Xijing Hospital

This phase 2 trial is testing whether giving a short course of targeted radiation (SBRT) followed by a reduced-dose chemotherapy (nab-paclitaxel) plus an immunotherapy drug (toripalimab) before surgery can improve outcomes for people with HR-positive, HER2-negative breast cancer.…

This trial is testing whether close follow-up is as good as adjuvant chemotherapy for patients with early-stage (IB-IIA) stomach or gastroesophageal junction cancer after curative surgery. Patients are divided into low-risk and high-risk groups based on factors like lymph node in…

This phase II trial is testing whether giving a combination of two immunotherapies (sintilimab and IBI-310) along with chemotherapy before surgery can improve outcomes for people with a specific type of locally advanced rectal cancer (MSI-H/dMMR). The main goal is to see how ofte…

This pilot trial tests whether a non-invasive device that gently stimulates a nerve in the ear, called transcutaneous auricular vagus nerve stimulation (taVNS), is feasible and well-tolerated in people undergoing in vitro fertilization (IVF). The study will enroll 90 infertility …

This early study tests a new treatment called S103 (BCMA-CAR T cells) in 9 adults with progressive or hard-to-treat multiple sclerosis (MS). The main goal is to see if the treatment is safe and to find the best dose. Researchers will also look for early signs that it might help c…

This study follows 3,000 ischemic stroke patients who also have cerebral microbleeds — tiny spots of old blood in the brain. Researchers are tracking how different antithrombotic drugs (blood thinners) affect the number of microbleeds and the risk of future strokes or brain bleed…

This trial investigates whether barbed sutures are a safe and effective way to close deep tissue incisions in obese patients undergoing posterior cervical spine surgery. Researchers will measure changes in spinal function, neck disability, and pain levels, as well as monitor for …

This study tests whether a precise, individualized version of a common spinal surgery can safely improve function and reduce pain in people with cervical spinal stenosis. Researchers will compare outcomes in 500 patients who receive the standardized open-door procedure with a tit…

This trial tests whether injections of platelet-rich plasma (PRP) — a concentrate from a person's own blood — can repair knee osteoarthritis and injuries to cartilage, meniscus, and ligaments. Researchers will compare PRP against standard hyaluronic acid injections in 300 adults …

This study looks at how the angle of the opened bone and other surgical details affect recovery in people with cervical spinal stenosis who undergo a single open-door surgery. Researchers will review records from 500 patients across multiple centers to see which factors lead to b…

This phase 3 trial tests whether giving inhaled nitric oxide during and after heart surgery can lower the risk of death or major complications like kidney failure, stroke, and heart failure. About 3,650 adults having elective heart surgery with a heart-lung machine will receive e…

This study looks at how safe and effective a less invasive heart valve replacement (called Sapien 3 TAVR) is for younger patients (ages 50-70) in China with severe aortic stenosis. Researchers will track 450 participants for up to 5 years to see survival rates and complications. …

This early-phase trial is testing whether a combination of two drugs—cadonilimab and a high-dose interferon—can safely shrink tumors in people with stage III or IV melanoma before they have surgery. Ten participants will receive the drugs for three months, and researchers will mo…

This study is testing whether a low branched-chain amino acid (BCAA) diet, when combined with an immunotherapy drug (anti-PD-1), is safe and effective for people with stage III melanoma. About 80 participants will receive either the special diet or a normal diet alongside the imm…

This study tests a drug called picankibart in 60 adults with moderate-to-severe palmoplantar pustulosis, a painful skin condition causing pus-filled blisters on hands and feet. Participants receive injections of picankibart over nearly a year. The goal is to see if it reduces the…

This phase 2 trial tests whether adding the immunotherapy drug serplulimab to standard chemotherapy before surgery helps patients with advanced stomach or gastroesophageal junction cancer. About 116 participants will receive either the combo or chemo alone for three cycles before…

This study compares a new dissolvable heart stent (Firesorb BRS) to a standard metal stent in 2000 people with coronary artery disease. The dissolvable stent is designed to support the artery temporarily and then disappear, potentially avoiding long-term risks of permanent stents…

This study tests a new 3D-printed biodegradable mesh used with a silicone implant for immediate breast reconstruction after mastectomy in women with breast cancer. The goal is to see if the mesh improves cosmetic results, patient satisfaction, and safety. The trial will enroll 25…

This phase 2 trial tests whether meplazumab, an antibody given by IV, can reduce inflammation and fatty buildup in the arteries of people with coronary artery disease. The study involves 18 participants and will compare three different doses to a placebo. It is an early, explorat…

This study tests a daily pill called ivarmacitinib for palmoplantar pustulosis (PPP), a chronic skin condition causing painful blisters on hands and feet. Sixty adults who haven't improved with other treatments will take the pill for 12 weeks. Researchers will check if symptoms l…

This early trial tests whether a device that sends mild electrical pulses to the sacral nerve can safely help control symptoms of ulcerative colitis. The study will enroll 15 adults whose disease has not responded well to standard medications. Researchers will track changes in di…

This study tests whether a non-invasive brain stimulation technique called TMS can improve recovery in people who have had a stroke and undergone a clot removal procedure. Sixty participants will receive either real or sham TMS sessions alongside standard care. Researchers will m…

This study compares two anesthetics—desflurane gas and propofol—during coronary artery bypass surgery. Researchers want to see if desflurane helps prevent major heart problems like heart attack or heart failure within 30 days after surgery. About 3,560 adults having planned bypas…

This early-phase study tests a new immunotherapy drug (QL1706) combined with short cycles of chemotherapy in 30 people with early-stage triple-negative breast cancer. The goal is to see if this approach can eliminate all signs of cancer before surgery. Participants receive either…

This large study is testing whether a combined screening approach—using a blood test for DNA markers plus stool tests for hidden blood and inflammation—can catch gastrointestinal cancers earlier and save lives. Researchers will randomly assign 10,000 adults aged 45–74 to either r…

This study aims to see if testing stool samples for multiple markers can accurately screen for stomach and colorectal cancers. About 5,000 adults scheduled for endoscopy will provide a stool sample before the procedure and be followed for two years. The goal is to develop a non-i…

This study aims to develop a blood test that detects RNA from tiny particles (exosomes) to predict if prostate cancer has spread to the bones. Researchers will analyze blood samples from 1,000 men with newly diagnosed prostate cancer and compare results with PSMA PET scans. The g…

This study is testing whether taking a delayed PET/CT scan 2-3 hours after injection of a radioactive tracer can better detect aggressive prostate cancer compared to the standard 60-minute scan. Researchers will enroll 1,000 men with suspected prostate cancer who have not yet had…

This study is testing a new blood test that looks for genetic material from tiny particles called exosomes to diagnose aggressive prostate cancer. The goal is to see if this test can accurately identify men who need a biopsy, avoiding unnecessary procedures. Researchers plan to e…

This study compares a special PET scan (68Ga-PSMA) with standard CT scans to see which better detects where kidney cancer has spread in 300 adults with advanced disease. Participants will receive both scans, and doctors will check if the PET scan changes treatment plans. The goal…

This trial tests whether a sedative nasal spray, given the night before and just before cardiac surgery, can reduce the chance of postoperative delirium—a state of confusion that can complicate recovery. The idea is that improving sleep before surgery may protect the brain. About…

This study tests whether a mild, painless electrical stimulation at specific acupoints on the hands can help people with disorders of consciousness after severe brain injury. The treatment is given daily for 14 days. Researchers will compare the stimulation to a sham (fake) treat…

This trial tests whether a technique called temporal interference (TI) stimulation can improve symptoms in people with narcolepsy type 1, a chronic brain disorder that causes severe daytime sleepiness. TI stimulation uses electric fields to target the hypothalamus, the brain regi…

This study tests whether a new painkiller called oliceridine fumarate can control pain after lumbar spine surgery while helping the gut recover faster. Standard opioids often cause constipation and slow digestion. The trial will compare oliceridine to the usual drug sufentanil in…

This study compares two common anesthetics—propofol and sevoflurane—to see which one causes less confusion (delirium) after surgery in older diabetic patients. Researchers will enroll 450 people aged 60 and older undergoing non-cardiac surgery. The goal is to find the best anesth…

This early-stage trial tests whether sodium aescinate, a compound from horse chestnut seeds, can safely reduce pain and disability in adults with chronic low back pain. Forty participants will take either the drug or a placebo twice daily for six weeks. Researchers will measure p…

This study is testing whether a device called TENS, which sends mild electrical pulses through the skin, can safely reduce chronic low back pain. Forty adults with mild pain will use the device for 20-30 minutes, five times a week for four weeks. Researchers will track pain level…

This study tests if a gentle magnetic pulse to the back of the brain (cerebellum) can help people with mild Alzheimer's disease think more clearly and feel better day-to-day. About 100 adults aged 50-85 will receive either real or fake stimulation over three months. The goal is t…

This study follows 1,500 adults having planned heart surgery to learn why some become confused or delirious afterward. Researchers will look at factors before surgery that raise the risk, and track patients over time to see how delirium affects their recovery and long-term health…

This observational study will follow 180 stroke patients who had a clot-removal procedure. Researchers will measure brain blood flow and electrical activity at days 1-3 and day 7 after treatment. The goal is to see if early changes in brain function can predict how well patients …

This study enrolls 200 people with acral or cutaneous melanoma who are starting standard immunotherapy. Researchers will collect blood samples every 3 weeks and tumor tissue after about 3 months of treatment. By analyzing circulating tumor cells, DNA, and other markers, they aim …

This study is testing whether a special type of scan called PSMA PET can better monitor how prostate cancer responds to treatment. Researchers will scan 110 men with high-risk prostate cancer before and after treatment to see if changes in the scan match standard measures like PS…

This study is testing whether a special type of PET scan (PSMA PET) can predict how prostate cancer will progress in people who are newly diagnosed and have not yet had any treatment. Researchers will follow 1000 participants for at least 2 years to see if the scan results can fo…

This study asks 600 people—heart disease patients and healthcare providers—to rate how serious different complications are, like heart attack or stroke, compared to death. The goal is to better understand if patients and doctors value these events differently. The results could h…

This study looks at what heart disease patients and their doctors prefer when choosing between two treatments: a permanent metal stent or a drug-coated balloon that dissolves over time. Researchers want to understand how much extra risk people are willing to accept to avoid havin…

This study looks at how sleep problems affect people with ulcerative colitis, a type of inflammatory bowel disease. Researchers will study 152 participants to see how sleep quality relates to gut bacteria, nerve function, and disease activity. The goal is to understand the connec…

This study looks at whether changes in DNA markers in the blood can show how well esophageal cancer treatment is working. Researchers will compare these markers with standard CT/MRI scans and tumor markers. The goal is to find a simpler, less invasive way to track treatment respo…

This study looks at how taking multiple medications (polypharmacy) affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older over two years to understand their medicati…