, not proof of effectiveness. The device may not meaningfully improve IVF outcomes, and individual responses can vary.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Xijing Hospital

    RECRUITING

    Xi'an, Shaanxi, 710032, China

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